Clinical trials: Air Pollution
Blood Pressure, Heart Rate Variability
The Cardiovascular Benefits of Reducing Personal Exposure to Air Pollution
Exposure to air pollution is an important risk factor for cardiovascular morbidity and mortality, and is associated with increased blood pressure, reduced heart rate variability, endothelial dysfunction and myocardial ischaemia.
- Trial name
- NCT00809432
- Testing
- Face mask (Dust Respirator), No Face mask
- Where
- China
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Pollution; Exposure, Neurodevelopmental Disorders
Air Pollution and Development in the Boricua Youth Study
This study seeks to understand the relationship between prenatal maternal air pollution exposure and offspring risk for ADHD and examine two potential -modifiable- mechanisms: prenatal maternal inflammation and offspring sleep…
- Trial name
- NCT05368493
- Testing
- MRI task
- Where
- 2 sites in United States, Puerto Rico
- Volunteers
- 182 people, healthy volunteers welcome
- Sponsor
- New York State Psychiatric Institute
Air Pollution
The Role of Macrophage Activation in Lung Injury Following Ozone Exposure
The purpose of the study is to better understand the mechanisms of lung injury from ozone exposure. Subjects will participate in two exposure sessions: filtered air and 0.2 ppm ozone.
- Trial name
- NCT05794087
- Testing
- Clean Air, Ozone
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Rutgers, The State University of New Jersey
Lung Function, Heart Rate Variability
Effects of Exposure to Biomass-burning Air Pollution on Lung Function, Heart Rate Variability and Inflammatory Markers in Sugarcane Workers
Introduction: Non-mechanized sugar cane harvesting preceded by burning, an important and prevalent professional activity of agribusiness segment of the Brazilian economy, exposes workers and people of neighboring towns to high…
- Conditions
- Lung Function, Heart Rate Variability, Oxidative Stress, Systemic Inflammatory Response
- Trial name
- NCT01371188
- Where
- Brazil
- Volunteers
- 222 people, healthy volunteers welcome
- Sponsor
- InCor Heart Institute
Metabolic Disorder
Air Pollution and Cardiovascular Disease
To determine the effects of ambient airpollution exposures on cardiovascular responses among healthy adults without cardiovascular disease.
- Trial name
- NCT02573103
- Volunteers
- 73 people, healthy volunteers welcome
- Sponsor
- WeiHuang
Acute Respiratory Infection, Pneumonia Childhood
Impact of Improved "Injera" Baking Stove Use on Childhood Acute Respiratory Infection Prevention in Northwest Ethiopia
In Ethiopia, great majorities (95%) of households rely on solid biomass fuels such as wood, muck, crop residues, and charcoal burned in highly polluting stoves to meet the basic household energy needs with its severe health…
- Trial name
- NCT03612362
- Testing
- Improved "Injera" Baking Biomass Stove
- Where
- Ethiopia
- Volunteers
- 5,500 people, healthy volunteers welcome
- Sponsor
- Bahir Dar University
Asthma in Children, Pollution; Exposure
Evidence Driven Indoor Air Quality Improvement
The aim is to identify the underlying disease mechanisms driving specific asthma phenotypes as well as certain disease outcomes and their relation to impaired indoor air quality.
- Trial name
- NCT05992389
- Where
- Croatia
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Srebrnjak
Endothelial Dysfunction
The Cardiovascular Effects of Air Pollution: the Role of Nitric Oxide
Exposure to air pollution has been linked to increased cardiorespiratory morbidity and mortality. The exact component of air pollution that mediates this effect is unknown, but the link is strongest for fine combustion derived…
- Trial name
- NCT00845767
- Testing
- Forearm Vascular Study
- Where
- Sweden
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Endothelial Dysfunction, Systemic Inflammation
Cardiovascular Effects of Aerosols in Residences Study
This study is focused on the effects of HEPA filtration to reduce exposures to combustion-derived air pollution (CDAP). Specifically, the study will evaluate the health benefits of HEPA filters and compare the cardiovascular…
- Trial name
- CLEAR (NCT01570062)
- Testing
- HEPA Filter
- Where
- Canada
- Volunteers
- 83 people, healthy volunteers welcome
- Sponsor
- Simon Fraser University
Respiratory Conditions Due to Unspecified External Agent
Anti-pollution Effects of AP Green Tea Extracts
The objective of this clinical trial is to evaluate the anti-pollution effects of AP green tea extracts in subjects with discomforts related to the respiratory system by prolonged exposure to particulate matter in air pollution
- Trial name
- NCT04340375
- Testing
- AP green tea extracts
- Where
- South Korea
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Amorepacific Corporation
Tobacco Use, Pollution; Exposure
FRESHAIR4Life: Building the Case for Action
The goal of this observational study is to understand the burden and determinants of tobacco use and air pollution (AP) exposure among mid- to late adolescents in Greece, the Kyrgyz Republic, Pakistan, Romania, and Uganda.
- Conditions
- Tobacco Use, Pollution; Exposure, Non-communicable Disease
- Trial name
- NCT06074939
- Volunteers
- 1,750 people, healthy volunteers welcome
- Sponsor
- Leiden University Medical Center
Fetal Growth Restriction
A Randomized Air Filter Intervention Study of Air Pollution and Fetal Growth in a Highly Polluted Community
The purpose of this study is to use an air filter intervention to evaluate the relationship between particulate matter air pollution exposure during pregnancy and fetal growth.
- Trial name
- NCT01741051
- Testing
- HEPA Filter
- Where
- Mongolia
- Volunteers
- 540 people, healthy volunteers welcome
- Sponsor
- Simon Fraser University
Cognitive Function, Cardiopulmonary Function
Commuter Air Pollution Intervention Study
Traffic related air pollution is a well-recognised and much studied contributor to smog and is linked to a number of adverse health outcomes.
- Conditions
- Cognitive Function, Cardiopulmonary Function, Saliva Stress Hormones, Air Pollution Exposure
- Trial name
- CAPI (NCT02277002)
- Testing
- Cabin Air Filtration
- Where
- Canada
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Health Canada
Vascular Function
Effect of Woodsmoke on Vascular Function
Exposure to air pollution is a well established risk factor for the development of heart disease. Firefighters are exposed to excess air pollution in the form of wood smoke during the extinguishing of forest or woodland fires.
- Trial name
- FIREWOOD (NCT01495325)
- Testing
- Forearm Vascular Study, Badimon Chamber
- Where
- Sweden
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Respiratory Disease
Luftibus in the School: a Study on the Respiratory Health of Schoolchildren.
This study assessed the respiratory health of schoolchildren from the canton of Zurich by combining self-reported information on respiratory symptoms with lung function test results and air pollution measurements.
- Trial name
- LUIS (NCT03659838)
- Where
- Switzerland
- Volunteers
- 3,500 people, healthy volunteers welcome
- Sponsor
- University Children's Hospital, Zurich
Cardiovascular (CV) Risk
Democratizing Access to Cleaner Residential Air
The purpose of this research study is to determine whether the use of in-home air filtration to reduce exposure to air pollution benefits health.
- Trial name
- DACRA (NCT07629518)
- Testing
- Portable air purifiers with HEPA filtration
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Douglas Brugge
Asthma, Chronic Obstructive Pulmonary Disease (COPD)
Lungs on Fire: Wildfire Smoke, Incident Diseases, Susceptible Populations, and Community Values in Canada
Wildfire smoke (WFS) is the leading climate-related risk in Canada and the main source of harmful air pollution. While short-term breathing problems caused by smoke are well known, there is limited knowledge on how repeated…
- Conditions
- Asthma, Chronic Obstructive Pulmonary Disease (COPD), Lung Cancer
- Trial name
- LoF (NCT07536178)
- Testing
- Woodsmoke (Lodgepole Pine) exposure, Filtered air exposure
- Where
- Canada
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Oxidant Imbalance, Pulmonary Function
In Utero Household Air Pollution Exposure and Lung Development in Ghana
Household air pollution from cook stoves using solid fuels dominates total population air pollution exposures. Females and young children are disproportionately affected as they either perform or are present for the majority of…
- Trial name
- NCT02200289
- Where
- Ghana
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Exposure to Pollution, Heart Failure
Effects of Air Pollution Exposure Reduction by Filter Mask on Heart Failure
Exposure to air pollution is associated with increase in cardiovascular morbidity and mortality. Controlled human exposure studies have demonstrated impaired vascular function and heart rate variability on healthy volunteers.
- Trial name
- NCT01960920
- Testing
- Filtered diesel exhaust, Unfiltered diesel exhaust, Clean air
- Where
- Brazil
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- InCor Heart Institute
Heat Strain
Mitigation of Health Effects in Outdoor Workers by Reducing Exposure to Heat and Air Pollution
The goal of this clinical trial is to assess the effectiveness of an intervention (combination of behavioural recommendations and technical measures) in reducing personal exposure to heat and air pollution and related health…
- Trial name
- ISMED-CLIM OW (NCT07634952)
- Testing
- Heat intervention, Heat and air pollution mitigation intervention
- Where
- 2 sites in Greece, Spain
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- University of Cyprus