Clinical trials: Anemia in Pregnancy
Malaria
Intermittent Preventive Treatment During Pregnancy in Benin
Malaria in pregnancy is one of the most important preventable causes of low birthweight worlwide and a major cause of severe maternal anaemia contributing to maternal mortality.
- Trial name
- NCT00274235
- Testing
- sulfadoxine-pyrimethamine / mefloquine
- Where
- Benin
- Volunteers
- 1,600 people
- Sponsor
- Institut de Recherche pour le Developpement
End Stage Renal Disease
Less Frequency Hemodialysis and COVID-19
Facing the unusual situation imposed by the coronavirus disease, the aim of this study is to evaluate the risk and effects of less frequent hemodialysis on prevalent patients
- Trial name
- NCT04374058
- Testing
- less-frequency hemodialysis
- Where
- Argentina
- Volunteers
- 50 people
- Sponsor
- Dialisis Madariaga
Anemia, Kidney Disease, Chronic
A Study of The Effect of Altitude on Mircera (Methoxy Polyethylene Glycol-Epoetin Beta) Dose Requirements in Participants With Chronic Renal Anemia in Pre-Dialysis or Dialysis
This comparative, open-label, multicenter, parallel-group study evaluated the effect of altitude on the dose requirements of Mircera (methoxy polyethylene glycol-epoetin beta) to achieve a target hemoglobin concentration of 11-12…
- Trial name
- ALTITUD (NCT01519947)
- Testing
- Methoxy polyethylene glycol-epoetin beta
- Where
- 7 sites in Mexico
- Volunteers
- 87 people
- Sponsor
- Hoffmann-La Roche
Chronic Kidney Disease, Kidney Disease
Study for Subjects With Chronic Kidney Disease(CKD) Not Receiving Dialysis
The proposed study is designed to test a novel dosing paradigm that would facilitate the treatment of anemia in CKD patients not on dialysis.
- Trial name
- NCT00112008
- Testing
- De Novo Administration of Darbepoetin Alfa
- Volunteers
- 100 people
- Sponsor
- Amgen
Anemia, Chronic Renal Failure
Safety & Efficacy of Peginesatide for Treatment of Anemia in Participants on Dialysis Not Receiving an ESA
The purpose of this study is to evaluate the safety and efficacy of peginesatide for the treatment of anemia in participants with chronic kidney disease who are on dialysis and are not taking any treatment to increase their red…
- Conditions
- Anemia, Chronic Renal Failure, Chronic Kidney Disease
- Trial name
- NCT00680043
- Testing
- peginesatide, Epoetin Alfa
- Where
- 11 sites in Russia
- Volunteers
- 114 people
- Sponsor
- Affymax
Iron Deficiency Anemia of Pregnancy, Iron Metabolism Disorders
Hepcidin and Glucose Metabolism
Gestational diabetes mellitus (GDM), defined as hyperglycemia with blood glucose values above normal but below those diagnostic of DM, and iron deficiency (ID) with or without anemia (IDA) are common during pregnancy.
- Conditions
- Iron Deficiency Anemia of Pregnancy, Iron Metabolism Disorders, Glucose Intolerance, Gestational Diabetes
- Trial name
- NCT04008147
- Testing
- 100mg iron fumarate, Burgerstein Schwangerschaft & Stillzeit
- Where
- Switzerland
- Volunteers
- 30 people
- Sponsor
- Swiss Federal Institute of Technology
Cardiac Diseases, Sickle Cell Disease
Domestication and Implementation of the PEN-Plus Clinical Model in the Zambian Health System
Cognizant of the prevalence of complicated non communicable diseases (NCD) and the attendant capacity problems faced by the health workers in primary care settings, we propose to adapt and pilot the Package of Essential…
- Conditions
- Cardiac Diseases, Sickle Cell Disease, Hypertension, Diabetes Mellitus
- Trial name
- PEN Plus (NCT07753681)
- Testing
- Supportive treatment
- Where
- Zambia
- Volunteers
- 2,084 people
- Sponsor
- Centre for Infectious Disease Research in Zambia
Chronic Kidney Disease
A Study to Evaluate the ePidemiology of anEmia Associated With chroNic Kidney Disease in Patients in Primary Care Using The Stockholm CREAtinine Measurement (SCREAM) Register
The objectives of this analysis is to determine the incidence of anemia occurring in patients with chronic kidney disease (CKD) in primary care (i.e. prior to any eventual referral to nephrology care).
- Trial name
- NCT05015998
- Testing
- Non-interventional
- Where
- Sweden
- Volunteers
- 45,637 people
- Sponsor
- Astellas Pharma Europe Ltd.
Atypical Hemolytic-Uremic Syndrome
An Open-Label, Multi-Center Clinical Trial of Eculizumab in Pediatric Patients With Atypical Hemolytic-Uremic Syndrome
The primary purpose is to assess the efficacy and safety of eculizumab in pediatric patients with aHUS to control TMA as characterized by thrombocytopenia, hemolysis and renal impairment.
- Trial name
- aHUS (NCT01193348)
- Testing
- Eculizumab
- Where
- 17 sites in United States, Australia and 7 more
- Volunteers
- 22 people
- Sponsor
- Alexion Pharmaceuticals, Inc.
Cardio-Renal Syndrome
Roxadustat Combined With Sacubitril Valsartan Sodium Tablets in the Treatment of Cardiorenal Anemia Syndrome
A randomized and parallel controlled trial design of comparing the new treatment group of Roxadustat combined with Sacubitril Valsartan Sodium Tablets with the traditional treatment group of recombinant human erythropoietin (EPO)…
- Trial name
- NCT05053893
- Testing
- Roxadustat;Sacubitril Valsartan Sodium Tablets;, EPO; ACEI / ARB
- Where
- China
- Volunteers
- 40 people
- Sponsor
- The Affiliated Hospital of Qingdao University
Anemia, Renal Insufficiency, Chronic
A Study of Molidustat for Correction of Renal Anemia in Non-dialysis Subjects
The purpose of this study is to evaluate the efficacy and safety of molidustat in non-dialysis subjects with renal anemia who are not treated with Erythropoiesis-Stimulating Agents (ESAs).
- Trial name
- MIYABI ND-C (NCT03350321)
- Testing
- Molidustat (BAY85-3934), Darbepoetin alfa
- Where
- 61 sites in Japan
- Volunteers
- 162 people
- Sponsor
- Bayer
Kidney Disease
Repeat Dose Safety and Efficacy Study for Compound to Treat Anemia
The purpose of this study is to characterize the safety and efficacy of repeat doses of compound 1278863A in subjects with anemia.
- Trial name
- NCT01047397
- Testing
- 1278863A
- Where
- 37 sites in Australia, India and 2 more
- Volunteers
- 107 people
- Sponsor
- GlaxoSmithKline
Sickle Cell Disease, Chronic Kidney Disease
Hydroxyurea and Erythropoietin to Treat Sickle Cell Anemia
This study will examine the use of hydroxyurea and erythropoietin for treating sickle cell disease in patients who also have kidney disease or pulmonary hypertension (high blood pressure in the lungs).
- Conditions
- Sickle Cell Disease, Chronic Kidney Disease, Pulmonary Hypertension
- Trial name
- NCT00270478
- Testing
- Erythropoietin and Hydroxyurea
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Birth Outcomes, Stunting
Uganda Birth Cohort Study
The UBC was a USAID-funded longitudinal prospective cohort study of pregnant women (n= 5030) aged 15-49 years from rural North and South-Western regions of Uganda, conducted between 2014 and 2016.
- Conditions
- Birth Outcomes, Stunting, Wasting, Anemia
- Trial name
- UBC (NCT04233944)
- Where
- United States
- Volunteers
- 5,044 people
- Sponsor
- Tufts University
Chronic Kidney Diseases, Anemia of Chronic Kidney Disease
A Post Marketing Surveillance to Evaluate the Safety of Desidustat for the Treatment of Anemia in Subjects With Chronic Kidney Disease (CKD).(Real World Evidence Study)
A Phase 4, 52 week, single arm, multicentre post marketing surveillance to evaluate the safety of Desidustat for the treatment of anemia in subjects with chronic kidney disease (CKD)
- Trial name
- NCT05515367
- Testing
- Desidustat
- Where
- India
- Volunteers
- 1,004 people
- Sponsor
- Zydus Lifesciences Limited
Sickle Cell Disease, Pregnancy Related
LEARNER- Low dosE AspiRiN prEterm tRial (Angola)
This study is being conducted to evaluate the safety and effect of starting daily use of low dose (100 mg) aspirin in pregnant women with sickle cell disease, who are being followed in two county hospitals in Angola, in the first…
- Conditions
- Sickle Cell Disease, Pregnancy Related, Pregnancy Complications, Pre-Eclampsia
- Trial name
- LEARNER (NCT06417411)
- Testing
- Aspirin 100mg
- Where
- Angola
- Volunteers
- 450 people
- Sponsor
- Instituto Nacional de Investigacao em Saude, Angola
Sickle Cell Disease, Kidney Failure, Chronic
Kidney Function in Sickle Cell Anemia
This is a prospective clinical cohort study that involves a baseline study visit followed by up to 3 annual follow-up study visits for a total follow-up of 36-48 months to evaluate the age- and sex-adjusted rate of change in…
- Trial name
- NCT03277547
- Where
- 3 sites in United States
- Volunteers
- 300 people
- Sponsor
- Kenneth Ataga MD
Iron Deficiency Anemia of Pregnancy
Intravenous Iron Versus Oral Iron for the Treatment of Iron Deficiency Anemia
This study aims to assess whether administering intravenous iron early in pregnancy, compared to standard oral iron treatment, can enhance hemoglobin levels before delivery and reduce the need for blood transfusions in patients…
- Trial name
- IDA (NCT06366698)
- Testing
- Venofer 200 MG Per 10 ML Injection, Ferrous sulfate
- Where
- United States
- Volunteers
- 900 people, healthy volunteers welcome
- Sponsor
- Arrowhead Regional Medical Center
Iron Deficiency Anemia
Lactoferrin Versus Ferrous Sulfate in Iron-deficiency During Pregnancy
The main drawbacks with oral iron are side-effects, poor compliance, and limited absorption from the gut. It has become very apparent gastrointestinal intolerance with oral iron therapy is dose related and common (up to 20% of…
- Trial name
- NCT03759353
- Testing
- Baseline ferritin level, Lactoferrin, Ferrous Sulfate
- Where
- Egypt
- Volunteers
- 98 people
- Sponsor
- Ain Shams University
Sickle Cell Disease, Pregnancy, High Risk
TAPS2 Transfusion Antenatally in Pregnant Women With SCD
Sickle Cell Disease (SCD) is a serious inherited blood disorder affecting red blood cells. When oxygen levels drop the red cells become abnormally shaped and unable to move through the blood vessels easily.
- Conditions
- Sickle Cell Disease, Pregnancy, High Risk, Blood Transfusion Complication
- Trial name
- TAPS2 (NCT03975894)
- Testing
- Serial prophylactic exchange blood transfusion (SPEBT).
- Where
- 6 sites in United Kingdom
- Volunteers
- 50 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust