Clinical trials: Adverse Reaction
HIV
Male Engagement in PMTCT Services
The study employs a quasi-experimental design in 8 public health centers in southwest Uganda offering care and treatment (C\&T) services.
- Trial name
- NCT01903889
- Testing
- clinic based intervention, clinic and community based intervention
- Where
- 7 sites in Uganda
- Volunteers
- 3,806 people, healthy volunteers welcome
- Sponsor
- FHI 360
Cardiovascular Diseases, B-cell Acute Lymphoblastic Leukemia
CAR T Cell Therapy Related Cardiovascular Outcomes
This will be a cohort study of all patients receiving Cluster of Differentiation 19 (CD19)-specific CAR T cell therapy for relapsed/refractory B cell haematological malignancies.
- Conditions
- Cardiovascular Diseases, B-cell Acute Lymphoblastic Leukemia, B-cell Lymphoma Refractory, B-cell Lymphoma Recurrent
- Trial name
- CARTCO (NCT05130489)
- Where
- United Kingdom
- Volunteers
- 150 people
- Sponsor
- University College London Hospitals
Nicotinamide Adverse Reaction
Tolerance and Efficacy Nicotinamide (Vitamin B3) in Dominant Optic Atrophy OPA1
Dominant Optic Atrophy (hereafter known as DOA) is a neurodegenerative pathology of the optic nerve inducing progressive loss of central visual field and visual acuity. There is currently no proven treatment for this disease.
- Trial name
- NICOPA1-TOL (NCT06007391)
- Testing
- Nicotinamide
- Where
- France
- Volunteers
- 25 people
- Sponsor
- University Hospital, Angers
Rectal Cancer, Gastric Cancer
The Effect of Bone Marrow-sparing Intensity-Modulated Radiotherapy to GI Cancer
Concurrent chemotherapy with external beam radiotherapy is the standard treatment of bulky or locally advanced cervical cancer, gastric cancer and rectal cancer.Despite excellent therapeutic results, acute hematologic toxicity…
- Conditions
- Rectal Cancer, Gastric Cancer, Bone Marrow Toxicity, Adverse Effect of Radiation Therapy
- Trial name
- IMRT (NCT01863420)
- Testing
- Bone Marrow-sparing Intensity-Modulated Radiotherapy
- Where
- China
- Volunteers
- 58 people
- Sponsor
- Chinese Academy of Medical Sciences
COVID-19 Vaccine Adverse Reaction
Assessment of Safety and Satisfaction Toward COVID-19 Vaccines.
This is a cross-sectional, web-based online survey done with the use of a Google Form-questionnaire to gather information from the general public regarding their knowledge, satisfaction, and tolerability about the COVID-19…
- Trial name
- NCT05857176
- Testing
- COVID-19 Vaccine questionnaire
- Where
- Egypt
- Volunteers
- 508 people
- Sponsor
- Damanhour University
Dyskinesia, Drug-Induced, Parkinson Disease
Safinamide for Levodopa-induced Dyskinesia (PD-LID)
This will be a prospective, multi-center, randomized, double-blind, parallel group, placebo-controlled study, in participants with PD who are on a stable regimen of dopaminergic medication and have at least mild levodopa-induced…
- Trial name
- NCT03987750
- Testing
- Safinamide Methanesulfonate 150mg, Safinamide Methanesulfonate 100mg
- Sponsor
- Zambon SpA
Cardiotoxicity, Thoracic Radiotherapy
Optimizing Radiation Dose and Utilizing Wearable Devices to Reduce Arrhythmia Risk in Patients Undergoing Thoracic Radiotherapy: A Prospective Cohort Study
This prospective observational cohort study aims to assess the risk of radiation-induced cardiotoxicity in patients undergoing thoracic radiotherapy by integrating real-time arrhythmia monitoring using wearable cardiac…
- Conditions
- Cardiotoxicity, Thoracic Radiotherapy, Wearable Electronic Devices, Thoracic Neoplasms
- Trial name
- NCT06897189
- Where
- South Korea
- Volunteers
- 111 people
- Sponsor
- Yonsei University
Breast Cancer, Cardiac Toxicity
Lisinopril or Coreg CR® in Reducing Side Effects in Women With Breast Cancer Receiving Trastuzumab
RATIONALE: Lisinopril or Coreg CR®, may help reduce side effects caused by trastuzumab. It is not yet known whether lisinopril or Coreg CR® are more effective than a placebo in reducing side effects caused by trastuzumab.
- Trial name
- NCT01009918
- Testing
- Coreg CR®, lisinopril
- Where
- 174 sites in United States
- Volunteers
- 468 people
- Sponsor
- University of South Florida
Procedural Sedation, Colonoscopy
Effect of Discontinuing Propofol After Cecal Intubation on Patient's Psychomotor Recovery Following Colonoscopy
This study investigates whether discontinuing the continuous intravenous infusion of propofol immediately after cecal intubation would reduce the patient's recovery time without compromising their comfort or convenience.
- Conditions
- Procedural Sedation, Colonoscopy, Cecal Intubation Success Rate, Propofol Adverse Reaction
- Trial name
- NCT07168135
- Testing
- propofol (drug)
- Where
- Lebanon
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- American University of Beirut Medical Center
Beta Lactam Adverse Reaction
Optimization of Perioperative Antibiotic Prophylaxis in Patients Allergic to Beta-lactams in the Orthopedic Surgery and Trauma Departments
When surgery is required, a consultation with an anesthesiologist is mandatory. This preoperative consultation allows for the selection of the appropriate antibiotic prophylaxis tailored to the patient and the type of procedure.
- Trial name
- ORTHO-PEN (NCT07342647)
- Where
- France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Strasbourg, France
Kidney Failure, Acute
Achieving Medication Safety During Acute Kidney Injury
The utilization of clinical decision support (CDS) is increasing among healthcare facilities which have implemented computerized physician order entry or electronic medical records.
- Trial name
- NCT01134900
- Testing
- Pharmacy Dashboard Review and Intervention
- Where
- United States
- Volunteers
- 540 people
- Sponsor
- Vanderbilt University
Neuralgia, Postherpetic
Lamictal in the Treatment of Post-Herpetic Neuralgia
To assess the efficacy of Lamictal for the treatment of pain and reduction of allodynia in patients with post herpetic neuralgia.
- Trial name
- NCT00295776
- Testing
- Lamictal in the treatment of Post-Herpetic Neuralgia
- Where
- United States
- Sponsor
- George Washington University
Pregnancy Prevention
Continuous Use of COCs
The primary objective is to determine if continuous COC use leads to higher continuation rates over 12 months of follow up than use of the standard 28-day COC regimen.
- Trial name
- NCT00570440
- Testing
- Oral contraceptives--ethinyl estradiol, levonorgestrel
- Where
- 2 sites in Dominican Republic, Nicaragua
- Volunteers
- 362 people, healthy volunteers welcome
- Sponsor
- FHI 360
Cisplatin Nephrotoxicity, Cisplatin Adverse Reaction
Safety Study of GMDTC Injection in Participants With Solid Tumors and Cisplatin-Induced Renal Dysfunction
This trial is a multicenter, combined hydration, multiple-dose, dose-escalation phase Ib clinical study, designed to evaluate the safety, tolerability, pharmacokinetic and pharmacodynamic characteristics of the injection product…
- Trial name
- NCT07824843
- Testing
- GMDTC 1 mg/ml, GMDTC 2mg/ml, GMDTC 3mg/ml
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Guangdong Jianersheng Pharmaceutical Technology Co., Ltd.
Cardioplegia Solution Adverse Reaction
Outcome of Esmolol Potassium Cardioplegia Compared to Potassium Cardioplegia in Patients With Solitary Valvular Disease; Randomized Controlled Study
Perioperative myocardial injury remains one of the most serious complications of cardiac surgery. Numerous factors have been implicated during the pathogenesis process, including the technique of cardiac surgery, induction of…
- Trial name
- NCT04306913
- Testing
- Esmolol, Potassium Cardioplegic Solution
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Kasr El Aini Hospital
Side-effect of Antibiotic, Efficacy
Pharmacokinetics and Pharmacodynamics of Linezolid Continuous and Intermittent Administration
The purpose of this study is to evaluate the therapeutic efficacy expressed in pharmacokinetic/pharmacodynamic (PK/PD) indices, the clinical response and the risk of adverse reactions following the continuous and intermittent…
- Conditions
- Side-effect of Antibiotic, Efficacy, Pharmacokinetics, Critical Illness
- Trial name
- NCT05801484
- Testing
- Linezolid continuous infusion
- Where
- Romania
- Volunteers
- 60 people
- Sponsor
- Cluj Municipal Clinical Hospital
Cardiotoxicity, Atherosclerosis
Atherosclerosis in Chemotherapy-related Cardiotoxicity
Cardiological complications of oncological treatment, including the most serious of them cardiotoxicity and heart failure, constitute a significant and still unsolved clinical problem.
- Trial name
- ANTEC (NCT05118178)
- Testing
- echocardiography, computed tomography
- Where
- Poland
- Volunteers
- 80 people
- Sponsor
- Maria Sklodowska-Curie National Research Institute of Oncology
Cardiotoxicity, Osteosarcoma
Evaluation of Myocardial Injury After Anthracycline Chemotherapy in Osteosarcoma Patients Using CMR
using a contrast-enhanced (CE) cardiac magnetic resonance imaging(CMR) which included the measurement of T1 mapping, T2 mapping, T2* mapping and late gadolinium enhancement(LGE) sequences, as well as LVEF and extracellular…
- Conditions
- Cardiotoxicity, Osteosarcoma, Myocardial Injury, Chemotherapy Induced Systolic Dysfunction
- Trial name
- NCT04461223
- Testing
- contrast-enhanced cardiac magnetic resonance imaging(MAGNETOM Aera 1.5T)
- Where
- China
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Sedative Adverse Reaction
Target Controlled Infusion Using Propofol and Remifentanil for Moderate Sedation in Dentistry
The purpose of this university study is to evaluate the use of an advanced dental sedation technique involving two syringe-type pumps called Target Controlled Infusion (TCI) pumps.
- Trial name
- NCT03995134
- Testing
- Propofol and Remifentanil administered by TCI pump
- Where
- 2 sites in Canada, New Zealand
- Volunteers
- 101 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Tuberculosis, Alcohol Consumption
The Impact of Alcohol Consumption on Tuberculosis Treatment Outcomes
After HIV/AIDS, tuberculosis (TB) remains the second leading cause of death due to an infectious disease globally. Retrospective studies from many countries, including the United States and South Africa, have consistently…
- Conditions
- Tuberculosis, Alcohol Consumption, Treatment Adverse Effect
- Trial name
- NCT02840877
- Testing
- DOT Adherence Monitoring
- Where
- South Africa
- Volunteers
- 303 people
- Sponsor
- Boston Medical Center
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