Clinical trials: Aged 60 Years or Older
Aging
Automatic Reaction to Physical Activity and Sedentary Stimuli in Aging
Most individuals are aware of the benefits to health of regular physical activity and have good intentions to exercise. Yet, 1.4 billion people worldwide are inactive, which suggests that turning intention into action can be…
- Trial name
- NCT05704660
- Testing
- Adjusted Cognitive-biased modification task, Cognitive-biased modification task
- Volunteers
- 216 people, healthy volunteers welcome
- Sponsor
- University of Ottawa
Fall Prevention, Falls (Accidents) in Old Age
Validation of the Self-Assessment for Falls in the Elderly (SAFE) Questionnaire to Assess the Risk of Falls in People Aged 60 or Over.
This single-centre, cross-sectional diagnostic study will determine whether the new self-completed Self-Assessment for Falls in the Elderly (SAFE) questionnaire can classify fall-risk level (low, moderate, high) in adults ≥ 60…
- Trial name
- SAFE (NCT06961812)
- Testing
- Questionnaire and Physical Exam, Safe Self-Administered Questionnaire
- Where
- France
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- University Hospital, Montpellier
B-Cell Non-Hodgkin Lymphoma, Multiple Myeloma
Geriatric Assessment Guided Interventions to Accelerate Functional Recovery After CAR-T Therapy for Patients 60 Years and Older With B-cell Non-Hodgkin Lymphoma or Multiple Myeloma, GOCART Study
This clinical trial compares the effectiveness of geriatric assessment (GA) guided interventions to accelerate functional recovery after chimeric antigen receptor T-cell (CAR-T) therapy compared to standard of care (SOC) in…
- Trial name
- NCT06052826
- Testing
- Best Practice, Cognitive Intervention, Comprehensive Geriatric Assessment
- Where
- 4 sites in United States
- Volunteers
- 164 people
- Sponsor
- City of Hope Medical Center
Lung Cancer, Tobacco Use Disorder
Standard Medical Care or Urgent Chest X-ray in Diagnosing Lung Cancer in Smokers With Chest Symptoms Who Are Older Than 60 Years
RATIONALE: Diagnostic procedures, such as an urgent chest x-ray, may help in planning cancer treatment. It is not yet known whether standard medical care is more effective than an urgent x-ray in diagnosing lung cancer in smokers…
- Trial name
- NCT01344005
- Testing
- caregiver-related intervention or procedure, questionnaire administration, quality-of-life assessment
- Volunteers
- 386 people
- Sponsor
- Wales Cancer Trials Unit
Influenza
Immunogenicity of Standard-Dose Versus High-Dose Influenza Vaccines in Older Adults in Singapore
The goal of this clinical trial is to learn if the high-dose influenza vaccine can improve year-round protection in older adults aged 60 years and above.
- Trial name
- SingVax-01 (NCT07883421)
- Testing
- High-dose influenza vaccine, Standard-dose influenza vaccine
- Where
- Singapore
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Tan Tock Seng Hospital
E.Coli Infections
Study to Collect Information About Invasive Disease Caused by Extraintestinal Pathogenic Escherichia Coli (EXPECT-1)
The purpose of this study is to collect information from study participants who develop an invasive disease caused by Extraintestinal pathogenic E. coli (ExPEC) during a period of 12 months.
- Trial name
- EXPECT-1 (NCT04087681)
- Where
- 8 sites in United States, Canada and 6 more
- Volunteers
- 4,479 people, healthy volunteers welcome
- Sponsor
- MJM Bonten
E. Coli Infection
Study to Collect Information About Invasive Disease Caused by Extraintestinal Pathogenic Escherichia Coli-2 (EXPECT-2)
The purpose of this study is to collect information from study participants who are hospitalized with an invasive disease caused by Extraintestinal pathogenic E. coli (ExPEC).
- Trial name
- EXPECT-2 (NCT04117113)
- Where
- 8 sites in United States, Canada and 6 more
- Volunteers
- 238 people
- Sponsor
- UMC Utrecht
Dengue Fever
A Study of Dengue Tetravalent Vaccine (TDV) in Adults (Age 45 to 60 and >60 to 79 Years)
Dengue fever is caused by an infection with the dengue virus. Vaccination with Dengue Tetravalent Vaccine (TDV) can help prevent dengue fever.
- Trial name
- NCT06579755
- Testing
- TDV
- Where
- 7 sites in Argentina, Brazil and 2 more
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- Takeda
Digital Health Literacy, AI Chatbot
Artificial Intelligence and Digital Health Literacies Among Older Adults: A Mixed-method Pilot Intervention Study
The goal of this pilot study is to determine the feasibility and to learn if a training program called E2NGAGE-Literacy (Empowering Elders in Navigating Generative AI for Greater E-health Literacy) can potentially help older…
- Conditions
- Digital Health Literacy, AI Chatbot, Aged 60 Years or Older
- Trial name
- NCT07881510
- Testing
- AI and digital health literacy program (E2NGAGE-Literacy)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- National University of Singapore
Non-cancer Affected Volunteers
Ascertainment of Saliva or Blood Samples For Genetic Epidemiology Studies of Cancer and Aging
The purpose of this study is to help us learn more about the roles of genes in cancers. Genes are short pieces of DNA which determine the inherited characteristics that distinguish one individual from another.
- Trial name
- NCT00579618
- Testing
- Saliva or Blood samples
- Where
- United States
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- Memorial Sloan Kettering Cancer Center
Elderly Individuals Aged 60 Years or Older, Mild Cognitive Impairment (MCI)
THE EFFECTS OF GAMBIR CATECHIN (UNCARIA GAMBIR ROXB) SUPPLEMENTATION ON COGNITIVE FUNCTION, EXPRESSION OF APP, MAPT, BDNF, IL-10, TGF-Β GENES, AND PLASMA MDA LEVELS IN THE ELDERLY.
Objective The primary objective of this clinical trial is to investigate the effects of gambir catechin administration on cognitive function, the expression of amyloid precursor protein (APP), microtubule-associated protein tau…
- Trial name
- NCT06604390
- Testing
- catechin extracts (health food), plasebo
- Where
- 2 sites in Fiji, Indonesia
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Rahmi Novita Yusuf
Patients (>=60 Years Old) Suffering From Mild-moderate Stroke (Ischemic or Hemorrhagic, Stroke Severity Assessed by NIHSS <16 Points)
IMAGINE Study Protocol
Background: Rehabilitation pathways are crucial to reduce stroke-related disability. Motivational Interviewing (MI), a centred-person intervention aimed to empower and motivate the patient, could be a resource to improve…
- Trial name
- IMAGINE (NCT03434938)
- Testing
- Motivational interviewing
- Where
- 6 sites in Spain, Sweden
- Volunteers
- 272 people
- Sponsor
- Parc Sanitari Pere Virgili
Ann Arbor Stage IB Hodgkin Lymphoma, Ann Arbor Stage II Hodgkin Lymphoma
Nivolumab and Brentuximab Vedotin in Treating Older Patients With Untreated Hodgkin Lymphoma
This phase II trial studies how well nivolumab and brentuximab vedotin work in treating older patients with untreated Hodgkin lymphoma.
- Conditions
- Ann Arbor Stage IB Hodgkin Lymphoma, Ann Arbor Stage II Hodgkin Lymphoma, Ann Arbor Stage IIA Hodgkin Lymphoma, Ann Arbor Stage IIB Hodgkin Lymphoma
- Trial name
- NCT02758717
- Testing
- Brentuximab Vedotin, Nivolumab
- Where
- 9 sites in United States
- Volunteers
- 46 people
- Sponsor
- Academic and Community Cancer Research United
Aged 60 Years or Older, Volunteering to Participate in the Study
The Effect of Health Belief Model-Based Education on Knowledge and Behavioral Changes Regarding Dementia in Older Adults
While age is one of the strongest known risk factors for the onset of dementia, dementia is not an inevitable consequence of aging.
- Conditions
- Aged 60 Years or Older, Volunteering to Participate in the Study, Dementia Education, Prevention Intervention
- Trial name
- NCT07505693
- Testing
- 1. Introduction Session: Increasing Perceived Sensitivity, Session 2: Increasing the Perception of Seriousness/Importance, Session 3: Increasing the Perception of Benefit
- Where
- Turkey (Türkiye)
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Hasan Kalyoncu University
Respiratory Syncytial Virus Infection, Healthy Volunteers
Study of the Safety and Immune Response of an Investigational mRNA Vaccine for the Prevention of Respiratory Syncytial Virus and/or Human Metapneumovirus in Participants Aged 18 to 49 Years and 60 Years and Older
The purpose of this study is to evaluate the safety and immunogenicity an investigational messenger ribonucleic acid (mRN)A vaccine for the prevention of lower respiratory tract disease (LRTD) caused by respiratory syncytial…
- Conditions
- Respiratory Syncytial Virus Infection, Healthy Volunteers, Metapneumovirus Infection
- Trial name
- NCT06237296
- Testing
- RSV/hMPV mRNA LNP 1, RSV/hMPV mRNA LNP 2, RSV mRNA LNP 1
- Where
- 17 sites in United States, Australia
- Volunteers
- 558 people, healthy volunteers welcome
- Sponsor
- Sanofi Pasteur, a Sanofi Company
Leukemia
Biomarkers in Bone Marrow and Blood Samples From Older Patients With Acute Myeloid Leukemia Treated With Cytarabine-Based Therapy
RATIONALE: Studying samples of bone marrow and blood from patients with cancer in the laboratory may help doctors predict how well patients will respond to treatment.
- Trial name
- NCT01169363
- Testing
- proteomic profiling, flow cytometry, laboratory biomarker analysis
- Volunteers
- 200 people
- Sponsor
- ECOG-ACRIN Cancer Research Group
Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities, Adult Acute Myeloid Leukemia With Del(5q)
Clofarabine and Cytarabine in Treating Older Patients With AML or High-Risk MDS
This phase I/II trial studied the side effects and best dose of clofarabine when given together with cytarabine and to see how well they work in treating older patients with acute myeloid leukemia (AML) or high-risk…
- Conditions
- Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities, Adult Acute Myeloid Leukemia With Del(5q), Adult Acute Myeloid Leukemia With Inv(16)(p13;q22), Adult Acute Myeloid Leukemia With t(16;16)(p13;q22)
- Trial name
- NCT00839982
- Testing
- clofarabine, cytarabine
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- Fred Hutchinson Cancer Center
Acute Myelogenous Leukemia
Plerixafor and Clofarabine in Frontline Treatment of Elderly Patients With Acute Myelogenous Leukemia (AML)
The goal of Part 1 of this clinical research study is to learn about the safety of the combination of plerixafor and clofarabine when given to patients with previously untreated AML who are at least 60 years old.
- Trial name
- NCT01160354
- Testing
- Plerixafor, Clofarabine
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- M.D. Anderson Cancer Center
Acute Lymphoblastic Leukemia (ALL), Newly Diagnosed Philadelphia Chromosome Negative
Intravenous Erwinia Chrysanthemi Asparaginase in Patients With Newly Diagnosed Philadelphia Chromosome Negative Acute Lymphoblastic Leukemia Aged 60 Years or Older
The purpose of this study is to test the safety of Erwinia Chrysanthemi asparaginase when used alone and together with chemotherapy and find out what effects, if any, it has on people.
- Conditions
- Acute Lymphoblastic Leukemia (ALL), Newly Diagnosed Philadelphia Chromosome Negative, Aged 60 Years or Older
- Trial name
- NCT02647190
- Testing
- Erwinia Chrysanthemi asparaginase
- Where
- United States
- Sponsor
- Memorial Sloan Kettering Cancer Center
Influenza, Vaccination Adverse Event
A Post-marketing Safety Study of Beijing Tiantan Biological's Influenza Virus Vaccine in Elderly
To monitor the safety of Beijing Tiantan Biological's influenza vaccine in elderly through Adverse Events Following Immunization Surveillance System of China.
- Trial name
- NCT01906593
- Volunteers
- 536,812 people, healthy volunteers welcome
- Sponsor
- Centers for Disease Control and Prevention, China