Clinical trials: Alcohol Use Disorders
Alcohol Use Disorder (AUD)
LSD Treatment for Persons With Alcohol Use Disorder
Lysergic acid diethylamide (LSD) was investigated in numerous clinical trials during the 1950s and 1960s. Specifically, the use of LSD in the treatment of AUD was investigated extensively.
- Trial name
- LYTA (NCT05474989)
- Testing
- LSD
- Where
- 2 sites in Switzerland
- Volunteers
- 128 people
- Sponsor
- Felix Mueller
Alcohol Use Disorder (AUD)
Combining a Smartphone App With Medications to Manage Heavy Drinking
One in 10 Veterans have an alcohol use disorder. However, few Veterans receive evidenced-based psychosocial interventions or medications to treat alcohol use disorder.
- Trial name
- NCT06303778
- Testing
- Stand Down mobile app, Standard Care
- Where
- 15 sites in United States
- Volunteers
- 330 people
- Sponsor
- VA Office of Research and Development
Alcohol Use Disorder
A Study of Brenipatide in Participants With Moderate-to-Severe Alcohol Use Disorder
The purpose of this study is to see if brenipatide when compared to a placebo works and is safe for participants with moderate-to-severe Alcohol Use Disorder (AUD). Participation in this study will last approximately 56 weeks.
- Trial name
- RENEW-ALC-1 (NCT07219966)
- Testing
- LY3537031
- Where
- 117 sites in United States, Belgium and 6 more
- Volunteers
- 1,100 people
- Sponsor
- Eli Lilly and Company
Alcohol Use Disorder
The Connect Trial: Connecting Hospital Patients to Alcohol Care
The main objective of this pilot study is to assess feasibility of conducting a definitive RCT with concealed allocation, blinded outcome assessment and a 1:1 parallel group design of A) an invitation to meet an AUD therapist for…
- Trial name
- NCT07482150
- Testing
- AUD treatment sessions with an outreach alcohol therapist at the hospital, Guidance and leaflet on AUD treatment facilities outside the hospital
- Where
- Denmark
- Volunteers
- 60 people
- Sponsor
- Zealand University Hospital
Alcohol Use Disorder
Sex Differences in Trauma, Inflammation and Brain Function and the Implications for Treatment Efficacy in Alcohol Use Disorder
The goal of this clinical trial is to identify sex-specific biomarkers that confer greater susceptibility for Alcohol Use Disorder (AUD) and differentiate how treatment response varies by sex in people with Alcohol Use Disorder.
- Trial name
- ABSTAIN (NCT06426303)
- Testing
- Naltrexone
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Milky Kohno
Alcohol Use Disorder, Alcohol Related Liver Disease
Peer Support for Liver Transplant Recipients With History of ALD
Liver transplant (LT) recipients with a history of alcohol-related liver disease (ALD) may encounter various psychosocial and medical challenges during post-LT recovery, even beyond the initial post-transplant period.
- Conditions
- Alcohol Use Disorder, Alcohol Related Liver Disease, Liver Transplant Recipient
- Trial name
- THRIVE (NCT07397598)
- Testing
- Peer Support
- Where
- United States
- Volunteers
- 95 people
- Sponsor
- Johns Hopkins University
Alcohol Use Disorder (AUD), Alcohol Abstinence
SER-ABS-AUD: Neuropsychosocial-Spiritual Correlates of Serene Abstinence in Adults With AUD
SER-ABS-AUD is a single-centre, non-interventional, mixed retrospective-prospective longitudinal cohort study of 70 adults aged 18-70 years with documented alcohol use disorder, at least 12 consecutive months of continuous…
- Trial name
- SER-ABS-AUD (NCT07561749)
- Where
- Romania
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Grigore T. Popa University of Medicine and Pharmacy
Alcohol Drinking, Cannabis Use
Cannabis' Impact on Alcohol Consumption
This study employs a repeated measures experimental design to examine the effect of THC-dominant dose of cannabis and CBD-dominant dose of cannabis, relative to placebo, on subsequent drinking in an alcohol choice task in which…
- Conditions
- Alcohol Drinking, Cannabis Use, Cannabis, Alcohol Use Disorder
- Trial name
- NCT05389930
- Testing
- THC-dominant cannabis, CBD-dominant cannabis, Alcohol
- Where
- United States
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- Brown University
Posttraumatic Stress Disorder, Alcohol Use Disorder
Testing a PTSD m-Health Intervention to Improve Alcohol Treatment Outcomes
The purpose of this study is to learn whether a mobile health application (mHealth App) for posttraumatic stress disorder (PTSD) with brief support can help individuals who are in treatment for alcohol problems.
- Trial name
- NCT05564663
- Testing
- PTSD Coach App + Brief Support, Enhanced Usual Care (EUC)
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Michigan State University
Head and Neck Cancer, Alcohol Use, Unspecified
Alcohol Cessation Among Head and Neck Cancer Survivors
Head-and-neck cancers (HNC) account for 4 percent of cancer diagnoses in the United States and for more than 66,000 annual cancer diagnoses.
- Trial name
- NCT05570851
- Testing
- Alcohol Cessation Text Messages, Usual Care
- Where
- United States
- Volunteers
- 126 people
- Sponsor
- Northwell Health
Alcohol Use Disorder
Enhancing Prospective Thinking in Early Recovery (BEAM)
The goal of this clinical trial is to test the prosocial effects of personally-relevant, high-intensity episodic future-thinking (EFT) cues in alcohol use disorder persons and related brain mechanisms.
- Trial name
- BEAM (NCT06283472)
- Testing
- High-Intensity Cue, Low-Intensity Cue
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Indiana University
Well Being, Drug Addiction
Evaluation of Effectiveness of the LifeSkills Training - Lombardia - Primary Shool Program ( Val3P-LST )
Life Skills Training is a school-based prevention program aiming at promoting wellbeing and at preventig use of substances. It has a version for middle school and another for primary school students.
- Conditions
- Well Being, Drug Addiction, Tobacco Use, Alcohol Abuse
- Trial name
- Val3P-LST (NCT07858513)
- Testing
- life skills primary prevention
- Where
- Italy
- Volunteers
- 3,927 people, healthy volunteers welcome
- Sponsor
- Agenzia di Tutela della Salute della Città Metropolitana di Milano
Alcohol Use Disorder, Depression
Testing a Lifestyle Physical Activity Intervention for Women With Depression in Alcohol Treatment
The primary aim of this project is to test the efficacy of a technology-supported lifestyle physical activity (LPA) intervention for preventing relapse among women with depression engaged in alcohol treatment.
- Trial name
- HEART (NCT04667520)
- Testing
- Lifestyle Physical Activity (LPA), Fitbit Only
- Where
- United States
- Volunteers
- 176 people
- Sponsor
- Butler Hospital
Alcohol Use Disorder
Dexamethasone to Target Stress and Immune System Mechanisms Underlying Alcohol Craving
This is a double-blind, placebo-controlled, proof of concept laboratory study to recruit N=70 (35 Males / 35 Females) non-treatment seeking, heavy drinkers with alcohol use disorder (AUD).
- Trial name
- NCT05305404
- Testing
- Dexamethasone Oral
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- Stony Brook University
Substance Use Disorders, Substance Use
Harnessing Telemedicine to Improve Alcohol Use Disorder Outcomes in Primary Care Patients
The purpose of this trial is to test new programs to see if they might help people manage their health and health behaviors related to alcohol use and well-being.
- Conditions
- Substance Use Disorders, Substance Use, Substance Dependence
- Trial name
- NCT05410561
- Testing
- Enhanced Usual Care (EUC), TeleTx intervention
- Where
- 2 sites in United States
- Volunteers
- 277 people
- Sponsor
- University of Michigan
Alcohol Use Disorder (AUD), Withdrawal From Addictive Substance; Detoxification
Cannabidiol as an Adjunct Treatment for Alcohol Withdrawal and Craving
Cannabidiol (CBD), one of the most prevalent cannabinoids in cannabis (marijuana) has been shown to reduce alcohol withdrawal symptoms in laboratory animals.
- Conditions
- Alcohol Use Disorder (AUD), Withdrawal From Addictive Substance; Detoxification, Craving
- Trial name
- NCT07148843
- Testing
- Cannabidiol (CBD)
- Where
- United States
- Volunteers
- 105 people
- Sponsor
- Johns Hopkins University
Opioid Agonist Treatment, Alcohol Use Disorder
Mobile Platform for Optimizing Wellness and Engagement in Recovery
This pilot study addresses the urgent public health crisis of co-occurring opioid and alcohol use disorders (OUD-AUD), leading causes of mortality in the United States, by testing a scalable digital contingency management (CM)…
- Conditions
- Opioid Agonist Treatment, Alcohol Use Disorder, Opioid Use Disorder
- Trial name
- MPOWER (NCT07178990)
- Testing
- Digital Contingency Management Intervention Arm, Digital Wellness Arm
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Michigan
Alcohol Use Disorder
Combination Therapy for Alcohol Use Disorder
This human laboratory study will collect preliminary safety and efficacy data from a sample of participants enrolled in a 4-week in-patient treatment program for alcohol use disorder.
- Trial name
- NCT07249554
- Testing
- Glucagon-Like Peptide-1 Agonist (GLP-1), Naltrexone (oral tablets)
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Johns Hopkins University
Alcohol Use Disorder (AUD)
Alpha Down Electroencephalography (EEG) Neurofeedback for Alcohol Use Disorder: Feasibility Trial
This pilot study is testing a short brain training program called neurofeedback in adults with alcohol use disorder. Participants will complete three sessions over about one week.
- Trial name
- Neurofeedback (NCT07746154)
- Testing
- EEG Neurofeedback
- Volunteers
- 10 people
- Sponsor
- Brigham and Women's Hospital
Alcohol Use Disorder
Intranasal Insulin for Treatment of Alcohol Use Disorder
This is a randomized controlled trial (RCT), within-subject, crossover, double-blind, placebo-controlled in non-treatment-seeking individuals with Alcohol Use Disorder (AUD) (N=40, 50% female) randomized to IN insulin or placebo.
- Trial name
- ITA (NCT05988632)
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Brown University