Clinical trials: Alignment
Mitochondrial Degradation, Autophagy
Mitophagy and Mitochondrial DNA Dynamics During Ramadan Dry Fasting vs 16:8 Time-Restricted Feeding
This study investigates how different types of fasting affect cell health, specifically focusing on how mitochondria (the energy-producing parts of cells) are cleared and renewed.
- Conditions
- Mitochondrial Degradation, Autophagy, Fasting, Healthy Volunteers
- Trial name
- MITO FAST (NCT07638696)
- Testing
- Ramadan Intermittent Dry Fasting (Sawm), 16:8 Time-Restricted Feeding (TRF)
- Where
- Cyprus
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Bahcesehir Cyprus University
Other Cancer
Advance Care Planning: Promoting Effective and Aligned Communication in the Elderly
In this research study, the investigators are working to help oncologists better serve patients by delivering more patient-centered, goal-concordant care that may improve health care delivery.
- Trial name
- ACP-PEACE (NCT03609177)
- Testing
- Clinician Communication Skills Training, Advance Care Planning (ACP) Decisions Videos Decisions Aids, Video Declarations (ViDec)
- Where
- 4 sites in United States
- Volunteers
- 13,800 people
- Sponsor
- Dana-Farber Cancer Institute
Osteoarthritis, Knee
Mechanically or Kinematically Aligned Total Knee Prosthesis
The mechanical alignment technique (Mechanical Alignment - MA) of a total knee prosthesis (TKA) was developed with the aim of making the installation of a TKA simple and reproducible, and that the prosthetic biomechanics are…
- Trial name
- BIOMAKA (NCT06158646)
- Testing
- kinematic knee prosthesis, biomechanic knee prosthesis
- Where
- France
- Volunteers
- 120 people
- Sponsor
- Clinique du Sport, Bordeaux Mérignac
Multiple Chronic Conditions
Patient Priority Care for Older Adults With Multiple Chronic Conditions
Healthcare for older adults with multiple chronic conditions (MCCs) is burdensome and of uncertain benefit, resulting in unwanted and unhelpful care.
- Trial name
- PPC-CCF (NCT04510948)
- Testing
- Patient Priorities Care
- Where
- United States
- Volunteers
- 264 people
- Sponsor
- The Cleveland Clinic
Double-Lumen Endotracheal Tube Placement
Effect of Head Turn on Double-Lumen Tube Alignment
This study evaluated how simple external airway maneuvers affect the alignment of the left main bronchus during placement of a left-sided double-lumen endotracheal tube.
- Trial name
- NCT07755722
- Testing
- Right Tracheal Displacement, Right Head Turn Maneuver, Left Head Turn Maneuver
- Where
- Taiwan
- Volunteers
- 35 people
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Orthodontic Tooth Movement, Tooth Alignment
Effect of 3 Week vs 6 Week Orthodontic Appointment Intervals on Teeth Alignment
Effect of 3 week vs 6 week orthodontic appointment intervals on teeth alignment in patients with moderate to severe dental crowding: a randomized clinical trial.
- Trial name
- NCT06032702
- Testing
- tooth alignment
- Where
- Pakistan
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Bkahtawar Amin Medical and Dental College Multan
Severe Aortic Valve Stenosis
Validation of Accurate Commissural Alignment During Transcatheter Aortic Valve Implantation
Background: Transcatheter aortic valve replacement (TAVR) has become the preferred therapy for aortic stenosis. Given the growing life-expectancy, the risk of requiring coronary interventions or of developing prosthesis…
- Trial name
- ACA (NCT05097183)
- Testing
- Accurate Commissural Alignment (ACA)
- Where
- 15 sites in Spain
- Volunteers
- 274 people
- Sponsor
- Ignacio J. Amat Santos
Neck Pain, Body Awareness
Cervical Sagittal Alignment and Clinical Outcomes in Chronic Neck Pain
This observational, cross-sectional study investigates the relationship between cervical sagittal alignment parameters, pain-related disability, and body awareness in patients with chronic neck pain.
- Conditions
- Neck Pain, Body Awareness, Neck Disability
- Trial name
- NCT07215819
- Where
- Turkey (Türkiye)
- Volunteers
- 76 people
- Sponsor
- Prof. Dr. Cemil Tascıoglu Education and Research Hospital Organization
Obese, Limb Deformities
Longitudinal Changes in Lower Extremity Alignment and Mechanical Axis Parameters After Bariatric Surgery in Patients With Morbid Obesity: A Prospective Observational Study
The goal of this prospective observational study is to understand whether major weight loss after bariatric surgery is associated with changes in the alignment of the lower limbs in adults with morbid obesity.
- Conditions
- Obese, Limb Deformities, Arthritis
- Trial name
- BARILIMBSALIGN (NCT07794566)
- Testing
- Obese.
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Marmara University
Orthodontic
Comparing HANT and Conventional NiTi Archwires in Alignment
This randomized clinical trial evaluated the efficiency of two orthodontic archwire sequences for correcting maxillary anterior crowding.
- Trial name
- NCT07176871
- Testing
- Archwires
- Where
- Vietnam
- Volunteers
- 52 people
- Sponsor
- Can Tho University of Medicine and Pharmacy
Orthodontic Brackets
Damon vs MBT Braces: Patient Compliance and Treatment Efficiency
Comparison between two bracket prescription systems, MBT and DAMON Ultima brackets and evaluate whether the changes incorporated in DAMON Ultima brackets can drive earlier improvement on teeth position, clinically visual…
- Trial name
- NCT07185087
- Testing
- passive self-ligating, Damon Ultima brackets, Conventional ligation, MBT brackets
- Where
- Iraq
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- University of Baghdad
Osteoarthritis of the Knee
Total Knee Replacement Study Using Standard Cutting Guide vs Otismed MRI Generated Cutting Guide
Patients are referred to the VA orthopedic surgical clinic because of osteoarthritis and are requesting consideration for a total knee replacement. Those who qualify for the knee replacement are informed about the study.
- Trial name
- NCT00837772
- Testing
- Standard cutting guide for TKA, Otismed MRI generated cutting guide for TKA
- Where
- 2 sites in United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Phoenix VA Health Care System
Knee Arthroplasty, Total
Evaluation of Walking Analysis After a Total Knee Arthroplasty With Kinematic Alignment Versus Mechanical Alignment
Total knee arthroplasty (TKA) is a treatment for advanced femoro-tibial osteoarthritis. This surgery is justified in case of significant discomfort and failure of medical treatment.
- Trial name
- KneeKG Sphere (NCT04226339)
- Testing
- total knee arthroplasty with a kinetic alignment, total knee arthroplasty with a mechanical alignment
- Where
- France
- Volunteers
- 104 people
- Sponsor
- Hospices Civils de Lyon
Trauma Surgery, General Anesthesia
Comparison of the GMA-TULIP and I-gel Laryngeal Mask for Airway Management in General Anaesthesia: a Randomized Controlled Trial
The goal of this clinical trial is to learn if GMA-TULIP laryngeal mask willfit well in the right place in participants undergoing trauma surgery in a supine position under general anaesthesia.
- Trial name
- NCT07019961
- Testing
- the GMA-TULIP laryngeal mask, the i-gel laryngeal mask
- Where
- China
- Volunteers
- 198 people
- Sponsor
- Qilu Hospital of Shandong University
Orthodontic Appliance, Pain
The Effect of Intraoral Transcutaneous Electrical Nerve Stimulation in Orthodontics Pain
The goal of this clinical trial is to determine whether an intraoral Transcutaneous Electrical Nerve Stimulation (TENS) device can reduce pain during orthodontic alignment and leveling in adolescents and adults.
- Conditions
- Orthodontic Appliance, Pain, Transcutaneous Electric Nerve Stimulation, Orthodontic Appliance Complication
- Trial name
- NCT06573996
- Testing
- Active TENS Device
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of the Pacific
Muscle Planes, Muscle Volumes, Fat Infiltration in Cervical MRI
Comparison of Cervical Extensor Muscle Thickness, Fat Infiltration, and Cervical Alignment in Patients With Ankylosing Spondylitis With a Healthy Population: a Retrospective Controlled Study
In the literature, we found only one study evaluating the thickness of the cervical paraspinal muscles (multifidus, semispinalis cervicis, semispinalis capitis, splenius capitis, and trapezius) in patients with AS.
- Trial name
- NCT07148167
- Testing
- Magnetic resonance imaging
- Where
- Turkey (Türkiye)
- Volunteers
- 158 people, healthy volunteers welcome
- Sponsor
- Kayseri City Hospital
Spinal Deformity
Intraoperative Alignment in Adult Spinal Deformity Surgery
The purpose of this study is to conduct a prospective study which assesses the utility of the ATEC Intraoperative Alignment (IOA) Imaging Platform tool in intraoperative imaging for patients undergoing adult spinal deformity…
- Trial name
- NCT07416565
- Testing
- ATEC IntraOperative Alignment (IOA) Imaging Platform, Standard 36" cassette imaging, EOS radiographs
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- NYU Langone Health
Stroke
Assessing Posture and ROM With PhysioMaster in Stroke Patients
The smartphone application named PhysioMaster is an easy-to-use, accessible, and freely available application. Although it has been used in several previous studies, no validity or reliability study has yet been conducted in…
- Trial name
- NCT07690982
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Istinye University
Contraceptive Behavior, Social Norms
Impact of Gender-Transformative Interventions on Contraceptive Use and Reproductive Autonomy in Somalia
Since 2019, the International Rescue Committee (IRC) has led family planning programming in Somalia under the Women's Integrated Sexual Health (WISH) program, funded by the United Kingdom's Foreign, Commonwealth and Development…
- Trial name
- FPIL-SOM (NCT07902700)
- Testing
- Intensive Gender-Transformative Programming, Light-Touch Gender-Transformative Programming, Standard Family Planning Services (WISH-2)
- Where
- Somalia
- Volunteers
- 5,436 people, healthy volunteers welcome
- Sponsor
- Guttmacher Institute
Pain, Pain, Acute
Assessing Opioid Care Practices Using CPV Patient Simulation Modules
This study will test the quality of opioid-related physician care decisions using a patient-simulation based measurement and feedback approach that combines multiple-choice care decisions with real-time, personalized scoring and…
- Conditions
- Pain, Pain, Acute, Pain, Chronic, Pain, Neuropathic
- Trial name
- NCT04080037
- Testing
- Quality IQ Patient Simulations
- Where
- United States
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- Qure Healthcare, LLC