Clinical trials: Aetiology
Sciatica, Radiating Pain
The Effect of Early MSAT Treatment on Sciatica Caused by Traffic Accidents.
The investigators would like to conduct a pilot study prior to a practical randomized control study on the effectiveness of initial MSAT treatment on inpatients complaining of radiating pain and abnormal sensation in the lower…
- Conditions
- Sciatica, Radiating Pain, Paresthesia, Dysesthesia
- Trial name
- NCT06179901
- Testing
- Integrative Korean Medicine Treatment, lower limb motion style acupuncture treatment
- Where
- South Korea
- Volunteers
- 40 people
- Sponsor
- Jaseng Medical Foundation
Fever
Procalcitonin in Fever of Unknown Etiology
The purpose of this study is to determine whether new blood test (procalcitonin) can help to reduce unnecessary use of antibiotics in patients with unexplained fever.
- Trial name
- NCT00398775
- Testing
- antibiotic discontinuation
- Where
- Singapore
- Volunteers
- 90 people
- Sponsor
- Changi General Hospital
Injury
Causes and Circumstances of Horse Related Injuries and Impact on Quality of Life
Horse-related activity can be risky. Horses are the leading cause of animal-related fatalities in Oregon and Oregon's annual death rate from animals is 45% higher than the national rate.
- Trial name
- NCT00935428
- Where
- United States
- Volunteers
- 231 people
- Sponsor
- Oregon Health and Science University
Obesity
Obesity and Brain: Genes and Environment
The aim of this study is to investigate the effects of genetic and environmental risk factors on central nervous system (CNS) reward and satiety circuits in the etiology of obesity.
- Trial name
- NCT02025595
- Where
- Netherlands
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Amsterdam UMC, location VUmc
Chronic Pancreatitis, Distal Pancreatectomy
A Phase IIa Study With Escalating Dose of MS1819-SD
This is a Phase IIa study sponsored by AzurRx SAS and Syneos Health is a local representative sponsor and involves testing of a new medication for the compensation of exocrine pancreatic insufficiency (EPI) caused by chronic…
- Trial name
- NCT03481803
- Testing
- MS1819-SD
- Where
- 6 sites in Australia, France and 1 more
- Volunteers
- 11 people
- Sponsor
- AzurRx SAS
Biliary Strictures Caused by Malignant Neoplasms
Study of the WallFlex™ Biliary Partially-covered Stent for the Palliative Treatment of Malignant Bile Duct Obstruction
This is a a prospective study of the WallFlex™ Biliary Partially-covered Stent designed to collect data to support regulatory clearance by the FDA in the United States and to determine the functionality of the WallFlex™ Biliary…
- Trial name
- NCT00713427
- Testing
- WallFlex™ Biliary Partially-Covered Stent
- Where
- 6 sites in Belgium, France and 4 more
- Volunteers
- 70 people
- Sponsor
- Boston Scientific Corporation
Diarrhea Caused by Drug, Clostridium Difficile Infections
Faecal Bacteriotherapy for Postantibiotic Diarrhoea in Critically Ill Patients
Rationale: Postantibiotic diarrhoea in critically ill patients is common, often prolonged and currently there is no effective treatment of it.
- Trial name
- FEBATRICE (NCT05430269)
- Testing
- Faecal bacteriotherapy (FBT), standard-of-care protocolised treatment of postantibiotic diarhea
- Where
- 2 sites in Czechia
- Volunteers
- 36 people
- Sponsor
- Charles University, Czech Republic
Ischemia and No Obstructive Coronary Artery Disease, Coronary Microvascular Dysfunction
The DISCOVER INOCA Prospective Multi-center Registry
The overall objective of this multi-center registry is to identify specific phenotypes of INOCA with both an anatomic evaluation (coronary angiography and intravascular imaging) and physiologic assessment with the Abbott…
- Conditions
- Ischemia and No Obstructive Coronary Artery Disease, Coronary Microvascular Dysfunction, Coronary Vasospasm, Endothelial Dysfunction
- Trial name
- DISCOVER INOCA (NCT05288361)
- Testing
- Coroventis Coroflow Cardiovascular System and PressureWire™ X Guidewire
- Where
- 9 sites in United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Yale University
Lower Extremity Lymphedema
Diaphragmatic Exercises and Fascial Release Techniques on the Treatment of Lower Extremity Lymphedema
The aim of this study is to determine the effect of multidimensional breathing exercises and fascial release techniques performed in addition to the conventional treatment program on the treatment of lymphatic fluid in women with…
- Trial name
- NCT05483569
- Testing
- Complex Decongestive Physiotherapy, Multidimensional Diaphragmatic Breathing Exercises, Facial Release Technique
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Istanbul Medeniyet University
Nausea, Vomiting
A Study to Evaluate LY3537021 for the Treatment of Nausea and Vomiting Caused by Chemotherapy in Adults With Cancer
The purpose of this study is to check how well LY35327021 works and how safe it is for controlling nausea and vomiting caused by chemotherapy.
- Conditions
- Nausea, Vomiting, Drug-Related Side Effects and Adverse Reactions, Neoplasms
- Trial name
- NCT07169851
- Testing
- LY3537021, Standard of Care Antiemetic Therapies, Background Chemotherapy
- Where
- 67 sites in United States, Australia and 8 more
- Volunteers
- 204 people
- Sponsor
- Eli Lilly and Company
External Causes of Morbidity and Mortality
Post Operative Walking Enhancements for Recovery (POWER) Trial
This study is a non-blinded randomized controlled trial. Consenting participants will be randomized to routine post-operative ambulation vs.
- Trial name
- POWER (NCT01254851)
- Testing
- goal-augmented post-operative care
- Where
- 2 sites in United States
- Volunteers
- 146 people
- Sponsor
- Loyola University
All-cause Mortality
ADL and CONUT for Predicting 1-year Mortality Risk in Older Adults After Hip Fracture
Hip fracture has a serious impact on the quality of life and even the survival of older adults. The multidisciplinary management of hip fracture has been shown to be effective in improving patient outcome and cost-effective in…
- Trial name
- NCT05814172
- Testing
- no intervention
- Where
- China
- Volunteers
- 303 people
- Sponsor
- Beijing Tongren Hospital
Elbow Joint Destruction, Post-traumatic Lesions
Clinical Outcomes Study of the Nexel Total Elbow
The objectives of the study are to confirm safety and performance of the Zimmer Nexel Total Elbow when used in primary or revision total elbow replacement.
- Conditions
- Elbow Joint Destruction, Post-traumatic Lesions, Ankylosed Joints, Advanced Rheumatoid Arthritis
- Trial name
- NCT02469662
- Testing
- Nexel Total Elbow
- Where
- 11 sites in United States, Australia and 6 more
- Volunteers
- 134 people
- Sponsor
- Zimmer Biomet
Sarcoma, Environmental Exposure
Etiosarc: Environmental Aetiology of Sarcomas From a Multicenter French Population-based Case-control Study Among Adults
Introduction: Sarcomas are rare tumors of connective tissue. The exact overall incidence of sarcomas is unknown due to diagnostic difficulties and the various histological subtypes (over 80 subtypes).
- Conditions
- Sarcoma, Environmental Exposure, Occupational Exposure, Life Style
- Trial name
- ETIOSARC (NCT03670927)
- Testing
- Environmental, occupational and lifestyle-related exposures
- Where
- 10 sites in France
- Volunteers
- 2,237 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
PIK3CA-Related Overgrowth Spectrum (PROS), Growth Disorder
Study of Sirolimus Therapy for Segmental Overgrowth Caused by Somatic PI3K Activation
Background: PIK3CA-related overgrowth spectrum (PROS) is caused by changes in the PIK3CA gene. This gene makes a protein that communicates with other proteins in the body to cause cells to grow.
- Conditions
- PIK3CA-Related Overgrowth Spectrum (PROS), Growth Disorder, Genetics
- Trial name
- NCT02428296
- Testing
- Sirolimus
- Where
- United States
- Volunteers
- 39 people
- Sponsor
- National Human Genome Research Institute (NHGRI)
Bronchitis
Therapy of Ventilator-associated Tracheobronchitis Caused by Gram Negative Bacteria With Nebulized Colistin
The purpose of this study is to determine whether inhaled colistin is effective in the treatment of ventilator associated tracheobronchitis due to gram negative organism susceptible to colistin.
- Trial name
- NCT02619786
- Testing
- Inhaled colistin
- Volunteers
- 62 people
- Sponsor
- Mahidol University
Dementia, Alzheimer Type, Mild Cognitive Impairment
Cardiac Amyloid Deposits and Heart Dysfunction in Alzheimer's Disease
This study seeks to explore the possible common pathogenesis of both cardiac amyloidosis and Alzheimer's disease, which can both be associated with amyloid deposits.
- Conditions
- Dementia, Alzheimer Type, Mild Cognitive Impairment, Cardiac Amyloidosis
- Trial name
- NCT07154394
- Where
- Germany
- Volunteers
- 15 people
- Sponsor
- University Hospital, Essen
Vascular Dysfunction, Genetic Mutations
Vascular Disease Discovery Protocol
Background: Some genetic diseases put increase the risk of heart and blood diseases, which are the number one cause of death and disability in the U.S. Researchers want to study diseases of the heart and/or blood vessels.
- Conditions
- Vascular Dysfunction, Genetic Mutations, Genetic Predisposition
- Trial name
- NCT03538639
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Idiopathic Anaphylaxis, Drug Anaphylaxis
Cause of Unexplained Anaphylaxis
This study will explore the possible cause of unexplained, or idiopathic, anaphylaxis. Anaphylaxis is a rapid, life-threatening, severe reaction that occurs suddenly after contact with an allergy-causing substance, usually a…
- Conditions
- Idiopathic Anaphylaxis, Drug Anaphylaxis, Venom Anaphylaxis, Food Anaphylaxis
- Trial name
- NCT00719719
- Where
- United States
- Volunteers
- 115 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Prosthetic Joint Infection, Staphylococcus
Clindamycin in Prosthetic Joint Infections Caused by Staphylococcus (CISTA)
The alternatives to the combination of Fluoroquinolone and Rifampicin in prosthetic joint infections (PJI) caused by staphylococcus are currently unclear.
- Trial name
- CISTA (NCT04946500)
- Where
- France
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University Hospital, Brest
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