Clinical trials: Anesthesia; Adverse Effect
Anesthesia; Adverse Effect, Spinal and Epidural
Paramedian Incidence Angles in Spinal Anaesthesia
The objective here is to quantify the number of punctures and redirections during routine practice in the anesthesiology department, verify the final angle of incidence and the sac-skin distance by ultrasound, and determine the…
- Trial name
- NCT07210892
- Testing
- Measurement of needle insertion angles
- Where
- Spain
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Consorci Sanitari de Terrassa
Analgesics, Opioid, Anesthesia; Adverse Effect
Comparison of Total Intravenous Anesthesia and Inhalational Anesthesia in Opioid-Free Anesthesia for Bariatric Surgery: A Randomized Controlled Trial
Total intravenous general anesthesia and combined general anesthesia are recognized methods used during anesthesia. They allow you to effectively control pain and reduce the number of complications associated with taking large…
- Trial name
- NCT06390046
- Testing
- TIVA versus Inhalation
- Where
- Poland
- Volunteers
- 280 people
- Sponsor
- Jagiellonian University
Cognitive Decline, Cognitive Change
Building a Platform for Precision Anesthesia in the Geriatric Surgical Patient
The research team is creating a foundational infrastructure in order to develop a precision medicine approach for geriatric patients who require surgery with anesthesia.
- Conditions
- Cognitive Decline, Cognitive Change, Cognitive Impairment, Postoperative Delirium
- Trial name
- NCT03839784
- Testing
- Neurocognition Interventions
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- Stanford University
Anesthesia, Propofol Adverse Reaction
Propofol and Etomidate Admixtures Comparisons Trial (PEAC Trial)
The purpose of this study is to evaluate the hemodynamics and adverse event profile in comparison between two treatment arms, one using an admixture of propofol and etomidate at a ratio by volume of 25%/75% (P2E7), and one using…
- Conditions
- Anesthesia, Propofol Adverse Reaction, Etomidate Adverse Reaction, Anesthesia Complication
- Trial name
- PEAC (NCT05358535)
- Testing
- Admixture of propofol and etomidate at a ratio by volume of 75%/25% (P7E2), Admixture of propofol and etomidate at a ratio by volume of 25%/75% (P2E7)
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- University of Texas Southwestern Medical Center
Anesthesia; Adverse Effect, Cardiac Arrhythmia
Effects of HSK3486 on Cardiac Repolarization in Health Subjects (TQT)
To assess the effects of a single IV bolus of HSK3486 single dose on cardiac repolarization (QTc interval of the electrocardiogram, and to evaluate the safety and tolerability of a single IV bolus of HSK3486 in healthy subjects
- Trial name
- NCT06795204
- Testing
- HSK3486, Moxifloxacin Hydrochloride
- Where
- China
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Haisco-USA Pharmaceuticals, Inc.
Emergence Delirium, Anesthesia; Adverse Effect
Language During Inhalational Induction
The aim of this study is to compare the impact of common (standard of care) language vs positive language used by clinicians during inhalational induction of anesthesia on anxiety and negative behaviors in children.
- Trial name
- NCT06324955
- Testing
- Standard/common language during induction, Positive language during induction
- Where
- United States
- Volunteers
- 128 people
- Sponsor
- Boston Children's Hospital
Anesthesia; Adverse Effect, Spinal and Epidural
Granisetron Versus Pethidine in Treatment of Post Spinal Shivering in Cesarean Sections
Granisetron Versus Pethidine in Treatment of Post Spinal Shivering in Cesarean Sections
- Trial name
- NCT06513806
- Testing
- Granisetron 1 Mg/mL Intravenous Solution, Pethidin
- Where
- Egypt
- Volunteers
- 330 people
- Sponsor
- Ain Shams University
Sore-throat, Dysphonia
No Post Intubation Laryngeal Symptoms
The purpose of the study is to test a novel endotracheal tube support device that reduces pressure of the tube on the voice box for prevention of post intubation laryngeal symptoms including sore throat, change in voice and…
- Conditions
- Sore-throat, Dysphonia, Dysphagia, Intubation Complication
- Trial name
- No-PILS (NCT05383417)
- Testing
- EndoClip
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Anesthesia; Adverse Effect, Breast Cancer
Nociception Level Monitor (NOL) During Guided Analgesic Delivery in Breast Surgeries
To assess if perioperative consumption of opioids can be optimized with the assistance of a Nociception Level (NOL) monitor in breast surgery patients receiving pectoral and parasternal nerve blocks as supplementation to general…
- Trial name
- NCT05546021
- Testing
- NOL monitor
- Where
- Denmark
- Volunteers
- 60 people
- Sponsor
- University of Southern Denmark
Hypospadias, Anesthesia; Adverse Effect
The EPigenetic Consequences in Children of Intravenous vs Volatile Anaesthesia for Surgery (EPIVA)
More than half a million children have an anaesthetic each year in the UK. Though anaesthesia is usually thought to be safe and necessary to improve health, concerns remain the effects that the drugs used may have on brain…
- Conditions
- Hypospadias, Anesthesia; Adverse Effect, Perioperative Complication, Pediatric ALL
- Trial name
- EPIVA (NCT05936853)
- Testing
- Intravenous approach to anaesthetic maintenance, Inhalational approach to anaesthetic maintenance
- Where
- United Kingdom
- Volunteers
- 16 people
- Sponsor
- University Hospital Southampton NHS Foundation Trust
Anesthesia, Adverse Effect
Comparison of Two Doses of Norepinephrine in Preventing Hypotension After Spinal Anesthesia
The purpose of the study is to determine the more effective intravenous bolus of norepinephrine for maintaining blood pressure during a spinal anesthesia for a cesarean delivery with the fewer side effects.
- Conditions
- Anesthesia, Adverse Effect, Hypotension, Cesarean Section Complications
- Trial name
- NCT03706755
- Testing
- Norepinephrine: 1mcg/kg, Norepinephrine 0,5mcg/kg
- Where
- Tunisia
- Volunteers
- 124 people, healthy volunteers welcome
- Sponsor
- University Tunis El Manar
Anesthesia, Anesthesia; Adverse Effect
EEG-guided Propofol Sedation Versus Standard Care for Oesophagogastroduodenoscopy and Colonoscopy in Children
The goal of this clinical trial is to compare electroencephalogram (EEG) guided propofol sedation versus standard care in paediatric patients aged 6-16 undergoing oesophagogastroduodenoscopy and colonoscopy.
- Conditions
- Anesthesia, Anesthesia; Adverse Effect, Anesthesia Emergence Delirium, Sedation Complication
- Trial name
- EPOC (NCT06225037)
- Testing
- Sedline EEG monitoring, Sedline EEG with output concealed
- Where
- Singapore
- Volunteers
- 50 people
- Sponsor
- KK Women's and Children's Hospital
Oxygen Deficiency, Desaturation of Blood
THRIVE Use in Pediatric Populations- Multi Site
THRIVE (Transnasal Humidified Rapid-Insufflation Ventilatory Exchange) refers to the use of high-flow nasal cannula to augment the ability to oxygenate and ventilate a patient under general anesthesia.
- Conditions
- Oxygen Deficiency, Desaturation of Blood, Hypoventilation, Anesthesia; Adverse Effect
- Trial name
- NCT04322994
- Testing
- Transnasal Humidified Rapid-Insufflation Ventilatory Echange
- Where
- 5 sites in United States
- Volunteers
- 175 people, healthy volunteers welcome
- Sponsor
- Stanford University
Anesthesia, Airway Complication of Anesthesia
Apnoeic Oxygenation During Pediatric Tracheal Intubation
The goal of this randomized, controlled, single-blinded clinical trial is to evaluate the effectiveness of apnoeic Oxygenation in pediatric anesthesia.
- Conditions
- Anesthesia, Airway Complication of Anesthesia, Anesthesia; Adverse Effect
- Trial name
- NCT06576596
- Testing
- apnoeic Oxygenation
- Where
- Germany
- Volunteers
- 200 people
- Sponsor
- University Hospital Heidelberg
Elderly Patients, Major Surgery
Anesthesia-handover Checklist and Perioperative Outcomes in Elderly
With the increasing number of surgical cases, intraoperative handover of anesthesia care is common and inevitable. Verbal handover from one anesthesiologist to another during surgery are being used in many hospitals.
- Conditions
- Elderly Patients, Major Surgery, Anesthesia; Adverse Effect, Prevention
- Trial name
- NCT04377633
- Testing
- Oral handover, Checklist handover
- Where
- China
- Volunteers
- 1,421 people
- Sponsor
- Peking University First Hospital
Preeclampsia, Intracranial Pressure Increase
Assessment of Optic Nerve Sheath Diameter in Preeclamptic Pregnant Women Using Ultrasonography and Anesthetic Management
Preeclampsia is a serious condition associated with complications such as pulmonary edema, placental abruption, hemolysis, thrombocytopenia, and cardiac, renal, and neurological complications, occurring at a rate of 2.7-8% in…
- Conditions
- Preeclampsia, Intracranial Pressure Increase, Pregnancy; Anesthesia, Adverse Effect, Central Nervous System
- Trial name
- NCT06522295
- Testing
- ultrasonography
- Where
- Turkey (Türkiye)
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Kocaeli University
Sleep Disturbance, Anesthesia; Adverse Effect
Effects of Anesthetics and Surgery on Sleep Quality in Patients Undergoing Posterior Spinal Instrumentation Surgery
Investigators aimed to evaluate the impact of the anesthesia method and surgical procedure on the sleep patterns and sleep quality of patients undergoing posterior spinal instrumentation using the Pittsburgh Insomnia Rating…
- Trial name
- NCT06523881
- Testing
- Sevoflurane (Sevorane® liquid 100%, Abbvie Pharmaceuticals, Istanbul, Turkey), Propofol (Propofol-PF® 1% (Polifarma Pharmaceuticals, Tekirdag, Turkey)
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Uludag University
Sedation, Pediatric Anesthesia
Frequency of Adverse Events in Pediatric Patients Receiving Sedation for Magnetic Resonance Imaging
Introduction:The application of anesthesia outside the operating room for pediatric patients has increased in recent years. For diagnostic and treatment follow-up purposes, magnetic resonance imaging (MRI) requires the pediatric…
- Conditions
- Sedation, Pediatric Anesthesia, Magnetic Resonance Imaging, Adverse Effect
- Trial name
- NCT06467045
- Testing
- Pediatric patients who received sedation for magnetic resonance imaging
- Where
- Turkey (Türkiye)
- Volunteers
- 500 people
- Sponsor
- Sisli Hamidiye Etfal Training and Research Hospital
Anesthesia; Adverse Effect
Postoperative Consequences of Intraoperative NOL Titration
To demonstrate that intraoperative NOL-guided titration of fentanyl improves initial recovery characteristics.
- Trial name
- NCT04679818
- Testing
- Routine opioid management, PMD-200 Nol-guided opioid administration
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- The Cleveland Clinic
Anesthesia; Adverse Effect, Biliary Tract Diseases
Ciprofol vs Propofol for Reducing Hypoxia Incidence in ERCP
Intravenous anesthesia has been widely used in endoscopic retrograde cholangiopancreatography (ERCP). In the past decade, many practices have been carried out under the propofol-based monitored anesthesia care without…
- Trial name
- NCT06015074
- Testing
- Propofol, Ciprofol
- Where
- China
- Volunteers
- 136 people
- Sponsor
- RenJi Hospital