Clinical trials: Affective Psychoses
Schizophrenia, Bipolar Disorder
Multi-modal Assessment of Gamma-aminobutyric Acid (GABA) Function in Psychosis
The purpose of this study is to better understand mental illness and will test the hypotheses that, while viewing affective stimuli, patient groups will show increased blood oxygenation level dependent (BOLD) signal by fMRI after…
- Conditions
- Schizophrenia, Bipolar Disorder, Healthy, Psychosis
- Trial name
- GABAmech (NCT04004416)
- Testing
- Lorazepam and fMRI
- Where
- United States
- Volunteers
- 143 people, healthy volunteers welcome
- Sponsor
- University of Michigan
MDD, Bipolar Disorder
Evaluation of Generalization Paradigm Patterns Among Different Psychiatric Disorders
Learning includes the ability to generalize to new situations and respond to similar, yet not identical stimuli. In previous work, focused on stimulus generalization in healthy volunteers, tones that were negatively reinforced…
- Conditions
- MDD, Bipolar Disorder, Schizophrenia Disorder, Anxiety Disorder (Panic Disorder or GAD)
- Trial name
- NCT01501812
- Testing
- Generalization pattern
- Where
- Israel
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Shalvata Mental Health Center
Schizophrenia, Schizo Affective Disorder
Memantine Effects on Sensorimotor Gating and Neurocognition in Schizophrenia
This application seeks to determine if neurophysiological metrics of memantine (MEM)-enhanced early auditory information processing (EAIP) in schizophrenia (SZ) mediate gains in auditory processing fidelity (APF) and auditory…
- Conditions
- Schizophrenia, Schizo Affective Disorder, Schizoaffective Disorder, Healthy
- Trial name
- NCT03860597
- Testing
- Memantine
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Psychosis, Schizophrenia Disorders
DIALOG: Understanding Disorganisation: A Language-focused Global Initiative in Psychosis
Disorganized speech, language and communication, also called 'formal thought disorder,' is a key part of severe mental illnesses like psychosis and mood disorders.
- Conditions
- Psychosis, Schizophrenia Disorders, Bipolar Affective Disorder, Depressive Disorder
- Trial name
- DIALOG (NCT06978465)
- Where
- Canada
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Douglas Mental Health University Institute
Schizophrenia, Psychotic Disorders
Comparative Study of Aripiprazole, Quetiapine and Ziprasidone in the Treatment of First Episode Nonaffective Psychosis
The selection of antipsychotic in early stages of the illness is mainly determined by its clinical effectiveness. Second generation antipsychotics (SGAs) are the first line drug treatment for individuals suffering from…
- Trial name
- PAFIP2 (NCT02305823)
- Testing
- Aripiprazole, Quetiapine, Ziprasidone
- Where
- Spain
- Volunteers
- 203 people, healthy volunteers welcome
- Sponsor
- Fundación Marques de Valdecilla
Psychosis, Schizophrenia
Levetiracetam in Early Psychosis
In order to establish target engagement and identify an effective dose the investigators will conduct a placebo-controlled single-dose parallel group trial of levetiracetam 185 mg and 500 mg in 24 medication-naïve early psychosis…
- Conditions
- Psychosis, Schizophrenia, Schizo Affective Disorder, Schizophreniform
- Trial name
- NCT03129360
- Testing
- Levetiracetam
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Schizophrenia, Bipolar Disorder
Technology-Assisted Implementation of a Mobile Health Program for Serious Mental Illness
The goal of this clinical trial is to learn about how a digital training platform can enhance implementation and effectiveness of a validated mHealth system, called FOCUS, in people with serious mental illness.
- Conditions
- Schizophrenia, Bipolar Disorder, Major Depressive Disorder, Schizo Affective Disorder
- Trial name
- NCT05725785
- Testing
- FOCUS participants
- Where
- 3 sites in United States
- Volunteers
- 191 people, healthy volunteers welcome
- Sponsor
- University of Washington
Schizophrenia, Schizo Affective Disorder
Clinical Trial of an IL-23 Inhibitor for Immune Activation in Clinical Trial of an IL-23 Inhibitor for Immune Activation in People With Schizophrenia
This 16 week clinical trial investigates a precision-medicine approach to schizophrenia by targeting a biologically distinct subgroup,-approximately one-third of patients-characterized by the presence of anti-gliadin antibodies…
- Conditions
- Schizophrenia, Schizo Affective Disorder, Healthy
- Trial name
- NCT07615075
- Testing
- IL-23
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Schizophrenia, Schizo Affective Disorder
Peripheral Immune System in Individuals With Schizophrenia
The investigators are seeking healthy volunteers and people with schizophrenia or schizoaffective disorder for a clinical study of the immune system in psychotic disorders.
- Conditions
- Schizophrenia, Schizo Affective Disorder, Schizophreniform Disorders
- Trial name
- NCT05109065
- Testing
- SCID (Standardized Clinical Interview for DSM-V), PSS (Perceived Stress Score), Urine Toxicology Screen
- Where
- United States
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- Stanford University
Depression Disorders, Bipolar Affective Disorder
Epidemiological Study on the Prevalence of Mental Disorders in Slovakia
This study maps the current epidemiological situation of mental disorders in Slovakia. The aim of the study is to determine the prevalence of selected mental disorders in the adult population of the Slovak Republic, assess the…
- Conditions
- Depression Disorders, Bipolar Affective Disorder, Generalized Anxiety Disorder (GAD), Panic Disorder
- Trial name
- EpiMentDisSK (NCT07129408)
- Where
- Slovakia
- Volunteers
- 3,100 people, healthy volunteers welcome
- Sponsor
- Comenius University
Mental Disorders, Affective Disorders
A Pilot Study of Boredom in a Community Sample of Adolescents and a Clinical Sample of Adolescents
The aim of the following pilot study is to examine boredom in a community sample of adolescents and a clinical sample of adolescents.
- Conditions
- Mental Disorders, Affective Disorders, Anxiety Disorders, Attention Deficit and Disruptive Behavior Disorders
- Trial name
- NCT00163865
- Where
- Australia
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- Bayside Health
Schizophrenia, Psychotic Disorders
Comparative Study of Aripiprazole, Quetiapine and Ziprasidone in Treatment of First Episode Psychosis: 3-year Follow-up
The selection of antipsychotic in early stages of the illness is mainly determined by its clinical effectiveness. Second generation antipsychotics (SGAs) are the first line drug treatment for individuals suffering from…
- Trial name
- PAFIP2_3Y (NCT02526030)
- Testing
- Aripiprazole, Quetiapine, Ziprasidone
- Where
- Spain
- Volunteers
- 203 people, healthy volunteers welcome
- Sponsor
- Fundación Marques de Valdecilla
Depression, Schizophrenia
Symptom Based Treatment Affects Brain Plasticity - Cognitive Training in Patients With Affective Symptoms
The aim of the study is the examination of brain plasticity on on affective symptoms after neuromodulation with fMRI (functional magnetic resonance imaging) neurofeedback.
- Trial name
- APIC-II (NCT03183947)
- Testing
- fMRI, Neurofeedback, PANAS
- Where
- Germany
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- RWTH Aachen University
Schizophrenia
Study of Electrophysiological Markers Related to the Cognitive and Affective Processes Behind Empathic Behaviour in Schizophrenic Spectrum Disorder
Disorders of social cognition, and empathy more specifically, are at the heart of schizophrenic pathology in that they are strongly linked to the social handicap of patients.
- Trial name
- SchizoEmp (NCT04278339)
- Testing
- Evoked Related Potentials
- Where
- France
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Nice
Schizophrenia, Psychotic Disorders
Neurocognitive Effectiveness in Treatment of First-episode Non-affective Psychosis: 1-year Follow-up
Cognitive enhancement is a primary goal in treating individuals with schizophrenia. Cognitive deficits are already present at the first break of the illness, seem to remain stable during early phases and noticeably influence…
- Trial name
- PAFIP2_nc1Y (NCT02534363)
- Testing
- Aripiprazole, Quetiapine, Ziprasidone
- Where
- Spain
- Volunteers
- 136 people, healthy volunteers welcome
- Sponsor
- Fundación Marques de Valdecilla