Clinical trials: Affective Disorder
Major Depression
Evaluation of a Natural Experiment to Improve Statewide Depression Care in Minnesota (MN)
The study will evaluate a unique natural experiment that aims to transform the primary care of patients with depression. The experiment's aim is to cause statewide implementation of an evidence-based care model for depression by…
- Trial name
- DIAMOND (NCT00781703)
- Testing
- DIAMOND depression care model
- Volunteers
- 2,631 people
- Sponsor
- HealthPartners Institute
Postnatal Depression
Three Model Care Pathways for Postnatal Depression
The study evaluates three best-practice care pathways for postnatal depression (PND) by comparing sole General Practitioner (GP) management to GP management in combination with CBT-based counselling from either a Psychologist or…
- Trial name
- NCT01002027
- Testing
- CBT-Counselling
- Where
- Australia
- Volunteers
- 68 people
- Sponsor
- University of Melbourne
Schizophrenia, Schizoaffective Disorder
Lifestyle Intervention for Young Adults With Serious Mental Illness
This is a four year project evaluating the effectiveness of a group-based lifestyle intervention (PeerFIT) supported by mobile health (mHealth) technology and social media compared to Basic Education in fitness and nutrition…
- Conditions
- Schizophrenia, Schizoaffective Disorder, Bipolar Disorder, Major Depressive Disorder
- Trial name
- NCT02815813
- Testing
- PeerFIT, BEAT
- Where
- 2 sites in United States
- Volunteers
- 150 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Major Depressive Disorder
EEG Biomarkers for Predicting Response to Antidepressant Therapy
The purpose of this study is to evaluate the potential early EEG predictors of an individual's response to treatment with antidepressant medications.
- Trial name
- NCT00289523
- Where
- 10 sites in United States
- Volunteers
- 375 people
- Sponsor
- Medtronic - MITG
Bipolar Disorder
12 Week Study of the Safety/Efficacy of Asenapine When Added to Lithium/Valproate in the Treatment of Bipolar Disorder (A7501008 / P05844 / MK-8274-017)
This is a 12-week study that will test the safety and efficacy of asenapine when used in addition to lithium or valproate for subjects with acute manic or mixed episodes of Bipolar I Disorder.
- Trial name
- NCT00145470
- Testing
- Asenapine
- Volunteers
- 326 people
- Sponsor
- Organon and Co
Bipolar Disorder
Controlled Study of the Use of Quetiapine Fumarate in the Treatment of Patients With Bipolar Depression
The purpose of this study is to determine the efficacy of quetiapine compared to placebo in the treatment for a major depressive episode in patients with bipolar disorder after receiving treatment for up to 8 weeks.
- Trial name
- NCT00083954
- Testing
- Quetiapine Fumarate
- Where
- 36 sites in United States
- Volunteers
- 530 people
- Sponsor
- AstraZeneca
Major Depressive Disorder
Amygdala Neurofeedback for Depression - Large Scale Clinical Trial
The goal of this study is to evaluate whether rtfMRI-nf training to increase the amygdala response to positive memories may serve as a stand-alone intervention for major depressive disorder
- Trial name
- NCT05703256
- Testing
- Amygdala real-time fMRI neurofeedback
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Kymberly Young
Major Depression
Antidepressant Effects of the Glycine Receptor Antagonist AV-101 (4-chlorokynurenine) in Major Depressive Disorder
Background: Drugs and talk therapy help treat depression, but these treatments usually take quite a bit of time to work. Ketamine is a fast-acting antidepressant, but it has side effects like unusual dreams and experiences.
- Trial name
- NCT02484456
- Testing
- AV 101 (4-Chlorokynurenine)
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- National Institute of Mental Health (NIMH)
Postpartum Depression
Effects of Esketamine on Postpartum Depression
Different concentrations of Esketamine were used after cesarean section. Through the evaluation of postoperative psychological status and analgesic effect, the optimal dosage of Esketamine to exert the effects of depression and…
- Trial name
- EEPD (NCT05229913)
- Testing
- Esketamine is not added, Esketamine 0.2mg/kg, Esketamine 0.4mg/kg
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Qinghai University
Post-partum Depression, Maternal Health
Prevalence of Postpartum Depression Among Patients of the CHUM GARE Clinic
Postpartum depression (PPD) is a frequent complication of the postnatal period but remains underdetected in routine clinical practice.
- Conditions
- Post-partum Depression, Maternal Health, Mental Health Issue
- Trial name
- PPD-GARE (NCT07200323)
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Bipolar Disorder
Metformin for Overweight & OBese ChILdren and Adolescents With BDS Treated With SGAs
A prospective, large, pragmatic, randomized trial to study the impact of METFORMIN and healthy lifestyle intervention (LIFE) vs.
- Trial name
- MOBILITY (NCT02515773)
- Testing
- Metformin, healthy lifestyle intervention (LIFE)
- Where
- 29 sites in United States
- Volunteers
- 1,565 people
- Sponsor
- Melissa Delbello
Bipolar Disorder, Depressive Disorder
Acute Effectiveness of Additional Drugs to the Standard Treatment of Depression
This study will compare the effectiveness of relatively new antidepressants which have different mechanisms of action. Buproprion (Wellbutrin) works on dopamine and the dopaminergic pathway.
- Trial name
- NCT00001483
- Testing
- buproprion (Wellbutrin), sertraline (Zoloft), venlafaxine (Effexor)
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- National Institute of Mental Health (NIMH)
Psychosis, Schizo Affective Disorder
TOPUS - Testing an Implemented Intervention to Reduce Duration of Untreated Psychosis
This study examines whether an early-detection program for psychosis can shorten the time patients remain untreated after the first appearance of psychotic symptoms, and whether such a reduction improves later functioning for…
- Conditions
- Psychosis, Schizo Affective Disorder, SCHIZOPHRENIA 1 (Disorder)
- Trial name
- TOPUS (NCT07716969)
- Testing
- No intervention (Observational Study)
- Where
- 2 sites in Denmark
- Volunteers
- 250 people
- Sponsor
- Mental Health Centre Copenhagen, Bispebjerg and Frederiksberg Hospital
Depressive Disorder
Primary Care Patients With Depression for Internet-Based Social Support
The purpose of this study is to develop and pilot test two interventions that lead to at least 30% of individuals with depression presenting to primary care engaging with an Internet-based depression support group.
- Trial name
- Psychobabble (NCT00886730)
- Testing
- Simple Card, Patient Centered Brochure, Physician's endorsement
- Where
- United States
- Volunteers
- 49 people
- Sponsor
- University of Chicago
Depression, Major Depressive Disorder
Predictors of Depression Treatment Response to Exercise
50 subjects with Major Depressive Disorder who are not currently receiving treatment will be enrolled in a 12-week exercise program, supervised by a trained exercise interventionist.
- Trial name
- NCT02583867
- Testing
- Exercise
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- University of Texas Southwestern Medical Center
Post Traumatic Stress Disorder PTSD, Major Depressive Disorder (MDD)
Accelerated iTBS for PTSD and Depression
The goal of this pilot clinical trial is to learn if a faster brain stimulation schedule is practical, safe, tolerable, and acceptable. This study looks at accelerated intermittent theta burst stimulation, or accelerated iTBS.
- Trial name
- NCT07682207
- Testing
- Accelerated intermittent theta burst stimulation
- Where
- Canada
- Volunteers
- 16 people
- Sponsor
- Lawson Research Institute of St. Joseph's
Schizophrenia
A Study of Dopamine Type 2 (D2) Receptor Occupancy Following a Single Oral Dose of OROS Paliperidone
The purposes of this study are to estimate the relationship of D2-receptor occupancy to plasma concentration and to assess the safety of OROS paliperidone.
- Trial name
- NCT00796432
- Testing
- OROS paliperidone
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Depression, Cognitive Impairment
Efficacy of Gamified Cognitive Control Training Using de:)Press on Depression Severity add-on to Treatment as Usual
Depression is one of the most frequent and devastating psychiatric diseases with a substantial bur-den for patients and society.
- Conditions
- Depression, Cognitive Impairment, Cognitive Dysfunction, Depressive Disorder
- Trial name
- de-press-2 (NCT05385614)
- Testing
- de:)press
- Where
- Germany
- Volunteers
- 112 people
- Sponsor
- University Hospital Tuebingen
Treatment-Resistant Major Depressive Disorder, Major Depressive Disorder
Precision Closed-loop Brain-Computer Interface Neuromodulation for Treatment-Resistant Depression
The goal of this clinical trial is to evaluate whether precision closed-loop neuromodulation treatments can improve depressive symptoms and daily functioning in people with treatment-resistant major depressive disorder (TRD).
- Trial name
- NCT07783906
- Testing
- Closed-loop Deep Brain Stimulation (DBS), Transcutaneous Auricular Vagus Nerve Stimulation (taVNS)
- Volunteers
- 70 people
- Sponsor
- Shanghai Mental Health Center
Bipolar Depression
A Prophylactic Trial of Omega-3 Polyunsaturated Fatty Acids in Bipolar Disorder
This study is a 52 week double-blind placebo controlled study of omega-3 polyunsaturated fatty acids (PUFAs) in bipolar disorder (who have a history of 3 or more episodes) to ascertain if omega-3 PUFAs reduce the risk of further…
- Trial name
- NCT04210804
- Testing
- Smoothie 1g Eicosapentaneoic Acid (EPA) and 1g Docoshaexanoic Acid (DHA)
- Where
- Ireland
- Volunteers
- 80 people
- Sponsor
- National University of Ireland, Galway, Ireland
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