Clinical trials: All Comers
Coronary Artery Disease
Intravascular Ultrasound Guided Drug Eluting Stents Implantation in "All-comers" Coronary Lesions （ULTIMATE Trial）
A number of 1448 patients scheduled for elective percutaneous coronary intervention (PCI) with a native coronary stenosis suitable for DES implantation and IVUS imaging are openly randomized 1:1 to either IVUS guidance or…
- Trial name
- ULTIMATE (NCT02215915)
- Testing
- Angiography, IVUS, DES implantation
- Where
- China
- Volunteers
- 1,448 people
- Sponsor
- Nanjing First Hospital, Nanjing Medical University
Coronary Artery Disease
The PIONEER-IV Study is Comparing Clinical Outcomes Between Angiography-derived Physiology Guidance to Usual Care in an All-comers PCI Population With Unrestrictive Use of the HT Supreme Sirolimus-eluting Stent
PIONEER-IV is a prospective, single-blind (patient), randomized, 1:1, controlled, multi-center study comparing clinical outcomes between angiography-derived physiology guidance to LRDP and usual care in an all-comers patient…
- Trial name
- PIONEER-IV (NCT04923191)
- Testing
- Angiography-derived physiology guidance/Local routine diagnostic procedure (LRDP) and usual care
- Where
- 19 sites in Belgium, Ireland and 3 more
- Volunteers
- 2,540 people
- Sponsor
- National University of Ireland, Galway, Ireland
Coronary Artery Disease, Myocardial Ischemia
BIOFLOW-III Belgium Satellite Registry
This registry is a clinical post-market evaluation of the Orsiro LESS in subjects requiring coronary revascularization with Drug Eluting Stents (DES).
- Trial name
- NCT01831336
- Where
- 8 sites in Belgium
- Volunteers
- 332 people
- Sponsor
- Biotronik Belgium NV
Coronary Artery Disease, Acute Coronary Syndrome
Personalized Vs. Standard Duration of Dual Antiplatelet Therapy and New-generation Polymer-Free vs- Biodegradable-Polymer DES
New-generation metallic drug-eluting stents represent the standard of care among patients undergoing percutaneous coronary intervention (PCI).
- Conditions
- Coronary Artery Disease, Acute Coronary Syndrome, Chronic Coronary Syndrome, Myocardial Infarction
- Trial name
- PARTHENOPE (NCT04135989)
- Testing
- Percutaneous coronary intervention with implantation of amphilimus-eluting stents for coronary artery disease., Percutaneous coronary intervention with implantation of everolimus-eluting stents for coronary artery disease., Personalized DAPT duration
- Where
- 13 sites in Italy
- Volunteers
- 2,106 people
- Sponsor
- Federico II University
Atherosclerotic Disease
Treatment of Femoro-popliteal Atherosclerotic Lesions Using the Ranger Paclitaxel Coated Balloon Catheter. All Comers Registry.
A total of up to 250 patients from an all-comers patient population with infrainguinal atherosclerotic disease who are implanted or scheduled for an implant with a Ranger Drug coated balloon.
- Trial name
- NCT02462005
- Where
- 6 sites in Germany, Switzerland
- Volunteers
- 171 people
- Sponsor
- Klinikum Arnsberg
Coronary Heart Disease, Angioplasty, Balloon
Drug-coated Balloons and Drug-eluting Stents in Diabetic Patients
Drug-eluting stents (DES) have long been recommended as the default device for patients undergoing percutaneous coronary intervention (PCI).
- Trial name
- NCT05937230
- Testing
- Drug-coated balloon, Drug-eluting stents
- Where
- China
- Volunteers
- 1,500 people
- Sponsor
- Xijing Hospital
Coronary Artery Disease
BioFreedom Ultra Registry
Over the past three decades, coronary stent struts have been made progressively thinner. Thin strut drug-eluting stents (DES) performed better than their thicker counterparts in a recent study.
- Trial name
- NCT05094284
- Testing
- BioFreedom Ultra
- Where
- Hong Kong
- Volunteers
- 300 people
- Sponsor
- Chinese University of Hong Kong
Tumor, Solid, Tumor Metastasis
Autologous TLPO Vaccine Basket
The goal of this clinical trial is to learn about TLPO cancer vaccine in cases of solid tumor malignancies. The main objectives it aims to learn about are: What is the time to progression/recurrence of disease after vaccination…
- Conditions
- Tumor, Solid, Tumor Metastasis, Cancer, Tumor
- Trial name
- NCT06175221
- Testing
- Tumor lysate, particle only (TLPO) vaccine
- Where
- United States
- Volunteers
- 63 people
- Sponsor
- Elios Therapeutics, LLC
Coronary Artery Disease
Comparison of the Everolimus Eluting With the Biolimus A9 Eluting Stent
This is a prospective, randomized, multi center study. Approximately 2700 patients will be entered in the study and will be randomized on a 2:1 basis.
- Trial name
- COMPARE-II (NCT01233453)
- Testing
- the everolimus eluting ® stent, the Biolimus A9 eluting NOBORI® stent
- Where
- 11 sites in Greece, Netherlands and 2 more
- Volunteers
- 2,700 people
- Sponsor
- Maasstad Hospital
Frequent Heartburn
A Study to Investigate Use Patterns and Safety in Simulated Actual Over-the-counter (OTC) Use of Rabeprazole Sodium for the Treatment of Heartburn Symptoms
This is a multi-center, open-label, all-comers OTC actual use study in pharmacy sites where the principal investigator will be a pharmacist.
- Trial name
- NCT01286194
- Testing
- Rabeprazole sodium
- Where
- 33 sites in United States
- Volunteers
- 1,500 people
- Sponsor
- Eisai Inc.
Percutaneous Coronary Intervention, Angioplasty, Balloon, Coronary
The All-comers Sirolimus-coated Balloon European Registry
The purpose of this study is to observe and evaluate the performance of a Sirolimus-eluting Drug Coated Balloon for the treatment of any type of coronary lesions, including native vessel disease and in stent restenosis.
- Conditions
- Percutaneous Coronary Intervention, Angioplasty, Balloon, Coronary, Coronary Angioplasty, Transluminal Balloon, Arteriosclerosis, Coronary
- Trial name
- EASTBOURNE (NCT03085823)
- Testing
- Sirolimus Coated Balloon
- Where
- Italy
- Volunteers
- 2,123 people
- Sponsor
- Fatebenefratelli and Ophthalmic Hospital
Coronary Artery Disease, Myocardial Ischaemia
SeQuent® SCB "All Comers" Post Market Clinical Follow-up (PMCF)
The aim of the study is to assess continued safety and efficacy of the SeQuent® SCB. The product under investigation will be used in routine clinical practice according to the latest European Society of Cardiology (ESC)…
- Trial name
- SCORE (NCT04470934)
- Testing
- SeQuent® SCB drug-coated balloon catheter
- Where
- Germany
- Volunteers
- 1,302 people
- Sponsor
- B. Braun Melsungen AG
Coronary Artery Disease Aggravated, Myocardial Ischemia
Biofreedom Prospective Multicenter Observational Registry
LEADERS-FREE trial demonstrated the safety and efficacy of polymer-free drug-coated stent (Biofreedom, Biosensors International Technologies, Singapore) in patients with high bleeding risk.
- Conditions
- Coronary Artery Disease Aggravated, Myocardial Ischemia, Myocardial Infarction
- Trial name
- NCT03045848
- Testing
- Biofreedom drug-coated stent
- Where
- 16 sites in South Korea
- Volunteers
- 194 people
- Sponsor
- Wonju Severance Christian Hospital
Aortic Valve Stenosis, Transcatheter Aortic Valve Implantation
CoreValve™ Evolut R™ 34 mm System Registry (CoreValve34)
With the introduction of the CoreValve™ Evolut R™ 34mm (Medtronic™) prosthesis, patients with severe symptomatic aortic stenosis (AS) and large aortic annulus have become eligible for transcatheter aortic valve implantation…
- Trial name
- TAVI34mm (NCT03621709)
- Where
- Spain
- Volunteers
- 100 people
- Sponsor
- Fundacin Biomedica Galicia Sur
Peripheral Arterial Disease
BIOLUX P-III SPAIN All-Comers Registry
The purpose of the BIOLUX P-III Spain registry is to further investigate the safety and clinical performance of the Passeo-18 Lux Drug Coated Balloon in the treatment of long atherosclerotic femoropoliteal artery lesions in daily…
- Trial name
- NCT03052296
- Testing
- Passeo-18 Lux DCB
- Where
- 5 sites in Spain
- Volunteers
- 44 people
- Sponsor
- Biotronik AG
Acute Coronary Syndrome
The Effect on EPCs by Statin Loading in "All Comers" With an ACS
Cardiovascular disease is a major cause of morbidity and mortality worldwide. There are a number of risk factors for coronary artery disease and all to often patients admitted with an acute coronary syndrome have these…
- Trial name
- ALL COMERS (NCT02957162)
- Testing
- Atorvastatin, Blood samples
- Where
- United Kingdom
- Volunteers
- 40 people
- Sponsor
- University Hospitals of North Midlands NHS Trust
Coronary Artery Disease
Efficacy and Safety of Xience in Coronary arEry Disease aLL-comers After stENTing Using the PRIME Platform (EXCELLENT-PRIME Registry)
Objectives: 1. To evaluate the safety and long-term effectiveness of coronary stenting with the XIENCE PRIMETM in a cohort of "real world" patients and lesion subsets. 2.
- Trial name
- NCT01605721
- Testing
- XIENCE PRIMETM everolimus-eluting coronary stent
- Where
- South Korea
- Volunteers
- 2,000 people
- Sponsor
- Seoul National University Hospital
Sirolimus-eluting Stainless Steel Coronary Stent Prolim®
First-in-man Sirolimus-eluting Prolim® Stent Registry
The aim of this study was to assess the safety and the efficacy of the novel sirolimus-eluting Prolim® stent with a biodegradable polymer in the all-comers population.
- Trial name
- NCT02545985
- Testing
- Prolim stent deployment
- Volunteers
- 204 people
- Sponsor
- Central Clinical Hospital of the Ministry of Internal Affairs and Administration, Warsaw, Poland
Peripheral Arterial Occlusive Disease
Clinical Post Market Clinical Follow-up (PMCF) on Peripheral Arteries Treated With SeQuent® Please Over The Wire (OTW)
The aim of the study is to assess the safety and efficacy of the paclitaxel-releasing balloon catheter SeQuent® Please OTW to treat de novo and restenotic lesions in peripheral arteries.
- Trial name
- CONSEQUENT (NCT02460042)
- Testing
- drug coated balloon angioplasty, SeQuent® Please OTW Paclitaxel Coated Balloon Catheter
- Where
- Germany
- Volunteers
- 960 people
- Sponsor
- B. Braun Melsungen AG
Coronary Artery Diseases
BIOFLOW-III VIP Russia Registry Orsiro Stent System
Clinical evaluation of the Orsiro LESS in subjects requiring coronary revascularization with Drug Eluting Stents (DES). Along with it, an explanatory (hypothesis-finding) problem will be investigated, whether the patient's body…
- Trial name
- NCT02247492
- Where
- 7 sites in Russia
- Volunteers
- 200 people
- Sponsor
- Biotronik Russia