Clinical trials: Adverse Reaction
Advanced Neuroendocrine Neoplasm, Carcinoid Syndrome
Retifanlimab (INCMGA00012) and Telotristat Ethyl for the Treatment of Advanced Neuroendocrine Tumors and Carcinoid Syndrome
This phase II trial studies the effect of retifanlimab and telotristat ethyl in treating patients with neuroendocrine tumors that have spread to other places in the body (advanced) and carcinoid syndrome.
- Trial name
- NCT04776876
- Testing
- Retifanlimab, Telotristat Ethyl
- Sponsor
- M.D. Anderson Cancer Center
Elderly, Chronic Disease
Pharmaceutical Care and Clinical Outcomes for the Elderly Taking Potentially Inappropriate Medication
The investigators propose that clinical pharmacist interventions would reduce the rate of adverse drug events in elderly patients taking potentially inappropriate medication.
- Trial name
- NCT00844025
- Testing
- Pharmacist intervention
- Where
- Taiwan
- Volunteers
- 120 people
- Sponsor
- Shin Kong Wu Ho-Su Memorial Hospital
Chemotherapy-Related Cognitive Impairment, Chemotherapeutic Toxicity
Investigating Cognitive Impairment in Young Patients With Cancer Prospectively
The MyBrain study investigates the brain function of children, adolescents and young adults during and after chemo treatment for cancer.
- Conditions
- Chemotherapy-Related Cognitive Impairment, Chemotherapeutic Toxicity, Chemo-brain, Cancer
- Trial name
- MyBrain (NCT05840575)
- Where
- Denmark
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Acute Kidney Injury, Melatonin
Melatonin for Renal Protection in Patients Receiving Polymyxin B
This study has the objective to evaluate the effect in renal function of 30mg of Melatonin versus placebo in patients ≥18 years old treated with polymyxin B.
- Conditions
- Acute Kidney Injury, Melatonin, Polymyxin B Adverse Reaction
- Trial name
- NCT03725267
- Testing
- Melatonin Pill
- Where
- 2 sites in Brazil
- Volunteers
- 88 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Toxic Epidermal Necrolysis
Topical Clobetasol for the Treatment of Toxic Epidermal Necrolysis
The primary objectives of this study are to investigate the efficacy and safety of topical steroid ointment (clobetasol 0.05%) for the treatment of the cutaneous manifestations of toxic epidermal necrolysis (TEN).
- Trial name
- TEN (NCT02319616)
- Testing
- Clobetasol 0.05% ointment
- Where
- United States
- Sponsor
- University of California, Davis
Enteral and Supplement Feeds Adverse Reaction, Gastrointestinal Diseases
Using Magnetic Field Tracking to Confirm Nasogastric Tube Placement at Point of Care
This is a trial on the feasibility of magnetic tracking for the confirmation of nasogastric tube location in human patients.
- Conditions
- Enteral and Supplement Feeds Adverse Reaction, Gastrointestinal Diseases, Esophagus Disorder
- Trial name
- NCT05204901
- Testing
- Insertion and withdrawal of a magnetic-tipped wire into the lumen of the nasogastric tube for tracking of its position
- Where
- Singapore
- Volunteers
- 10 people
- Sponsor
- Tan Tock Seng Hospital
Immune Checkpoint Inhibitors, Cardiotoxicity
Cardiac Magnetic Resonance Monitoring of Immune Checkpoint Inhibitor-related Cardiotoxicity
This study is a prospective cohort clinical research that analyzes the changes in CMR parameters before and after immune checkpoint inhibitors (ICIs) therapy in patients with gynecologic malignancies.
- Trial name
- NCT06132984
- Testing
- Cardiac magnetic resonance
- Where
- China
- Volunteers
- 22 people
- Sponsor
- West China Second University Hospital
Adverse Drug Reaction, Anxiety Disorders and Symptoms
Antidepressant Monotherapy on Depressive and Anxiety Symptom in Chinese Patients
The primary objective is to evaluate the improvement of antidepressant monotherapy on depressive and anxiety symptom in Chinese patients who meet Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5)…
- Trial name
- NCT02012504
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Shanghai Zhongshan Hospital
Toxicity, Drug
Observation Study of the Pharmacokinetics of Adductor Canal Block
With the aging of the population, osteoarthritis of knees and hips become major orthopedic problems worldwide. Osteoarthritis of the knees and hips is associated with a significant pain problem and functional disability.
- Trial name
- NCT04916392
- Testing
- Liposomal bupivacaine
- Where
- Hong Kong
- Volunteers
- 10 people
- Sponsor
- The University of Hong Kong
Drug Allergy
Study of Omalizumab as Adjuvant Therapy in Chemotherapy Desensitization
This research study is evaluating a drug called omalizumab (brand name 'Xolair') as a potential treatment to be used in conjunction with drug desensitization to prevent reactions from recurring and allowing the participant to be…
- Trial name
- NCT02118987
- Testing
- Omalizumab
- Where
- 2 sites in United States
- Volunteers
- 5 people
- Sponsor
- Dana-Farber Cancer Institute
Anesthesia, Anesthesia; Adverse Effect
Dexamethasone vs Bicarbonate to Intracuff Lignocaine 2% in General Anaesthesia
This study is designed to evaluate and compare the effect on hemodynamics, extubation response and patients satisfaction score in patients with ETT cuff filled with either mixture of lignocaine with sodium bicarbonate or with a…
- Conditions
- Anesthesia, Anesthesia; Adverse Effect, Anesthesia Intubation Complication
- Trial name
- NCT03833947
- Testing
- lignocaine+bicarbonate, lignocaine+dexamethasone
- Where
- India
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Aligarh Muslim University
Vitamin D, Neoadjuvant Therapy
Effect of Vitamin D Supplementation on the Efficacy and Adverse Effects of Neoadjuvant Therapy in Patients with Breast Cancer
This randomized controlled Phase III trial was designed to evaluate the impact of supplemental vitamin D (VD) on the efficacy and side effects of neoadjuvant therapy in patients with breast cancer.
- Conditions
- Vitamin D, Neoadjuvant Therapy, Breast Cancer, Adverse Reaction
- Trial name
- NCT06642428
- Testing
- Neoadjuvant therapy + vitamin D2, Neoadjuvant therapy
- Where
- 2 sites in China
- Volunteers
- 140 people
- Sponsor
- Jiuda Zhao
In Vitro Fertilization, Stress
What Amount of Stress is Enough for a Successful Conception?
The aim of the study is to determine whether premedication with midazolam before oocyte aspiration in IVF procedures affects the amount of (oxidative) stress in women undergoing IVF and whether stress is also transmitted to the…
- Conditions
- In Vitro Fertilization, Stress, Midazolam Adverse Reaction, Stress, Emotional
- Trial name
- NCT04160611
- Testing
- Midazolam 7.5mg
- Where
- Croatia
- Volunteers
- 40 people
- Sponsor
- University Hospital Sestre Milosrdnice
Peripheral Arterial Disease, Paclitaxel Adverse Reaction
Safety Assessment of Femoropopliteal Endovascular Treatment With PAclitaxel-coated Devices (SAFE-PAD Study)
The SAFE-PAD Study aims to evaluate the long-term safety of paclitaxel-coated devices compared with non-paclitaxel-coated devices for femoropopliteal artery revascularization among a broad, real-world population of patients with…
- Conditions
- Peripheral Arterial Disease, Paclitaxel Adverse Reaction, Safety Issues
- Trial name
- SAFE-PAD (NCT04496544)
- Testing
- Retrospective data collection
- Where
- United States
- Volunteers
- 168,553 people
- Sponsor
- Beth Israel Deaconess Medical Center
Transfusion Adverse Reaction, Major Trauma
Blood Storage Related Mortality and Adverse Effects in Trauma Patients
The purpose of this retrospective study is to examine the following factors related to blood storage time in severely injured trauma patients who received large blood transfusions: 1.
- Conditions
- Transfusion Adverse Reaction, Major Trauma, Blood Product Transfusion for All Conditions
- Trial name
- NCT07341139
- Where
- United States
- Volunteers
- 101 people
- Sponsor
- Kocaeli City Hospital
Antiviral Drug Adverse Reaction
Effect Of DAAs For Treatment Of HCV On Normal Kidney
The aim of the study is to determine the effect of different direct acting antiviral drugs used for treatment of chronic HCV infected patients on normal kidney.
- Trial name
- NCT03296930
- Testing
- Sofosbuvir 400 MG Oral Tablet,, Ombitasvir/paritaprevir/ritonavir
- Volunteers
- 100 people
- Sponsor
- Assiut University
Epidermal Necrolysis, Lyell Syndrome
LYell SYndrome MEsenchymal Stromal Cells Treatment
Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are rare severe cutaneous adverse reactions (SCARs) to drugs.
- Conditions
- Epidermal Necrolysis, Lyell Syndrome, Toxic Epidermal Necrolysis, Overlap Syndrome
- Trial name
- LYSYME (NCT04711200)
- Testing
- Adipose derived stromal cells intravenously injected
- Where
- France
- Volunteers
- 15 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Aortic Stenosis, Chemotherapy Induced Systolic Dysfunction
Fibrosis in Chronic and Delayed Myocardial Infarction
In this study the investigators aim to examine the role that fibrosis plays in heart conditions such as aortic stenosis , chemotherapy-induced cardiotoxicity and carcinoid syndrome .
- Conditions
- Aortic Stenosis, Chemotherapy Induced Systolic Dysfunction, Carcinoid Syndrome
- Trial name
- FCDMI (NCT05756608)
- Testing
- 68Ga-FAPI and 18F-AlF-FAPI PET-MR
- Where
- United Kingdom
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Breast Cancer, Cardiotoxicity
Cardiotoxicity in Breast Cancer Patients Treated With Proton or Photon Radiotherapy: A RadComp Companion Study
This is a companion study to the "Pragmatic Randomized Trial of Proton vs Photon Therapy for Patients with non-Metastatic Breast Cancer Receiving Comprehensive Nodal Radiation: A Radiotherapy Comparative Effectiveness (RadComp)…
- Trial name
- NCT04361240
- Testing
- Proton vs Photon Radiation
- Where
- 6 sites in United States
- Volunteers
- 172 people
- Sponsor
- Abramson Cancer Center at Penn Medicine
Pain Syndrome, Propofol Infusion Syndrome
Warm Patch Decrease Propofol Injection Pain
Propofol causes injection pain is still a common clinical unsolved problem. Mixing a small amount of lidocaine with propofol or injecting lidocaine in advance can reduce the pain caused by propofol injection.
- Conditions
- Pain Syndrome, Propofol Infusion Syndrome, Injection Site Irritation
- Trial name
- NCT04555980
- Testing
- Warming patch, Cotton patch
- Where
- China
- Volunteers
- 120 people
- Sponsor
- First People's Hospital of Chenzhou
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