Clinical trials: Analgesia
Analgesia
A Study Investigating the Pharmacokinetic Profiles of Four Extended Release Paracetamol Formulations
A study investigating the pharmacokinetic profiles of four extended release paracetamol formulations
- Trial name
- NCT01568749
- Testing
- Paracetamol, Paracetamol formulation 1, Paracetamol Formulation 2
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Osteoarthritis of the Knee
Efficacy of Celecoxib 200mg in Relieving Pain and Walking Dysfunction in Osteoarthritis of the Knee
The purpose of this study is to compare the efficacy of celecoxib versus placebo in delaying the onset of pain and improving walking function in subjects with knee Osteoarthritis
- Trial name
- NCT00597415
- Testing
- celecoxib
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University Hospitals Cleveland Medical Center
Rotator Cuff Tear
A Selective COX-2 Inhibitor Provides Pain Control But Hinders Healing Following Arthroscopic Rotator Cuff Repair
Selective cyclooxygenase (COX)-2 inhibitors are commonly used analgesics that provide similar analgesia but reduced adverse effects compared to other analgesics.
- Trial name
- NCT02850211
- Testing
- Celecoxib, Ibuprofen, Tramadol
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Seoul National University Bundang Hospital
Craniotomy Surgery
Sphenopalatine Ganglion Block Combined With Either Scalp Nerve Block or Local Wound Infiltration for Postoperative Analgesia in Adult Patients Undergoing Craniotomy: A Randomized Controlled Trial
The use of multimodal regional analgesia (scalp block, local scalp infiltration, and sphenopalatine ganglion block) for postoperative pain management after craniotomy
- Trial name
- NCT07886034
- Testing
- Group (c): control group patients will receive general anesthesia., Group (SS): Sphenopalatine Ganglion Block with either Scalp Nerve Block, Group (SL): patients will receive Sphenopalatine Ganglion Block with local wound infiltration
- Volunteers
- 54 people
- Sponsor
- Zagazig University
Cervical Pain, Lumbar Pain
EVALUATION OF THE TOLERABILITY AND BIOMEDICAL POTENTIAL OF A GARMENT CONTAINING PRINTED CERAMICS IN MUSCULAR PAIN
Today, a new revolution is underway in the textile industry with the introduction of new technologies that add special functions and properties to fabrics.
- Conditions
- Cervical Pain, Lumbar Pain, Muscular, Chronic Pain (Back / Neck)
- Trial name
- DZero (NCT07274293)
- Testing
- DZero
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- noiVita Srls
Anesthesia
Hypnoanalgesia for Dermatological Surgery in Children
This randomized clinical trial will evaluate the effect of hypnosedation on the need of sedation and analgesia in a pediatric population undergoing dermatological surgery, both during the procedure, and 24 hours after surgery.
- Trial name
- NCT04707014
- Testing
- Hypnosis, Attention-distracting techniques
- Where
- Spain
- Volunteers
- 28 people
- Sponsor
- Complejo Hospitalario de Toledo
Surgical Blood Loss, Postoperative Pain
PVI vs ESP Block for Reducing Bleeding and Postoperative Pain in Lumbar Fusion Surgery.
This randomized controlled trial compares periarticular vasoconstrictor infiltration (PVI) versus erector spinae plane block (ESP) to reduce bleeding and postoperative pain in adults undergoing lumbar fusion surgery (up to 3…
- Conditions
- Surgical Blood Loss, Postoperative Pain, Lumbar Spinal Fusion Surgery
- Trial name
- NCT07550114
- Testing
- Periarticular vasoconstrictor infiltration (PVI), Erector Spinae Block (ESP)
- Where
- 2 sites in Spain
- Volunteers
- 62 people
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Assess Women Awareness and Fear About EDA for Labor
"Awareness, Preconception, and Fear of Epidural Analgesia Among Childbearing Women in Saudi Arabia."
The aim of our study is to measure the level of awareness, preconceptions, and level of fear regarding epidural analgesia among childbearing women in KKUH in Riyadh.
- Trial name
- NCT05596604
- Testing
- survey- no intervention
- Where
- Saudi Arabia
- Volunteers
- 202 people, healthy volunteers welcome
- Sponsor
- King Khalid University Hospital
Labor, Analgesia, Epidural
Effect of Timing on Efficacy of Morphine Analgesia After 2-chloroprocaine Anesthesia
Epidural chloroprocaine is often used in obstetrical anesthesia because of its fast onset and short duration. These properties make it an ideal drug to use for epidural anesthesia in patients undergoing postpartum tubal ligation.
- Trial name
- NCT00487084
- Testing
- Morphine-CP-saline (MCS), saline-2CP-morphine (SCM), saline-lidocaine-morphine (SLM)
- Where
- United States
- Volunteers
- 136 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Cesarean Section, Cesarean Delivery
Pain Management After Cesarean Section - A Before-and-After Cohort Study
Inadequate pain relief remains a challenge after Cesarean section (CS) and may significantly impair postoperative recovery. A recent Danish single-center study (n=100) revealed that 66% of elective CS patients experienced severe…
- Conditions
- Cesarean Section, Cesarean Delivery, Pain Management, Pain Management in Postoperative Care
- Trial name
- NCT06813638
- Where
- Denmark
- Volunteers
- 100 people
- Sponsor
- Nordsjaellands Hospital
Lower Extremity, Nerve Block
Bupivacaine-Lidocaine vs Bupivacaine for Ultrasound-Guided Popliteal Sciatic Nerve Block
This prospective, randomized, double-blind clinical trial aims to compare the efficacy of two local anesthetic regimens for ultrasound-guided popliteal sciatic nerve block in adult patients undergoing elective distal lower…
- Conditions
- Lower Extremity, Nerve Block, Pain, Postoperative, Pain, Nerve
- Trial name
- PSSNB-BL (NCT07550348)
- Testing
- Bupivacaine-Lidocaine Combination, Bupivacaine
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Ataturk University
Coronary Artery Bypass, Anesthesia, Conduction
Effect of Transversus Thoracic Muscle Plane Block (TTMP) on Analgesia
In this prospective and controlled study, the investigators investigated the effect of transversus thoracic muscle plane block (TTMP) on analgesia in patients who undergo coronary artery bypass graft (CABG) surgery with median…
- Conditions
- Coronary Artery Bypass, Anesthesia, Conduction, Nerve Block, Pain, Postoperative
- Trial name
- NCT06601530
- Testing
- Transversus Thoracic Muscle Plane Block, Tramadol
- Where
- Turkey (Türkiye)
- Volunteers
- 46 people
- Sponsor
- Istanbul University - Cerrahpasa
Analgesia, Postoperative Pain, Acute
Effects of Pericapsular Nerve Group Block on Postoperative Recovery for Total Hip Arthroplasty
The hypothesis of this study is that patients who undergo PENG block in before Total Hip Artroplasthy (THA) surgery with spinal anesthesia will have reduced postoperative pain scores, less need for opioid analgesics and earlier…
- Trial name
- NCT06183528
- Testing
- Pericapsular Nerve Group (PENG) Block
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Umraniye Education and Research Hospital
Fractures
Preemptive Analgesia With OxyContin Versus Placebo Before Surgery for Long Bone Fractures
We would like to check whether pre-operative administration of an oral controlled-release opioid formulation (Oxycodone hydrochloride (OxyContin)) could result in a clear effect of preemptive analgesia.
- Trial name
- NCT00254631
- Testing
- Oxycodone hydrochloride
- Where
- Israel
- Volunteers
- 65 people
- Sponsor
- Rambam Health Care Campus
Knee Osteoarthritis, Total Knee Arthroplasty
Remimazolam Total Intravenous Anesthesia Under Analgesia Nociception Index-guidance
The investigators hypothesized that intraoperative opioid consumption would be different between remimazolam and propofol if the ANI-guided remifentanil continuous infusion rate was adjusted when the depth of anesthesia was…
- Conditions
- Knee Osteoarthritis, Total Knee Arthroplasty, Remimazolam
- Trial name
- NCT05322902
- Testing
- remimazolam group, propofol group
- Where
- South Korea
- Volunteers
- 84 people
- Sponsor
- Gangnam Severance Hospital
Pregnancy Related, Analgesia, Epidural
Dural Puncture Epidural vs Standard Epidural Analgesia in Labor
This randomized prospective study compares Dural Puncture Epidural (DPE) and Standard Epidural Analgesia in term laboring women.
- Conditions
- Pregnancy Related, Analgesia, Epidural, Labor Pain
- Trial name
- DPE-LABOR (NCT07278895)
- Testing
- Dural Puncture Epidural (DPE), Standard Epidural Analgesia
- Where
- Turkey (Türkiye)
- Volunteers
- 102 people
- Sponsor
- Saglik Bilimleri Universitesi Gazi Yasargil Training and Research Hospital
Post Operative Analgesia, Opioid Sparing Anaesthesia
To Compare Post-op Analgesic Effectiveness of Ropivicaine+Dexamethasone and Ropivacane+Dexmetomidine in TAP Block in Stoma Reversal Under GA in Terms of Duration of Analgesia.
Controlling pain is of major concern in intra-operative as well as post-operative period inpatients undergoing all surgeries especially abdominal surgeries.Adequate pain control in post-operative period directly effect patient's…
- Conditions
- Post Operative Analgesia, Opioid Sparing Anaesthesia, Hypotension, Controlled, Bradycardia
- Trial name
- NCT07368075
- Testing
- TAP Block with Ropivacaine+Dexamethasone, TAP Block with Ropivacaine+Dexmedetomidine
- Where
- Pakistan
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- Sahiwal medical college sahiwal
Chronic Pain
Registro Italiano Dei Pazienti Affetti da Dolore Cronico
The goal of this Multicenter, non-profit, noninterventional, prospective observational cohort study is to create a register of patients suffering from Chronic Pain of any origin in subject with diagnosis of Chronic Pain according…
- Trial name
- REALIZER (NCT06228300)
- Volunteers
- 2,500 people
- Sponsor
- Societa Italiana Anestesia Analgesia Rianimazione e Terapia Intensiva
Cardiac Pacing, Permanent Pacemaker Implantation
Ultrasound-Guided PECS II Block for Permanent Pacemaker Implantation
This single-center, prospective, randomized, controlled clinical trial aims to evaluate whether ultrasound-guided PECS II block, when added to standard local infiltration anesthesia, improves perioperative analgesia in patients…
- Conditions
- Cardiac Pacing, Permanent Pacemaker Implantation, Postoperative Pain
- Trial name
- PACE-PECS (NCT07739407)
- Testing
- Ultrasound-Guided PECS II Block, Standard Local Infiltration Anesthesia
- Volunteers
- 72 people
- Sponsor
- ferdi gülaştı
Pain, Postoperative; Anesthesia, Regional, Arthroplasty, Replacement, Hip
Analgesic Efficacy of Continuous SESP vs Continuous FICB After Hip Arthroplasty
The primary objective of this prospective, randomized, observer-blinded controlled trial is to compare the postoperative analgesic efficacy of continuous intermediate-approach sacral erector spinae plane (SESP) block versus…
- Trial name
- SESP-HIP (NCT07516795)
- Testing
- Continuous Sacral Erector Spinae Plane Block, Continuous Fascia Iliaca Compartment Block
- Where
- Vietnam
- Volunteers
- 60 people
- Sponsor
- Bach Mai Hospital