Clinical trials: Alzheimer's Dementia (AD)
Financial Hardship, Alzheimer's Disease (AD)
Development of Measures to Screen for Financial Hardship in Alzheimer's Disease and Dementia
Alzheimer's Disease and related dementias (AD/ADRD) are common and debilitating conditions. Financial hardship, a multidimensional construct of financial strain, financial stress and asset depletion, is common in AD/ADRD due to…
- Conditions
- Financial Hardship, Alzheimer's Disease (AD), Alzheimer's Disease and Related Dementia (ADRD)
- Trial name
- AD/ADRD (NCT06922188)
- Where
- United States
- Volunteers
- 2,460 people, healthy volunteers welcome
- Sponsor
- Fred Hutchinson Cancer Center
Alzheimer's Disease (AD)
Biomarkers in a Candian Memory Clinic
This is a prospective, observational, case control study in a real-world cohort of patients referred by a primary care physician to a tertiary memory clinic for cognitive concerns.
- Trial name
- BioMIND (NCT06843109)
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Parkinson Disease, Amyotrophic Lateral Sclerosis (ALS)
Discovery and Validation of Protein Structural Complexes in Circulating Biofluids As Novel Biomarkers for Early Diagnosis, Prognosis and Therapeutic Management of Patients Affected by Neurodegenerative Disorders
Neurodegenerative disorders (NDDs), such as Parkinson¿s disease (PD), Alzheimer¿s disease (AD), Frontotemporal dementia (FTD) and Amyotrophic Lateral Sclerosis (ALS) are characterized by aggregation and intracellular accumulation…
- Conditions
- Parkinson Disease, Amyotrophic Lateral Sclerosis (ALS), Frontotemporal Dementia (FTD), Alzheimer's Disease (AD)
- Trial name
- NCT06803784
- Testing
- Genetic: whole genome sequencing, whole exome sequencing
- Where
- Italy
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Neuromed IRCCS
AD - Alzheimer's Disease, Sarcopenia
A Study of Silkworm Pupa Powder Intervention in the Nutritional Status of Patients With Alzheimer's Disease.
The goal of this clinical trial is to learn if silkworm pupa powder works to improve the nutritional status of Alzheimer's disease patients.
- Conditions
- AD - Alzheimer's Disease, Sarcopenia, Asthenia
- Trial name
- AD (NCT07059871)
- Testing
- Silkworm pupa powder
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Zhejiang Hospital
Alzheimer Type Dementia, Alzheimer's Disease (AD)
Impact of Ketoflex 12/3 Diet on Early-to-Mid Stage Alzheimer's Progression
This study investigates the effects of the Ketoflex 12/3 diet on the clinical progression of early-to-mid stage Alzheimer's disease.
- Trial name
- NCT06898424
- Testing
- Ketoflex 12/3 Diet
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Prof. Lutfu Hanoglu, MD
Alzheimer's Disease, MCI-AD, Early Stage Alzheimer's Disease
Efficacy and Safety of Conventional Symptomatic Drugs Combined with Lencanizumab in the Treatment of Early Alzheimer's Disease: a Multicenter, Prospective, Observational Study
According to the World Health Organization, China will become the "oldest" country in the world by 2050, with 35 percent of the elderly population.
- Trial name
- NCT06868030
- Volunteers
- 120 people
- Sponsor
- First Hospital of China Medical University
Alzheimer&Amp;Amp;#39;s Disease, Alzheimer Disease
Large-coil Parietal Repetitive Transcranial Magnetic Stimulation (rTMS) for Alzheimer Disease (AD)
The goal of this clinical trial is to learn if using large-coil (or "deep") repetitive transcranial magnetic stimulation (rTMS) targeting the precuneus and surrounding areas is feasible, tolerable, and potentially efficacious for…
- Conditions
- Alzheimer&Amp;Amp;#39;s Disease, Alzheimer Disease, Dementia Alzheimer Type, Mild Alzheimer&Amp;Amp;#39;s Disease
- Trial name
- PROMIS-AD (NCT06597942)
- Testing
- TMS
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- University of California, Los Angeles
Mild Cognitive Impairment (MCI), Alzheimer Dementia (AD)
Safety Of Nrtis for Alzheimer's Therapeutic Advancement in Singapore Study
Recent studies have identified an association between Alzheimer's Disease (AD) and an expansion of DNA content in the brain (prefrontal cortex).
- Trial name
- SONATAS (NCT07210528)
- Testing
- Emtricitabine (FTC), Descovy® (TAF/FTC)
- Where
- Singapore
- Volunteers
- 48 people
- Sponsor
- National University Hospital, Singapore
Alzheimer Disease, Dementia Alzheimer Type
Cervical Lymphatico-Venous Bypass for Treatment of Alzheimer's Disease - Proof of Concept Study (CLyVeB-AD-1 Study)
Alzheimer's disease (AD), one of the most common causes of dementia in Singapore and the developed world, is a neurodegenerative disorder with high socioeconomic impact. Accumulation of neurotoxic proteins (ie.
- Conditions
- Alzheimer Disease, Dementia Alzheimer Type, Dementia Alzheimer's Type, Alzheimer's Disease
- Trial name
- CLyVeB-AD-1 (NCT06965062)
- Testing
- Deep cervical lymph node to venous bypass (DCLNV-BP)
- Where
- Singapore
- Volunteers
- 10 people
- Sponsor
- Vincent Tay Khwee Soon
Dementia, Neurodegenerative Disease
VR-based Physical Activity and Reminiscence Therapy
The goal of this clinical trial is to learn if active Physical activity + virtual reality cognitive therapy (aPAVRCT) works to slow the progression of AD cognitive decline in older adults.
- Conditions
- Dementia, Neurodegenerative Disease, Mild Cognitive Impairment (MCI), Virtual Reality
- Trial name
- NCT06934720
- Testing
- aPAVRCT
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Hong Kong University of Science and Technology
Alzheimer Disease, Mild Cognitive Impairment Due to Alzheimer's Disease
Alzheimer's Disease Multinuclear Imaging Neuro-Enhanced Resolution (AD-MINER)
This single-center prospective cohort study will enroll 750 participants (250 cognitively Normal (CN) individuals, 250 with mild cognitive impairment (MCI), and 250 with Alzheimer's disease (AD)).
- Trial name
- AD-MINER (NCT07089303)
- Where
- China
- Volunteers
- 750 people, healthy volunteers welcome
- Sponsor
- Chinese PLA General Hospital
Alzheimer's Disease (AD)
Cognitive Health in Ageing Register: Investigational and Observational Trial Studies in Dementia Research (CHARIOT): Prospective Readiness Cohort (PRO) Longitudinal Study
Alzheimer's disease is a degenerative condition affecting the brain and is the most frequent form of dementia in older adults. Dementia is currently a major healthcare issue in the UK, affecting approximately a million people.
- Trial name
- CPLS (NCT06953167)
- Where
- United Kingdom
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Alzheimer Disease (AD)
Nasal Protollin in Early Symptomatic Alzheimer's Disease
In this research study investigators aim to learn more about a new drug called Protollin as a possible new treatment for Alzheimer's Disease (AD). The primary goal is to assess the safety and tolerability.
- Trial name
- NCT07187141
- Testing
- Protollin
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Brigham and Women's Hospital
Alzheimer Disease, Alzheimer Disease (AD)
DUVAX: A Phase 1 Alzheimer's Vaccine Study Targeting Amyloid-Beta and Tau
This Phase 1 study will test the safety and immune response of the investigational vaccine DUVAX in healthy adults. Participants will be randomly assigned to receive either DUVAX or placebo by intramuscular injection.
- Conditions
- Alzheimer Disease, Alzheimer Disease (AD), Preclinical Alzheimer's Disease
- Trial name
- DU-PRISM (NCT07142278)
- Testing
- DUVAX 200 µg, DUVAX 400 µg
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Nuravax, Inc.
Mindfulness, Alzheimer's Disease Related Dementia
Mindfulness to Enhance Cognitive Health in Latino Older Adults
The primary objective of the proposed research is to investigate the promise and underlying mechanisms of mindfulness training as a preventative lifestyle intervention to enhance cognitive health in Latino older adults, thereby…
- Trial name
- MLX (NCT07040904)
- Testing
- mindfulness
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Mild Cognitive Impairment (MCI), Mild Cognitive Impairment (MCI) Due to Alzheimer's Disease
Mindfulness for Cognition in Early-stage Alzheimer's Disease
The goal of this clinical trial is to learn if mindfulness meditation can improve outcomes in older adults with and without cognitive impairment. The main questions it aims to answer are: 1.
- Conditions
- Mild Cognitive Impairment (MCI), Mild Cognitive Impairment (MCI) Due to Alzheimer's Disease, TBI (Traumatic Brain Injury), Aging
- Trial name
- NCT06792877
- Testing
- Mindfulness Intervention, Waitlist then mindfulness
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- VA Boston Healthcare System
Alzheimer's Dementia (AD)
AMPER Proof of Concept Study
The AMPER (Agent-based Memory Prosthesis to Encourage Reminiscing) system has been built to help people with Alzheimer's disease by improving their memory recall and quality of life.
- Trial name
- AMPER (NCT06894953)
- Testing
- Personalised Agent-based Memory Prosthesis to Encourage Reminiscing (AMPER), Non-Personalised Agent-based Memory Prosthesis to Encourage Reminiscing (AMPER)
- Where
- United Kingdom
- Volunteers
- 40 people
- Sponsor
- University of Strathclyde
Down Syndrome, Down Syndrome (DS)
LEvetiracetam to Prevent Seizures in Symptomatic Alzheimer's Disease in Adults With Down Syndrome
The purpose of this study is to evaluate whether levetiracetam can prevent epileptic seizures in patients with Alzheimer's disease associated with Down syndrome.
- Conditions
- Down Syndrome, Down Syndrome (DS), Down Syndrome (Trisomy 21), Alzheimer Dementia
- Trial name
- LESS-AD (NCT07234695)
- Testing
- Levetiracetam 500mg
- Where
- 5 sites in Spain
- Volunteers
- 120 people
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Alzheimer's Disease (AD)
Using SRT to Improve The Drinking Problem Behavior of Elderly People With Dementia During The Care of Day Care
Objective: To explore the effects of intermittent retrieval training on cognitive function, daily water intake, body weight, total body water, drinking problem behaviors in day care centers, and caregiver distress in day care…
- Trial name
- NCT07086261
- Testing
- Spaced Retrieval Training
- Where
- Taiwan
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- National Taipei University of Nursing and Health Sciences
Alzheimer's Disease (AD), Mild Cognitive Impairment Due to Alzheimer's Disease
An Evaluation of Treatments for Sustained Clinical Response (18 Months) in Symptomatic Alzheimer's Disease
A multicentre, interventional, multi-arm, multi-stage Phase 3 trial including randomisation, double blinding, placebo control evaluation of treatments for sustained clinical response (18 months) in symptomatic Alzheimer's Disease…
- Conditions
- Alzheimer's Disease (AD), Mild Cognitive Impairment Due to Alzheimer's Disease, Alzheimer Disease Dementia
- Trial name
- AD-SMART (NCT07724132)
- Testing
- Atomoxetine, Metformin 1000 mg Oral Tablet
- Where
- 2 sites in United Kingdom
- Volunteers
- 1,200 people
- Sponsor
- University College, London