Clinical trials: Analgesia, Postoperative
Postoperative Protein Catabolism
Effect of Intravenous Nutrition and Epidural Analgesia on Protein Loss After Surgery
Loss of muscle mass and body protein are the main causes of fatigue after bowel surgery, which may result in a longer hospital stay and a higher rate of complications.
- Trial name
- NCT00614133
- Testing
- Intravenous nutrition with glucose and amino acids, Intravenous nutrition with glucose and amino acids.
- Where
- Canada
- Volunteers
- 22 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Osteoarthritis (OA) of the Knee
Postoperative Pain and Analgesic Requirements After Preoperative Methadone for Primary TKA
The goal of this prospective, randomized study is to compare the outcomes of two cohorts of patients undergoing primary Total Knee Arthroplasty (TKA) and to determine whether a single dose of methadone administered preoperatively…
- Trial name
- NCT06691633
- Testing
- Preoperative Methadone, Preoperative Oxycodone
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- University of Louisville
Postoperative Pain
Comparison of Paravertebral Versus Epidural Block for Post-thoracotomy Pain Control
This is a randomized, assessor-blinded, non-inferiority clinical trial comparing continuous thoracic paravertebral block (BPV) versus continuous thoracic epidural block (BPD) for postoperative pain control in adult patients…
- Trial name
- NCT07763249
- Testing
- Continuous Thoracic Paravertebral Block, Continuous Thoracic Epidural Block
- Where
- Brazil
- Volunteers
- 80 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Postoperative Pain
PENG Block Versus Intrathecal Morphine for Early Postoperative Recovery After Total Hip Arthroplasty
The goal of this clinical trial is to compare the PENG block with intrathecal morphine for early postoperative recovery and pain control in adults undergoing elective total hip arthroplasty.
- Trial name
- NCT07803133
- Testing
- Pericapsular nerve group (PENG) block, Intrathecal Morphine
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Erzincan Binali Yildirim Universitesi
Acute Post-operative Pain Following Caesarean Section
Opioid-free Analgesia for the Management of Acute Post-operative Pain Following Caesarean Section
Background: Multimodal analgesia; a combination of opioid and non-opioid analgesics, for management of acute post-operative pain significantly reduces the incidence of adverse effects associated with liberal post-operative opioid…
- Trial name
- OFAAPPCS (NCT04539249)
- Testing
- Magnesium sulphate, Pentazocine
- Where
- Nigeria
- Volunteers
- 324 people
- Sponsor
- Olakunle Ifeoluwa Makinde
Pain
Lidocaine For Treatment of Post-operative Pain From Donor Sites Following Burn Injury.
Burn pain is known to be one the most severe forms of acute pain often requiring large amounts of narcotics in addition to other adjuvants.
- Trial name
- LidocaineBurn (NCT02229578)
- Testing
- Lidocaine
- Where
- 2 sites in United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- University of Florida
Breathing, Mouth, Muscle Relaxation
Comparison of Breathing Yoga and Progressive Muscle Relaxation Techniques After Transplantation
The study aims to compare the effectiveness of breathing yoga and progressive muscle relaxation techniques in relieving pain, respiratory complications and kinesiophobia in liver transplant recipients.
- Conditions
- Breathing, Mouth, Muscle Relaxation, Pain, Postoperative, Kinesiophobia
- Trial name
- NCT07066384
- Testing
- breathing yoga, PMRTs-Progressive Muscle Relaxation Techniques
- Where
- Turkey (Türkiye)
- Volunteers
- 125 people
- Sponsor
- Bitlis Eren University
Postoperative Pain, Analgesia
Postoperative Analgesis for Pain Management After Thoracotomy
Thoracotomy is among the most painful surgical procedures and can cause severe pain. Postoperative pain causes many complications. Therefore, pain management is important in patients undergoing thoracotomy.
- Trial name
- NCT06177652
- Testing
- Paravertebral Block, Serratus Plane Block
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 58 people
- Sponsor
- Kocaeli University
Pain, Postoperative
Preoperative Ketamine Has no Preemptive Analgesic Effect in Patients Undergoing Colon Surgery.
The analgesic properties of ketamine are associated with its non-competitive antagonism of the N-methyl-D-aspartate receptor; these receptors exhibit an excitatory function on pain transmission and this binding seems to inhibit…
- Trial name
- NCT02241278
- Testing
- Ketamine
- Where
- Spain
- Volunteers
- 48 people
- Sponsor
- Hospital Arquitecto Marcide
Postoperative Pain, Anterior Cruciate Ligament Injury
Combined Saphenous Nerve and IPACK Blocks Versus Infiltration Analgesia After Anterior Cruciate Ligament Reconstruction
A lot of patient have posterior knee pain after ACL reconstruction despite saphenous nerve block. Recently a new block has been described, know as IPACK block (interspace between the popliteal artery and the capsule of the…
- Conditions
- Postoperative Pain, Anterior Cruciate Ligament Injury, Anterior Cruciate Ligament Rupture
- Trial name
- NCT03680716
- Testing
- Ropivacaine injection
- Where
- Switzerland
- Volunteers
- 60 people
- Sponsor
- Centre Hospitalier Universitaire Vaudois
Post Operative Pain, Thoracic Surgery
Comparative Study Between Erector Spinae Plane Block Versus Combined Pectoralis and Serratus Interfascial Plane Blocks for Post-operative Analgesia After Thoracic Surgery.
The aim of this study is to evaluate the effect of combined pectoralis II and serratus interfascial plane blocks in comparison with erector spinae plane block on post-operative analgesia after thoracic surgeries.
- Trial name
- NCT07855549
- Testing
- Erector spinae plane block, Combined pectoralis and serratus anterior plane blocks
- Where
- Egypt
- Volunteers
- 66 people
- Sponsor
- Minia University
Cholecystectomy, Postoperative Pain
Erector Spinae Plane Block Versus External Oblique Intercostal Plane Block for Analgesia in Open Cholecystectomy
This randomized controlled trial aims to compare the analgesic efficacy of bilateral ultrasound-guided erector spinae plane block (ESPB) versus bilateral external oblique intercostal plane (EOI) block in patients undergoing open…
- Conditions
- Cholecystectomy, Postoperative Pain, Erector Spinae Plane Block, Regional Anesthesia
- Trial name
- NCT07533279
- Testing
- Erector Spinae Plane Block, External Oblique Intercostal Plane Block
- Volunteers
- 66 people
- Sponsor
- Sohag University
Aged, Surgery
Virtual Reality as a Postoperative Pain Management Adjunct in Older Adults: An Acceptability and Feasibility Study
This single-arm mixed methods study aims to determine potential differences in self-reported postoperative pain intensity levels, anxiety, and state of relaxation through immediate pre-post intervention evaluation among those…
- Conditions
- Aged, Surgery, Pain, Postoperative, Virtual Reality
- Trial name
- VR (NCT06095661)
- Testing
- REAL System i-Series VR head-mounted display (HMD) from Penumbra, Inc.
- Where
- United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Transversus Thoracic Plane Block, Cardiac Surgery
Transversus Thoracic Plane Block for Perioperative Analgesia in Cardiac Surgery
The goal of this clinical trial is to learn if perioperative Transversus Thoracic Plane Block (TTPB) decrease perioperative pain after cardiac surgery. The main questions it aims to answer are: 1.
- Conditions
- Transversus Thoracic Plane Block, Cardiac Surgery, Post Operative Pain
- Trial name
- NCT06546722
- Testing
- Transversus Thoracic Plane Block
- Where
- Lebanon
- Volunteers
- 150 people
- Sponsor
- Saint-Joseph University
Lung Diseases
Serratus Posterior Superior Interfascial Plane Block for Thoracoscopic Surgery
Regional techniques can be used for postoperative pain control following VATS. Ultrasound (US) guided serratus posterior superior block (SPSPB) is a new interfacial plane block defined by Tulgar et al in 2023.
- Trial name
- NCT05972122
- Testing
- Analgesia management; group S and C
- Where
- Turkey (Türkiye)
- Sponsor
- Medipol University
Postoperative Pain
Parasternal Block and TENS for Cardiac Surgery
the objective of the present study was to compare the efficacy of TENS and parasternal block with local anesthetic infiltration in relieving pain during the first 24 h period following median sternotomy.
- Trial name
- NCT02725229
- Testing
- parasternal block, TENS group, control group
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people
- Sponsor
- Antalya Training and Research Hospital
Postoperative Pain
The Analgesic Efficacy of Bilateral Erector Spinae Plane Block in Comparison With Intrathecal Morphine After Elective Cesarean Section
The aim of this study was to assess the analgesic efficacy of bilateral erector spinae plane block in comparison with intrathecal morphine after elective cesarean section under spinal anesthesia.
- Trial name
- NCT03935412
- Testing
- Erector Spinae Plane Block
- Where
- Egypt
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Fayoum University
Opioid Use, Pain, Postoperative
Erector Spinae Plane Block Versus Conventional Analgesia in Complex Spine Surgery
Enhanced recovery pathways (ERPs) emphasize evidence-based, multimodal anesthetic and analgesic choices to minimize opioid consumption while providing adequate pain control after surgery.
- Trial name
- ESPB-Spine (NCT04156581)
- Testing
- Bupivacaine, Dexamethasone, Saline
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- Hospital for Special Surgery, New York
Retinal Detachment, Proliferative Vitreoretinopathy
Postoperative Pain Control Following Vitreoretinal Surgery
The aim of this study is to evaluate if patients receiving a steroid (triamcinolone acetonide) combined with local anesthesia and antibiotic following retina surgery have better postoperative pain control those receiving local…
- Conditions
- Retinal Detachment, Proliferative Vitreoretinopathy, Retinoschisis
- Trial name
- NCT01995045
- Testing
- Triamcinolone, Bupivicaine Hydrochloride
- Where
- United States
- Volunteers
- 58 people
- Sponsor
- Emory University
Opioid-use Disorder, Pain, Acute
Effect of Buprenorphine/Naloxone Continuation on Pain Control and Opioid Use
The aim of this study is to determine the effect of continuation of buprenorphine/naloxone in patients with history of Opioid Use Disorder (OUD) scheduled for surgery compared to reduced dose buprenorphine/naloxone prior to…
- Conditions
- Opioid-use Disorder, Pain, Acute, Surgery
- Trial name
- NCT03266445
- Testing
- buprenorphine/naloxone
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
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