Clinical trials: Aetiology
Meningitis, Epiglottitis, Pneumonia, Arthritis Caused by Haemophilus Influenzae Type b
Persistency Study After Hib-CRM (Cross-Reacting Material)197 or Hib-TT (Tetanus Toxoid) Vaccines in Chinese Children
Evaluate the persistency of immune response against Haemophilus influenzae type b by assessing anti-PRP antibody levels in children vaccinated with either Hib-CRM197 or Hib-TT booster vaccine approximately 4 years before.
- Trial name
- NCT02139228
- Testing
- Hib-CRM197, Hib-TT
- Where
- China
- Volunteers
- 426 people, healthy volunteers welcome
- Sponsor
- Novartis Vaccines
Cerebral Palsy
The Changing Panorama in Risk Factors of Cerebral Palsy
The study will be carried of scanning the database of 296 individuals with cerebral palsy followed in the university pediatric rehabilitation clinic.
- Trial name
- NCT04716530
- Testing
- No intervention is associated with the study.
- Where
- Turkey (Türkiye)
- Volunteers
- 296 people
- Sponsor
- Istanbul Medeniyet University
Lumbar Disc Herniation
STA363 in the Treatment of Lumbar Disc Herniation
The goal of this clinical trial is to establish safety and tolerability of STA363 injected into a herniated intervertebral disc in patients with sciatica due to disc herniation. The main questions the trial aims to answer are: 1.
- Trial name
- NCT06022263
- Testing
- Lactic Acid
- Where
- Poland
- Volunteers
- 25 people
- Sponsor
- Stayble Therapeutics
Pleural Effusion
Modified Thoracoscopic Pleural Cryobiopsy in Diagnosis of Exudative Pleural Effusion
Background: Rigid thoracoscopy is the gold standard tool for diagnosing exudative pleural effusion but sometimes it is difficult to obtain sufficient biopsies using the conventional forceps.
- Trial name
- NCT04683419
- Testing
- Modified Thoracoscopic pleural Cryobiopsy
- Where
- Egypt
- Volunteers
- 24 people
- Sponsor
- Alexandria University
Leigh Syndrome
Sirolimus for Leigh Syndrome
The purpose of this study is to evaluate the safety and efficacy of the drug Sirolimus in participants with Leigh syndrome.
- Trial name
- NCT06843811
- Testing
- Sirolimus
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Matthew Demczko
Pneumonia, Bacterial, Infections, Bacterial
Thermal Imaging of the Lung on a Smartphone to Differentiate Bacterial From Non Bacterial Causes of Pneumonia
This is a study of up to 275 participants from birth to 12 months who are having a chest x-ray while a patient at the Queen Elizabeth Central Hospital in Blantyre, Malawi.
- Trial name
- NCT02778672
- Testing
- Thermal imaging of infant's chest with a mobile phone
- Where
- Malawi
- Volunteers
- 273 people
- Sponsor
- Boston University
Oxidative Stress is an Important Cause of Parkinson's Disease
Idebenone Treatment of Early Parkinson's Diseasesymptoms
On May 30,2018 ,Investigators intend to conduct a multicenter, randomized, double-blind, placebo-controlled study of idebenone in the treatment of early-stage Parkinson's disease with motor and non-motor symptoms which is to…
- Trial name
- ITEP (NCT03727295)
- Volunteers
- 180 people
- Sponsor
- Second Affiliated Hospital of Soochow University
Non-progressive Congenital Ataxia, Ataxic Cerebral Palsy
ARTEMIS - The ARTEMIS Cohort
This multinational European observational clinical study focuses on non-progressive congenital ataxia (NPCA), a very rare early-onset neurological condition also within the cerebral palsy (CP) concept as ataxic CP.
- Trial name
- ARTEMIS (NCT07421219)
- Where
- 7 sites in Belgium, Denmark and 5 more
- Volunteers
- 50 people
- Sponsor
- Vastra Gotaland Region
Community-Acquired Pneumonia (CAP)
A Study to Learn How Effective is PCV20 to Help Stop Adults Who Have a Higher Chance of Getting Pneumonia
The purpose of this study is to learn how well PCV20 stops adults from getting community-acquired pneumonia. Pneumonia is an infection of the lungs that can be caused by germs like bacteria, virus, or fungi.
- Trial name
- NCT07251465
- Testing
- Receipt of PCV20
- Where
- United States
- Volunteers
- 846,279 people
- Sponsor
- Pfizer
Lymphatic Disorders
Application of 68Ga NEB PET Imaging in the Diagnosis and Evaluation of Lymphatic Disorders
This is an open-label whole-body PET/CT study for investigating the value of 68Ga NEB PET imaging in the diagnosis and evaluation of lymphatic disorders including lymphedema, lymphangioma, lymphangioleiomyomatosis, plastic…
- Trial name
- NCT04273334
- Testing
- 68Ga-NEB
- Where
- China
- Volunteers
- 90 people
- Sponsor
- Peking Union Medical College Hospital
Bile Duct Diseases
The Role of Endoscopic Ultrasound in Evaluation of Patients With Indefinite Cause of Bile Duct Dilatation
In the era of diagnostic imaging advances, Bile Duct Dilatation becomes a common incidental finding in patients present with either gastrointestinal symptoms or undergone the imaging study for any other complaints.
- Trial name
- NCT05475964
- Testing
- Endoscopic ultrasound
- Where
- Egypt
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- HMHamed
Acute Heart Failure (AHF)
Risk Factors, Etiology and Predictable Outcomes With Risk Stratification Scores in Acute Heart Failure Patients
Clinical Characteristics, Etiology, Short-Term Outcomes, and Performance of Contemporary Risk Stratification Scores in Acute Heart Failure Patients Presenting to Assiut University Heart Hospital.
- Trial name
- NCT07785531
- Testing
- Echo, Ecg, Creatinine
- Where
- Egypt
- Volunteers
- 350 people
- Sponsor
- Assiut University
Periodontitis
Effects of Azithromycin as an Adjunct to Scaling and Root Planning in the Treatment of Periodontitis
The growing interest in the possibilities of modulating macrophages in inflammatory diseases with therapeutic purpose has prompted the development of new approaches for the treatment of periodontitis.
- Trial name
- NCT05506371
- Testing
- Az+SRP, SRP, No interventions
- Where
- Ukraine
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Ukrainian Medical Stomatological Academy
Infection of Upper Respiratory Tract Caused by 2019-nCoV
SA55 Injection Phase II Study in the Treatment of Mild/Moderate COVID-19 Patients
Evaluating the efficacy and safety of SA55 injection in light/medium COVID-19 patients
- Trial name
- NCT06042764
- Testing
- SA55 Injection
- Where
- China
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Sinovac Life Sciences Co., Ltd.
Acute Respiratory Distress Syndrome
Ventilation-Perfusion Matching in Early-stage Prone Position Ventilation
Prone positioning has been widely used in critical care medicine to improve oxygenation in patients with acute respiratory distress syndrome (ARDS).
- Trial name
- NCT05816928
- Where
- China
- Volunteers
- 29 people
- Sponsor
- Peking Union Medical College Hospital
Methicillin-Resistant Staphylococcus Aureus
Vancomycin Dosage Adjustment for MRSA Infections
An open-label randomized controlled trial to compare two vancomycin dosage adjustment methods
- Trial name
- NCT03412500
- Testing
- Vancomycin equation-based method, Vancomycin trough concentration method
- Where
- Thailand
- Volunteers
- 114 people
- Sponsor
- Pinyo Rattanaumpawan
Staphylococcal Skin Infections
Safety and Efficacy of Daptomycin for the Treatment of Complicated Skin and Skin-structure Infections
This study will evaluate the safety and efficacy of daptomycin against complicated skin and skin-structure infections in adults
- Trial name
- NCT00463801
- Testing
- Daptomycin
- Where
- 2 sites in Italy
- Volunteers
- 52 people
- Sponsor
- Novartis
Chronic Periprosthetic Joint Infection, Suspected Periprosthetic Joint Infection
Joint Endoprostheses Can Succesfully Treat Disabling Osteoarthritis. However, Infection is an Important Cause of Failure. Adequate Diagnostics Remains Challenging. Combining Advanced Imaging With Next-generation Sequencing of Samples Obtained Endoscopically Should Aid in Mapping and Characterizing.
This prospective observational diagnostic study aims to improve the accuracy and timeliness of diagnosing chronic periprosthetic joint infection (PJI).
- Conditions
- Chronic Periprosthetic Joint Infection, Suspected Periprosthetic Joint Infection, Prosthetic Joint Failure of Unclear Etiology
- Trial name
- PJI MAP/DEF (NCT07494630)
- Testing
- Comprehensive Diagnostic Work-up for Suspected Chronic Periprosthetic Joint Infection
- Where
- Belgium
- Volunteers
- 174 people
- Sponsor
- University Hospital, Ghent
Tetrahydrobiopterin Deficiency
Retrospective Observational Safety Effectiveness With Kuvan in hpA
A retrospective study to collect the effectiveness and safety data of the past treatment with KUVAN in Chinese patients with HPA caused by BH4 deficiency.
- Trial name
- ROSEKA (NCT03864029)
- Testing
- KUVAN
- Where
- China
- Volunteers
- 26 people
- Sponsor
- BioMarin Pharmaceutical
Accident Caused by Snow Avalanche
Evaluation of Gas Propagation in Snow During Breathing of Subjects Under Simulated Avalanche Snow
The study is aimed at investigation of respiratory gases propagation in snow. The study involves volunteers breathing into the snow whereas concentrations of gases are measured at various positions in the snow.
- Trial name
- GasProp (NCT05262894)
- Testing
- extreme hypercapnia induced by ventilation insufficiency
- Where
- Czechia
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Czech Technical University in Prague
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