Clinical trials: Anesthesia, Regional
Postoperative Pain
Comparison of Paravertebral Versus Epidural Block for Post-thoracotomy Pain Control
This is a randomized, assessor-blinded, non-inferiority clinical trial comparing continuous thoracic paravertebral block (BPV) versus continuous thoracic epidural block (BPD) for postoperative pain control in adult patients…
- Trial name
- NCT07763249
- Testing
- Continuous Thoracic Paravertebral Block, Continuous Thoracic Epidural Block
- Where
- Brazil
- Volunteers
- 80 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Dental Anxiety, Pain Management
Impact of Local Anesthesia Techniques on Children's Dental Treatment Experience
compare the effectiveness of several local anesthetic delivery systems in managing pain, anxiety, behavior, and vital signs among pediatric dental patients.
- Conditions
- Dental Anxiety, Pain Management, Pediatric Dentistry
- Trial name
- NCT07106138
- Testing
- Conventional syringe injection, Star Pen, Comfort-In
- Where
- Syria
- Volunteers
- 112 people
- Sponsor
- Latakia University
Anxiety
Effects of Stress Ball Use on Heart Rate Variability, Anxiety, and Pain During Awake Hand Surgery: A Randomized Controlled Trial
Preoperative anxiety begins from the decision-making of surgery to entering the operating room and may intensify as the surgery date approaches.
- Trial name
- NCT06742814
- Testing
- stress ball
- Where
- 2 sites in Taiwan
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Anesthesia, Regional
Comparison of an Interscalene Nerve Block With or Without Stellate Ganglion Block for Shoulder Surgery
This study describes the difference of analgesic effect of levobupivacaine 0.5% administered through an interscalene nerve block with or without a stellate ganglion block.
- Trial name
- NCT02879916
- Testing
- Levobupivacaine, NaCl 0.9%
- Volunteers
- 30 people
- Sponsor
- University Hospital, Antwerp
Dental Caries, Reversible Pulpitis
Assessment of Pain and Anxiety During Infiltration Anesthesia Using Dental Anesthesia Injector Versus Conventional Syringe in Pediatric Patients
This randomized controlled trial is conducted on pediatric dental patients to compare the effectiveness of local anesthesia administered using a dental anesthesia injector device versus the traditional syringe method.
- Trial name
- NCT07101068
- Testing
- Dental Anesthesia Injector, conventional syringe
- Where
- 2 sites in Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Pain, Postoperative
Regional Anesthesia for Head and Neck Reconstruction
By utilizing regional anesthesia blocks at the surgery tissue donor sites, it can potentially reduce post-operative pain while also reducing the use of opioids.
- Trial name
- NCT04304716
- Testing
- Regional Anesthesia
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Florida
Thoracic Injuries, Rib Fractures
Serratus Plane Block With Parenteral Opioid Analgesia Versus Patient Controlled Analgesia in Rib Fractures
In this multicentre randomised controlled trial, adult patients with isolated chest trauma and two or more unilateral rib fractures will be randomised to either serratus plane block and patient controlled analgesia or patient…
- Conditions
- Thoracic Injuries, Rib Fractures, Anaesthesia, Local, Levobupivacaine
- Trial name
- COPE (NCT03919916)
- Testing
- Serratus plane block, Patient controlled analgesia
- Where
- United Kingdom
- Volunteers
- 58 people
- Sponsor
- Chelsea and Westminster NHS Foundation Trust
Tympanomastoid Surgery, Cochlear Implant
Great Auricular Nerve Block for Children Undergoing Tympanomastoid Surgery
The investigators goal is to determine the efficacy and duration of analgesia with the addition of Clonidine, an alpha-2 agonist, to local anesthetic blockade using bupivacaine, of the great auricular nerve in children undergoing…
- Conditions
- Tympanomastoid Surgery, Cochlear Implant, Mastoidectomy, Cholesteatoma
- Trial name
- NCT01638052
- Testing
- 0.25% Bupivacaine + Clonidine
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- Ann & Robert H Lurie Children's Hospital of Chicago
Pain, Postoperative, Pain, Chest
Ideal Initial Bolus and Infusion Rate for Erector Spinae Plane Block Catheters
This study would like to identify the best starting dose and infusion rate for nerve blocks and nerve catheters related to the erector spinae plane block that can improve functional status and pain control on cardiac surgery…
- Trial name
- NCT03961048
- Testing
- Ropivacaine 0.2%-Sodium Chloride 0.9% Injectable Solution bilaterally, Ropivacaine 0.2%-Sodium Chloride 0.9% Injectable Solution unilaterally
- Where
- United States
- Sponsor
- Virginia Commonwealth University
Diagnostic, Procedures and Surgeries on or Through Accessible Mucous Membranes
Topical Application of Cocaine HCl 4% and 10% on Safety and Efficacy in Local (Topical) Anesthesia
This study aims to evaluate topical application of Cocaine HCl 4% and 10% on safety and efficacy in local (topical) anesthesia for diagnostic procedures and surgeries on or through accessible mucous membranes of the nasal…
- Conditions
- Diagnostic, Procedures and Surgeries on or Through Accessible Mucous Membranes, of the Nasal Cavities
- Trial name
- NCT01746940
- Testing
- Cocaine HCl 4% Topical Solution, Cocaine HCl 10% Topical Solution
- Where
- 2 sites in United States
- Volunteers
- 159 people, healthy volunteers welcome
- Sponsor
- Lannett Company, Inc.
Outcome Assessment, Patient Satisfaction
Evaluation of Factors Associated With Patient Satisfaction and Mood-State in Regional Anesthesia
Patient satisfaction is an important subjective measure of healthcare quality which contributes to evaluation of the structure, process and outcome of services.
- Trial name
- NCT03476278
- Testing
- Questionnaire
- Volunteers
- 300 people
- Sponsor
- Derince Training and Research Hospital
Cardiogenic Shock
Awake Axillary Impella 5.5 Placement - A Feasibility Trial
The Abiomed Impella 5.5 is a surgically placed temporary mechanical support device used in patients in cardiogenic shock. The investigators propose using regional anesthesia (3 separate peripheral nerve blocks) to facilitate…
- Trial name
- NCT05782491
- Testing
- Interscalene Block, PECS II Block, Superficial Cervical Plexus Block
- Where
- 2 sites in United States
- Sponsor
- University of Pennsylvania
Anesthesia, Anterior Cruciate Ligament Reconstruction
Postoperative Analgesic Benefit of iPACK Block in the Anterior Cruciate Ligament Reconstruction Surgery
This randomised clinical trial evaluates the analgesia provided by an iPack block associated with an adductor canal block in patients who undergo anterior cruciate ligament reconstruction surgery, compared to an adductor canal…
- Trial name
- Liga-PACK (NCT05136352)
- Testing
- adductor canal block, iPACK block
- Where
- France
- Volunteers
- 90 people
- Sponsor
- University Hospital, Toulouse
Anesthesia, Enteral Nutrition
Regional Anesthesia Block of the Transversus Abdominis Plane in Children Undergoing Gastric Tube Insertion
The objective of this trial is to examine if regional anesthetic blockade of the anterior abdominal wall via the transversus abdominis plane is a safe and feasible method of providing analgesia for children undergoing gastric…
- Trial name
- NCT00564655
- Testing
- bupivacaine with epinephrine (mid and upper abdomen), bupivacaine with epinephrine (transversus abdominis plane)
- Where
- Canada
- Volunteers
- 3 people
- Sponsor
- The Hospital for Sick Children
Post Operative Pain, Acute
Bupivacaine Alone vs Bupivacaine With Tramadol in Local Anesthesia Procedures
This study looked at two different medicines used during local anesthesia to control pain after surgery. Investigators compared bupivacaine alone with bupivacaine mixed with tramadol.
- Trial name
- NCT07469826
- Testing
- Tramadol, Bupivacaine
- Where
- Pakistan
- Volunteers
- 100 people
- Sponsor
- Jinnah Postgraduate Medical Centre
Arthroplasty, Replacement, Knee, Nerve Block
Does Continuous Adductor Canal Nerve Block Improve the Quality of Recovery for Outpatient Total Knee Arthroplasty Patients?
This is a randomized, double-blinded pilot study to determine whether patients undergoing ambulatory total knee arthroplasty (TKA) using a subvastus approach benefit from the addition of a continuous adductor canal nerve block…
- Conditions
- Arthroplasty, Replacement, Knee, Nerve Block, Anesthesia, Regional, Ambulatory Surgical Procedures
- Trial name
- NCT03038425
- Testing
- Normal Saline, Ropivacaine
- Where
- Canada
- Volunteers
- 81 people
- Sponsor
- Ottawa Hospital Research Institute
Topical Anesthesia
Pharmacokinetic Study of Nanoencapsulated Gel of Lidocaine, Prilocaine and Combination of Lidocaine and Prilocaine
This trial evaluated the pharmacokinetic interaction between fixed doses of lidocaine (2.5%), prilocaine (2.5%) or the association of both (Nanorap®) in healthy volunteers. The drug safety and tolerability was also evaluated.
- Trial name
- NCT03441841
- Testing
- Lidocaine + Prilocaine, Lidocaine, Prilocaine
- Where
- Brazil
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Galeno Desenvolvimento de Pesquisas Clínicas
Primary Inguinal Hernia
The Effect of Preemptive Regional Anesthesia (TAP-block) on Acute and Chronic Pain After Transabdominal Preperitoneal Inguinal Hernia Repair (TAPP)
The study is devoted to the impact of preemptive regional Transversus abdominal plane block on the postoperative acute and chronic pain after elective Transabdominal preperitoneal (TAPP) inguinal hernia repair.
- Trial name
- ERA-TAPP (NCT06406959)
- Testing
- Transversus abdominal plane block (TAP block)
- Where
- Russia
- Volunteers
- 78 people
- Sponsor
- Pirogov Russian National Research Medical University
Hypoxemia During Surgery, Atelectasis
Usage of High Flow Nasal Cannula in Preventing Desaturations in Elderly Patients Going for Lower Limb Surgeries
To study the effect of high flow nasal cannula in comparisons with nasoprong used intraoperatively in patients oxygenation status
- Trial name
- NCT06054022
- Testing
- high flow nasal cannula, nasoprong oxyen 2Litres per minute
- Where
- Malaysia
- Volunteers
- 50 people
- Sponsor
- Universiti Kebangsaan Malaysia Medical Centre
Lidocaine
Effect of Different Concentrations of Lidocaine in Relieving Pain in Wide Awake Hand Surgery Using Tumescence
Lidocaine has been used along with adrenaline in tumescent anesthesia for a variety of procedures. This has been quite popular especially in wide awake surgery of the hand with no tourniquet.
- Trial name
- NCT04692896
- Testing
- lidocaine
- Where
- Pakistan
- Volunteers
- 90 people
- Sponsor
- King Edward Medical University
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