Clinical trials: Anesthesia, Epidural
Labor Pain
Programmed Intermittent Epidural Bolus Versus Continuous Infusion in Labour Analgesia
This study aims to establish if programmed intermittent epidural bolus combined to patient controlled analgesia in labour analgesia will lower the hourly bupivacaine consumption when compared to continuous infusion combined with…
- Trial name
- NCT03730753
- Testing
- Programmed intermittent epidural bolus, Continuous infusion
- Where
- Canada
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Université de Sherbrooke
Gynecologic Disease Requiring Laparoscopic Hysterectomy Under Neuraxial Anesthesia
Dural Puncture Epidural Technique Versus Conventional Epidural Techmique
This study will be conducted on 50 patients of ASA grade I and II aged from 25 to 55 years and presented for laparoscopic hysterectomy.
- Trial name
- NCT05032677
- Testing
- Conventional Epidural Technique, Dural Puncture Epidural Technique using pencil-point 25G Whitacre needle
- Where
- Egypt
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Cairo University
Labor Pain, Nociceptive Pain
Nociception Level Index (NOL Index) for Obstetrical Pain Assessment Under Epidural Analgesia.
Pain has been defined by the International Association for the Study of Pain (IASP) as "an unpleasant sensory and emotional experience associated with actual or potential tissue damage, or described in terms of such damage".
- Conditions
- Labor Pain, Nociceptive Pain, Epidural Analgesia, NOL Index
- Trial name
- NCT05898737
- Testing
- NOL-Index
- Where
- Belgium
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire Saint Pierre
Incidence, Unilateral
Is There a Relation Between Unilateral Epidural Block and Repeated Epidural Anesthesia?
epidural block is today the most common method of pain relief during labor. With increased use of epidural analgesia, many women are found in the second or third pregnancy and require repeated epidural analgesia.
- Conditions
- Incidence, Unilateral, Epidural Block
- Trial name
- NCT03806673
- Testing
- marcaine
- Where
- Egypt
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Rib Fractures
Non-Inferiority Study of Erector Spinae Plane Block Compared to Thoracic Epidural in Pain Management of Rib Fractures
The purpose of this study is to compare 2 pain control treatments for people with 3 or more rib fractures.
- Trial name
- SUETHE-Ribs (NCT05069961)
- Testing
- ESPB, TEA
- Volunteers
- healthy volunteers welcome
- Sponsor
- Indiana University
Low Back Pain, Mechanical
Impact of Epidural Anesthesia on Low Back Function
Back pain is a common complication after the use of epidural anesthesia in obstetric and non-obstetric surgeries and occurs in 30-45% of cases (Brown, 2005).
- Trial name
- NCT04759963
- Where
- 2 sites in Egypt
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- South Valley University
Spinal Anesthesia, Epidural; Anesthesia
Bupivacaine With Epidural Volume Extension
In this study the investigator will address the efficacy of using low dose bupivacaine spinal anesthesia (SA) in combination with epidural volume extension (EVE) for patients undergoing short obstetric procedures.
- Trial name
- NCT03110003
- Testing
- 10 mg Bupivacaine, 5 mg Bupivacaine
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Labor Pain
Programmed Intermittent Epidural Bolus Time Interval and Injection Volume
Studies suggest that administration of maintenance epidural solutions as programmed or automated intermittent boluses, rather than continuous infusions, result in lower bupivacaine consumption, decreased need for manual boluses…
- Trial name
- NCT00417027
- Testing
- Programmed Intermittent Epidural Bolus (PIEB)
- Where
- United States
- Volunteers
- 190 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Pain
Preoperative Gabapentin for Acute and Chronic Post-thoracotomy Analgesia
One dose of either gabapentin or placebo will be given to patients prior to thoracotomy. Patients will also receive an epidural infusion, intravenous patient-controlled analgesia with fentanyl, oral acetaminophen and intravenous…
- Trial name
- NCT00588159
- Testing
- Gabapentin, Diphenhydramine
- Where
- United States
- Volunteers
- 146 people, healthy volunteers welcome
- Sponsor
- Michelle Kinney
Analgesia
Comparison of Standard Epidural and Dural Puncture Epidural Analgesia in Open Gynecological Surgery Techniques
The aim of this study is to compare the effectiveness of standard epidural and dural puncture epidural analgesia techniques used under NOL guidance.
- Trial name
- NCT05408052
- Testing
- Dural Puncture Epidural (DPE), Standart Epidural
- Where
- Turkey (Türkiye)
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Ataturk University
Anesthesia
Superiority of Epidural Placement Technique Using EpiFaith Syringe
The aim of this study is to evaluate the impact of EpiFaith® syringe on the establishment of successful epidural labor analgesia, change of elapsed time for identification of epidural space, and learning curve of CA-1 residents.
- Trial name
- NCT04793373
- Testing
- Syringe
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Harvard Medical School (HMS and HSDM)
Asepsis, Analgesia, Epidural
Chlorhexidine Versus Povidone-Iodine for Prevention of Epidural Needle Contamination in the Parturient
Infection after epidural catheter placement is fortunately rare. When it does happen, the affected person can become seriously ill.
- Conditions
- Asepsis, Analgesia, Epidural, Anesthesia, Epidural
- Trial name
- NCT00223002
- Testing
- Chlorhexidine
- Where
- Canada
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- University of Saskatchewan
Vaginal Laceration During Delivery
The PAIN (Pelvic Area Injection for Numbness) Study
Postpartum pain can interfere with patient's ability to care for themselves, and their newborn, and untreated pain is associated with risk of greater opioid use, postpartum depression, and development of persistent pain.
- Trial name
- PAIN (NCT05972681)
- Testing
- Bupivacaine, Epinephrine
- Where
- United States
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- Montefiore Medical Center
Anesthesia; Adverse Effect, Spinal and Epidural, Hypotension
Ephedrine vs. Nor Epinephrine Infusion in Preventing Hypotension After Spinal Anesthesia for Cesarean Section
The purpose of the study is to determine if norepinephrine is more effective as a continuous intravenous (IV) infusion compared to continuous IV ephedrine associated with crystalloid loading for maintaining blood pressure during…
- Conditions
- Anesthesia; Adverse Effect, Spinal and Epidural, Hypotension, Complications; Cesarean Section
- Trial name
- NCT02477501
- Testing
- Norepinephrine, Ephedrine
- Where
- Tunisia
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University Tunis El Manar
Hypovolemia, Surgery
Volume Deficit Prior to Surgery
It is the purpose of the researchers to identify the variation in intravascular deficits which can have relevance in high risk patients for minor and medium sized surgery.
- Trial name
- NCT00380107
- Where
- Denmark
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Post-Dural Puncture Headache
Effect of Small Versus Large Epidural Needles on Postdural Puncture Headache Study
The purpose of this study is to determine the effect of 19g versus =>18g traditional Tuohy-type epidural needles on the incidence and severity of postdural puncture headache (PDPH).
- Trial name
- NCT00370604
- Testing
- 19g Tuohy-type epidural needle, 23g catheter, => 18g Tuohy-type needle
- Where
- 4 sites in Canada
- Volunteers
- 1,081 people, healthy volunteers welcome
- Sponsor
- Sunnybrook Health Sciences Centre
Pain Insensitivity, Congenital
Comparison of Levobupivacaine, Ropivacaine and Bupivacaine in Epidural Anaesthesia
This study compares the clinical efficacy of newer local anaesthetic drugs Levobupivacaine and Ropivacaine with Bupivacaine in lumbar epidural anaesthesia for hip surgeries.
- Trial name
- NCT02513433
- Testing
- Bupivacaine, Levobupivacaine, Ropivacaine
- Where
- India
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Government Medical College, Haldwani
Labour Analgesia, Epidural Anaesthesia
Higher vs Lower Lumber Epidural Catheter Insertion During Labour: A Randomised Trial to Compare Efficacy.
This study will randomise pregnant women to labour epidural at a higher versus a lower lumbar level. Outcomes relating to success or failure of the epidural catheter at this level will be assessed.
- Trial name
- NCT06850636
- Testing
- Epidural Analgesia
- Where
- Ireland
- Volunteers
- 164 people, healthy volunteers welcome
- Sponsor
- The Rotunda Hospital
Discomfort, Psychological Well Being
Patient Experiences of Intraoperative Discomfort During Cesarean Delivery Under Neuraxial Anesthesia
During a cesarean delivery done under spinal or epidural anesthesia, many patients notice sensations they weren't expecting things like pressure, pulling, tugging, or nausea even though the anesthesia blocks pain.
- Trial name
- ICAT (NCT07867106)
- Testing
- Interview
- Where
- Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Samuel Lunenfeld Research Institute, Mount Sinai Hospital
Anesthesia, Epidural, Hypotension
Hypotension Prediction Index to Predict Epidural-labor Analgesia Induced Hypotension
The purpose of this pilot trial is to examine the feasibility and ease of use of monitoring by ClearSight in laboring and delivering patients with the intent to compare time-to-treatment of hypotension between conventionally…
- Trial name
- NCT05906368
- Testing
- ClearSight HPI Monitoring system, Standard of Care Blood Pressure Monitoring
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Grace Lim, MD, MS