Clinical trials: Anesthesia, Recovery
Pain, Postoperative, Analgesia
Prediction of Postoperative Pain by Nociception Monitoring
General anesthesia is a combination of hypnotic drugs and opioid analgesics. Modern general anesthesia aims to treat nociception induced by surgical stimulation while avoiding an overdose of opioid analgesics and reducing…
- Conditions
- Pain, Postoperative, Analgesia, Anesthesia Recovery Period, Opioid Use
- Trial name
- PredictPain (NCT05063227)
- Testing
- Observational: analgesia monitoring indices and changes in heart rate
- Where
- Germany
- Volunteers
- 60 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Postoperative Pain, Acute
Anterior Suprascapular Versus Interscalene Block for Postoperative Analgesia After Arthroscopic Shoulder Surgery in the Outpatient Setting
Shoulder surgery performed in the outpatient setting can be associated with moderate to severe postoperative pain, especially during the first hours after surgery.
- Trial name
- NCT07831096
- Testing
- Interscalene Nerve Block, Anterior suprascapular nerve block, Ropivacaine
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- ASST Sette Laghi
Hip Fracture, Postoperative Recovery
Total Intravenous Versus Inhalational Anesthesia in Patients Undergoing Hip Fracture Surgery
This prospective observational study aims to compare total intravenous anesthesia (TIVA) with sevoflurane-based inhalational anesthesia in patients aged 65 years and older undergoing hip fracture surgery under general anesthesia.
- Trial name
- NCT07860996
- Testing
- Propofol-based Total Intravenous Anesthesia, Sevoflurane-based Inhalational Anesthesia
- Where
- Turkey (Türkiye)
- Volunteers
- 110 people
- Sponsor
- Sehit Prof. Dr. Ilhan Varank Sancaktepe Training and Research Hospital
Surgery-Complications, Anesthesia Complication
Trajectories of Recovery After Intravenous Propofol Versus Inhaled VolatilE Anesthesia Trial
The investigators will conduct a 13,000-patient randomized multi-center trial to determine (i) which general anesthesia technique yields superior patient recovery experiences in any of three surgical categories ((a) major…
- Conditions
- Surgery-Complications, Anesthesia Complication, Anesthesia Awareness, Anesthesia
- Trial name
- THRIVE (NCT05991453)
- Testing
- Anesthetic technique Propofol TIVA, Anesthetic technique inhaled agent
- Where
- 24 sites in United States
- Volunteers
- 13,000 people
- Sponsor
- Washington University School of Medicine
Acute Pain, Regional Anesthesia
Regional Analgesia in Combination With Cryoanalgesia to Prevent Acute Pain Following Nuss Procedure
Funnel chest deformation is a painful procedure, which requires high doses and long time used of opioids. It makes difficult introduction of ERAS protocol.
- Trial name
- NCT05589246
- Testing
- regional analgesia with cryolesia
- Where
- 2 sites in Poland
- Volunteers
- 40 people
- Sponsor
- Pomeranian Medical University Szczecin
Anesthesia, Conduction
RCT Impact of Serratus Intercostal Plane Block in Video Assisted Thoracic Surgery
Rationale Video Assisted Thoracic Surgery (VATS) is known to be a moderate painful procedure. There are many ways to manage postoperative pain following this kind of surgery.
- Trial name
- NCT03449329
- Testing
- SIP
- Where
- Belgium
- Volunteers
- 21 people
- Sponsor
- AZ Sint-Jan AV
Total Hip Arthroplasty (THA), Femoral Neck Fractures
PNB Anesthesia Improves Older Patients' Postoperative Early Recovery Outcomes After Total Hip Arthroplasty
Early postoperative rehabilitation is an important issue for total hip arthroplasty, especially in older patients. This retrospective clinical trial is to assess the impact of peripheral nerve block anesthesia versus general…
- Trial name
- NCT07163598
- Testing
- No Intervention: Observational Cohort
- Where
- China
- Volunteers
- 516 people
- Sponsor
- RenJi Hospital
Anesthesia Recovery Period ； Postoperative Pain； Hemodynamic Stability During Surgery
Afentanil and Remifentanil for Anesthesia Quality and Recovery
The goal of this clinical trial is to compare two commonly used opioid pain medications-alfentanil and remifentanil-during general anesthesia for surgery, and to find out whether alfentanil is as good as (not worse than)…
- Trial name
- NCT07761312
- Testing
- alfentanil, Remifentanil
- Volunteers
- 990 people
- Sponsor
- Qianfoshan Hospital
Patients Undergoing Robotic Surgery
Quality of Recovery After Robotic Surgery
Robotic approach to laparoscopic surgery has greatly facilitated undertaking complex surgery inside the abdominal cavity with ease.
- Trial name
- NCT03659539
- Testing
- PROPOFOL, Desflurane
- Where
- India
- Volunteers
- 120 people
- Sponsor
- Nitin Sethi, DNB
Spinal Anesthesia, Total Knee Arthroplasty
Low Dose Spinal Bupivacaine for Total Knee Replacement and Recovery Room Wait Time
This study plans to investigate whether a reduced dose of bupivacaine (a local anesthetic numbing drug) injected into the spinal space for a total knee replacement will result in a shorter time to discharge from the recovery room…
- Trial name
- NCT00537472
- Testing
- Low dose bupivicaine in spinal anesthetic, Standard dose bupivacaine in spinal anesthetic
- Where
- Canada
- Volunteers
- 140 people
- Sponsor
- Queen's University
Humans, Anesthesia
Romanian Validation and Cross-cultural Adaptation of the QoR-15Ro
Optimal postoperative recovery after any surgical procedure requiring anesthesia is essential to achieving high-quality care. The Quality of Recovery questionnaire (QoR-15) was validated by its authors in 2013 in the study…
- Conditions
- Humans, Anesthesia, Recovery, Postoperative Care
- Trial name
- QoR-15Ro (NCT07258238)
- Where
- Romania
- Volunteers
- 250 people
- Sponsor
- SUUMC Central Military Hospital Dr Carol Davila
Diabetes Mellitus, Glycemic Control
Effect of Glycemic Control on Intraoperative NIRS and Postoperative Recovery in Diabetic Patients
This prospective observational study aims to evaluate the effect of glycemic control level on intraoperative cerebral oxygenation measured by near-infrared spectroscopy (NIRS) and postoperative recovery in patients with diabetes…
- Conditions
- Diabetes Mellitus, Glycemic Control, Cerebral Oxygenation, Anesthesia
- Trial name
- NIRS-DM (NCT07491185)
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Ege University
Anesthesia Emergence
Remifentanil and Desflurane Inhalational Anesthesia in Bariatric Surgeries
The number of obese and overweighted persons doubled since 1980. They are 600 million in 2014 all over the world. Obesity results in anatomical, physiological and pharmacological changes which represent a challenge for every…
- Trial name
- NCT03219788
- Testing
- Normal Saline, Remifentanil 0.1 ug/kg, Remifentanil 0.2 ug/kg
- Volunteers
- 120 people
- Sponsor
- Assiut University
Pain, Postoperative, Pain, Acute
Opioid Sparing Anesthesia in Lumbar Spine Surgery
The aim of this double blind randomized study will be to investigate the effect of an opioid-free anesthesia regimen with a mixture of dexmedetomidine-lidocaine-ketamine in the same syringe versus remifentanil analgesia in lumbar…
- Conditions
- Pain, Postoperative, Pain, Acute, Pain, Chronic, Pain, Nociceptive
- Trial name
- NCT05594407
- Testing
- dexmedetomidine-ketamine-lidocaine, Remifentanil
- Where
- Greece
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Aretaieion University Hospital
Breast Diseases
MAC vs TIVA Ambulatory Breast Augmentation
hypothesis: the combination of LA with remifentanil and ketofol [monitored anesthesia care (MAC)] for ambulatory breast augmentation may result in results in better QoR on day of surgery as compared with total i.v.
- Trial name
- NCT03764267
- Testing
- Remifentanil, general anesthetic
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Hip Fracture
Peripheral Nerve Blocks in Elderly Patients With Hip Fracture
As the population ages, the frequency of surgery is increasing proportionally, bringing with it the challenge of managing older patients with frequent comorbid diseases and an increased risk of complications.
- Trial name
- NCT02635763
- Testing
- Femoral nerve and the lateral cutaneous nerve block, Lumbar plexus and sacral plexus nerve block
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Shanghai Jiao Tong University Affiliated Sixth People's Hospital
Anesthesia, Depth of Hypnosis Monitoring
The Effect of DSA on Recovery of Anaesthesia in Children
In this randomised, blinded study, we will investigate the influence of DSA on recovery from general anaesthesia. DSA monitoring provides continuous information on depth of hypnosis.
- Trial name
- DSA-RCT-1 (NCT05525104)
- Testing
- Narcotrend Monitor (MT MonitorTechnik, Hannover, Germany)
- Where
- Netherlands
- Volunteers
- 112 people
- Sponsor
- Erasmus Medical Center
Hand Surgery, Quality of Recovery
Local Anesthesia With Minimal Sedation and Brachial Plexus Block in Hand Surgery
A major innovation in hand surgery in the last decade is the popularization of Wide Awake Hand Surgery (WAHS). This technique consists of numbing the surgical area with local anesthesia with epinephrine and allowing the patient…
- Conditions
- Hand Surgery, Quality of Recovery, Hand Injuries, Hand Fracture
- Trial name
- NCT03632304
- Testing
- Local anesthesia with minimal sedation
- Where
- 2 sites in Canada
- Volunteers
- 105 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Neuromuscular Blockade
Comparison of Mechanomyographic 100 Versus 200 Hz 5 Second Tetanic Fade Ratios During Neuromuscular Block Recovery
Two recent pilot studies suggested the potential interest of 100 and 200 Hz tetanic stimulations to detect with mechanomyography (MMG) very low levels of residual neuromuscular blockade (NMB).
- Trial name
- NCT05474638
- Testing
- Isometric Thumb Force (isometric mechanomyography) compared to TOF-Watch SX (acceleromyography)
- Where
- Belgium
- Volunteers
- 20 people
- Sponsor
- Centre Hospitalier Universitaire UCLouvain Namur
Quality of Recovery, Anesthesia
Improving ObsQoR-11 With Continuous Wound Infusion Versus Intrathecal Morphine After Elective Cesarean Delivery
The purpose of this prospective randomized double-blinded and controlled study is to evaluate the quality of recovery after elective cesarean delivery using the Obstetric Quality-of-Recovery-11 (ObsQoR-11) score at 24 hours…
- Conditions
- Quality of Recovery, Anesthesia, Postoperative Pain, Cesarean Section
- Trial name
- CIVIMEC (NCT05696678)
- Testing
- Intrathecal Morphine, Ropivacaine 0.2%
- Where
- Canada
- Volunteers
- healthy volunteers welcome
- Sponsor
- Ciusss de L'Est de l'Île de Montréal