Clinical trials: Adverse Effect
Tuberculosis, Drug-Induced Liver Injury
A Pharamcogenomic Study for Isoniazid According to NAT2 Polymorphism Status
A clinical trial to investigate the appropriate dose of isoniazid according to NAT2 polymorphism status in Korean subjects
- Conditions
- Tuberculosis, Drug-Induced Liver Injury, Adverse Drug Event
- Trial name
- NCT03665402
- Testing
- Isoniazid
- Where
- South Korea
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Anesthesia, Anesthesia; Adverse Effect
Co-induction Technique Compared to Standard Inhalational and Intravenous Induction Techniques
Co-induction technique refers to the use of a combination of medications to reach the desired therapeutic target. In the present study, the investigators examined the safety of a novel co-induction approach that relied on a…
- Trial name
- NCT04284644
- Testing
- Induction using propofol, Induction using sevoflurane, Induction using propofol and sevoflurane
- Where
- Jordan
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- University of Jordan
Adverse Effects, Aggression
Aggressive Behavior Induced by Selective Serotonin Reuptake Inhibitors (SSRIs) During the First Month of Treatment
SSRIs are the first line of therapy for anxiety and depressive disorders and for many other clinical diagnoses. One of the most disturbing side effects that is observed is a tendency towards aggressiveness among patients…
- Trial name
- NCT00361062
- Testing
- comparative computer simulation
- Where
- 2 sites in Israel
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- HaEmek Medical Center, Israel
Atrial Fibrillation, Medication Adherence
Adherence and Coagulation Assays in Dabigatran-treated Patients With Atrial Fibrillation
In patients with non-valvular atrial fibrillation treated with dabigatran etexilate, the level of adherence will be measured using a questionnaire, the Danish National Prescription Registry and pillcount and will be related to…
- Conditions
- Atrial Fibrillation, Medication Adherence, Blood Coagulation Tests, Anticoagulants; Circulating, Hemorrhagic Disorder
- Trial name
- ARCADE (NCT03280368)
- Testing
- Bloodtest, Questionnaires
- Where
- Denmark
- Volunteers
- 430 people, healthy volunteers welcome
- Sponsor
- Hospitalsenheden Vest
Patient Safety, Adverse Drug Event
Partnering With Patients for Improving Medication Safety During Transitions of Care: Implications for Work System Design
This project is to develop, implement, pilot evaluate, and disseminate a medication safety program (HomeTeam) that consolidates strategies to help patients by partnering with patients and their informal caregivers during…
- Trial name
- NCT03544034
- Testing
- HomeTeam Toolkit
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Anesthesia, Anesthesia; Adverse Effect
Dexamethasone vs Bicarbonate to Intracuff Lignocaine 2% in General Anaesthesia
This study is designed to evaluate and compare the effect on hemodynamics, extubation response and patients satisfaction score in patients with ETT cuff filled with either mixture of lignocaine with sodium bicarbonate or with a…
- Conditions
- Anesthesia, Anesthesia; Adverse Effect, Anesthesia Intubation Complication
- Trial name
- NCT03833947
- Testing
- lignocaine+bicarbonate, lignocaine+dexamethasone
- Where
- India
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Aligarh Muslim University
Anesthesia; Adverse Effect, Spinal and Epidural, Hip Arthropathy
Comparison of Three Different Sitting Positions for Performing Combined Spinal-Epidural Anesthesia
In this prospective and randomized study, we aimed to compare the effect of of three sitting positions (the traditional sitting position (TSP), the harmstring stretch position (HSP), and the squatting position on the success rate…
- Conditions
- Anesthesia; Adverse Effect, Spinal and Epidural, Hip Arthropathy, Knee Arthropathy
- Trial name
- NCT03541798
- Testing
- positions of patients for combined spinal-epidural anesthesia, Combined spinal epidural anesthesia
- Where
- Turkey (Türkiye)
- Volunteers
- 360 people, healthy volunteers welcome
- Sponsor
- Diskapi Teaching and Research Hospital
Adverse Effect of Drug Therapy Metabolism Medications (Diagnosis)
Bupropion Stereoselective Disposition and CYP2D6-mediated Drug Interactions in Healthy Volunteers
Primary objectives: 1. To comprehensively characterize steady state stereoselective pharmacokinetics of bupropion and its primary and secondary metabolites in healthy volunteers 2.
- Trial name
- NCT03420469
- Testing
- Bupropion
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Indiana University
Effect of Drugs, Adverse Effects of Medical Drugs
Comparison of Efficacy of Tranexamic Acid Mesotherapy Versus 0.9% Normal Saline for Melasma
It is a randomized controlled trial in which investigators determine the efficacy of tranexamic acid (TA) by mesotherapy in comparison to normal saline on participants having Melasma.
- Trial name
- NCT04170088
- Testing
- Tranexamic Acid, 0.9% Normal Saline
- Where
- Pakistan
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Jinnah Postgraduate Medical Centre
Drug-induced Disorder of Liver, Adverse Reaction to Drug
Cells of Monocytic Origin as Surrogate Markers for Individual Drug Effects and Hepatotoxicity
Drug metabolism in the liver is subject to large fluctuations (differences between women and men, people of different ethnic backgrounds, children and adults).
- Trial name
- NCT02353455
- Testing
- Blood sampling
- Where
- 5 sites in Australia, Germany and 3 more
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Andreas Benesic, MD
Noise; Adverse Effect
Impact of Noise on Anesthesiologists' and Trainees' Situational Awareness in a High Fidelity Simulation Environment
The study is a single blinded randomized control trial. Participants were blinded to the purpose of the study and to the level of noise they would be exposed.
- Trial name
- NCT04138082
- Testing
- Exposition to high-dB soundtrack
- Where
- Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Maisonneuve-Rosemont Hospital
Weightlessness, Weightlessness; Adverse Effect
Thigh Cuffs to Prevent the Deconditioning Induced by 5 Days of Dry Immersion
The objective of the study is to investigate whether thigh cuffs help to prevent and/or reduce the deconditioning induced by 5 days of dry immersion and in particular the fluid shift and its related ophthalmological disorders.
- Trial name
- DI-Cuff (NCT03915457)
- Testing
- Dry immersion Control Group, Thigh cuffs intervention
- Where
- France
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Centre National d'Etudes Spatiales
Medication Reconciliation, Adverse Drug Events
Using Novel Canadian Resources to Improve Medication Reconciliation at Discharge
The purpose of this study is to determine if a physician's use of electronic medication reconciliation software when writing a patient's discharge prescription will prevent adverse drug events and readmissions to the hospital.
- Trial name
- NCT01179867
- Testing
- Electronic Medication Reconciliation
- Where
- Canada
- Volunteers
- 4,014 people, healthy volunteers welcome
- Sponsor
- McGill University
Sickle Cell Trait, Environmental Exposure
Sickle Cell Trait and Exercise, Effect of Hot Environment
The heterozygous form of sickle cell disease is clinically asymptomatic. Nevertheless, it was observed that, the sickle cell trait is associated with serious medical complications especially during intense physical efforts.
- Conditions
- Sickle Cell Trait, Environmental Exposure, Adverse Effect
- Trial name
- TDex (NCT04028791)
- Testing
- Exercise on ergocycle
- Where
- Guadeloupe
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- University of the French West Indies and French Guiana
Central Line-Associated Bloodstream Infection (CLABSI), Venous Thromboembolism
Patient Safety Learning Laboratory: Making Acute Care More Patient-Centered
The Brigham and Women's Hospital (BWH) Patient Safety Learning Laboratory (PSLL) focuses on developing health information technology (HIT) tools to engage patients, family, and professional care team members in reliable…
- Conditions
- Central Line-Associated Bloodstream Infection (CLABSI), Venous Thromboembolism, Patient Fall, Catheter-Associated Infection
- Trial name
- PSLL (NCT02969343)
- Testing
- Patient Safety health information technology
- Where
- United States
- Volunteers
- 21,000 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Adverse Effect and Immunogenicity of Vaccine
Immunogenicity and Safety of A Lyophilized Purified Human Diploid Cell Rabies Vaccine .
Rabies is caused by rabies virus with a 100% mortality rate in humans. Most of cases occur in Africa and Asia, mainly in underserved populations. Rabies is a vaccine-preventable disease in both humans and animals.
- Trial name
- NCT03971370
- Testing
- Human diploid cell rabies vaccine (Minhai Biothechnology Co., Ltd), Human diploid cell rabies vaccine (Chengdu Kanghua Biological Products Co., Ltd.)
- Where
- China
- Volunteers
- 1,800 people, healthy volunteers welcome
- Sponsor
- Jiangsu Province Centers for Disease Control and Prevention
Anxiety, Surgery
Could Music be an Alternative to Sedation in Patients Treated Total Knee Arthroplasty With Regional Anesthesia?
Background: Anxiety is a common phenomenon in hospitalized patients. In order to reduce it during the surgical procedure, sedatives and anxiolytics are used, which can cause undesirable side effects for patients.
- Conditions
- Anxiety, Surgery, Drug Toxicity, Anesthesia
- Trial name
- NCT03882541
- Testing
- Music therapy, Sedation with midazolam
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- Consorci Sanitari de l'Anoia
Cognitive Changes Due to Organic Disorder (Finding), Dementia
Gerontology Research Programme: The Singapore Longitudinal Ageing Studies (SLAS I & II)
The Gerontology Research Programme (GRP) in the National University Singapore's Department of Psychological Medicine, was formed to coordinate and facilitate the conduct of multi-disciplinary research on in a wide range of…
- Conditions
- Cognitive Changes Due to Organic Disorder (Finding), Dementia, Mild Cognitive Impairment, Frailty
- Trial name
- SLAS (NCT03405675)
- Testing
- SLAS 1, SLAS 2
- Where
- Singapore
- Volunteers
- 6,183 people, healthy volunteers welcome
- Sponsor
- National University of Singapore
Acute Kidney Injury, Hypotension
A Pilot Analysis of the Association Between Anesthesia Induction Dosing and AKI in the Elderly Population
This study proposes to perform a pilot observational study looking at the doses of propofol used for the induction of general anesthesia and its association with the development of hypotension and AKI among elderly patients at…
- Conditions
- Acute Kidney Injury, Hypotension, Anesthesia; Adverse Effect
- Trial name
- NCT03699696
- Testing
- Propofol
- Where
- United States
- Volunteers
- 541 people, healthy volunteers welcome
- Sponsor
- Yale University
Drug-Related Side Effects and Adverse Reactions
A Positron Emission Tomography (PET) Imaging Study to Investigate the Biodistribution and Clearance of an Albumin Binding Domain Antibody (AlbudAb) GSK3128349 in Healthy Male Subjects
GSK3128349 is a small protein molecule (biopharmaceutical) that binds to albumin in the body, and by itself, has no pharmacological action.
- Trial name
- NCT02829307
- Testing
- 89Zr-GSK3128349 1 mg
- Where
- Netherlands
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline