Clinical trials: Alcohol-induced Disorders
Alcohol Drinking, Alcohol Intoxication
Evaluating Perceived Fitness to Drive While Intoxicated
The goal of this study is to conduct a laboratory-based pilot randomized control trial of smartphone-enabled breath alcohol monitoring on perceived fitness to drive a vehicle among intoxicated adults.
- Conditions
- Alcohol Drinking, Alcohol Intoxication, Perception, Self, Drinking, Alcohol
- Trial name
- NCT05028413
- Testing
- Participants Shown their Breath Alcohol Content Measurement
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
HIV Infections
Integrated Treatment of Marijuana Abuse for HIV+ Youth
This is an exploratory study that will adapt and test a combined cognitive behavioral treatment and contingency management intervention for alcohol and/or marijuana abuse for use in HIV-infected adolescents.
- Trial name
- NCT00683488
- Testing
- Focus Group, First Intervention Trial, Intervention Trial 2
- Where
- 3 sites in United States
- Volunteers
- 46 people
- Sponsor
- University of North Carolina, Chapel Hill
Marijuana Use, Marijuana Dependence
Examining Effects of Domain Specific Episodic Future Thinking on Cannabis Use
The overarching goal of this online study is to compare the efficacy of six (weekly) sessions of Domain-Specific Episodic Future Thinking (DS-EFT) relative an active control condition on improving the ability to value future…
- Conditions
- Marijuana Use, Marijuana Dependence, Tobacco Use, Alcohol Use, Unspecified
- Trial name
- NCT05324813
- Testing
- Domain-Specific Episodic Future Thinking
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Michael Sofis
Alcohol Use Disorder, Substance Use
Emergency Department Initiated Extended-Release Naltrexone and Case Management for the Treatment of Alcohol Use Disorder
This is a phase 4, open-label, feasibility study of extended release naltrexone (Vivitrol, Alkermes Pharmaceutical) and case management for treatment of alcohol use disorders in the ED.
- Conditions
- Alcohol Use Disorder, Substance Use, Alcohol Abuse or Dependence
- Trial name
- NCT04094584
- Testing
- Vivitrol (Extended Release Naltrexone)
- Where
- United States
- Volunteers
- 179 people
- Sponsor
- University of California, San Francisco
Alcoholism, Substance-related Disorders
CRP and S&A for Inpatient Veterans
The purpose of this study is to evaluate how well three types of treatments work to improve the outcomes for people with substance use problems.
- Conditions
- Alcoholism, Substance-related Disorders, Dual Diagnosis
- Trial name
- CRP and S&A (NCT05054738)
- Testing
- Combined Recovery Program, Stable & Able (S&A)
- Where
- United States
- Volunteers
- 197 people
- Sponsor
- VA Office of Research and Development
Binge Drinking
Brief Alcohol Intervention for School-to-Work Transitions
This is a 2-year research project to test the efficacy of brief motivational intervention for reducing heavy alcohol use in young adults transitioning out of high school.
- Trial name
- NCT01546025
- Testing
- Brief Motivational Counseling, Relaxation training
- Volunteers
- 168 people, healthy volunteers welcome
- Sponsor
- Brown University
HIV, Alcoholism
ARCH Research Protocol for Provider Alcohol Pharmacotherapy Training and Assessment
Phase 1: To train providers to offer alcohol pharmacotherapy to at-risk drinkers interested in quitting or reducing their drinking as part of overall HIV care.
- Trial name
- ARCH (NCT02610517)
- Testing
- Provider Training, Patient Intervention
- Where
- 3 sites in United States
- Volunteers
- 117 people
- Sponsor
- University of Alabama at Birmingham
Nicotine Dependence, Cigarette Smoking
New Approaches to Smoking Cessation in Heavy Drinkers
The purpose of this study is to develop and test an integrated cognitive-behavioral intervention for smoking and alcohol among heavy drinking smokers.
- Conditions
- Nicotine Dependence, Cigarette Smoking, Alcohol Consumption, Heavy Drinking
- Trial name
- NCT02151591
- Testing
- Varenicline
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Yale University
Alcohol Use Disorder, Stress Reaction
Stress-related Predictor Profiles in Human Addiction
Long-term aim is the definition of a setup of mobile sensors and their integration in a mobile infrastructure that allows the prediction of stress related alcohol intake in an ambulatory setting.
- Conditions
- Alcohol Use Disorder, Stress Reaction, Social Stress, Craving
- Trial name
- NCT03810924
- Testing
- Trier Social Stress Test, Ergometer, Barlab-Exposure
- Where
- Germany
- Volunteers
- 121 people
- Sponsor
- Central Institute of Mental Health, Mannheim
Substance Use, Stress
Automating Peer Learning to Reduce Alcohol Use and Related Deviant Behavior in Secondary School
Deviant peer affiliation is one of the most important predictors of alcohol use in adolescence. These affiliations arise when socially marginalized youth self-aggregate and reinforce alcohol use and other deviant activity (i.e.…
- Conditions
- Substance Use, Stress, Relation, Interpersonal, Bullying
- Trial name
- PeerLearning (NCT04478240)
- Testing
- PeerLearning.net
- Where
- United States
- Volunteers
- 924 people, healthy volunteers welcome
- Sponsor
- Oregon Research Behavioral Intervention Strategies, Inc.
Alcohol Use Disorder
The Role of Brief Potent Glutamatergic Modulation in Addressing Problem Drinking
The proposed project tests the efficacy of glutamate modulators in non-depressed individuals with alcohol use disorder (AUD); the primary hypothesis is that the glutamate modulator being tested reduces heavy drinking days…
- Trial name
- NCT04084860
- Testing
- CI-581a, CI-581b, MBRP
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- New York State Psychiatric Institute
Insomnia, Alcohol Use Disorder
Suvorexant in the Management Comorbid Sleep Disorder and Alcohol Dependence
Suvorexant (trade name Belsomra) is an orexin receptor antagonist that has TGA approval for the treatment of insomnia, characterised by difficulties with sleep onset and/or sleep maintenance.
- Trial name
- NCT03897062
- Testing
- Suvorexant 20 mg
- Where
- Australia
- Volunteers
- 22 people
- Sponsor
- The Florey Institute of Neuroscience and Mental Health
Alcohol Dependence, Bipolar Disorder
Open Label Trial of Acamprosate in Bipolar Alcoholics
The purpose of this study is to determine whether acamprosate (Campral) is safe and effective in treating alcohol dependence in individuals with bipolar disorder.
- Trial name
- NCT00330486
- Testing
- Acamprosate
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Medical University of South Carolina
Substance Abuse
Integrated Care (iCare) at Mount Sinai to Improve Substance Use Diagnosis and Treatment Practices in HIV Clinic Settings
Substance abuse and dependence is highly prevalent among people living with HIV and significantly exacerbates morbidity and mortality and accelerates HIV disease progression.
- Trial name
- NCT03092596
- Testing
- Patient-administered screening tool, Patient health navigator-administered screening tool, Patient health navigator-assisted linkage to treatment
- Where
- United States
- Volunteers
- 3,358 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Alcohol Use Disorder, Suicide Prevention
Adapting a Telehealth Intervention for Suicide Prevention Among Patients With Alcohol Use Disorder in Tanzania
Together, alcohol use and suicide account for approximately 4 million deaths per year, with a considerable burden on low and middle-income countries.
- Trial name
- IDEAS-AUD (NCT07475988)
- Testing
- IDEAS-AUD
- Volunteers
- 30 people
- Sponsor
- Duke University
Cannabis, Youth Drinking
Development and Evaluation of HighAlert
In Canada, youth ages 16-24 have the highest rates of cannabis use, impaired driving, and express the least concern for driving under the influence of cannabis (DUIC).
- Trial name
- NCT06098573
- Testing
- High Alert, Information condition, No contact
- Where
- Canada
- Volunteers
- 103 people
- Sponsor
- Western University, Canada
Alcohol Abuse
Motivational Interviewing Intervention For Risky Drinking Treatment Among Indigenous Population
The goal of this single-arm trial is to adapt and evaluate the effectiveness of motivational interviewing intervention for treating risky drinking behaviour among indigenous population in Pahang, Malaysia.
- Trial name
- MIRDIP (NCT06583356)
- Testing
- Motivational interviewing
- Where
- Malaysia
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Department of Public Health Medicine, MARA University of Technology
Alcohol Use Disorder
"ALCO-VR": Virtual Reality Cue Exposure Therapy for the Treatment of Alcohol Use Disorder
Alcohol-related stimuli emerge as high-risk cues for individuals diagnosed with alcohol use disorder (AUD). Relapse after treatment remains a challenge in AUD.
- Trial name
- NCT04858061
- Testing
- Virtual Reality Cue Exposure Therapy, Treatment-as-usual
- Where
- Spain
- Volunteers
- 80 people
- Sponsor
- University of Barcelona
Alcohol Use Disorder, Social Anxiety Disorder
Treatment for Comorbid Social Anxiety and Alcohol Use Disorders.
Alcohol use disorders (AUD) and social anxiety disorder (SAD) are highly comorbid and associated with significant impairment. Social anxiety comorbidity is associated with poorer addiction treatment engagement and outcomes.
- Trial name
- FIT (NCT03428490)
- Testing
- Fully integrated treatment, Stand-alone Intensive Outpatient Program
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- University of California, Los Angeles
Healthy Adult Male and Female Volunteers
Safety and PK Study of BICX104 With or Without Bupropion Compared to Vivitrol
Naltrexone (NTX), an opioid receptor antagonist, has a longstanding history of safe and effective use for the treatment of addictive disorders.
- Trial name
- NCT07269873
- Testing
- BICX104 naltrexone implantable pellet, Bupropion 150 mg XL, Naltrexone (depot)
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- BioCorRx Pharmaceuticals Inc
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