Clinical trials: Agitated Behaviour
Schizophrenia
A Study Comparing Rapid Acting Intramuscular Olanzapine and Placebo in Agitated Patients With Schizophrenia
The primary objectives of the study is to confirm if the efficacy of IM olanzapine in patients with schizophrenia is greater than IM placebo by comparing changes from baseline to 2 hours post first IM injection of agitation.
- Trial name
- NCT00640510
- Testing
- Rapid Acting Intramuscular Olanzapine, Isotonic sodium chloride solution
- Where
- 11 sites in Japan
- Volunteers
- 34 people
- Sponsor
- Eli Lilly and Company
Agitation in Patients With Dementia of the Alzheimer's Type
Efficacy, Safety and Tolerability of AVP-786 for the Treatment of Agitation in Patients With Dementia of the Alzheimer's Type
Participants with agitation secondary to dementia of the Alzheimer's type. The diagnosis of probable Alzheimer's disease (AD) was to be based on the "2011 Diagnostic Guidelines for Alzheimer's Disease" issued by the National…
- Trial name
- NCT02442765
- Testing
- AVP-786
- Where
- 126 sites in United States, Estonia and 4 more
- Volunteers
- 387 people
- Sponsor
- Otsuka Pharmaceutical Development & Commercialization, Inc.
Psychotic Disorders, Aggression
Rapid Tranquillization Trial: TREC-India II
Three hundred consecutive adult patients presenting to the emergency services of the department of psychiatry and who are diagnosed by the treating doctor to be needing tranquillization to control agitated or aggressive behavior…
- Trial name
- TRECIndia-II (NCT00455234)
- Testing
- Intramuscular Olanzepine 10 mg, Intramuscular Haloperidol 5-10 mg + Promethazine 25-50 mg
- Where
- India
- Volunteers
- 300 people
- Sponsor
- Christian Medical College, Vellore, India
Agitation, Emergence
Intramuscular Ketamine Effect on Postnasal Surgery Agitation
Emergence agitation (EA) is a common complication after nasal surgery. In this study, we aimed to investigate the effect of intramuscular ketamine on EA following septoplasty and open septorhinoplasty (OSRP) when administered at…
- Trial name
- NCT05313659
- Testing
- Ketamine Hydrochloride
- Where
- Jordan
- Volunteers
- 193 people, healthy volunteers welcome
- Sponsor
- Jordanian Royal Medical Services
Alzheimer Disease
Bathing Persons With Alzheimer's Disease aT Home (The BATH Study)
This study will evaluate the effectiveness of a 3-week reminiscence intervention applied during bathing persons with Alzheimer's disease (AD) in decreasing resistiveness to care (RTC), relieving patient discomfort, and improving…
- Trial name
- NCT00062569
- Testing
- Bathing Support Intervention (BSI), Caregiver reminiscence with coaching
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- National Institute of Nursing Research (NINR)
Agitation, Schizophrenia
Sub-Lingual Dexmedetomidine in Agitation Associated With Schizophrenia
This is a two-stage adaptive Phase Ib trial design, that will identify two doses (lowest dose with clinical benefit and highest safe dose) in a first stage and better evaluate safety, tolerability and variability of effect in the…
- Trial name
- NCT04010305
- Testing
- Sublingual film containing BXCL501 (Dexmedetomidine)
- Where
- 12 sites in United States
- Volunteers
- 135 people
- Sponsor
- BioXcel Therapeutics Inc
Cardiac Catheterization, Electrophysiology Procedure
Post Anesthesia Care Unit (PACU) Weighted Blanket Study
This study is being conducted to evaluate the safety and efficacy of weighted blankets to reduce agitation in patients in the post-procedural phase after cardiac catheterization and electrophysiology procedures in the post…
- Conditions
- Cardiac Catheterization, Electrophysiology Procedure, Pediatric Cardiology
- Trial name
- NCT05632640
- Testing
- Standard of Care, Weighted blanket
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- University of Michigan
Agitation
Dexmedetomidine Transdermal Systems (DMTS) Treatment for Agitation Associated With Dementia of the Alzheimer's Type
The primary objective of this study is to evaluate the efficacy of DMTS on frequency and severity of agitation associated with dementia of the Alzheimer's type, compared with placebo.
- Trial name
- NCT06052254
- Testing
- 12 cm2 - 2 Active DMTS Patches
- Where
- 8 sites in United States
- Volunteers
- 150 people
- Sponsor
- Teikoku Pharma USA, Inc.
Agitation in Patients With Dementia of the Alzheimer's Type
Study to Assess the Efficacy, Safety, and Tolerability of AVP-786 for the Treatment of Agitation in Patients With Dementia of the Alzheimer's Type
This study was conducted to evaluate the efficacy, safety, and tolerability of AVP-786 (deudextromethorphan hydrobromide [d6-DM]/quinidine sulfate [Q]) compared to placebo for the treatment of agitation in participants with…
- Trial name
- NCT04464564
- Testing
- AVP-786
- Where
- 106 sites in United States, Belgium and 11 more
- Volunteers
- 241 people
- Sponsor
- Otsuka Pharmaceutical Development & Commercialization, Inc.
Alzheimer's Disease, Alzheimer Dementia (AD)
Standardizing Care for Neuropsychiatric Symptoms and Quality of Life in Dementia
The object of this study to evaluation an Integrated Care Pathway (ICP) to treat Aggression and Agitation in Alzheimer's disease (AD-AA).
- Conditions
- Alzheimer's Disease, Alzheimer Dementia (AD), Aggression
- Trial name
- StaN (NCT03672201)
- Testing
- Non-Pharmacological Intervention, Pharmacological Intervention
- Where
- 6 sites in Canada
- Volunteers
- 187 people
- Sponsor
- Centre for Addiction and Mental Health
Agitation,Psychomotor
Olanzapine Versus Midazolam for Agitation
The goal of this research investigation is to conduct a prospective observation of the comparative efficacy of midazolam versus olanzapine for the treatment of acute undifferentiated agitation in the emergency department.
- Trial name
- OvM (NCT03899506)
- Testing
- Olanzapine, Midazolam
- Where
- United States
- Volunteers
- 206 people
- Sponsor
- Hennepin Healthcare Research Institute
Agitation
Effect of Deksmedetomidine and Remifentanil in Extubation Agitation
To compare the effect of two different agents deksmedetomidine, remifentanil and placebo, agitation and recovery condition, on nasal septum operation.
- Trial name
- EA (NCT02104297)
- Testing
- deksmedetomidine, Remifentanil, Saline
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Diskapi Yildirim Beyazit Education and Research Hospital
Dementia, Pain
Pain in Patients With Dementia and Behavioural Disturbances
In nursing homes (NHs) 80% of the patients have dementia, between 60%-80% exhibit behavioural disturbances (BPSD), and more than 60% have pain. Both pain and BPSD is more common in those with severe dementia.
- Conditions
- Dementia, Pain, Agitation
- Trial name
- NCT01021696
- Testing
- Paracetamol, Morphine, Buprenorphine plaster
- Where
- 18 sites in Norway
- Volunteers
- 352 people
- Sponsor
- University of Bergen
Competence
VR-Based Intervention for Caregiving Competence in Dementia
This study aims to develop and evaluate the effectiveness of a VR-based educational intervention designed to improve the dementia caregiving abilities of formal caregivers in residential care homes.
- Trial name
- VRE-ABC (NCT06797180)
- Testing
- Virtual Reality Education for Dementia Caregivers
- Where
- Taiwan
- Volunteers
- 120 people
- Sponsor
- Mackay Medical College
Acute Agitation
Medical Monitoring for Agitated Patients Pilot RCT - Medical Monitoring
The Psychiatric Emergency Services (PES) is an under researched area of clinical practice, largely in the management of acutely agitated and violent patients.
- Trial name
- NCT02512705
- Testing
- Pinel Restraints, Seclusion Room
- Volunteers
- 90 people
- Sponsor
- St. Joseph's Healthcare Hamilton
Traumatic Brain Injury, Delirium
Comparison of Haloperidol and Dexmedetomidine for Delirium and Agitation in ICU Patients With Traumatic Brain Injury
Traumatic brain injury is a serious and common medical condition that often requires admission to the intensive care unit and the use of mechanical ventilation.
- Conditions
- Traumatic Brain Injury, Delirium, Agitation
- Trial name
- NCT06993194
- Testing
- Haloperidol, Dexmedetomidine
- Volunteers
- 40 people
- Sponsor
- Benha University
Agitation, Pediatric Disorder
Addition of Magnesium Sulfate to Caudal to Prevent Postoperative Emergence Agitation.
Emergence agitation after sevoflurane anesthesia is still a problem needed to be solved.The aim of the study is to delineate the effect of caudal magnesium sulfate in children undergoing lower abdominal surgery to prevent…
- Trial name
- NCT02164773
- Testing
- Magnesium Sulfate, 0.9%normal saline
- Where
- Egypt
- Volunteers
- 70 people
- Sponsor
- Ain Shams University
Agitation Associated With Alzheimer's Dementia, Alzheimer's Dementia
Electroacupuncture for the Treatment of Agitated Symptoms of Alzheimer's Disease
The purpose of this study is to evaluate the efficacy of electroacupuncture in the treatment of agitation symptoms in patients with Alzheimer's disease (AD).
- Trial name
- NCT06495957
- Testing
- Electroacupuncture group, Micro-acupuncture group
- Where
- 7 sites in China
- Volunteers
- 224 people
- Sponsor
- Guang'anmen Hospital of China Academy of Chinese Medical Sciences
Schizophrenia, Psychosis
Quetiapine Extended Release (XR) for the Management of Psychotic Aggression or Agitation in Adult Acute Psychiatry
This study is a multi-site study examining the use of Quetiapine XR for psychotic aggression in an acute psychiatric setting. The study aims to demonstrate that management with Quetiapine XR significantly reduces aggressive…
- Trial name
- NCT00986167
- Testing
- Quetiapine XR
- Where
- 2 sites in Australia
- Volunteers
- 72 people
- Sponsor
- Bayside Health
Agitated; State, Acute Reaction to Stress, Agitation,Psychomotor
Mindful Melody: Feasibility of Implementing Music Listening on an Inpatient Psychiatric Unit and Its Relation to the Use of As Needed Medications for Acute Agitation
In this quality improvement project, our objectives were to assess the feasibility and effectiveness of using music as an adjunct to or replacement of pharmacological interventions for patient agitation on an inpatient…
- Trial name
- NCT04514432
- Testing
- Music
- Where
- United States
- Volunteers
- 172 people, healthy volunteers welcome
- Sponsor
- State University of New York - Upstate Medical University