Clinical trials: Amputation of Knee
Prosthesis, Lower Limb Amputation Knee
Clinical and Functional Assessment of Patients With Transfemoral Amputation Treated With Osteointegrated Implant
Limb amputation is a traumatic event that significantly reduces the ability to perform daily activities, impairs mobility, and lowers quality of life.
- Conditions
- Prosthesis, Lower Limb Amputation Knee, Amputation; Traumatic, Leg, Lower
- Trial name
- OSTEO-OUTCOME (NCT06737770)
- Testing
- osseointegrated surgery for transfemoral amputation
- Where
- Italy
- Volunteers
- 15 people
- Sponsor
- Istituto Ortopedico Rizzoli
Amputation
Passive Microprocessor-controlled Knees vs. Active Microprocessor-controlled Knees After Transfemoral Amputation
This study investigates prosthetic users´ report of passive microprocessor-controlled knees (pMPK) vs. active microprocessor-controlled knees (aMPK).
- Trial name
- NCT06406491
- Testing
- active microprocessor-controlled knee
- Where
- Germany
- Volunteers
- 10 people
- Sponsor
- Median
Amputation
Effectiveness of Frontal Plane Adaptability in a Novel Foot Prosthesis
People with lower extremity amputation (LEA) have persistent problems with balance, falls, residual limb pain, functional mobility, cognitive attention during gait, and satisfaction with participation in daily activities, despite…
- Trial name
- NCT06214026
- Testing
- META-Arc foot locked, META-Arc foot unlocked
- Where
- 3 sites in United States
- Volunteers
- 96 people
- Sponsor
- University of Washington
Ischemia, Peripheral Arterial Disease
A Clinical and Histological Analysis of Mesenchymal Stem Cells in Amputation
Patients undergoing semi-elective lower extremity major amputation from complications associated with atherosclerotic limb ischemia will received intra-muscular injections of allogeneic Mesenchymal Stromal Cells in the leg above…
- Conditions
- Ischemia, Peripheral Arterial Disease, Peripheral Vascular Disease, Vascular Disease
- Trial name
- CHAMP (NCT02685098)
- Testing
- Allogeneic bone marrow derived mesenchymal stem cells
- Where
- United States
- Volunteers
- 81 people
- Sponsor
- Indiana University
Transfemoral Amputees
Early Rehabilitation After Transfemoral Amputation in Moderately Active Patients Using the Avior Knee
The goal of this clinical trial is to compare microprocessor-controlled knee prostheses in early rehabilitation in amputees with transfemoral amputations and low mobility (K I-II).
- Trial name
- NCT07898098
- Testing
- knee prothesis - Avior, knee prothesis - Kenevo
- Where
- Germany
- Volunteers
- 33 people
- Sponsor
- Median
Lower Limb Amputation Above Knee (Injury)
C-Leg 3 and C-Leg 4 Study in Transfemoral Amputees
The aim of this post-market study is to confirm that the microprocessor controlled prosthetic knee components (C-Leg 3 and C-Leg 4) in comparison to mechanical knee joints can bring additional benefit to the users primarily on…
- Trial name
- NCT02765035
- Testing
- C-Leg 4, C-Leg 3
- Where
- 2 sites in Austria, Belgium
- Volunteers
- 18 people
- Sponsor
- Otto Bock Healthcare Products GmbH
Lower Limb Amputation Below Knee (Injury), Lower Limb Amputation Above Knee (Injury)
Asymmetry of the Center of Pressure During Gait After Amputation of Lower Limbs
Retrospective, non-randomized, observational, single-center longitudinal study at the University Rehabilitation Hospital of Grau du Roi CHU of Nîmes, France.
- Trial name
- ASCOPALL (NCT05803317)
- Testing
- usual care : Evaluation of walking on a baropodometric platform
- Where
- France
- Volunteers
- 130 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Traumatic Amputation of Lower Extremity
Effects of Wearing a Powered Ankle-Foot Prosthesis on Amputee Walking
Amputees wearing a conventional prosthesis require 20-30% more metabolic energy to walk at the same speeds as non-amputees and this discrepancy is more apparent at faster walking speeds.
- Trial name
- NCT00869947
- Testing
- Powered ankle-foot prosthesis, No device
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- US Department of Veterans Affairs
Amputation, Lower Limb Amputation Above Knee (Injury)
Evaluation of a Microprocessor-controlled Prosthetic Knee-ankle System (SPCM)
The main aim of this study is to compare the adaptation capabilities of the microprocessor-controlled knee-ankle prosthesis system with the comparator covered by the French LPPR, known as the "usual prosthesis".
- Trial name
- SPCM (NCT06522646)
- Testing
- SPCM, Usual Prothesis
- Where
- 4 sites in France
- Volunteers
- 12 people
- Sponsor
- Institution Nationale des Invalides
Amputation of Knee
Comparative Study of Through Knee Amputation Versus Above Knee Amputation Regarding Infection Rate and Function
The aim of this study is to search and compare outcomes of through knee amputation (TKA) and above knee amputation (AKA) in terms of Technique ,wound healing ,infection rate , function and ambulation
- Trial name
- NCT06365203
- Testing
- Through knee amputation, Above knee Amputation
- Volunteers
- 60 people
- Sponsor
- Assiut University
Lower Limb Amputation Knee, Lower Limb Amputation Below Knee (Injury)
Validity and Reliability of The 3-Meter Backward Walk Test in Individuals With Lower Limb Amputation
Clinicians are routinely required to make decisions about fall risk among lower limb prosthesis users. For these decisions, clinicians should use valid, reliable, quantitative, and multidimensional measures of balance test for…
- Trial name
- NCT05095584
- Testing
- 3 meter backward walk test
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Tezel Yıldırım Şahan
Transfemoral Amputation
Use of Passive, Adaptive, and Active Prosthetic Knees in Persons With Unilateral, Transfemoral Amputation
The goals of this study are to assess measured, observed, and self-reported outcomes achieved through the use of passive (mechanical), active(motorized) and adaptive (magnetorheological) prosthetic knee control systems in…
- Trial name
- OPK (NCT02219230)
- Testing
- Active knee (Ossur Power Knee II), Adaptive knee (Ossur Rheo), Passive knee (Various manufacturers)
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University of Washington
Lower Limb Amputation Below Knee (Injury)
Auto Control of Volume Management for Limb Loss
The aim of this research is to create a prosthetic system that will automatically adjust the fit of the socket and create a well-fitting prosthesis for people with leg amputations who experience volume fluctuations when using…
- Trial name
- NCT03550118
- Testing
- Adjustable socket
- Where
- United States
- Volunteers
- 104 people
- Sponsor
- University of Washington
Amputation, Traumatic, Phantom Sensation
Investigating The Effect of Phantom Sensation on Gait in Individuals With Unilateral Below-Knee Amputation
Amputation is a problem that can be encountered for many reasons, can cause functional disability in varying severities and puts a multifaceted financial burden on individuals, society, and states.
- Trial name
- NCT05177341
- Testing
- Determining Preferred Walking Speed
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Trakya University
Amputation
The Effect of Different Microprocessor Knee Prostheses on Mobility and Gait Parameters in Transfemoral Amputees
Microprocessor knee joints are prosthetic knee joints with an integrated processor or a computer that can analyze data. During walking, parameters such as step speed, joint angles, and weight transferred through sensors are…
- Trial name
- NCT04966936
- Testing
- questionnaires for clinical assessments, 2 minute walking test, The gait analysis at the motion analysis laboratory.
- Where
- Turkey (Türkiye)
- Volunteers
- 27 people
- Sponsor
- Gaziler Physical Medicine and Rehabilitation Education and Research Hospital
Amputation
Penetration of Ertapenem Into Bone
The aim of the study is to determine the penetration levels of ertapenem into bone tissues in patients with Diabetes Mellitus (D.M) or Peripheral Vascular Diseases (P.V.D) undergoing amputation, and to correlate theme to the…
- Trial name
- NCT00392028
- Testing
- ertapenem
- Where
- 3 sites in Israel
- Volunteers
- 12 people
- Sponsor
- HaEmek Medical Center, Israel
Peripheral Vascular Disease
Safety/Feasibility Study of HBOC-201 in Amputation at/Below Knee From Critical Lower Limb Ischemia
The purpose of this study is to assess the safety and feasibility of HBOC-201 in increasing adequate wound healing in patients with severe peripheral vascular disease who are undergoing lower limb amputation.
- Trial name
- NCT00300040
- Testing
- Hemoglobin glutamer 250 - bovine, 6% Hydroxyethylstarch
- Where
- 5 sites in South Africa, United Kingdom
- Volunteers
- 16 people
- Sponsor
- Biopure Corporation
Through Knee Amputation
Comparing OutcomeS of Through Knee and Above Knee Amputation
Major lower limb amputation is a life changing surgical procedure to treat complications of diabetes mellitus and peripheral vascular disease.
- Trial name
- COSTAA (NCT04120558)
- Testing
- Qualitative interviews and focus groups, Functional mobility tests and questionnaires
- Where
- United Kingdom
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Hull University Teaching Hospitals NHS Trust
Amputation of Lower Limb Above Knee, Sequelae
Effect of Eight-week Concurrent Training on Functional Capacity in Patients With Unilateral Transtibial Amputation
OBJECTIVES: To assess the effect of concurrent training (CT) of an eight-week on strength, power and cardiorespiratory fitness on muscle condition, balance, load distribution in the lower limbs and aerobic capacity in patients…
- Trial name
- NCT04165434
- Testing
- Concurrent Training
- Where
- Brazil
- Volunteers
- 26 people
- Sponsor
- University of Sao Paulo General Hospital
Amputation
The Effects of Dual Task Balance Training In Individuals With Above Knee Amputation
The people with transfemoral amputation who use mechanical prosthesis will be include to this study. All participants will be assessed and then they will be randomly assigned to two groups.
- Trial name
- NCT03094208
- Testing
- dual task balance training, traditional balance training
- Volunteers
- 20 people
- Sponsor
- Hacettepe University