Clinical trials: Alcohol Drug Interaction
Alcohol Drinking, Depression
Effect of Ethanol and Genetic Polymorphisms on Bupropion Metabolism
The two purposes of this study are 1. to determine what effect the chronic and moderate/heavy drinking of alcoholic beverages has 1.
- Conditions
- Alcohol Drinking, Depression, Smoking Cessation, Attention Deficit Disorder
- Trial name
- NCT00330434
- Testing
- Trial Withdrawn 1, Trial Withdrawn 2
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Tufts University
Alcohol, Alcohol Use Disorders
A Phase I Study of the Interaction of Alcohol With Oral AFA-281 in Healthy Volunteers
The goal of this clinical trial is to evaluate if alcohol interacts with the drug candidate AFA-281 in adults (healthy volunteers). This trial will evaluate blood concentration levels of AFA-281 and ethanol.
- Trial name
- NCT06719908
- Testing
- AFA-281 is a small molecule, orally available, Alcohol (Ethanol)
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Afasci Inc
Major Depressive Disorder
A Study of LY2216684 in Healthy Participants
This study will evaluate the pharmacodynamic and pharmacokinetic interaction of LY2216684 with alcohol in healthy participants. This study will run approximately for 34 days.
- Trial name
- NCT01380691
- Testing
- LY2216684, Alcoholic beverage
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Eli Lilly and Company
Alcohol, Phosphodiesterase Inhibitor
A Study of the Hemodynamic Interactions of TPN171H Tablets & Alcohol in Healthy Male Subjects
The purpose of this study is primarily to evaluate the effects of taking TPN171H tablets with alcohol on blood pressure, pulse,and pharmacokinetic in Chinese healthy male subjects.
- Conditions
- Alcohol, Phosphodiesterase Inhibitor, Erectile Dysfunction
- Trial name
- NCT05316428
- Testing
- TPN171H tablet plus alcohol, alcohol, TPN171H tablet
- Where
- China
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Vigonvita Life Sciences
Breast Cancer
Effect of PPARγ2 Polymorphism and NSAIDs on Acute Alcohol-induced Changes in Serum Estrogens Among Post-menopausal Women
Postmenopausal women, stratified by a peroxisome proliferator-activated receptor gamma-2 (PPARG) polymorphism, were given the following treatments in a random order with a 5w wash-out period: a 400mg ibuprofen tablet or a placebo…
- Trial name
- EPPNASE (NCT02463383)
- Testing
- Ibuprofen Tab 400 MG
- Where
- Denmark
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Professor Lars Ove Dragsted
Potential Treatment for Alcohol Dependence-Alcohol Interaction
Effects of Ethanol on the Pharmacokinetics of PT-150 (Formerly ORG34517) (PT150 PK Study)
The purpose of this clinical study is to assess pharmacokinetic interactions between ethanol (EtOH) and PT150 (900 mg qd) in non-treatment-seeking alcohol-experienced volunteers-(to include military service members, veterans…
- Trial name
- NCT04331288
- Testing
- PT150, Beverage
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Pop Test Oncology LLC
Alcohol-Related Disorders, Drinking and Driving
Interaction of Alcohol With Energy Drinks
The main objective of the project is to assess whether there is an interaction between the effects of ethanol and energy drinks on driving performance.
- Trial name
- AEDED (NCT02771587)
- Testing
- Alcohol and energy drink, Alcohol, Energy drink
- Where
- 2 sites in Spain
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Parc de Salut Mar
Alcoholism
GSK1521498 Alcohol Interaction Study
The aim of the study is to assess the safety and tolerability of GSK1521498 in combination with alcohol and to determine the amount of GSK1521498 and alcohol in your blood after you have been given these together.
- Trial name
- NCT01366573
- Testing
- GSK1521498
- Where
- United States
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Healthy
Comparison of KADIAN 100 mg When Dosed With Alcohol Under Fasting and Fed Conditions Compared to Water
The objective of this study was to compare the single-dose relative bioavailability of Alpharma Branded Products Division Inc. (KADIAN) 100 mg morphine sulfate extended-release capsules when dosed with alcohol under fasting and…
- Trial name
- NCT00768183
- Testing
- KADIAN Capsule + alcohol (under fasting conditions), KADIAN Capsule + water (under fasting conditions), morphine sulfate IR oral solution + water
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Actavis Inc.
Drug Interactions
Alcohol Inhibits Drug Metabolism by Carboxylesterases
The purpose of this study is to determine if alcohol is able the affect the body's ability to eliminate two commonly used medication, oseltamivir and aspirin.
- Trial name
- NCT01708369
- Testing
- Ethanol, Oseltamivir, Aspirin
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- University of Tennessee
Alcohol Related Disorders, Alcohol Drug Interactions
Healthy Living as You Age
Older persons who drink can be vulnerable to negative consequences of drinking. This trial aims to prevent harm from alcohol use in older adults through a program of screening and brief advice followed up with several health…
- Trial name
- HLAYA (NCT00379093)
- Testing
- Brief advice
- Where
- United States
- Volunteers
- 631 people, healthy volunteers welcome
- Sponsor
- National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Erectile Dysfunction
A Study of the Interaction of Tunodafil Hydrochloride Tablets and Alcohol
The purpose of this study is primarily to evaluate the effects of simultaneous administration of Tunodafil Hydrochloride Tablets with alcohol on blood pressure, pulse rate and pharmacokinetics in healthy Chinese male participants.
- Trial name
- NCT05976503
- Testing
- Tunodafil Hydrochloride Tablets, Alcohol
- Where
- China
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Yangtze River Pharmaceutical Group Co., Ltd.
Nicotine Dependence
Drug /Cue Interactions In Alcohol-Tobacco Comorbidity
The purpose of this study is to determine how people react to different combinations of alcohol and nicotine.
- Trial name
- NCT00816231
- Testing
- Tobacco, Alcoholic Beverage
- Where
- United States
- Volunteers
- 244 people, healthy volunteers welcome
- Sponsor
- H. Lee Moffitt Cancer Center and Research Institute
Healthy Subjects
Study of Lemborexant-Alcohol Interaction in Healthy Subjects
This study will be conducted to evaluate the effects on cognitive performance (Power of Attention domain) and postural stability of lemborexant in combination with alcohol versus lemborexant alone and versus alcohol alone in…
- Trial name
- NCT03483636
- Testing
- Lemborexant, Alcohol
- Where
- Canada
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Eisai Inc.
Psychological Stress, Social Interaction
Exploring the Decision to Drink (More) Alcohol Following Manipulations of Stress and Social Context
This preregistration documents an experiment examining the effects of acute stress and social context on alcohol-related decision-making. The study uses a 2x2 factorial design (stress vs. control × social vs.
- Trial name
- DoraR00 (NCT07390084)
- Testing
- Stress, Social Context
- Where
- United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- University of Washington
HIV Infections, Hepatitis C
Interaction of Alcohol and Highly Active Antiretroviral Therapy (HAART) in HIV/AIDS and HIV/AIDS With Hepatitis C Virus (HCV) Co-Infection
The proposed studies will examine the extent of pharmacokinetic and pharmacodynamic interactions between alcohol and various antiretroviral therapies in those with HIV/AIDS, HIV/HCV co-infection, mild HCV and healthy subjects.
- Trial name
- NCT00879047
- Testing
- Alcohol
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Healthy Volunteers, Erectile Dysfunction
Phase I Study to Investigate the Alcohol Interaction of DA8159
This study is designed to to investigate the effects of alcohol on the pharmacokinetics of Udenafil tablet in healthy male volunteers
- Trial name
- DA8159_DIA_I (NCT01241032)
- Testing
- Udenafil, Alcohol
- Where
- South Korea
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Asan Medical Center
Erectile Dysfunction
Phase I Study to Investigate the Alcohol Interaction of SK3530
This study was designed to investigate the alcohol effect of SK3530 on the pharmacokinetics (PKs) and safety.
- Trial name
- NCT00489450
- Testing
- SK3530
- Where
- South Korea
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- SK Chemicals Co., Ltd.
Drug Interactions
A Study to Evaluate the Interaction Between Vicodin® CR and Ethanol in Healthy Male and Female Moderate Alcohol Drinkers
The purpose of this research study is to determine if varying strengths of ethanol affect the drug level and safety profile of Vicodin® CR.
- Trial name
- NCT00429468
- Testing
- Vicodin® CR (extended-release hydrocodone/acetaminophen)
- Where
- Canada
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Abbott
Opioid-Related Disorders, Substance-Related Disorders
Effects of Combined Alcohol and Nitrous Oxide Intake - 15
The purpose of this study is to determine the effects of combined alcohol and nitrous oxide intake on mood, psychomotor performance, and the pain response in healthy volunteers.
- Trial name
- NCT00000263
- Testing
- 30% Nitrous oxide, 0.25 g/Kg ethanol, 0.5 g/KG ethanol
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- University of Chicago