Clinical trials: Aging and Cognitive Health
Brain Aging, Cerebrovascular Function
AKG and Brain Health in Aging
This proposal will test the hypothesis that AKG supplementation will improve NGVC responses and cognitive performance in older adults.
- Trial name
- NCT07861867
- Testing
- Calcium AKG
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Oklahoma
Aging
Breaking Sitting with High-intensity Interval Training for Brain Health
This trial will examine whether interrupting 3.5 hours of sitting every 30 min with 6 min high intensity interval training (HIIT) breaks compared to light intensity interval training (LIIT) will improve brain health in…
- Trial name
- HIIT2SITLess (NCT06243016)
- Testing
- High-Intensity Interval Training (HIIT) Breaks to Sitting, Light-Intensity Interval Training (LIIT) Breaks to Sitting
- Where
- United States
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- University of Illinois at Urbana-Champaign
Depression, Depressive Disorder
Beyond Ageing Project: A Study for the Prevention of Depression
The purpose of this study is to determine whether folate and vitamin B12, physical activity and mental health literacy can prevent depression, and folate and vitamin B12 and physical activity can prevent cognitive impairment in…
- Trial name
- NCT00214682
- Testing
- Folate (400mcg) and Vitamin B12 (100 mcg), mediated physical activity promotion, Mental health literacy
- Where
- Australia
- Volunteers
- 909 people
- Sponsor
- Australian National University
Healthy Aging
Food Anthocyanins and Flavanols as a Strategy for a Healthy Ageing: Cardiovascular Health and Cognitive Performance
The study examines the effect of cocoa flavanols, red-berries anthocyanins or a combination of both on markers of cardiovascular health and cognition.
- Trial name
- POLYAGE (NCT04348162)
- Testing
- Cocoa flavanols and berries anthocyanins
- Where
- Spain
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- National Research Council, Spain
Sedentary Older Adults, Sedentariness and Well-being
A-B-C Program for Sedentary Older Adults With Depressive Symptoms
The importance and benefits of leading a physically active lifestyle have been long studied. Examples of the multiple advantages from physical activity are improved health of the heart and brain, having a more independent living…
- Conditions
- Sedentary Older Adults, Sedentariness and Well-being, Sedentary; Aging
- Trial name
- A-B-C (NCT07176637)
- Testing
- A-B-C Program, Physical Activity Educational Program
- Volunteers
- 66 people
- Sponsor
- The Royal Ottawa Mental Health Centre
Mild Cognitive Impairment (MCI), Dementia
Culturally Familiar Nostalgic VR Cognitive Training for Older Adults
This randomized controlled trial investigates the effects of a nostalgia-based cognitive training intervention delivered via Virtual Reality (VR) on emotional well-being and cognitive functioning among community-dwelling older…
- Conditions
- Mild Cognitive Impairment (MCI), Dementia, Cognitive Decline, Psychological Well-being
- Trial name
- NCT06973551
- Testing
- Brain Health Nostalgic VR Program
- Where
- Taiwan
- Volunteers
- 64 people
- Sponsor
- National Taiwan Normal University
Intrinsic Capacity, Frailty
Project ICOPE Brazil: Assessment of Intrinsic Capacity in Brazilian Older Adults
The ICOPE Brazil study aims to understand aging trajectories in Brazil, especially healthy aging trends based on intrinsic capacity, a collective of mental and physical capacities one may have to maintain their functional ability…
- Conditions
- Intrinsic Capacity, Frailty, Aging, Healthy Aging
- Trial name
- ICOPE-BR (NCT06968702)
- Volunteers
- 3,838 people
- Sponsor
- University of Sao Paulo
Dementia, Dementia, Vascular
Promoting Goals-of-Care Discussions for Patients With Memory Problems and Their Caregivers
The goal of this clinical trial is to improve communication among clinicians, patients with memory problems, and their family members.
- Conditions
- Dementia, Dementia, Vascular, Mixed Dementias, Alzheimer Disease
- Trial name
- PICSI-M (NCT05596760)
- Testing
- Jumpstart Guide
- Where
- 3 sites in United States
- Volunteers
- 1,802 people
- Sponsor
- University of Washington
Healthy Aging, Healthy
Investigating the Effects of Daily Consumption of Blueberry (Poly)Phenols on Vascular Function and Cognitive Performance
Foods rich in certain (poly)phenols, particularly flavonoids, such as berries and cocoa, have been shown to improve measures of vascular function as well as cognitive performance in human intervention studies.
- Trial name
- BluFlow (NCT04084457)
- Testing
- Wild Blueberry powder
- Where
- United Kingdom
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- King's College London
Aging, Exercise
Assessing Cognitive and Health Improvements in the Elderly Via Exercise (ACHIEVE) - Study.
In Colombia, a demographic transition is occurring that is reflected in an inverted population pyramid, with an increase in the proportion of older adults due to a better quality of life, as well as a decrease in the young…
- Trial name
- NCT06052644
- Testing
- Exercise Dose-Response
- Where
- Colombia
- Volunteers
- 118 people
- Sponsor
- University of Jaén
Engagement, Patient, Mood
SimpleC Wellness Platform With Social Robot Interaction
This implementation study will be conducted to test a Socially-Assistive Robot (SAR) system for residents in an Assisted Living environment. The goal of the SAR system is to enhance social engagement and connectedness.
- Conditions
- Engagement, Patient, Mood, Quality of Life, Aging
- Trial name
- NCT05296239
- Testing
- SimpleC Wellness Platform with Social Robot Interaction
- Where
- 2 sites in United States
- Volunteers
- 26 people
- Sponsor
- SimpleC, LLC
Mild Dementia, Cognitive Impairment, Mild
Support Monitoring and Reminder Technology
This multicentre randomized control trial aims to evaluate the effects of an intervention consisting of an health application developed to improve the quality of life (QoL) in older people with mild dementia and their informal…
- Trial name
- SMART4MD (NCT03325699)
- Testing
- SMART4MD Health Application
- Where
- 5 sites in Belgium, Czechia and 2 more
- Volunteers
- 1,200 people
- Sponsor
- Johan Sanmartin Berglund
Active Aging Individuals Aged 65 and Over, Aging
Italian Validation of the dNA Scale and Its Correlation With Neurocognitive Variables
The goal of this experimental multicentric intervention study is to validate, in Italian, the dynamic Neurocognitive Adaptation (dNA) Scale, which has already been validated in English, among a healthy elderly population (aged 65…
- Conditions
- Active Aging Individuals Aged 65 and Over, Aging, Mild Cognitive Impairment (MCI), Dementia
- Trial name
- NCT07533084
- Where
- 8 sites in Italy
- Volunteers
- 265 people, healthy volunteers welcome
- Sponsor
- Neuromed IRCCS
Age-related Cognitive Decline
The Dortmund Vital Study: Impact of Biological and Lifestyle Factors on Cognitive Performace and Work Ability
The goal of the Dortmund Vital Study is to validate previous hypotheses and to generate and validate new hypotheses about the relationship of ageing, working conditions, genetic makeup, stress, metabolic functions, cardiovascular…
- Trial name
- DVS (NCT05155397)
- Where
- Germany
- Volunteers
- 627 people, healthy volunteers welcome
- Sponsor
- Technical University of Dortmund
Aging, Physical Activity in Adults
Health Effects of Taekwondo Training for Elderly Over the Age of 60 Years
This randomized controlled trial investigates the effects of a 10-week Taekwondo (TKD) training intervention on physical and cognitive function in community-dwelling adults aged 60 years and older.
- Trial name
- TKD 60+ (NCT07451288)
- Testing
- Taekwondo training
- Where
- Norway
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Vegard Vereide Iversen
Cognitive Dysfunction, Aging
Study on Aging and Cognitive Impairment in China
Background: By the end of 2022, China had about 280 million people aged 60 and older, making up 19.8% of the population. This number is projected to exceed 300 million by the end of the 14th Five-Year Plan and 400 million by…
- Trial name
- HAPCAD (NCT06679296)
- Where
- China
- Volunteers
- 20,000 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital of Wenzhou Medical University
Engagement, Patient, Quality of Life
SimpleC Wellness Platform With Social Robot Interaction (Long-term)
This study will be conducted to test a Socially-Assistive Robot (SAR) system for residents in an Assisted Living environment. The goal of the SAR system is to enhance social engagement and connectedness.
- Conditions
- Engagement, Patient, Quality of Life, Mood, Aging Well
- Trial name
- NCT05599503
- Testing
- Behavioral Interventions, Robot Interventions
- Where
- 2 sites in United States
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- SimpleC, LLC
Memory Deficits, Mood Change
The Effects of Microbiological Spectrum Changes to Improve Cognitive Health in Aging Population
The goal of this project is to develop probiotic dietary supplements intended for the elderly, which can modify the composition of the intestinal microbiota typically occurring in the aging population.
- Conditions
- Memory Deficits, Mood Change, Gut Health, Aging Problems
- Trial name
- CleverAgeBiota (NCT05051501)
- Testing
- Probiotics C2P
- Where
- 2 sites in Czechia
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health, Czech Republic
Mild Cognitive Impairment (MCI), Aging
Elderberry Functional Gum and Cognitive & Oral Health in Older Adults
Globally, the aging population is increasing rapidly, leading to a dramatic rise in the prevalence of Alzheimer's disease and other types of dementia.
- Conditions
- Mild Cognitive Impairment (MCI), Aging, Oral Microbiome
- Trial name
- NCT07054645
- Testing
- Elderberry Anthocyanin Chewing Gum
- Where
- Turkey (Türkiye)
- Volunteers
- 34 people
- Sponsor
- Burdur Mehmet Akif Ersoy University
Alzheimer Disease (AD), Cardio Vascular Disease
Arlington Longitudinal Optimal Healthy Aging Study (ALOHA)
The Arlington Longitudinal Optimal Healthy Aging (ALOHA) Study is a community-based research project led by the Marymount University Center for Optimal Aging (MCOA).
- Conditions
- Alzheimer Disease (AD), Cardio Vascular Disease, Mild Cognitive Impairment (MCI), Frailty Syndrome
- Trial name
- ALOHA (NCT07180147)
- Where
- United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Marymount University