Clinical trials: Allergic
Allergic Rhinitis
Safety, Tolerability, and Pharmacokinetics of PA9159 Nasal Spray in Healthy Adult Subjects
PA9159 is a highly potent novel corticosteroid. The purpose of this study is to exam the safety, tolerability, and pharmacokinetics of single and repeat dosing of intranasal PA9159, to establish maximum tolerated dose in healthy…
- Trial name
- NCT05170763
- Testing
- PA9159 nasal spray solution, 10 μg one day treatment, PA9159 nasal spray solution, 20 μg one day treatment, PA9159 nasal spray solution, 40 μg one day treatment
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Anhui Palo Alto Pharmaceuticals, Inc.
Maxillary Sinus Disease
Do Penicillin-allergic Patients Presents a High Risk of Sinus Lift Failure
This retrospective study aims to evaluate clinical histories to determine if there is a relationship between patients allergic to penicillin and sinus lift failure and the possible post-operative complications that may arise.
- Trial name
- NCT06504888
- Testing
- Penicillin
- Where
- Spain
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Universitat Internacional de Catalunya
Healthy, Allergic Rhinitis
Tolerability/Safety of Intranasal AZD8848 in Healthy Male Volunteers and Seasonal Allergic Rhinitis Male Patients Out of Season
Investigate safety/tolerability after a single dose intranasal administration of AZD8848 comparator placebo to healthy male volunteers and seasonal allergic rhinitis male patients out of season
- Trial name
- SAD (NCT00688779)
- Testing
- AZD8848
- Where
- Sweden
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Asthma
Pilot Study to Identify the Mediators and Inflammatory Cell Surface Receptors Involved in Allergic Airway Inflammation
Asthma is a heterogeneous disorder in which multiple potential inflammatory pathways contribute to airway obstruction. The biological basis for airway inflammation is the subject of intensive investigation.
- Trial name
- NCT00595491
- Testing
- Bronchoscopy, Segmental Allergen Challenge, and Broncheoalveolar Lavage
- Where
- United States
- Volunteers
- 313 people, healthy volunteers welcome
- Sponsor
- Benjamin Medoff
Allergic Contact Dermatitis
Efficacy of Baricitinib In Treatment of Delayed-Type Hypersensitivity Versus Irritant Skin Reactions in Healthy Adult Male Subjects
The treatment of allergic contact dermatitis (ACD) can be unsatisfactory, and that other skin diseases such as atopic dermatitis have an increased likelihood of ACD, improved systemic treatments are needed.
- Trial name
- NCT03945760
- Testing
- Baricitinib
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Wright State Physicians
Allergic Rhinitis, Asthma
The Effect of Pollen Season on Subcutaneous Allergen Immunotherapy Reactions
Subcutaneous allergen immunotherapy (SCIT) is a widely used and effective treatment modality for allergic rhinoconjunctivitis and asthma.
- Conditions
- Allergic Rhinitis, Asthma, Allergic Conjunctivitis
- Trial name
- SCIT (NCT01878929)
- Testing
- Allergen(Tree, Grass, Weeds)
- Where
- United States
- Volunteers
- 245 people, healthy volunteers welcome
- Sponsor
- University Hospitals Cleveland Medical Center
Allergic Rhinitis
Study to Assess the Effects of Allergic Rhinitis and Co-administration of Mometasone or Oxymetazoline on the Pharmacokinetics, Safety, and Tolerability of Intranasal Esketamine
The purpose of this study is to evaluate the effects of allergic rhinitis (group of symptoms affecting the nose) and co-administration of mometasone or oxymetazoline on the pharmacokinetics (explores what the body does to the…
- Trial name
- NCT02154334
- Testing
- Esketamine, Mometasone, Oxymetazoline
- Where
- Germany
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- Janssen Research & Development, LLC
Allergic Conjunctivitis
Comparison of CL Wear Between Two Allergy Drops
Comparison of two allergy drops for enhancing comfort and performance of contact lens wear
- Trial name
- NCT00489398
- Testing
- epinastine HCL and olopatadine HCL
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Hom, Milton M., OD, FAAO
Lung Transplant, Lung Resection
Developing Optimal Parameters for Hyperpolarized Noble Gas and Inert Fluorinated Gas MRI of Lung Disorders
The goal of this research is to optimize the MRI system to obtain ideal lung images using Hyperpolarized (HP) Noble and Inert Fluorinated Gases as contrast agents. Lung coils tuned to the frequencies of these gases will be used.
- Conditions
- Lung Transplant, Lung Resection, Lung Cancer, Asthma
- Trial name
- NCT02748798
- Testing
- HP 3He, HP 129Xe, PFP
- Where
- Canada
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Thunder Bay Regional Health Research Institute
Hymenoptera Venom Allergy
Virtual-reality Induced Immune Modulation in Allergic Patients
This study investigates whether immersive virtual reality (VR) exposure to allergen-related stimuli can modulate behavioural, neurophysiological, psychophysiological, and immune responses in adults with bee or wasp venom allergy.
- Trial name
- NCT07721233
- Testing
- Allergen-related immersive virtual reality exposure, Control immersive virtual reality exposure
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- University of Geneva, Switzerland
Allergic Contact Dermatitis Due to Nickel
Short Repeated Nickel Exposures
The former Nickel Directive was introduced in EU in 1994 limiting the release of nickel from items intended for prolonged contact with skin.
- Trial name
- NCT03309215
- Testing
- Experimental stimulation with nickel discs
- Where
- Denmark
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Herlev and Gentofte Hospital
Allergic Conjunctivitis
Safety Study for Bepotastine Besilate Ophthalmic Solution in Normal Volunteers
Safety study for bepotastine besilate ophthalmic solution in normal volunteers
- Trial name
- NCT00586625
- Testing
- Bepreve
- Volunteers
- 861 people, healthy volunteers welcome
- Sponsor
- Bausch & Lomb Incorporated
Allergic Disorder
Study of ASLAN004 in Healthy Subjects
This is an open-label, two-part, single-center, first in human (FIH), single ascending dose (SAD) study to assess the effects of single doses of ASLAN004 when administered to healthy subjects.
- Trial name
- NCT03721263
- Testing
- ASLAN004
- Where
- Singapore
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- ASLAN Pharmaceuticals
Atopy, Allergy
Biodiversity Intervention and Atopic Sensitization
Children will receive biodiversity intervention or placebo. The proof of concept trial is double blind. Intervention will start at the age of 2 months and last 10 months. Children will be randomized to arms.
- Conditions
- Atopy, Allergy, Allergic Rhinitis, Allergic Sensitisation
- Trial name
- PREVALL (NCT03872219)
- Testing
- Nature-based materials
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- University of Helsinki
Allergic Asthma
A Study of Genolair in Two Dosage Forms (Solution and Lyophilisate) and Xolair® in Healthy Volunteers
This is a phase I an open-label randomized comparative study in parallel groups of pharmacokinetics, pharmacodynamics, immunogenicity, and safety of Genolair in two dosage forms (solution for subcutaneous administration and…
- Trial name
- NCT06494345
- Testing
- Genolair, solution for subcutaneous administration, 150 mg, Genolair, lyophilisate for the preparation of solution for subcutaneous administration, Xolair®, solution for subcutaneous administration, 150 mg
- Where
- Russia
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- AO GENERIUM
Allergic Conjunctivitis
Safety Study of a Contact Lens With Ketotifen in Healthy, Normal Volunteers
The purpose of this study is to evaluate the safety of a novel contact lens in healthy normal volunteers
- Trial name
- NCT00569777
- Testing
- K-Lens (generic name not established) and Ketotifen
- Where
- 3 sites in United States
- Volunteers
- 310 people, healthy volunteers welcome
- Sponsor
- Vistakon Pharmaceuticals
Acne Vulgaris
A Study to Evaluate the Potential of Tazarotene Foam to Cause an Allergic Reaction When Applied to the Skin and Exposed to Light on Healthy Volunteers.
The purpose of this study is to evaluate the potential of Tazarotene Foam to induce a photoallergic reaction when exposed to UV and VIS light on skin of healthy volunteers.
- Trial name
- NCT01119651
- Testing
- Tazarotene (Patch application in Challenge Phase)
- Where
- United States
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- Stiefel, a GSK Company
Asthma, Allergic Rhinitis
Examination of the Role of Atrial Natriuretic Peptide Polymorphisms in Allergic Rhinitis and Asthma Severity
Asthma is an inflammatory condition of the airways in the lungs that results in obstruction of airflow in those with the condition.
- Trial name
- NCT00584051
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of South Florida
Rhinitis, Allergic, Perennial
Long Term Safety Of GW685698X Via Nasal Biopsy
Long term safety (52 weeks) of GW685698X on the nasal mucosa via nasal biopsy with an active control group (Nasonex®) and a healthy volunteers control group in subjects 18 years old with perennial allergic rhinitis .
- Trial name
- NCT00224523
- Testing
- GW685698X, mometasone furoate
- Where
- 4 sites in Belgium, Netherlands
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Rhinitis, Allergic, Seasonal
Drug Utilization Study for Pirinase Hayfever Relief
The purpose is to obtain real-world information on how consumers are complying with the product labelling This study will coincide with the launch of Pirinase Hayfever Relief for Adults 0.05% Nasal Spray in the United Kingdom…
- Trial name
- NCT02856282
- Testing
- Pirinase Hayfever Relief for Adults 0.05% Nasal Spray
- Where
- United Kingdom
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline