Clinical trials: Analgesia, Postoperative
Laparoscopic Surgery, Visceral Pain, Postoperative
Anrikefon-based Patient-controlled Intravenous Analgesia Following Laparoscopic Surgery
Visceral pain following laparoscopic surgery is frequently underestimated, yet it is associated with a range of adverse outcomes.
- Conditions
- Laparoscopic Surgery, Visceral Pain, Postoperative, Anrikefon, Patient-controlled Intravenous Analgesia
- Trial name
- NCT07525986
- Testing
- High-dose anrikefon, Medium-dose anrikefon, Low-dose anrikefon
- Where
- 4 sites in China
- Volunteers
- 140 people
- Sponsor
- Peking University First Hospital
Lung Cancer, Lung Diseases
Erector Spinae Plane Block Versus Intercostal for VATS
The Erector Spinae Plane (ESP) block is a new interfascial regional anesthesia technique recently described by Forero et al. Currently the literature shows the ESP block being used for analgesia after thoracic surgery, breast…
- Trial name
- NCT03902782
- Testing
- ESP block, Intercostal block, Bupivacaine-epinephrine
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Postoperative Pain
Effect of Quadratus Lumborum Block on Perioperative Analgesia and Inflammatory Responses in Laparoscopic Nephrectomy
Quadratus lumborum (QL) block can reduce intraoperative opioid consumption, decrease inflammation responses of IL-6, and reduce acute pain intensity in comparison with non-receiving QL block as the control group.
- Trial name
- NCT03879980
- Testing
- Bilateral QL block, Non-QL block
- Where
- Indonesia
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Universitas Indonesia
Postoperative Pain, Nerve Block
Investigation of the Effects of Serratus Posterior Superior Intercostal Plane Block and Serratus Anterior Plane Block on Perioperative Analgesia Management in Patients Scheduled for Mastectomy
This study aims to evaluate and compare the analgesic efficacy of two ultrasound-guided regional anesthesia techniques, the serratus anterior plane (SAP) block and the serratus posterior superior intercostal plane (SPSIP) block…
- Conditions
- Postoperative Pain, Nerve Block, Mastectomy, Patient Outcome Assessment
- Trial name
- NCT07510269
- Testing
- SAP Block, SPSIP Block
- Where
- Turkey (Türkiye)
- Volunteers
- 66 people
- Sponsor
- Uludag University
Shoulder Pain, Post-operative Pain
Can Parecoxib Reduce Post-operative Ipsilateral Shoulder Pain?
The purpose of this study is to compare the efficacy of parecoxib with placebo on the incidence and severity of postthoracotomy shoulder pain, the amount of analgesic requirement for relieving severity of postthoracotomy shoulder…
- Trial name
- NCT01288924
- Testing
- Parecoxib, Control
- Where
- 2 sites in Thailand
- Volunteers
- 160 people
- Sponsor
- Chiang Mai University
Anesthesia
Erector Spinae Plane Block Versus Quadratus Lumborum Block For Postoperative Analgesia After Abdominal Hysterectomy
The aim of this study is to compare the analgesic efficacy of erector spinae plane block and quadratus lumborum block after abdominal hysterectomy surgery and postoperative opioid consumption.
- Trial name
- NCT05541588
- Testing
- peripheral nerve block
- Where
- Egypt
- Volunteers
- 64 people
- Sponsor
- Ain Shams University
Postoperative Pain
Local Anesthetics After Total Knee Arthroplasty
The aim of this randomized, double-blind and placebo-controlled study is to evaluate the specific role of injection of local anesthetic into the intra- vs. extraarticular tissues after toal knee arthroplasty.
- Trial name
- NCT00518674
- Testing
- local infiltration analgesia
- Volunteers
- 32 people
- Sponsor
- Hvidovre University Hospital
Post Operative Pain, Analgesia
Newborn Infant Parasympathetic Evaluation (NIPE) for Guiding Intraoperative Fentanyl in Children Under 2 Years
During general anesthesia, objective monitoring for analgesia is still lacking. The administration of opioids relies on the experience of the anesthesiologist.
- Conditions
- Post Operative Pain, Analgesia, Children, Only, Narcotic Use
- Trial name
- NCT05758090
- Testing
- NIPE monitor, Control
- Where
- Thailand
- Volunteers
- 70 people
- Sponsor
- Khon Kaen University
Postoperative Pain
Anrikefon Injection for Postoperative Analgesia in Thoracoscopic Lung Surgery: A Randomized, Double-Blind, Active-Controlled, Parallel-Group, Single-Center Clinical Study
This is a randomized, double-blind, active-controlled clinical study evaluating the efficacy and safety of Anrikefon (HSK21542) Injection for patient-controlled analgesia (PCA) in patients undergoing thoracoscopic lung surgery.
- Trial name
- NCT07810413
- Testing
- Anrikefon Injection, Sufentanil Citrate Injection
- Volunteers
- 88 people
- Sponsor
- The First People's Hospital of Lianyungang
Gastrocnemius, Ankle Surgery
Efficacy of Gastrocnemius Plane Block for Foot and Ankle Surgery
The study aim is to evaluate the efficacy of the gastrocnemius plane block (GPB) in providing postoperative analgesia for patients undergoing foot and ankle surgery.
- Conditions
- Gastrocnemius, Ankle Surgery, Foot Surgery, Postoperative Analgesia
- Trial name
- NCT07877974
- Testing
- GPB Group : This group will receive ultrasound-guided Gastrocnemius plane block with 30 mL bupivacaine (0.25%), SAB
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Cairo University
Postoperative Pain
Rectus Sheath Block: Postoperative Analgesia and Proinflammatory Cytokines
Good quality of postoperative analgesia would lead to attenuate or prevent the adverse effects on the common functions of the immune system.
- Trial name
- NCT03074097
- Testing
- Bupivacaine 0.25%
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Assiut University
Cholecystectomy, Laparoscopic, Anesthesia
Deep Rectus Sheath Block for Laparoscopic Cholecystectomy
Postoperative pain after laparoscopic cholecystectomy can be considerable. Regional techniques such as erector spinae plane (ESP) block or transversus abdominis plane (TAP) block may be suitable for patients at increased risk of…
- Conditions
- Cholecystectomy, Laparoscopic, Anesthesia, Postoperative Pain
- Trial name
- NCT06976320
- Testing
- Intravenous morphine patient control analgesia, Intravenous patient control analgesia, Deep rectus sheath block
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Istinye University
Laparoscopic Cholecystectomy
Dexamethasone-Enhanced TAP Block in Lapchole
The transversus abdominis plane (TAP) block is widely used as part of analgesia for abdominal surgeries such as laparoscopic cholecystectomy. While bupivacaine is commonly used for TAP blocks with reported success.
- Trial name
- NCT07182110
- Testing
- Dexamethasone enhanced TAP Block, Marcaine- 0.25%
- Where
- Lebanon
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Makassed General Hospital
Pain, Postoperative
Perioperative Pain Management for Lumbar Spine Surgery
Perioperative pain management is crucial for patients undergoing elective lumbar spine surgery. Moderate to severe postoperative pain can significantly impact recovery, worsen patient outcomes, and potentially lead to chronic…
- Trial name
- NCT06662318
- Testing
- Fentanyl Citrate, Dexmedetomidine, Lidocaine Hydrochloride
- Where
- Egypt
- Volunteers
- 75 people
- Sponsor
- Benha University
Arthropathy of Knee, Analgesia
Fascia Iliaca Compartment Block and IPACK Block in Total Knee Arthroplasty
The investigators sought to compare the effectiveness of postoperative pain control between the standard intravenous multimodal analgesia procedure used in managing patients undergoing total knee surgery, who experience severe…
- Trial name
- NCT06125067
- Testing
- no peripheral block, Fascia Iliaca Compartment Block, iPACK Block
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people
- Sponsor
- Ankara Ataturk Sanatorium Training and Research Hospital
Analgesia
Erector Spinae Plane Block in Pediatric Hip Surgery
Hip Surgery in pediatric patients is considered an extremely painful procedure. Managing pain in this surgery is challenging even with several available options, each with limitations.
- Trial name
- NCT04354571
- Testing
- Erector spinae plane block, caudal block
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Alexandria University
Cholecystectomy, Laparoscopic, Anesthesia, General
Effect of Pupilometer Guided Analgesia on Postoperative Pain
In this study, the investigators measure a pupil size every 5 minutes during the operation in patients undergoing laparoscopic cholecystectomy under general anesthesia.
- Conditions
- Cholecystectomy, Laparoscopic, Anesthesia, General, Reflex, Pupillary
- Trial name
- PUPIL_pain (NCT03794271)
- Testing
- Pupilometer guided anesthesia, SPI guided anesthesia
- Where
- South Korea
- Volunteers
- 84 people
- Sponsor
- Daegu Catholic University Medical Center
Video-assisted Thoracoscopic Surgery (VATS), Pain Management
The Efficacy and Safety of Liposomal Bupivacaine in Relieving Postoperative Pain After Video-assisted Thoracoscopic Surgery
Video-assisted thoracoscopic surgery (VATS) is less invasive compared to traditional thoracotomy. It is reported that the incidence of acute pain following VATS exceeds 80%.
- Conditions
- Video-assisted Thoracoscopic Surgery (VATS), Pain Management, Liposomal Bupivacaine, Local Injection
- Trial name
- NCT07432711
- Testing
- Bupivacaine hydrochloride, Liposomal bupivacaine plus bupivacaine
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Beijing Tiantan Hospital
Pain, Postoperative
Dexmedetomidine Infusion as an Analgesic Adjuvant During Laparoscopic Cholecystectomy
The aim of this study was to evaluate efficacy and safety of dexmedetomidine infusion during laparoscopic cholecystectomy. The randomized, single-center, controlled study was carried out from May 2016 to June 2017 at department…
- Trial name
- NCT03211871
- Testing
- Dexmedetomidine, Normal Saline Flush, 0.9% Injectable Solution_#1
- Where
- Ukraine
- Volunteers
- 60 people
- Sponsor
- Bogomolets National Medical University
Postoperative Pain, Acute, Postoperative Complications
Minimally Invasive Esophagectomy Pain Control Trial
A pilot randomized controlled trial comparing intercostal nerve blocks, cryo-ablation plus intercostal nerve blocks, and serratus plane catheter plus intercostal nerve blocks in patients undergoing esophagectomies with minimally…
- Trial name
- NCT05906134
- Testing
- Local intercostal nerve block, Cryo-analgesia and intercostal nerve block, Serratus plane catheter blocks and intercostal nerve blocks
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Swedish Medical Center
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