Clinical trials: Alcohol Addiction
Alcohol Use Disorder, Alcoholism
Effect of Social Isolation on the Role of Pavlovian Mechanisms for Control Over Alcohol Use
During the first funding period (1st FP) we investigated the impact of acute and chronic stress (Trier Social Stress Test, TSST) on Pavlovian-to-instrumental transfer (PIT).
- Conditions
- Alcohol Use Disorder, Alcoholism, Stress Reaction, Ostracism
- Trial name
- ReCoDe (NCT06256952)
- Testing
- PIT paradigm, social exclusion (Cyberball task), Saliva samples
- Where
- Germany
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Charite University, Berlin, Germany
Alcohol Use Disorder
Brain Functional Connectivity in Alcohol Use Disorder
Due to the relapsing nature of alcoholism, excessive alcohol consumption represents a significant cost to US society ($249 billion in 20101). About 64% of those entering treatment will relapse within one year.
- Trial name
- NCT02877849
- Testing
- MRI: Brain Imaging data collection
- Where
- United States
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Alcohol Consumption, Alcohol Abuse
Reducing Hazardous Alcohol Use in Social Networks Using Targeted Intervention
Alcohol use is almost ubiquitous on college campuses and first-year students are at particularly high risk of alcohol-related harm when they first make the transition to college.
- Trial name
- NCT02895984
- Testing
- Single-session alcohol intervention (BMI)
- Volunteers
- 1,424 people, healthy volunteers welcome
- Sponsor
- Brown University
Alcohol Dependence
Changing the Vulnerable Brain: A Neuromodulation Study in Alcohol Dependence
This current project investigates the effect of a single session of right dlPFC repetitive transcranial magnetic stimulation on emotion regulation abilities and craving in alcohol dependent patients and healthy controls.
- Trial name
- NCT02557815
- Testing
- Repetitive Transcranial Magnetic Stimulation
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Alcohol Use Disorder
Effect of Endotoxin on Alcohol Consumption
For this protocol, the investigators plan to collect pilot data to examine the effect of endotoxin on drinking behavior in the human laboratory.
- Trial name
- NCT04527185
- Testing
- Endotoxin
- Where
- United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Yale University
Alcohol Dependence
ALK29-002: A Study of Baclofen Formulations in Healthy Adults
The purpose of this study is to determine the pharmacokinetics, safety, and tolerability of different baclofen formulations.
- Trial name
- NCT00802035
- Testing
- Baclofen IR, Baclofen ER
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Alkermes, Inc.
Effects of Family History of Alcoholism and Sex on Alcohol Analgesia
Characterizing the Effects of Family History of Alcoholism on Alcohol Analgesia
Self-medication of pain with alcohol is a common, yet risky, behavior. Evidence suggests family history of alcoholism may affect the degree to which alcohol use relieves pain, but the independent contributions of expectation and…
- Trial name
- NCT04925076
- Testing
- Ethanol
- Where
- United States
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- University of Florida
Alcohol Use Disorder
Methylphenidate and Response to Alcohol Cues
The purpose of this study is to determine whether changes in attention levels related to taking a single dose of a medication called methylphenidate, also known as Ritalin, affects responses to alcohol cues.
- Trial name
- NCT07306078
- Testing
- Methylphenidate Pill
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Florida
Addictions
téléwork and Consumer Behavior: Longitudinal Study
Alcohol and nutritional factors are among the leading causes of preventable cancer. Knowing that so many health problems could be avoided thanks to behavioral changes, the identification of the factors at the origin of these…
- Trial name
- SUBSTANCES_1 (NCT07788352)
- Testing
- data collection
- Where
- France
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- Université de Reims Champagne-Ardenne
Alcohol Use Disorder
Suvorexant and Alcohol
This research will translate findings from preclinical research and provide the initial clinical evidence that orexin antagonism reduces motivation for alcohol, as well as other alcohol-associated maladaptive behaviors in people…
- Trial name
- NCT06326684
- Testing
- Alcohol, Suvorexant
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- William Stoops
Alcoholism, Pregnancy
Prevention of Fetal Alcohol Spectrum Disorder (FASD) by the Use of Technology
The Institute of Health Economics is conducting a study to determine how a breathalyzer linked to a cloud based alcohol monitoring system changes alcohol consumption during pregnancy in women with alcohol dependency issues.
- Trial name
- NCT02759874
- Testing
- specialized breathalyzer w face recognition technology
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Institute of Health Economics, Canada
Alcohol Abuse, Drug Abuse
Adventure: Teacher Delivered Personality-targeted Interventions for Substance Misuse
Several personality factors have been shown to be associated with risk for alcohol and substance misuse, and differentiate substance abusers based on clinical profile, treatment response and susceptibility to other forms of…
- Conditions
- Alcohol Abuse, Drug Abuse, Depression, Panic Disorder
- Trial name
- Adventure (NCT00776685)
- Testing
- Personality-targeted interventions
- Where
- United Kingdom
- Volunteers
- 3,190 people, healthy volunteers welcome
- Sponsor
- King's College London
Alcohol; Use, Problem
Alcohol & Mobile Phone Study to Reduce High-risk Alcohol Use and Consequences
The proposed study will develop a smartphone/mobile app intervention that incorporates ecological momentary assessment (i.e., two brief surveys per day) and daily intervention messaging (2 messages per day) for three weeks to…
- Trial name
- AMPS (NCT04213846)
- Testing
- Experimental: Mobile Alcohol Expectancy Intervention
- Where
- United States
- Volunteers
- 408 people, healthy volunteers welcome
- Sponsor
- University of Washington
Alcohol Consumption, Alcohol Abuse/Dependence
Social Facilitation of Alcohol Effects and Alcohol Misuse in Young Adults
The purpose of this study is to understand social contexts and alcohol use. We hope to learn how being around peers affects alcohol consumption in young adults.
- Trial name
- PALS (NCT06627803)
- Testing
- Alcohol (Oral)
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Southern California
Alcohol Use Disorder
The Role of Dopaminergic and Glutamatergic Neurotransmission for Dysfunctional Learning in Alcohol Use Disorders
The aim of this project is to assess reward- based learning behavior and its association with alterations in dopaminergic and glutamatergic transmission in detoxified alcohol-dependent patients and matched controls.
- Trial name
- LeADP5 (NCT02094196)
- Testing
- Alcohol detoxification
- Where
- 2 sites in Germany
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Technische Universität Dresden
Alcohol Abuse
Prevention of Alcohol Related Incidents in the US Air Force
Alcohol misuse poses significant public health concerns in the U.S. military. A Brief Alcohol Intervention (BAI) have been shown to reduce alcohol related incidents among Airmen undergoing training.
- Trial name
- AFIV (NCT01398319)
- Testing
- Group Brief Alcohol Intervention, Group Brief Alcohol Intervention Booster, Bystander Intervention
- Where
- United States
- Volunteers
- 26,231 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Healthy Subjects
The Critical Link Between Gut Microbiome Dysfunction, Cravings and Relapse: RECLAIM-GUT TRIAL
The human gut contains a vast community of microorganisms-including bacteria, viruses, and fungi-collectively known as the gut microbiota. This ecosystem co-evolves with humans and is shaped by diet, environment, and lifestyle.
- Trial name
- RECLAIM-GUT (NCT07350538)
- Testing
- Personalized prebiotic dietary Formulation 2, Personalized prebiotic dietary Formulation 3, Personalized prebiotic dietary Formulation 1
- Where
- United Kingdom
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Roehampton
Alcohol Consumption, Alcohol Abuse
Behavioral Counseling Intervention Trial to Reduce Alcohol-related Sexual Risk Behavior Among HIV-negative Men in Namibia
The overall purpose of this study is to evaluate an intervention that aims to reduce alcohol-related HIV sexual risk behaviors among HIV-negative men in Namibia.
- Conditions
- Alcohol Consumption, Alcohol Abuse, HIV, Sexual Behavior
- Trial name
- NCT02359487
- Testing
- Alcohol-HIV Risk Reduction Counseling
- Volunteers
- 550 people, healthy volunteers welcome
- Sponsor
- Centers for Disease Control and Prevention
BHB Transport, Alcohol Use Disorder
Metabolism in the Human Brain Following Consumption of a Keto-ester in Alcohol Use Disorder (AUD) With Proton Magnetic Resonance Spectroscopic Imaging (MRSI)
The objective of this study is to determine whether BHB levels in the brain will be positively associated with alcohol consumption, due to hypothesized enhancement of BHB transport into the brain.
- Trial name
- NCT05937893
- Testing
- Keto-ester followed by Magnetic Resonance Spectroscopic Imaging (MRSI) scans
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Yale University
Major Depressive Disorder (MDD), Anxiety Disorder
Identification and Molecular Characterisation of Urban-environmental Stress Patterns Affecting Mental Illness
Mental disorders have become a major contributor to the global burden of non-communicable diseases, with disability-adjusted life years (DALYs) attributable to these conditions continuing to rise.
- Conditions
- Major Depressive Disorder (MDD), Anxiety Disorder, Alcohol Use Disorder (AUD)
- Trial name
- NCT07571226
- Testing
- wearable monitoring devices
- Where
- 3 sites in China
- Volunteers
- 680 people, healthy volunteers welcome
- Sponsor
- Huashan Hospital