Clinical trials: Analgesic Medication
Analgesic Drug Dependence, Sensory Deficit
Quantitative Sensory Testing in Chronic Pain Patients Undergoing Opioid Treatment and Opioid Tapering
Few studies have used quantitative sensory tests to study the effect of chronic opioid treatment on sensation. The investigators will test chronic pain patients who are on different MEDDs, normal volunteers, and patients…
- Trial name
- NCT03375216
- Testing
- sensory testing (Heat, cold, and pressure), Promis Survey
- Where
- United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- The University of Texas Medical Branch, Galveston
Opioid Overdose, Drug Overdose
The Rhode Island Prescription and Illicit Drug Study
This study will test the efficacy of a novel drug-checking intervention to prevent fatal and non-fatal overdose among people who use drugs (PWUD), who are 18-65 years old at the time of enrollment.
- Trial name
- RAPIDS (NCT04372238)
- Testing
- RAPIDS Intervention, Standard OEND
- Where
- United States
- Volunteers
- 509 people, healthy volunteers welcome
- Sponsor
- Brown University
Endometrial Biopsy, Abnormal Uterine Bleeding
Effectiveness of Paracervical Block Versus Lidocaine Spray During Endometrial Biopsy
The purpose of this study to determine effectiveness of paracervical block, lidocaine spray and only oral analgesic drugs for pain relief during endometrial biopsy.
- Trial name
- NCT01908738
- Testing
- paracervical block with 1%lidocaine, 10%lidocaine spray
- Where
- Thailand
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Mahidol University
Opioid Pain Medication
Evaluating Postoperative Non-Opioid Pain Management Utilizing Local Anesthetics Coupled With Modulated Coagulation
This study is a prospective randomized trial examining the effect of topically combined antifibrinolytics (Tranexamic acid) with local anesthetics in all electively created surgical wound beds in hand surgery to provide long term…
- Trial name
- NCT04814433
- Testing
- Tranexamic acid, Aminocaproic acid, Recombinant Human Thrombin
- Where
- United States
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Burns, Pain, Burning
Effects of Applying Streaming Media on Reducing Pain in Patient With Second-degree Burn During Changing Dressing
During the acute phase of burn injuries, the focus for patients is primarily on wound pain and infection care. Patients often describe the pain during dressing changes as a sharp, stabbing sensation.
- Conditions
- Burns, Pain, Burning, Anxiety
- Trial name
- NCT06076031
- Testing
- Streaming Media
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Chiayi Christian Hospital
Analgesic Drugs, Antinociceptive Agents
Analgesic Effects of Midazolam in Human Volunteers
This study evaluates analgesic properties of midazolam compared to placebo and fentanyl. Each participant will receive all three drugs (midazolam, fentanyl, placebo) on three different occasions (study visits) and the effect on…
- Trial name
- GabA01 (NCT02629146)
- Testing
- Midazolam, Fentanyl, Isotonic saline
- Where
- Austria
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Wilhelminenspital Vienna
Hereditary Angioedema (HAE)
Open-label, Single-arm Study to Assess the Pharmacokinetics, Safety, and Tolerability of a Single Subcutaneous Dose of Icatibant in Healthy Japanese Volunteers
This is a single-dose study to evaluate the pharmacokinetics, safety, and tolerability of icatibant administered to adult Japanese subjects.
- Trial name
- NCT02045264
- Testing
- Icatibant (30 mg)
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Shire
Frozen Shoulder, Depression
Non-adherence to Pain Medication Increases Risk of Postoperative Frozen Shoulder
Background: Postoperative Frozen-Shoulder (FS) or adhesive capsulitis is a relatively frequent complication (5-20%), even after simple arthroscopic shoulder surgeries.
- Trial name
- NaFS (NCT04758585)
- Testing
- Arthroscopy
- Where
- Switzerland
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Kantonsspital Baden
Paracervical Block
Paracervical Block During Office Hysteroscopy
The purpose of this study is to determine the effectiveness of paracervical block for pain relief in office hysteroscopy - particularly with the placement of the Essure device.
- Trial name
- NCT00811187
- Testing
- Lidocaine paracervical block, Normal Saline
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Montefiore Medical Center
Pain
Patient and Provider Confidence and Satisfaction With the Clinical Use of CYP Genetic Variability
This study utilizes the Medication DNA Insight™ tests for pain and mental health medications. We are testing the pain and mental health medications commonly used in pain treatment.
- Trial name
- Genomics (NCT02568618)
- Testing
- Pain Medication DNA Insight (TM) test
- Where
- United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Defense and Veterans Center for Integrative Pain Management
Drugs, Investigational
Evaluate Analgesic Efficacy of Fast Release Aspirin
The objective of the study is to evaluate the analgesic efficacy of a single, oral dose of fast release aspirin tablets, 650 mg (2 x 325 mg) compared to regular aspirin tablets, 650 mg (2 x 325 mg) and placebo in subjects with…
- Trial name
- TAROT (NCT01122602)
- Testing
- Acetylsalicyclic acid (Fast acting Aspirin, BAY1019036), Acetylsalicyclic acid (Aspirin, BAYE4465)
- Where
- 2 sites in United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Bayer
Anesthesia, Local
The CIA Score: a Learner's Tool
The goal of this project is to use a previously described scoring system - the CIA system - as a teaching tool to help learners assess the bleeding risk of peripheral nerve blocks.
- Trial name
- NCT05153265
- Testing
- Survey
- Where
- United States
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- Stanford University
Analgesic Drug Dependence
Intravenous Lidocaine for Perioperative and Postoperative Analgesia
Postoperative pain continues to be untreated despite the application of multimodal analgesia, medication and new analgesic techniques.
- Trial name
- NCT03921567
- Testing
- Lidocaine Hydrochloride, Lidocaine Hydrochloride and Ketamine
- Where
- 2 sites in Kosovo
- Volunteers
- 520 people, healthy volunteers welcome
- Sponsor
- Rajmonda Nallbani-Komoni
Osteopathic Manipulative Treatment
By Potentially Adding a Century Old Therapeutic Measure to Pain Treatment Regimens Called Osteopathic Manipulative Treatment, Can Help Decrease Muscle and Bone Pain and the Usage of Opioid Pain Medication.
Osteopathic Manipulative Treatment (OMT) has been used to successfully treat patients for over a hundred years. Even though there have been many subjective clinical results, there is still little research measuring the actual…
- Trial name
- NCT06930196
- Testing
- Counterstrain, Muscle Energy, High Velocity Low Amplitude
- Where
- United States
- Volunteers
- 213 people, healthy volunteers welcome
- Sponsor
- Skagit Regional Health
Opioid-use Disorder, Opioid Use
The Analgesic Efficacy of Continuous Sub-fascial Bupivacaine Infusion and Lidocaine Patches in Post-cesarean Patients With Opiate Use Disorder: A Comparative Efficacy Analysis
Pregnant women with a history of opioid use disorder, chronic opioid use or those who are on medication assisted treatment will be randomly assigned to receive either a sub-fascial continuous infusion of bupivacaine or…
- Conditions
- Opioid-use Disorder, Opioid Use, Opioid Dependence, Opioid Abuse
- Trial name
- NCT04033562
- Testing
- Lidocaine patch, Ambu ACTion pump, 0.125% bupivacaine at 8cc/hr
- Where
- United States
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- WellSpan Health
Veisalgia
Safety and Efficacy of a Combination Product for the Prevention of Veisalgia
The purpose of this study is to determine the safety and efficacy of a combination product for the prevention of veisalgia. Common symptoms of veisalgia following the moderate consumption of alcohol includes headache, fatigue…
- Trial name
- NCT02737397
- Testing
- JMI-001 (SJP-304 and SJP-223), SJP-304, SJP-223
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Sen-Jam Pharmaceutical
Study Focus: Prescribing of Drugs
The Effect of Industry-independent Visits to Primary Care Physicians on Medication Prescribing for Pain Relief in Chronic Joint Pain.
Osteoarthritis is a common problem in primary care. Long-term use of non-steroidal anti-inflammatory drugs (NSAIDs) for pain relief can lead to serious (gastro-intestinal, cardiovascular and renal) adverse events, that can even…
- Trial name
- NCT01761864
- Testing
- academic detailing intervention
- Where
- Belgium
- Volunteers
- 4,000 people, healthy volunteers welcome
- Sponsor
- Universiteit Antwerpen
Pain
Experimental Medicine Study to Validate Pharmacodynamic Pain Assessments in Healthy Volunteers With an Opioid Analgesic (Remifentanil)
This was a single centre, randomised, double blind, placebo controlled, two-way cross-over design study to assess the feasibility of pain PD tests and to determine the variability and effects of a known analgesic drug (the opioid…
- Trial name
- NCT02602002
- Testing
- Remifentanil
- Where
- South Korea
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Pain, Appetite Loss
AnalgeSiC and appEtite-stimulating Effects of caNnabigerol and THC (ASCENT)
This study will assess the analgesic, appetite-stimulating, and subjective effects of cannabigerol (CBG) alone and in combination with THC.
- Conditions
- Pain, Appetite Loss, Abuse, Drug
- Trial name
- ASCENT (NCT04859296)
- Testing
- Low CBG, High CBG, Low THC
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Pain, Postoperative
Does IVPCA Increase Opioid Consumption and Side Effects in Fast Track Orthopedic Procedures?
The study aims to compare the use of intravenous patient controlled analgesia (IVPCA) versus the delivery of pain relief (per oral and intravenous (IV) medications as rescues analgesia) on an as needed basis within a well defined…
- Trial name
- NCT02880800
- Testing
- Morphine as IVPCA, Hydromorphone as IVPCA, Morphine
- Where
- Canada
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Mount Sinai Hospital, Canada