Clinical trials: Ambulation Disorder, Neurologic
Movement Disorders, Parkinson Disease
STEPWISE Parkinson: A Smartphone Based Exercise Solution for Patients With Parkinson's Disease
The aim of this study is to investigate whether a smartphone app can increase physical activity in patients with Parkinson's Disease in daily life for a long period of time (12 months).
- Trial name
- STEPWISE (NCT04848077)
- Testing
- Step count increase with the use of a motivational smartphone application
- Where
- Netherlands
- Volunteers
- 452 people
- Sponsor
- Radboud University Medical Center
Aging, Pain, Acute
Effects of Acute Pain on Motor Learning in Young vs Older Adults
To date, the effects of pain on motor learning have not been thoroughly investigated, particularly in older adults. Broadly, the purpose of this research is to investigate the impact of acute pain on locomotor learning and its…
- Conditions
- Aging, Pain, Acute, Cognitive Decline, Motor Activity
- Trial name
- NCT05471557
- Testing
- pain delivery
- Where
- United States
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- University of Delaware
Parkinson Disease (PD), Electromyography
EMG of Gait Under Dual-Task in Parkinson Desease
In this observational study embedded within a randomized controlled trial, the investigators aim to characterize the activation patterns of the tibialis anterior and medial gastrocnemius muscles in the more rigid leg of patients…
- Conditions
- Parkinson Disease (PD), Electromyography, Dual Task Walking
- Trial name
- EMG-DT-PD (NCT07584343)
- Where
- Spain
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Cadiz
Acquired Brain Injury
Re-Step: Dynamic Balance Treatment of Gait for Acquired Brain Injury (ABI) Victims
The purpose of this study is to: 1. Test the walking functionality of people following Acquired brain injury (ABI) 2. Suggesting a new treatment for their walking impairments 3.
- Trial name
- NCT02215590
- Testing
- Re-Step
- Where
- Israel
- Volunteers
- 41 people
- Sponsor
- Reuth Rehabilitation Hospital
Spinal Cord Injury
Improving Walking After Spinal Cord Injury
Locomotor recovery is one of the most important goals of individuals with spinal cord injury (SCI). Ambulatory deficits severely impact daily functions resulting in lower quality of life for people living with paralysis due to…
- Trial name
- NCT07223710
- Testing
- Paired Associative Stimulation, Locomotor Training
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Shirley Ryan AbilityLab
Bilateral Hearing Loss, Healthy Aging
Dual-Task Cost in Bilateral Hearing Loss
The specific aims of the research study are: 1. Compare single-task gait parameters between individuals with hearing loss (HL) and age and education matched controls with normal hearing [normal vs moderate-profound hearing loss…
- Trial name
- NCT05540535
- Testing
- Gait assessment, Cognitive assessment
- Where
- 2 sites in United States
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- New York University
Brain Cancer, Head and Neck Cancer
A Simple Walking Program to Enhance Concurrent Chemoradiotherapy Delivery
By utilizing fitness trackers, this study aims to demonstrate that a simple walking program improves patients' ability to tolerate curative concurrent chemoradiotherapy without treatment interruption.
- Conditions
- Brain Cancer, Head and Neck Cancer, Lung Cancer, Gastrointestinal Cancer
- Trial name
- NCT03115398
- Testing
- Pedometer-based Walking Program
- Where
- United States
- Volunteers
- 166 people
- Sponsor
- Montefiore Medical Center
Stroke
Action Observation Therapy for Lower Limb in Stroke
This study focuses on the effects of Action Observation therapy on stair walking, balance and self-efficacy in chronic stroke patients.
- Trial name
- NCT05557968
- Testing
- Conventional Therapy, Action Observation Therapy (AO)
- Where
- Pakistan
- Volunteers
- 40 people
- Sponsor
- Riphah International University
Stroke
Measurement Properties of Mechanical Cost of Walking for Individuals With Walking Impairment
Walking impairment following neurologic injury can increase the energy cost of walking threefold, acting as a functional barrier to independence.
- Trial name
- NCT07494890
- Testing
- Resisted walking
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- University of Cincinnati
Multiple Sclerosis (MS)
The Effect of Aerobic Exercise on an Elliptical Trainer Versus a Treadmill, in People With Multiple Sclerosis
The aim of this study is to examine the effects of aerobic exercise training using an elliptical trainer compared to a treadmill on gait and walking abilities, expressed in dynamic stability, balance, and walking speed, in people…
- Trial name
- MS (NCT06583967)
- Testing
- Physical Training
- Where
- 2 sites in Israel
- Volunteers
- 30 people
- Sponsor
- Soroka University Medical Center
Multiple Sclerosis, Pain Management
Cone Evasion Walk Test in Multiple Sclerosis
This cross-sectional methodological study aims to examine the test-retest reliability, intrasession reliability, and construct validity of the Cone Evasion Walk (CEW) Test in individuals diagnosed with Multiple Sclerosis (MS).
- Conditions
- Multiple Sclerosis, Pain Management, Function
- Trial name
- CEW-MS (NCT07786987)
- Testing
- Cone Evasion Walk Test and Clinical Assessments
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Hacettepe University
Stroke
The Effects of Augmented Reality Versus Virtual Reality
This randomized controlled trial aims to compare the effects of augmented reality (AR) and virtual reality (VR)-assisted treadmill gait training on balance and walking in individuals with stroke, within the framework of the…
- Trial name
- NCT07113093
- Testing
- Augmented Reality, Virtual Reality, Self Directed Exercises
- Where
- Turkey (Türkiye)
- Volunteers
- 75 people
- Sponsor
- Ankara Yildirim Beyazıt University
Spinal Cord Injuries
KAFO Orthoses Versus the ABLE Exoskeleton
This randomized crossover study will compare walking with KAFO type orthoses (current standard of care) versus the ABLE Exoskeleton device, during walking in patients with spinal cord injury in a hospital setting.
- Trial name
- NCT04855916
- Testing
- ABLE Exoskeleton, KAFO Orthosis
- Where
- Spain
- Volunteers
- 10 people
- Sponsor
- ABLE Human Motion S.L.
Parkinson Disease, Cognitive Deficit in Attention
The Effect of Different Types of Focus Instructions in Parkinson's Rehabilitation
Parkinson's disease is the most common progressive neurodegenerative movement disorder. Common movement impairments in Parkinson's include balance and walking difficulties.
- Conditions
- Parkinson Disease, Cognitive Deficit in Attention, Feedback, Psychological, Gait, Festinating
- Trial name
- NCT06615115
- Testing
- Exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Bahçeşehir University
Spinal Muscular Atrophy Type 3, Mitochondrial Myopathy
Oxidative Capacity and Exercise Tolerance in Ambulatory SMA
This proposal will focus on (1) estimating oxidative capacity of specific muscle groups during exercise using near infrared spectroscopy and (2) describing body composition to better understand exercise capacity and mitochondrial…
- Trial name
- NCT02895789
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Columbia University
Anesthesia, Spinal, Arthroplasty, Replacement, Knee
Mepivacaine vs. Bupivacaine Spinal Anesthetic in Total Knee Arthroplasty
The purpose of this study is to determine if a shorter-acting spinal anesthetic called mepivacaine has advantages over a longer-acting medication called bupivacaine.
- Conditions
- Anesthesia, Spinal, Arthroplasty, Replacement, Knee, Pain Management, Early Ambulation
- Trial name
- NCT02980926
- Testing
- Mepivacaine, Bupivacaine
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Henry Ford Health System
Gait, Unsteady
At-home Walking Cadence Functional Assessment and Recovery Trajectory for Older Adults Undergoing Major Surgery
This is a prospective observational study looking at gait-cadence in older adults who are scheduled to have major abdominal surgery at the University of Chicago.
- Trial name
- CADENCE (NCT05886725)
- Testing
- Patients using Step Test Application and Accelerometer
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Chicago
Multiple Sclerosis
Exploratory Study to Assess the Effect of Fampridine (BIIB041) on Walking Ability and Balance in Participants With Multiple Sclerosis.
The objectives of this study in Multiple Sclerosis (MS) participants treated with prolonged-released fampridine (BIIB041) 10 mg twice daily compared with participants treated with placebo are to assess the effect over 24 weeks on…
- Trial name
- MOBILE (NCT01597297)
- Testing
- BIIB041 (PR Fampridine)
- Where
- 23 sites in Belgium, Canada and 4 more
- Volunteers
- 132 people
- Sponsor
- Biogen
One Eye Blindness, Blind Left Eye
Multiplexing Prism Fitting for Field Expansion of Monocular Vision
The investigators are developing an assistive device, known as multiplexing prism that expands the field of view for individuals with acquired monocular vision (loss of an eye).
- Conditions
- One Eye Blindness, Blind Left Eye, Blind Right Eye
- Trial name
- NCT06027216
- Testing
- Multiplexing Prism
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Massachusetts Eye and Ear Infirmary
Spinal Cord Injuries, Complete Spinal Cord Injury
The Efficacy and Safety of a New Power Exoskeleton Robot for Improving Walking Ability in Spinal Cord Injury Patients
In Taiwan, there are more than 23,000 individuals with spinal cord injuries (SCI, mean age: 27 years), with an increment of new 1,200 SCI individuals each year.
- Conditions
- Spinal Cord Injuries, Complete Spinal Cord Injury, Incomplete Spinal Cord Injury
- Trial name
- NCT03548649
- Testing
- exoskeleton robot training
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- Taipei Veterans General Hospital, Taiwan
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