Clinical trials: Analgesic
Pain Management
Adductor Canal Block After Total Knee Replacement - a Suture-method Catheter vs a Standard Catheter vs a Single Bolus
In this study we wish to investigate the analgesic effect of the administration of 0.2% ropivacaine for an adductor canal block as repeated boluses (20 ml every 8 hours) through a new suture-method catheter or a standard…
- Trial name
- NCT03142789
- Testing
- Initial bolus (Certa and standard catheter groups), Initial bolus (Single bolus group), Intermittent boluses (Certa and standard catheter groups)
- Where
- Denmark
- Volunteers
- 153 people
- Sponsor
- University Hospital, Gentofte, Copenhagen
Femur Fracture
Evaluation of the Postoperative Analgesic Efficacy of the Quadroiliac Plane (QIP) Block in Femur Fracture Surgery
The goal of this clinical trial is to learn whether the Quadroiliac Plane (QIP) block helps reduce postoperative opioid use in adults undergoing femur fracture surgery.
- Trial name
- NCT07009782
- Testing
- QIP block
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Kanuni Sultan Suleyman Training and Research Hospital
Primary Dysmenorrhea
Evaluation of the Effect of TMS on Primary Dysmenorrhea
Based on the pain threshold and visual simulation score, primary dysmenorrhea patients will be divided into treatment effective group or non-effective group.According to the functional magnetic resonance imaging, the…
- Trial name
- NCT04168489
- Testing
- active rTMS
- Where
- China
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Analgesia
Comparison of Analgesic Effect and Prognosis of Butorphanol and Fentanyl in Patients With Mechanical Ventilation
ICU patients often in a strong stress environment. Various invasive procedures such as wound dressing change, sputum suction,Pull out the thoracic duct etc.
- Trial name
- NCT04315935
- Testing
- Butorphanol and Propofol, Fentanyl and Propofol
- Where
- China
- Volunteers
- 355 people
- Sponsor
- Jiangsu Hengrui Pharmaceutical Co., Ltd.
Postoperative Pain
Analgesic Effect of Perineural Fentanyl Additive to Local Anesthetics in Femoral Nerve Block
The purpose of this study is to evaluate the analgesic efficacy of perineural fentanyl combined with local anesthetics in the post operative pain control with continuous femoral nerve block after total knee arthroplasty.
- Trial name
- NCT02331576
- Testing
- rocaine, Fentanyl
- Where
- South Korea
- Volunteers
- 100 people
- Sponsor
- Chonnam National University Hospital
Osteoarthritis
Analgesic Efficacy And Safety of Tanezumab Added On To Diclofenac SR In Patients With Osteoarthritis Of The Knee Or Hip
The purpose of this study is to investigate the analgesic efficacy and safety of tanezumab added on to diclofenac SR in patients with osteoarthritis of the knee or hip currently experiencing partial benefit from, and are…
- Trial name
- NCT00864097
- Testing
- tanezumab, diclofenac
- Where
- 77 sites in Austria, France and 8 more
- Volunteers
- 607 people
- Sponsor
- Pfizer
Patients With Septic Shock Admitted to the ICU on Invasive Mechanical Ventilation
Comparison of Analgesic and Sedative Effects of Esmketamine and Remifentanil Combined With Propofol Respectively in Septic Shock Patients With Invasive Mechanical Ventilation
Septic shock patients with invasive mechanical ventilation who were randomly enrolled in ICU were divided into esketamine group (test group) and remifentanil group (control group) according to the ratio of 1:1.
- Trial name
- NCT05551910
- Testing
- Esketamine, Remifentanil, propofol
- Volunteers
- 120 people
- Sponsor
- The First Hospital of Jilin University
Pain
Safety and Efficacy Study of Hydromorphone and Morphine
To compare a standard weight-based dose of intravenous (IV) hydromorphone (Dilaudid) to a standard weight-based dose of IV morphine in adults presenting to the Emergency Department (ED) with acute severe pain.
- Trial name
- NCT00195910
- Testing
- Morphine, Hydromorphone
- Where
- United States
- Volunteers
- 198 people, healthy volunteers welcome
- Sponsor
- Montefiore Medical Center
Nausea, Pain
Prophylactic Analgesic and Antiemetic Regimen for Medical Abortion < 70 Days
Randomized trial which will aim to evaluate whether prophylactic use of ondansetron and ibuprofen will decrease side effects associated with medical abortion and increase patient satisfaction.
- Trial name
- NCT05819619
- Testing
- Prophylactic use of ibuprofen and ondansetron post misoprostol administration, Use of ibuprofen and ondansetron at symptom onset post misoprostol administration
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Hackensack Meridian Health
Pain
Baclofen as a Perioperative Analgesic Adjuvant
The purpose of this study is to determine whether a single, oral dose of baclofen alters postoperative opioid requirements.
- Trial name
- NCT03720717
- Testing
- Baclofen 10mg
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- University of Alabama at Birmingham
Osteoarthritis, Knee
A Phase 3 Efficacy and Safety Study of Intra-articular CNTX-4975-05 (Capsaicin) vs Placebo in Subjects With OA Knee Pain
This is a phase 3, randomized, double-blind, placebo-controlled, single injection, 52-week study to evaluate the analgesic efficacy and safety of a single intra-articular (IA) CNTX-4975-05 (capsaicin), compared to IA placebo, in…
- Trial name
- NCT03429049
- Testing
- CNTX-4975-05
- Where
- 33 sites in United States
- Volunteers
- 332 people
- Sponsor
- Centrexion Therapeutics
Comparing the Analgesic Outcome by ( 4 in 1 Block ) & ( Adductor Canal Block )
The Analgesic Efficacy of Ultrasound Guided Adductor Canal Block Versus 4 in 1 Block in Patients Undergoing Knee Surgeries: A Comparative Randomized Double Blinded Study .
Knee surgeries are associated with severe postoperative pain. Improper pain management affects patients' psychological status with prolongation of hospital stay time and rehabilitation period, with the possibility of progression…
- Trial name
- No acronym (NCT05794685)
- Testing
- adductor canal block, 4 in one block
- Where
- Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Mahmoud Hussein Bahr
Renal Colic, Pain
Analgesic Efficacy of Intranasal Desmopressin in Acute Renal Colic
In this study we will compare pain intensity and side effects at different time points after the intranasal administration of desmopressin or placebo in patients with acute renal colic pain.
- Trial name
- NCT01742689
- Testing
- Desmopressin intranasal spray, Indomethacin suppository
- Where
- 2 sites in Iran
- Volunteers
- 88 people
- Sponsor
- Tehran University of Medical Sciences
Chronic Shoulder Pain
Exparel for Total Shoulder Pain
Total shoulder surgery (arthroplasty) is a widely successful method of treating shoulder arthritis. Although the goal of the procedure is pain relief, post-operative pain is unavoidable.
- Trial name
- ETSP (NCT03739021)
- Testing
- Exparel, Ropivacaine
- Volunteers
- 60 people
- Sponsor
- University of South Florida
Postoperative Pain
An Open-label Study of Hydromorphone Oral Solution in Subjects Aged 28 Days to 16 Years for Postoperative Pain
The primary objective of this study is to characterize the pharmacokinetics and pharmacodynamics of hydromorphone oral solution in pediatric subjects aged 28 days to 16 years inclusive.
- Trial name
- Palladone (NCT00465647)
- Testing
- Hydromorphone
- Where
- 14 sites in United States
- Volunteers
- 116 people
- Sponsor
- Purdue Pharma LP
Rheumatism Knee
Single Shot Versus Continuous Adductor Canal Block in Patients Undergoing Total Knee Arthroplasty
Adductor canal block (ACB) has emerged as an option for postoperative regional analgesia in patients undergoing total knee arthroplasty (TKA).
- Trial name
- NCT04986878
- Testing
- single-shot adductor canal block
- Where
- 2 sites in Egypt
- Volunteers
- 60 people
- Sponsor
- Aswan University Hospital
Postoperative Pain Management, Postoperative Nausea and Vomiting
LAPOFAR Trial: Opioid-Free vs. Remifentanil Anesthesia in Laparoscopic Cholecystectomy
This study was a single-center, prospective, randomized clinical trial designed to compare the effects of opioid-free anesthesia (OFA) with standard opioid-based anesthesia during elective laparoscopic cholecystectomy.
- Conditions
- Postoperative Pain Management, Postoperative Nausea and Vomiting, Laparoscopic Cholecystectomy, Opioid-free Anesthesia
- Trial name
- LAPOFAR (NCT07307625)
- Testing
- Lidocaine + Dexmedetomidine, Remifentanil
- Where
- Turkey (Türkiye)
- Volunteers
- 101 people
- Sponsor
- Dr. Lutfi Kirdar Kartal Training and Research Hospital
Shoulder Arthroscopy, Peripheral Nerve Block
Comparison of the Postoperative Analgesic Efficacy of SPSIPB and ISBPB
Shoulder arthroscopy is one of the common surgical procedures performed today. After shoulder surgery, providing adequate analgesia is necessary for both the comfort of the patient and the ability to perform the necessary…
- Conditions
- Shoulder Arthroscopy, Peripheral Nerve Block, Pain Management
- Trial name
- NCT06626191
- Testing
- Interscalene brachial plexus block, Serratus posterior superior intercostal plane block, Group without peripheral nerve block
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Ankara Etlik City Hospital
Fibromyalgia
A Study to Assess the Analgesic Efficacy and Safety of ASP0819 in Patients With Fibromyalgia
This study assessed analgesic efficacy of ASP0819 relative to placebo as well as the safety and tolerability. This study assessed treatment differences in physical function as well as the improvements in overall subject status…
- Trial name
- NCT03056690
- Testing
- ASP0819
- Where
- 24 sites in United States
- Volunteers
- 186 people
- Sponsor
- Astellas Pharma Global Development, Inc.
Analgesia
Effect of Auto-Bolus Interval on Analgesic Quality During Labor Analgesia With Dural Puncture Epidural
It is aimed in this study to compare the effect of changing the interval time for programmed auto boluses of local anaesthetics on the total anesthetic consumption and quality of labor analgesia with dural puncture epidural…
- Trial name
- NCT06329713
- Testing
- Group I: 30 Min Interval Time, Group II: 60 Min Interval Time
- Where
- Turkey (Türkiye)
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Ataturk University
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