Clinical trials: Anesthesia; Regional
Regional Anesthesia Morbidity, Cesarean Section Complications
Height Adjusted Versus Standardized Dose of Bupivacaine for Spinal Anesthesia
General anesthesia during pregnancy is associated with several major risks including unanticipated difficult airway, pulmonary aspiration, and specific anesthetic effects on the newborn.
- Conditions
- Regional Anesthesia Morbidity, Cesarean Section Complications, Local Anesthetic Complication
- Trial name
- RAMCES (NCT05233462)
- Testing
- standardized dose, adjusted dose
- Where
- France
- Volunteers
- 250 people
- Sponsor
- University Hospital, Caen
Pain, Tooth Extraction
Rofecoxib and Bupivacaine to Prevent Pain After Third Molar (Wisdom Tooth) Extraction
This study will evaluate the ability of the drugs rofecoxib and bupivacaine to prevent pain following third molar (wisdom tooth) extraction. Rofecoxib is approved to treat pain of arthritis and menstrual cramps.
- Trial name
- NCT00050362
- Testing
- Rofecoxib and Bupivacaine
- Where
- United States
- Volunteers
- 136 people
- Sponsor
- National Institute of Dental and Craniofacial Research (NIDCR)
Propofol Injection Pain
Comparison of Bier Block and Lidocaine-Propofol Mixture for Prevention of Propofol Injection Pain
The goal of this clinical trial was to evaluate methods to prevent pain on intravenous administration of propofol during induction of anesthesia.
- Trial name
- BBLP (NCT07285980)
- Testing
- propofol, Lidocaine - Propofol Mixture, Lidocaine - Bier Block
- Where
- Tunisia
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Asma Ladib
Postoperative Pain, Third Molar
Effect of Oral Magnesium on Anesthesia and Postoperative Analgesia After Surgical Removal of the Lower Third Molars.
The operation of the lower third molars is one of the most common oral surgery procedures in the world. The surgery is mostly done in local anesthesia which makes the surgery as pleasant as possible for the patient.
- Conditions
- Postoperative Pain, Third Molar, Postoperative Complications
- Trial name
- NCT03398382
- Testing
- Magnesium tablet group, Magnesium lozenge group
- Where
- 2 sites in Croatia
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Daniel Jerković
Breast Cancer
Continuous Serrates Plane Block in Axillary Dissection
Patients undergone to axillary dissection during breast surgery with a PECS I, II block will be randomized to receive either a serratus plane continuous local anesthetic infusion through a multiple hole catheter or nothing.
- Trial name
- NCT03992859
- Testing
- Continuous serratus plane block
- Where
- Italy
- Volunteers
- 15 people
- Sponsor
- Azienda USL Reggio Emilia - IRCCS
Intracranial Pressure Increase
Comparison of ONSD and rSO2 Measurements Between General and Spinal Anesthesia in C-Section
General anesthesia and regional anesthesia can be chosen in cesarean operations. Endotracheal intubation and mechanical ventilation are components of general anesthesia.
- Trial name
- NCT04446013
- Testing
- Optic Nerve Sheath Diameter Measurement
- Where
- Turkey (Türkiye)
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- Bagcilar Training and Research Hospital
Transversus Abdominis Plane Block
Bupivacaine Pharmacokinetics Following TAP Block
The aims of this study are to determine population PK parameters of bupivacaine in children following TAP block using a population-based PK approach, and to evaluate the influence of patient covariates on drug disposition.
- Trial name
- NCT02015182
- Testing
- Blood sample for bupivicaine pharmacokinetics
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- The Hospital for Sick Children
Pain, Injection
Does Pre-injection Local Anesthesia Affect Experienced Pain During Intra-articular Hip Injections.
Intra-articular hip injections are commonly used for diagnostic and therapeutic purposes but are often associated with patient anxiety and fear.
- Conditions
- Pain, Injection, Prevention, Assessment
- Trial name
- NCT06760559
- Testing
- Intra-articular corticosteroid injection
- Where
- Israel
- Volunteers
- 60 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
Lower Eyelid Bags
The Effect of Inhalation Aromatherapy on Intraoperative Fear in Patients Undergoing Lower Blepharoplasty Under Local Anesthesia: A Randomized Controlled Trial
This study is a single-center, randomized, controlled, open-label clinical trial designed to evaluate the intervention effect of inhaled aromatherapy on intraoperative fear in patients undergoing lower blepharoplasty (eyelid bag…
- Trial name
- NCT07766902
- Testing
- inhaled aromatherapy
- Where
- China
- Volunteers
- 152 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Infection
PReclude Infection EVEnts With No Prophylaxis Transperineal Biopsy
Approximately one million transrectal prostate biopsies are performed annually in the U.S., and the risk of post- biopsy infection is increasing due to greater antibiotic resistance of rectal flora.
- Trial name
- PREVENT (NCT04843566)
- Testing
- Transperineal MRI-guided prostate biopsy, Transrectal MRI-guided prostate biopsy, Antibiotic (prophylaxis)
- Where
- 10 sites in United States
- Volunteers
- 687 people
- Sponsor
- Weill Medical College of Cornell University
Anesthesia, Local, Postoperative Pain
Comparison of Lateral and Medial Approaches to Costoclavicular Brachial Plexus Block in Pediatrics
In upper extremity surgeries, the brachial plexus block can be performed with different techniques at various levels depending on the proximal and distal level of the surgery.
- Trial name
- NCT04786756
- Testing
- Bupivacaine 0.25% Injectable Solution
- Where
- Turkey (Türkiye)
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Istanbul University
Ankle Fractures
Local Multimodal Injection Versus Regional Anesthesia in Controlling Pain for Treating Rotational Ankle Fractures
The investigators plan to evaluate the efficacy in reducing post-operative pain between local multimodal analgesia as compared to regional anesthesia in rotational ankle fractures.
- Trial name
- NCT05019638
- Testing
- Regional anesthesia group, Local multimodal analgesia group
- Where
- 2 sites in United States
- Volunteers
- 200 people
- Sponsor
- University of Utah
Intensive Care Unit
Regional Anaesthesia in Intensive Care Unit
Pain is a major problem in Intensive Care Unit (ICU). Adequate pain management not only means decreasing the pain intensity, but also improving the functionality and allowing the early mobilization that is a prerequisite for…
- Trial name
- Week'ALR (NCT05131633)
- Where
- 19 sites in France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Clermont-Ferrand
Anesthesia, Local, Anesthesia
Regional Anesthesia in Pediatric Orthopaedic Patients
To identify the benefits from regional anesthesia use as pain management in the pediatric population by delineating the differences in efficacy of continuous nerve blockade versus single-shot techniques after pediatric…
- Conditions
- Anesthesia, Local, Anesthesia, Orthopedic Disorder
- Trial name
- NCT04669145
- Testing
- Ropivacaine
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Ochsner Health System
Pain
S-Caine™ Peel (Skin Numbing Cream) to Treat Pain During Non-Ablative Facial Laser Resurfacing in Adults
Lasers are used for non-ablative resurfacing of facial rhytides, atrophic scars, and a variety of epidermal and dermal lesions. Pain associated with the non-ablative laser treatment has been described as moderate to severe.
- Trial name
- NCT00110747
- Testing
- S-Caine™ Peel (lidocaine and tetracaine topical cream 7%/7%)
- Where
- 3 sites in United States
- Volunteers
- 54 people
- Sponsor
- ZARS Pharma Inc.
Distal Upper Limb Surgeries
Comparative Study of Subcoracoid Tunnel Block Versus Costoclavicular Block
The purpose of this study is to compare the analgesic outcomes (time to first analgesic request, total amount of analgesic consumption, and pain scores) following the ultrasound-guided subcoracoid tunnel block or costoclavicular…
- Trial name
- NCT07305584
- Testing
- subcoracoid tunnel block, Costoclavicular block
- Where
- Egypt
- Volunteers
- 70 people
- Sponsor
- Zagazig University
Local Anesthesia
Effect of Lidocaine With Magnesium Sulfate on the Success of the Inferior Alveolar Nerve Block
68 healthy patients pulpitis and requiring root canal therapy are selected. . Sampling was done in a simple and non-experimental way from a dental clinic in Isfahan, and then the samples were randomly assigned to one of the two…
- Trial name
- NCT03262857
- Testing
- use of magnesium sulfate with lidocaine in inferior alveolar nerve block
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- Isfahan University of Medical Sciences
Spinal Anesthesia, Nursing
The Effect of Local Dry Heat Applıcatıon and Half Shower on The Development of Urinary Retentıon and Paın
Urinary retention is defined as the inability to empty the bladder spontaneously even though the bladder is full. Although urinary retention is seen in two forms as acute and chronic, acute urinary retention is defined by the…
- Conditions
- Spinal Anesthesia, Nursing, Bladder Retention, Dry Heat Application
- Trial name
- NCT05580289
- Testing
- half-shower and hot pack
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Duzce University
Hysterectomy, Postoperative Pain
Postoperative Analgesic Effectiveness of the Modified Thoracoabdominal Nerve Block Through a Perichondrial Approach in Total Laparoscopic Hysterectomy
This single-center retrospective cohort study evaluated the effect of the modified thoracoabdominal nerves block through a perichondrial approach (M-TAPA) on postoperative analgesia in patients undergoing elective total…
- Trial name
- MTAPA-TLH (NCT07740252)
- Testing
- Modified thoracoabdominal nerves block through a perichondrial approach (M-TAPA)
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Namik Kemal University
Head and Neck Surgery, Plastic Surgery
Preoperative Maxillary Nerve Block and Remifentanil Use in Septorhinoplasty
Septorhinoplasty is generally a prolonged surgical procedure that frequently involves osteotomy, which may lead to increased intraoperative remifentanil requirements.
- Conditions
- Head and Neck Surgery, Plastic Surgery, Rhinoplasty, Pain
- Trial name
- PRISM (NCT07233538)
- Testing
- Maxillary block
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Ankara Etlik City Hospital