Clinical trials: Age Related Cognitive Decline
Mobility Limitation, Cognitive Impairment
Combining tDCS and Neurorehabilitation to Treat Age-related Deficits of Mobility and Cognition: UPfront Walking Study
Loss of mobility and cognitive ability are serious conditions that threaten the independence of older adults. The objective of this study is to initiate a line of research to develop a novel therapeutic intervention to enhance…
- Trial name
- NCT03122236
- Testing
- Neurorehabilitation of Standard Walking, Neurorehabilitation of Complex Walking, Active Transcranial Direct Current Stimulation (Active tDCS)
- Where
- 3 sites in United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Florida
Health Services Accessibility, Rural Health
Health Ahead Comparative Effectiveness Study
The Health Ahead Comparative Effectiveness Study is a pragmatic, parallel-arm interventional platform that systematically compares successive changes to preventive health screening on the path toward a fully automated screening…
- Conditions
- Health Services Accessibility, Rural Health, Medically Underserved Area, Preventive Health Services
- Trial name
- HACE (NCT07669168)
- Testing
- AI-Assisted Screening Interpretation (AI Reads), Human-Only Screening Interpretation
- Where
- United States
- Volunteers
- 1,000,000 people, healthy volunteers welcome
- Sponsor
- William Brandenburg, MD
Age-related Cognitive Decline
The Dortmund Vital Study: Impact of Biological and Lifestyle Factors on Cognitive Performace and Work Ability
The goal of the Dortmund Vital Study is to validate previous hypotheses and to generate and validate new hypotheses about the relationship of ageing, working conditions, genetic makeup, stress, metabolic functions, cardiovascular…
- Trial name
- DVS (NCT05155397)
- Where
- Germany
- Volunteers
- 627 people, healthy volunteers welcome
- Sponsor
- Technical University of Dortmund
Age-related Cognitive Decline
Magnetic Resonance Imaging (MRI) and Decline of Aging Aviator Performance
The primary purpose of this study is to apply state-of-the-art Magnetic Resonance Imaging (MRI) and Magnetic Resonance Spectroscopic Imaging (MRSI) techniques to measure changes over time in the brain.
- Trial name
- NCT01120860
- Testing
- MRI
- Where
- United States
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- Palo Alto Veterans Institute for Research
Bipolar II Disorder
add-on Low Dose Memantine in Middle-to-old Aged Bipolar II Disorder Patients
The investigators hypothesized that add-on memantine (MM) 5 mg/day may reduce chronic inflammation, and subsequently improve neuro-progression process and cognitive function in middle-to-old aged bipolar II disorder (BP-II)…
- Trial name
- NCT04035798
- Where
- Taiwan
- Volunteers
- 120 people
- Sponsor
- National Cheng-Kung University Hospital
Bipolar Disorder (BD), Depression - Major Depressive Disorder
Epigenetic Enhancement of Cognitive Training in Aging Mood and Schizophrenia Spectrum Disorder Populations
The aim of this clinical trial is to investigate the effects of a three-week virtual reality-based cognitive remediation training (VR-CRT) programme in combination with daily intake of a histone deacetylase inhibitor (HDACi)…
- Conditions
- Bipolar Disorder (BD), Depression - Major Depressive Disorder, Cognitive Impairment, Schizophrenia Disorders
- Trial name
- EPIC (NCT07404085)
- Testing
- Virtual Reality-based cognitive remediation therapy (VR-CRT), Virtual Reality-based control treatment (VR-CT), HDACi butyrate
- Where
- Denmark
- Volunteers
- 160 people
- Sponsor
- Mental Health Centre Copenhagen, Bispebjerg and Frederiksberg Hospital
Age-related Cognitive Decline
Attention Training for Learning Enhancement and Resilience Trial
Healthy aging is associated with a decline in multiple cognitive domains, as well as motor control function. The long-term consequences of cognitive and functional impairment resulting from age-related cognitive decline are well…
- Trial name
- ALERT (NCT02416401)
- Testing
- Computerized Plasticity-Based Adaptive Cognitive Training, Commercially available computerized training
- Where
- 2 sites in United States
- Volunteers
- 83 people
- Sponsor
- Posit Science Corporation
Cognition Disorders, Brain Pathology
A Precision Rehabilitation Approach to Counteract Age-Related Cognitive Declines
This study examines the behavioral, molecular, and structural biomarkers of brain health that will allow for the stratification of individuals according to their "cognitive signature" and function.
- Conditions
- Cognition Disorders, Brain Pathology, Physical Disability, Physical Activity
- Trial name
- CogEx (NCT03696082)
- Testing
- Aerobic Activity, Resistance Training, Yoga
- Where
- United States
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Alzheimer Disease, Hearing Loss
Early Age-Related Hearing Loss Investigation (EARHLI)
Early Age-Related Hearing Loss Investigation (EARHLI) is a single site study that will randomize late middle age adults to either a hearing intervention (including hearing aids) or a health education intervention.
- Conditions
- Alzheimer Disease, Hearing Loss, Cognitive Impairment
- Trial name
- EARHLI (NCT06174038)
- Testing
- Hearing Intervention, Health Education Intervention
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Columbia University
Type2diabetes, Mild Cognitive Impairment
Feasibility and Adherence to a Technology-assisted Home-based Strength Training Program in Adults With Type 2 Diabetes Mellitus and Mild Cognitive Impairment
This is a single-arm feasibility study employing a pre-post design with a 12-week intervention period. The study utilizes a telehealth-assisted home-based resistance exercise program, with a structured progression from supervised…
- Conditions
- Type2diabetes, Mild Cognitive Impairment, Age-related Cognitive Decline
- Trial name
- NCT07416799
- Testing
- Progressive Exercise Program (12 Weeks)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- The University of Texas Medical Branch, Galveston
Mild Cognitive Impairment, Age-related Cognitive Decline
Interventions to Attenuate Cognitive Decline: Keys to Staying Sharp
Different cognitive intervention approaches have been developed to attenuate decline (e.g., cognitive engagement, training, or stimulation), but it is not clear which approaches are efficacious.
- Trial name
- NCT03528486
- Testing
- Music Training I
- Where
- United States
- Volunteers
- 268 people, healthy volunteers welcome
- Sponsor
- University of South Florida
Cancer, Breast, Age-related Cognitive Decline
Older Breast Cancer Patients: Risk for Cognitive Decline
The goal of this study is to evaluate the impact of systemic therapy on cognition in older breast cancer patients, explore change in APE, LM and Cognition domains, measure associations between cognitive decline and QOL, and…
- Conditions
- Cancer, Breast, Age-related Cognitive Decline, Cognitive Decline
- Trial name
- TLC (NCT03451383)
- Where
- United States
- Volunteers
- 1,700 people, healthy volunteers welcome
- Sponsor
- Georgetown University
Physical Activity, Age-related Cognitive Decline
The Effect of Age, Physical Fitness and a Single Bout of Aerobic Exercise on Motor and Cognitive Functions
The proposed study is intended to examine the connection between two types of inhibition - cognitive and motor and the connection between motor inhibitory functions and a single bout of physical exercise in the context of age and…
- Trial name
- NCT03750812
- Testing
- Aerobic Exercise, Watching television
- Where
- Israel
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Hillel Yaffe Medical Center
Age-related Cognitive Decline
Remediation of Age-related Cognitive Decline: Vortioxetine and Cognitive Training
The purpose of this research study is to examine the potential benefits of vortioxetine in combination with at-home computerized cognitive training program to improve cognition, such as memory, attention, and concentration.
- Trial name
- BBS (NCT03272711)
- Testing
- Vortioxetine 10 mg, Cognitive training program
- Where
- United States
- Volunteers
- 129 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Age-related Hearing Loss, Hearing Loss, Sensorineural
A Prospective Cohort Study On Change of Cognitive Function In Aged-related Hearing Loss With Hearing Aids
Background: Deafness is one of the nine potentially modifiable risk factors for dementia simulated by the Lancet dementia Prevention, intervention and Care Committee in 2017.
- Conditions
- Age-related Hearing Loss, Hearing Loss, Sensorineural, Hearing Aid, Cognitive Function Abnormal
- Trial name
- NCT05694039
- Testing
- Hearing Aids
- Where
- China
- Volunteers
- 388 people, healthy volunteers welcome
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Age-related Cognitive Decline, Mild Cognitive Impairment
The Active Mind Trial: An Adaptive Randomized Trial to Improve Function and Delay Dementia
Older adults at risk for dementia show a variety of cognitive deficits, which can be ameliorated by different cognitive training (CT) exercises. The best combination of CT exercises is unknown.
- Conditions
- Age-related Cognitive Decline, Mild Cognitive Impairment, Dementia
- Trial name
- NCT04171323
- Testing
- Cognitive Training, Computerized Cognitive Stimulation
- Where
- 6 sites in United States
- Volunteers
- 1,305 people
- Sponsor
- University of Alabama at Birmingham
Age-related Cognitive Decline
Cognitive Engagement and Aging Mind
The purpose of this research is to examine whether and to what extent training of different types of cognitive engagement will improve performance on fluid cognitive abilities that typically decline with age.
- Trial name
- NCT05924490
- Testing
- Real-time strategy-based videogame training, Semantic Knowledge training
- Where
- United States
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- The University of Texas at Dallas
Intermittent Fasting, Aging
The Effect of Intermittent Fasting on Brain Health
The central hypothesis of this study is that closer adherence to time restricted eating (TRE) will improve endothelial function, neurovascular (NVC) responses, resulting in improved cognitive performance, potentially through…
- Trial name
- NCT06019195
- Testing
- Time restricted eating
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of Oklahoma
Age-related Hearing Loss, Age-related Cognitive Decline
Cognitive Function and EEG Brain Network Remodeling Among Users of Hearing Aids With ARHL
This study intends to retrospectively collect and analyze the case data of patients with age-related hearing loss who were admitted to the Otolaryngology Department of Sun Yat-sen Memorial Hospital from January 2020 to June 2024.
- Conditions
- Age-related Hearing Loss, Age-related Cognitive Decline, Depression, Sleep Disturbance
- Trial name
- EEG/ARHL (NCT06893432)
- Testing
- hearing aids
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Mild Cognitive Impairment
The Relationship Between Metamemory and Memory in Old Age
The purpose of this research is to explore the relationship of metamemory and memory of elders and to evaluate the effectiveness of a metamemory cognitive intervention on elders with mild cognitive impairment and low memory…
- Trial name
- M&Mresearch (NCT02113345)
- Testing
- Metamemory Cognitive Intervention
- Where
- Hong Kong
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong