Clinical trials: Aging and Cognitive Health
Age-related Cognitive Decline, Cognitive Deterioration
Decoding the Cognitive Trajectory of Hong Kong SuperAgers: a Longitudinal Follow-up Study
This is a prospective follow-up study conducted at the Department of Psychiatry, The Chinese University of Hong Kong. The participants, including high-performing elderly (SuperAgers), normal ageing elderly and neurocognitive…
- Conditions
- Age-related Cognitive Decline, Cognitive Deterioration, Dementia, Mild
- Trial name
- NCT05728801
- Testing
- Ageing
- Where
- Hong Kong
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Adherence, Treatment
Smart Reminders to Promote Home-based Cognitive Training
This study will examine whether among older adults an adaptive and personalized reminder system can better support adherence to home-based cognitive training over typical reminder systems.
- Trial name
- NCT05016856
- Testing
- Adherence Promotion With Person-centered Technology (APPT) System, Standard Reminder System (Active Control)
- Where
- United States
- Volunteers
- 199 people, healthy volunteers welcome
- Sponsor
- Florida State University
Autophagy, Healthy Aging
Effects of Miricell Supplementation on Biomarkers of Healthy Aging and Autophagy
The goal of this clinical trial is to learn if a dietary supplement called Miricell works to improve cellular health and signs of healthy aging in adults. It will also learn about the safety of Miricell.
- Trial name
- NCT07675200
- Testing
- Spermidine
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Nutraland USA, Inc.
Aging, Mild Cognitive Impairment
Internet-based Conversational Engagement Clinical Trial
The study aims to randomize 320 (160 Caucasian, 160 African American) socially isolated adults 75+ years old (50:50 split between those with normal cognition and mild cognitive impairment (MCI)) recruited from the community to…
- Trial name
- I-CONECT (NCT02871921)
- Testing
- Conversational Engagement
- Where
- 2 sites in United States
- Volunteers
- 186 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Frailty, Pre-Frailty
In-Person, Online, and Hybrid Healthy-Aging Education for Pre-Frailty and Frailty in Older Adults
The goal of this clinical trial is to determine whether a 6-month healthy-aging education program delivered in person, online, or in a hybrid format reduces frailty and is cost-effective compared with usual care in…
- Trial name
- FRAGSALUD-ON (NCT07738393)
- Testing
- In-person healthy aging education program, Hybrid healthy aging education program, Online healthy aging education program
- Where
- Spain
- Volunteers
- 276 people
- Sponsor
- University of Cadiz
Aging, Alzheimer Disease
Lifestyle for the BRAin Health - Nutrition and Exercise Training Intervention
Due to the increasing incidence of dementia and the lack of causal treatment, non-pharmacological interventions represent an attractive and effective therapeutic strategy of neurodegenerative diseases, such as Alzheimer's…
- Conditions
- Aging, Alzheimer Disease, Life Style, Healthy, Exercise
- Trial name
- LIBRA-NET (NCT06986096)
- Testing
- Aerobic-strength training and nutritional counseling, Cognitive training and stretching.
- Where
- Slovakia
- Volunteers
- 40 people
- Sponsor
- Slovak Academy of Sciences
Aging, Mortality
Longevity Metrics AI/ML Development Study
This study builds AI models that score diagnostic screening tests, and that predict screening results, clinical judgment, and life expectancy.
- Conditions
- Aging, Mortality, Cardiovascular Disease Prevention, Metabolic Syndrome
- Trial name
- NCT07808619
- Testing
- AIML scored health screening battery
- Where
- United States
- Volunteers
- 1,000,000 people, healthy volunteers welcome
- Sponsor
- Longevity Metrics, Inc.
Aging, Physical Activity in Adults
Health Effects of Taekwondo Training for Elderly Over the Age of 60 Years
This randomized controlled trial investigates the effects of a 10-week Taekwondo (TKD) training intervention on physical and cognitive function in community-dwelling adults aged 60 years and older.
- Trial name
- TKD 60+ (NCT07451288)
- Testing
- Taekwondo training
- Where
- Norway
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Vegard Vereide Iversen
Frailty, Vision and Hearing Loss
Health Determinants in Older Adults Living At Home
The observational study will conduct interprofessional assessments by registered nurses, physiotherapists, and occupational therapists of health determinants (i.e., frailty, physical, cognitive, and sensory function, mental and…
- Conditions
- Frailty, Vision and Hearing Loss, Cognitive Function, Social 1, Mental Health Issue
- Trial name
- NCT05837728
- Testing
- Health promoting assessment of older adults living at home
- Where
- Norway
- Volunteers
- 40 people
- Sponsor
- University of Stavanger
Dance, Older Adults
Dose-response Effect of Community Dance Programme
The goal of this interventional study is to examine the dose-response effect of Community Dance Programme (CDP) on the physical, cognitive and psychological health of pre-frail and mildly frail community-dwelling older adults.
- Conditions
- Dance, Older Adults, Frailty at Older Adults, Active Ageing
- Trial name
- NCT07081191
- Testing
- Dance, Active Control
- Where
- Singapore
- Volunteers
- 284 people, healthy volunteers welcome
- Sponsor
- National University of Singapore
Ageing, Frailty
Physiotherapy Interventions on Functional Capacity, Balance and Mental Domains in Community-Dwelling Older Adults: A Randomized Clinical Trial With Two Parallel Groups
This study will investigate whether two different physiotherapy exercise programs can improve physical function, balance and mental well-being in older adults living in the community in Angola.
- Conditions
- Ageing, Frailty, Sarcopenia, Decline, Cognitive
- Trial name
- NCT07424274
- Testing
- Multicomponent Physiotherapy Exercise Program, Reduced Functional Physiotherapy Exercise Program
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- Aveiro University
Cognitive Decline, Aging
Zinde Zihin Program to Reduce Alzheimer's Disease Risk in Adults Aged 65 and Older
This study aims to evaluate the feasibility and implementation of the Zinde Zihin ("Fit Mind") multidomain lifestyle program for older adults aged 65 years and older living in public nursing homes.
- Conditions
- Cognitive Decline, Aging, Alzheimer Disease
- Trial name
- ZZ-MIND (NCT07244848)
- Testing
- Zinde Zihin (Fit Mind) Multidomain Lifestyle Intervention
- Where
- Turkey (Türkiye)
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Burdur Mehmet Akif Ersoy University
Healthy Aging
Food Anthocyanins and Flavanols as a Strategy for a Healthy Ageing: Cardiovascular Health and Cognitive Performance
The study examines the effect of cocoa flavanols, red-berries anthocyanins or a combination of both on markers of cardiovascular health and cognition.
- Trial name
- POLYAGE (NCT04348162)
- Testing
- Cocoa flavanols and berries anthocyanins
- Where
- Spain
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- National Research Council, Spain
Cancer, Cognitive Impairment
Cancer and Mild Cognitive Impairment a Patient-Caregiver Behavioral Intervention
The purpose of this study is to see whether programs that include both a patient and their spouse or a patient and family caregiver (known as a dyad) are helpful for families in which one member of the dyad has cancer and mild…
- Trial name
- NCT04826315
- Testing
- COPE +
- Where
- United States
- Sponsor
- Duke University
Aging, Cognitive Impairment
Leveraging Social Networks to Improve Sleep and Mindfulness Among Older Adults in Residential Housing Facilities
The aim of this study is to design a sleep and mindfulness intervention to improve sleep, quality of life, and cognitive function among older adults.
- Conditions
- Aging, Cognitive Impairment, Sleep
- Trial name
- NCT06989619
- Testing
- Sleep health and mindfulness intervention
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Obesity & Overweight
Multimodal Intervention for Weight Management and Health in the Elderly Population
Aging may be accompanied by changes in body composition, muscle strength, metabolic health, and well-being. In older adults with overweight or obesity, strategies that combine physical exercise, behavioral changes, and…
- Trial name
- NCT07820774
- Testing
- Nutritional guidance focused on adopting a high-protein diet., Group Cognitive Behavioral Therapy Intervention, Resistance Training Program
- Where
- Brazil
- Volunteers
- 54 people
- Sponsor
- Universidade Cesumar (UNICESUMAR)
Cognitive Decline, Cognitive Function
A Clinical Trial to Investigate the Efficacy of a Supplement to Improve and Maintain Cognitive Function and Memory
This study will evaluate the efficacy of 1MD Nutrition's MindMD supplement in improving and maintaining cognitive function and memory.
- Trial name
- NCT06523218
- Testing
- MindMD Supplement
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Scale Media Inc
Cognitive Decline, Cognitive Impairment, Mild
Efficacy of a Mobile-based Multidomain Intervention to Improve Cognitive Function and Health-related Outcomes Among Older Korean Adults With a High Risk of Dementia
This study investigated the efficacy of the Silvia program, a mobile-based multidomain intervention, to improve cognitive function and health-related outcomes of older adults with a high risk of dementia.
- Conditions
- Cognitive Decline, Cognitive Impairment, Mild, Aging, Dementia
- Trial name
- NCT05675137
- Testing
- mobile-based, paper-based
- Where
- South Korea
- Volunteers
- 80 people
- Sponsor
- Silvia Health
Dementia, Alzheimer Dementia (AD)
Fuzhou Aging Brain Health Initiative
The goal of this observational study is to learn about the pathophysiological characterization and evolutionary patterns of Alzheimer's disease (AD) in older adults in Fujian Province, China.
- Conditions
- Dementia, Alzheimer Dementia (AD), Mild Cognitive Impairment (MCI), Subjective Cognitive Decline (SCD)
- Trial name
- FAITH (NCT07891429)
- Testing
- Fluids biomarker and neuroimaging of AD diagnosis
- Where
- 4 sites in China
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Fujian Medical University Union Hospital
Aging
The Psychobiological Effects of Participation in a One-Month Insight Meditation Retreat
The purpose of this study was to examine how participation in a 1 month intensive Insight (vipassana) Meditation retreat (a) affects biological markers of cellular aging, social affiliation, and inflammation, which are important…
- Trial name
- NCT03056105
- Testing
- Residential Insight Meditation Retreat
- Where
- United States
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- University of California, Davis