Clinical trials: Anaesthesia
Anesthesia, Local
Ropivacaine Plasma Concentrations and Pharmacokinetics Following Erector Spinae Plane Block in the Pediatric Population
The primary aim of this study is to evaluate the pharmacokinetics of serum ropivacaine concentrations following erector spinae plane peripheral nerve blocks in the pediatric population.
- Trial name
- NCT04298099
- Testing
- Ropivacaine
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Baylor College of Medicine
Benign Prostatic Hyperplasia
UroLift System TOlerability and ReCovery When Administering Local Anesthesia
The purpose of the study is to evaluate procedure tolerability and surgical recovery following the UroLift® system procedure when conducted with local anesthesia in subjects with symptomatic benign hyperplasia (BPH).
- Trial name
- LOCAL (NCT01876706)
- Testing
- UroLift® System
- Where
- 7 sites in United States
- Volunteers
- 51 people
- Sponsor
- NeoTract, Inc.
Anesthesia Induced Hypothermia, Inadvertent Perioperative Hypothermia
Study to Evaluate Safety and Efficacy of Blanket Used to Prevent Anesthesia Induced Hypothermia
The investigation was designed as an Open-Label, Multicenter, Randomised, Controlled Investigation to Evaluate the Efficacy and Safety of the BARRIER® EasyWarm Active Self-Warming Blanket Used for Continuous Active Warming to…
- Trial name
- NCT01900067
- Testing
- BARRIER® EasyWarm Active Self-Warming Blanket
- Volunteers
- 271 people
- Sponsor
- Molnlycke Health Care AB
Anesthesia, General
Comparison of Sugammadex With Neostigmine During Laparoscopic Cholecystectomy or Appendectomy (P05699)
The current trial was designed to demonstrate faster recovery from a neuromuscular blockade (NMB) induced by rocuronium after reversal at 1-2 Post Tetanic Count (PTC) by 4.0 mg.kg-1 sugammadex compared to 50 µg.kg-1 neostigmine…
- Trial name
- NCT00724932
- Testing
- Rocuronium, Sugammadex, Neostigmine
- Volunteers
- 140 people
- Sponsor
- Merck Sharp & Dohme LLC
Emergence From Anesthesia
Emergence From Anesthesia in Anterior Temporal Lobectomy and Amygdalohippocampectomy Patients
Smooth emergence (wake up) from anesthesia is an important consideration in patients undergoing neurosurgical procedures as blood pressure changes associated with violent emergence can cause intracranial hemorrhage and brain…
- Trial name
- NCT02360098
- Testing
- Emergence from Anesthesia
- Where
- Canada
- Volunteers
- 36 people
- Sponsor
- Lashmi Venkatraghavan
Anesthesia, Local
A Safety Study of of AG-920 Sterile Topical Ophthalmic Solution
A Phase 3, randomized, placebo-controlled, double-masked, parallel study in healthy subjects. It is designed to evaluate the ocular safety of a single topical ocular administration of AG-920 sterile topical ophthalmic solution…
- Trial name
- NCT05501860
- Testing
- AG-920
- Where
- 2 sites in United States
- Volunteers
- 249 people, healthy volunteers welcome
- Sponsor
- American Genomics, LLC
Anesthesia; Adverse Effect, Cardiac Arrhythmia
Effects of HSK3486 on Cardiac Repolarization in Health Subjects (TQT)
To assess the effects of a single IV bolus of HSK3486 single dose on cardiac repolarization (QTc interval of the electrocardiogram, and to evaluate the safety and tolerability of a single IV bolus of HSK3486 in healthy subjects
- Trial name
- NCT06795204
- Testing
- HSK3486, Moxifloxacin Hydrochloride
- Where
- China
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Haisco-USA Pharmaceuticals, Inc.
Postoperative Nausea and Vomiting, Respiratory Conditions Due to Other External Agents
A Study to Compare Neostigmine vs Sugammadex in Length of PACU Stay in Patients Undergoing Sleeve Gastrectomy Surgery
The investigators will track bariatric patients who received sugammadex versus neostigmine in the post anesthesia care unit until discharge and assess their length of stay and possible nausea / vomiting / hypoxia episodes.
- Trial name
- NCT03276026
- Testing
- Sugammadex, Neostigmine
- Where
- United States
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Virtua Health, Inc.
Anesthesia Airway Management
Comparison Study of Two Supraglottic Airway Devices Used for Patients Under General Anesthesia
This study will compare two supraglottic airway devices currently on the market. Supraglottic airway devices are used during general anesthesia to provide a patent airway.
- Trial name
- NCT01001078
- Testing
- I-Gel supraglottic airway device, LMA Supreme supraglottic airway device, Standard endotracheal tube
- Where
- Canada
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Maisonneuve-Rosemont Hospital
Clubfoot
Clubfoot Tenotomy Trial
Infants undergoing Ponseti treatment for idiopathic clubfoot often require percutaneous tendoachilles lengthening (TAL) after serial casting.
- Trial name
- ClubTT (NCT04766684)
- Testing
- Jet injection of 1% lidocaine, 4% liposomal lidocaine cream
- Where
- United States
- Volunteers
- 107 people
- Sponsor
- Vanderbilt University Medical Center
Postoperative Pain, Adverse Effects
Continuous Interscalene Block Results in Superior Recovery Throughout the First Postoperative Week
The investigators undertook this prospective, randomized trial to compare the recovery profile throughout the first postoperative week in patients receiving continuous (CISB) interscalene brachial plexus block, single injection…
- Trial name
- NCT01881776
- Testing
- ISB
- Where
- United States
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- St. Luke's-Roosevelt Hospital Center
Airway Morbidity, Intubation Complication
Comparison of Double Lumen Tube Placement Techniques
The purpose of this study is to compare three different standard of care methods of double-lumen endobronchial tube (DLT) placement in patients who are scheduled to have thoracic surgery in which lung isolation is required.
- Conditions
- Airway Morbidity, Intubation Complication, Tracheal Intubation Morbidity, Anesthesia Intubation Complication
- Trial name
- NCT02495259
- Testing
- ZU-bend stylet, GlideScope, GlideRite stylet
- Where
- 2 sites in United States
- Volunteers
- 19 people
- Sponsor
- Emory University
Anesthesia, Epidural, Hypotension
Hypotension Prediction Index to Predict Epidural-labor Analgesia Induced Hypotension
The purpose of this pilot trial is to examine the feasibility and ease of use of monitoring by ClearSight in laboring and delivering patients with the intent to compare time-to-treatment of hypotension between conventionally…
- Trial name
- NCT05906368
- Testing
- ClearSight HPI Monitoring system, Standard of Care Blood Pressure Monitoring
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Grace Lim, MD, MS
Nausea, Vomiting
Acupuncture Point P6 Stimulation for Reduction of Nausea and Vomiting During Cesarean
The purpose of this study is to compare the effectiveness of acupressure point P6 stimulation versus intravenous ondansetron plus metoclopramide versus no antiemetic prophylaxis during elective cesarean section under regional…
- Conditions
- Nausea, Vomiting, Satisfaction
- Trial name
- NCT02959840
- Testing
- Acupressure Point P6 stimulator, Metoclopramide, Ondansetron
- Where
- United States
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Rutgers, The State University of New Jersey
Perioperative Care, Surgery--Complications
Perioperative Hypothermia and Myocardial Injury After Non-cardiac Surgery
We propose to test the hypothesis that aggressive warming reduces the incidence of major cardiovascular complications, compared to routine care.
- Conditions
- Perioperative Care, Surgery--Complications, Hypothermia; Anesthesia, Myocardial Injury
- Trial name
- PROTECT (NCT03111875)
- Testing
- aggressive warming, routine thermal management
- Where
- 11 sites in United States, China
- Volunteers
- 5,056 people
- Sponsor
- The Cleveland Clinic
Pain, Needle Phobia
The Efficacy of EMLA Cream vs. Synera Patch for Pain Reduction During Venipuncture in Children
This study compares the efficacy of the Synera patch with Eutectic Mixture of Local Anesthetics (EMLA) as a topical anesthetic for venipuncture in pediatric patients.
- Trial name
- NCT00530803
- Testing
- EMLA Cream, Synera Patch
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Montefiore Medical Center
Pain, Postoperative
Injection of Local Anesthetic to Trocar Insertion Sites After Laparoscopy
The primary objective of this study is to assess if injection of local anesthetic to the laparoscopic trocar sites after a hysterectomy will make a difference in a patient's pain after surgery.
- Trial name
- NCT01688596
- Testing
- Bupivacaine
- Where
- United States
- Volunteers
- 135 people
- Sponsor
- Milton S. Hershey Medical Center
Thoracic Epidural Anesthesia
CompuFlo Thoracic Epidural Study
Traditionally, loss-of-resistance (LOR) to air or saline with a special ground-glass syringe is the technique used to identify epidural space, but failure rates up to 30% have been reported using this technique for thoracic…
- Trial name
- NCT03826186
- Testing
- Traditional (loss-of-resistance technique) thoracic epidural placement, CompuFlo thoracic epidural placement
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- YATISH SIDDAPURA RANGANATH
Delayed Emergence From Anesthesia
Recovery Profile Comparison Between Remifentanil-propofol or Desflurane Anesthesia Monitored With Bispectral Index.
Bispectral monitoring anesthesia with remifentanil-desflurane has a better post-operative recovery than remifentanil-propofol.
- Trial name
- NCT02631525
- Testing
- Desflurane, Propofol
- Volunteers
- 40 people
- Sponsor
- Federal University of Minas Gerais
Pregnancy
Use of Peanut Labor Ball Following Epidural Anesthesia
The purpose of the study is to look at the impact of using the Peanut Labor Ball (PLB) after epidural anesthesia in patients who have never given birth.
- Trial name
- NCT02190591
- Testing
- Peanut Labor Ball
- Where
- United States
- Volunteers
- 204 people, healthy volunteers welcome
- Sponsor
- TriHealth Inc.