Clinical trials: Adverse Effects
Birth Weight, Birth, Preterm
The Effect of Non-surgical Periodontal Therapy on Adverse Birth Outcomes Randomized Controlled Trial
The main objective of this study is to determine whether the provision of non-surgical periodontal therapy to pregnant women with periodontitis is effective in reducing the incidence of low birth weight, preterm birth and still…
- Trial name
- NSPT (NCT03126006)
- Testing
- NSPT plus oral hygiene, Oral hygiene alone
- Where
- Pakistan
- Volunteers
- 115 people, healthy volunteers welcome
- Sponsor
- Aga Khan University
Acne Vulgaris
Reduced Side-Effects of Photodynamic Therapy for the Treatment of Moderate to Severe Acne (i-PDT)
This research study aims to compare different methods for helping difficult to treat or scarring (cystic) acne, ALA-PDT and i-PDT.
- Trial name
- i-PDT (NCT01689935)
- Testing
- 20 % Aminolevulinic Acid, Red light only, Blue light only
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Injection Site Reaction
Prospective Study to Assess Tissue Responses After Injection With Biostimulatory Products
The objective of this study is to identify and assess in vivo tissue responses after injection with various biostimulatory products at various timepoints.
- Trial name
- NCT06093815
- Testing
- Injection
- Where
- Spain
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Merz North America, Inc.
Chemotherapy Side Effects, Machine Learning
Prospective Validation of Machine Learning Model to Predict Platinum Induced Nephrotoxicity in Cancer Patients
This study aims to investigate the utility of predictive models for chemotherapy-induced nephrotoxicity in the Taiwanese cancer population.
- Conditions
- Chemotherapy Side Effects, Machine Learning, Acute Kidney Injury, Acute Kidney Disease
- Trial name
- NCT07114276
- Testing
- Machine learning models predictions of acute kidney injury and acute kidney disease
- Where
- Taiwan
- Volunteers
- 77 people, healthy volunteers welcome
- Sponsor
- Taipei Medical University
Obesity
Evaluation of the Efficacy of Chinese Herbal Medicine in Patients With Obesity
Obesity is defined as abnormal or excessive fat accumulation. It is a complex disease with multifactorial etiology. Although the prevalence of obesity is generally greater in elders and women, obesity rates have increased in all…
- Trial name
- NCT04481464
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- China Medical University Hospital
Laryngeal Mask Airway
Three Inflation Methods of Ambú Auragain™ and Its Adverse Effects
Laryngeal mask is a common supraglottic device (SGD) used in the daily practice for airway management. Consecutive generations have permitted an expansion of its use.
- Trial name
- NCT04795544
- Testing
- Intracuff pressure measurement
- Where
- Spain
- Volunteers
- 210 people, healthy volunteers welcome
- Sponsor
- Instituto de Investigación Hospital Universitario La Paz
Turner Syndrome, Hypogonadism; Ovarian
Long Term Effects of Oral Versus Transdermal Estrogen Replacement Therapy in Turner Syndrome
This 14-month, phase IV, randomized controlled crossover trial aims to compare the effects of oral versus transdermal estrogen replacement therapy (ERT) in women with Turner syndrome (TS).
- Conditions
- Turner Syndrome, Hypogonadism; Ovarian, Hormone Replacement Therapy, Estrogen Replacement Therapy
- Trial name
- NCT06570460
- Testing
- 17-beta estradiol
- Where
- Denmark
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Aarhus University Hospital
Adverse Effects, Healthy
Effect of Probiotic Intake in Healthy Population
The main objective of this project is to evaluate the absence of adverse gastrointestinal effects following the consumption of a daily probiotic capsule during 15 days.
- Trial name
- PROBIO (NCT07165457)
- Testing
- Probiotic group
- Where
- Spain
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Clinica Universidad de Navarra, Universidad de Navarra
Post Operative Pain, Opioid Side Effects
Find the Adequate Dose of Nalbuphine for Laparoscopic Cholecystectomy
This study evaluate the adequate dose of mutonpain for laparoscopic cholecystectomy in the management of post operative pain. The investigators will randomize patients into three groups to compare the analgesia effects and side…
- Trial name
- NCT04135534
- Testing
- group A, group B, group C
- Where
- Taiwan
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Kaohsiung Medical University Chung-Ho Memorial Hospital
Poisoning
Mechanisms of N-acetylcysteine Mediated Vascular Adverse Effects
Paracetamol overdose is the leading cause of acute liver failure in the Western World. N-acetylcysteine (NAC) has been the antidote of choice for over 30 years but its use is associated with adverse effects in 40% of cases.
- Trial name
- NCT01209455
- Testing
- Chlorphenamine and Ranitidine, Paracetamol
- Where
- United Kingdom
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Adverse Effect of Drugs and Medicaments in Therapeutic Use
Study to Assess the Safety and Pharmacokinetics of ATL-001 (Ciclopirox Olamine) in Healthy Volunteers
The goal of this clinical trial is to assess the safety, tolerability and pharmacokinetics of ATL-001 (ciclopirox olamine) in healthy volunteers
- Trial name
- NCT05647343
- Testing
- Ciclopirox Olamine Oral
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Atlas Molecular Pharma
Laryngeal Mask Airway
Three Inflation Methods of the Ambú Auraonce™ and Its Adverse Effects
Laryngeal mask airway device (LMA) is a common device used in the daily practice for airway management. Consecutive generations have permitted an expansion of its use, probably because of a rapid increase of ambulatory surgical…
- Trial name
- NCT04769791
- Testing
- intracuff pressure measurement
- Where
- Spain
- Volunteers
- 210 people, healthy volunteers welcome
- Sponsor
- Instituto de Investigación Hospital Universitario La Paz
Antibiotic Allergy
Support Tool for Antibiotic Allergy deLabeling
Antibiotic allergy labels (AAL) are reported in 7% of inpatient's charts, especially for beta-lactams (86% of AAL, i.e., prevalence of 6%).
- Trial name
- STAAL (NCT06771440)
- Testing
- EPR search
- Where
- Belgium
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Hot Weather; Adverse Effect, Kidney Dysfunction
Renal Considerations in the Heat Stress Recommendations (Aim2)
An epidemic of chronic kidney disease is occurring in laborers who undertake physical work outdoors in hot conditions. The reason for this is largely unknown, but may be related to kidney dysfunction caused by increases in body…
- Conditions
- Hot Weather; Adverse Effect, Kidney Dysfunction, Kidney Injury, Hyperthermia
- Trial name
- NCT05458843
- Testing
- Fluid replacement, No fluid replacement
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Indiana University
Airway Morbidity, Smoking Cessation
Adverse Airway Effects From Tobacco and E-Cigarettes
The purpose of the study conducted at VA Medical Center in Miami is to determine if smoking electronic cigarettes (known as e-cigarettes) that contain nicotine have less negative effects than regular cigarettes on the person's…
- Conditions
- Airway Morbidity, Smoking Cessation, Nicotine Adverse Reaction, Smoking, Tobacco
- Trial name
- NCT03251053
- Testing
- Electronic cigarette use, Control regular cigarette smokers
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Miami VA Healthcare System
Cancer Survivor, Childhood Acute Lymphoblastic Leukemia in Remission
Culturally Adapted Parenting Intervention for Spanish-Speaking Parents in Improving Outcomes of Younger Acute Lymphoblastic Leukemia or Acute Myeloid Leukemia Survivors at Risk for Late Neurocognitive Effects
This pilot clinical trial studies a culturally adapted skills training and educational intervention in guiding parents of younger acute lymphoblastic leukemia (ALL) or acute myeloid leukemia (AML) survivors at risk for long-term…
- Conditions
- Cancer Survivor, Childhood Acute Lymphoblastic Leukemia in Remission, Childhood Acute Myeloid Leukemia in Remission, Cognitive Side Effects of Cancer Therapy
- Trial name
- NCT02559557
- Testing
- Educational Intervention, Quality-of-Life Assessment, Questionnaire Administration
- Where
- United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- City of Hope Medical Center
Human Papillomavirus Vaccines, Efficacy, Self
A Multicenter Cohort Study Assessing the Efficacy and Adverse Effects of HPV Vaccination in Chinese Women
Human papillomavirus (HPV) is currently one of the most common sexually transmitted infections, according to its carcinogenicity is divided into high-risk genotypes and low-risk genotypes, research has confirmed that carcinogenic…
- Conditions
- Human Papillomavirus Vaccines, Efficacy, Self, Adverse Effect, China
- Trial name
- NCT05932576
- Where
- 5 sites in China
- Volunteers
- 12,000 people, healthy volunteers welcome
- Sponsor
- Fujian Maternity and Child Health Hospital
Drug-Induced Liver Injury, Liver Failure
Comparative Study of Circulating microRNA Changes in Patients With Liver Injury and Healthy Subjects
The objectives are to: 1. validate a panel of tissue-specific miRNAs that are differentially expressed in the plasma of patients with and without liver injuries 2.
- Trial name
- NCT03000621
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Electronic Science and Technology of China
Iron Deficiency Anemia of Pregnancy
Daily vs Intermittent Iron Therapy in Pregnancy
This is a randomized non inferiority trial to evaluate the response to iron therapy in the standard daily vs. intermittent (three-four times a week on nonconsecutive days) groups by using hematological markers (hemoglobin…
- Trial name
- NCT03706638
- Testing
- Ferrous Sulfate
- Where
- United States
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- UConn Health
Sickle Cell Trait, Environmental Exposure
Sickle Cell Trait and Exercise, Effect of Hot Environment
The heterozygous form of sickle cell disease is clinically asymptomatic. Nevertheless, it was observed that, the sickle cell trait is associated with serious medical complications especially during intense physical efforts.
- Conditions
- Sickle Cell Trait, Environmental Exposure, Adverse Effect
- Trial name
- TDex (NCT04028791)
- Testing
- Exercise on ergocycle
- Where
- Guadeloupe
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- University of the French West Indies and French Guiana