Clinical trials: Anesthesia Effectiveness
Hypotension During Cesarean Delivery, Postoperative Nausea and Vomiting (PONV)
Dexamethasone to Prevent Side Effects of Spinal Anesthesia in Cesarean Delivery
The goal of this clinical trial is to evaluate the effectiveness of intravenous dexamethasone in preventing adverse effects of spinal anesthesia and prolonging postoperative analgesia in parturients undergoing elective cesarean…
- Conditions
- Hypotension During Cesarean Delivery, Postoperative Nausea and Vomiting (PONV), Pain, Postoperative
- Trial name
- NCT07615595
- Testing
- Dexamethasone
- Where
- Vietnam
- Volunteers
- 176 people
- Sponsor
- University Medical Center Ho Chi Minh City (UMC)
Tourniquet-induced Pain, Tourniquet-induced Hypertension
Efficacy of Gabapentin in Prevention of Tourniquet Pain and Hypertension
The purpose of the study is to find out if taking a dose of gabapentin 600 mg by mouth (po) before surgery will help prevent the development of tourniquet pain and hypertension while the tourniquet is inflated during orif of…
- Trial name
- NCT01441531
- Testing
- gabapentin 600 mg po
- Where
- United States
- Sponsor
- Baylor College of Medicine
Hemorrhoid, Peri Anal Fistula
Discharge Conditions of Spinal Anesthesia With Heavy Prilocaine-Fentanyl and Heavy Bupivacaine-Fentanyl
In this prospective randomized study the investigators aimed to investigate difference of the duration of spinal anesthesia, discharge times and efficacy between low dose heavy Prilocaine-Fentanyl and heavy Bupivacaine-Fentanyl…
- Trial name
- NCT01880775
- Testing
- Prilocaine, Bupivacaine
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Diskapi Teaching and Research Hospital
Anesthesia, Local, Intravitreal Injection
Cooling Anesthesia for Intravitreal Injection
The purpose of this clinical study is to evaluate the safety and efficacy of cooling anesthesia application to the eye as anesthesia for intravitreal injection using a novel cooling anesthesia device and determine the effects of…
- Conditions
- Anesthesia, Local, Intravitreal Injection, Macular Degeneration, Diabetic Macular Edema
- Trial name
- COOL-1 (NCT03732287)
- Testing
- Cooling Anesthesia
- Where
- 2 sites in United States
- Volunteers
- 40 people
- Sponsor
- Recens Medical, Inc.
Depressive Disorder, Major, Treatment Resistant Depression
Efficacy of Deep Anaesthesia With Isoflurane as a Fast-response Antidepressant Agent
In this study the investigators will submit patients with treatment resistant depression to deep anesthesia with isoflurane to get 15 minutes of cortical burst suppression on electroencephalogram, once a week for six weeks.
- Conditions
- Depressive Disorder, Major, Treatment Resistant Depression, Depressive Episode
- Trial name
- ISORADAR (NCT04171193)
- Testing
- Isoflurane, Sertraline Pill
- Where
- Brazil
- Volunteers
- 30 people
- Sponsor
- University of Sao Paulo
Laparoscopy, Anesthesia, Intravenous
The Efficacy and Safety of Esketamine in Elective Laparoscopic Surgery
The objective is to evaluate the efficacy and safety of BT-KTM-I(Esketamine Hydrochloride Injection produced by Chengdu Brilliant Pharmaceutical Co., Ltd.) for general anesthesia, using the Originator drug Ketanest®S(Esketamine…
- Trial name
- NCT06092684
- Testing
- BT-KTM-I, Ketanest®S
- Where
- 12 sites in China
- Volunteers
- 358 people
- Sponsor
- Chengdu Brilliant Pharmaceutical Co., Ltd.
Anesthesia
Comparison of the Effectiveness of Articaine Local Infusion and Lidocaine Nerve Block in Lower Posterior Tooth Extraction.
In this study 60 adult patients will participate and divided into two groups (30 for each). The first group will be anesthetized using 2 % lidocaine with 1:80,000 adrenaline by inferior alveolar nerve block technique, while the…
- Trial name
- NCT07048834
- Testing
- lidocaine local anesthetic drug, articaine local anesthetic drug
- Where
- Iraq
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Amjed Fouad Hussein
Postoperative Pain
The Analgesic Efficacy of Wound Infiltration With Tramadol
This double-blind, randomized trial examined whether tramadol wound infiltration decreased postoperative pain following cesarean delivery under general anesthesia or reduced the need for analgesics in the immediate postoperative…
- Trial name
- NCT02518438
- Testing
- Tramadol
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Yeditepe University Hospital
Pregnant Women
Estimation of the Effective Dose (ED) 95 of Intrathecal Hyperbaric Prilocaine 2% for Scheduled Cesarean Delivery.
Prilocaine is a local anesthetic drug which as an intermediate duration of action shorter than bupivacaine 0,5% that is usually used for spinal anesthesia in scheduled cesarean section.
- Trial name
- NCT03607916
- Testing
- Hyperbaric prilocaine 2%, Morphine
- Where
- Belgium
- Volunteers
- 40 people
- Sponsor
- Centre Hospitalier Universitaire Saint Pierre
Regional Anesthesia Morbidity, Supratentorial Brain Tumor
Ketamine Versus Dexmedetomidine as an Adjuvant in Scalp Block in Supratentorial Brain Tumor Excision Surgeries
Supratentorial brain tumor surgeries are associated with significant nociceptive stimulation and postoperative pain, which may adversely affect patient outcomes.
- Conditions
- Regional Anesthesia Morbidity, Supratentorial Brain Tumor, Acute Pain
- Trial name
- NCT07698665
- Testing
- Scalp Block with Bupivacaine
- Where
- 2 sites in Egypt
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Cairo University
Total Hip Arthroplasty (THA)
Evaluating the Efficacy of the Psoas Sheath Block for Post Operative Analgesia Following Hip Arthroplasty
This study will be a single-centre, assessor-blind, randomised controlled trial to compare the efficacy of the psoas sheath block (experimental group) with the suprainguinal fascia iliaca plane block (control group) in patients…
- Trial name
- NCT07453498
- Testing
- Psoas Sheath Block, Suprainguinal Fascia Iliaca
- Where
- Ireland
- Volunteers
- 130 people
- Sponsor
- University College Hospital Galway
Acute Pain
Efficacy and Safety in a Randomised Acute Pain Study of MR308: STARDOM2.
The MR308-3502 study is a multicenter double-blind, randomised, placebo- and active comparator-controlled study in female subjects to evaluate the efficacy and safety of MR308 with acute pain after TAH or STAH (total or subtotal…
- Trial name
- STARDOM2 (NCT03062644)
- Testing
- MR308
- Where
- 8 sites in Belarus, Bulgaria and 6 more
- Volunteers
- 1,138 people
- Sponsor
- Mundipharma Research GmbH & Co KG
Regional Anaesthesia, Transversus Abdominis Plane Block (TAP Block)
Transversus Abdominis Plane Block on Postoperative Analgesic Efficacy in Elderly Patients Undergoing Minimally Invasive Gastrointestinal Tumor Surgery
Elderly patients undergoing minimally invasive gastrointestinal tumor surgery face complex postoperative pain management due to age-related physiological decline and surgical particularities, where traditional opioids are prone…
- Conditions
- Regional Anaesthesia, Transversus Abdominis Plane Block (TAP Block), Pain, Postoperative
- Trial name
- NCT07013721
- Testing
- Transversus Abdominis Plane Block, TAPB
- Volunteers
- 102 people
- Sponsor
- Chinese PLA General Hospital
Hysterectomy, Postoperative Pain
Postoperative Analgesic Effectiveness of the Modified Thoracoabdominal Nerve Block Through a Perichondrial Approach in Total Laparoscopic Hysterectomy
This single-center retrospective cohort study evaluated the effect of the modified thoracoabdominal nerves block through a perichondrial approach (M-TAPA) on postoperative analgesia in patients undergoing elective total…
- Trial name
- MTAPA-TLH (NCT07740252)
- Testing
- Modified thoracoabdominal nerves block through a perichondrial approach (M-TAPA)
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Namik Kemal University
Anesthesia, Analgesia
Transversus Abdominis Plan (TAP) Block for Transcatheter Aortic Valve Implantation (TAVI)
Hemodynamic stability is the main goal of the anesthetic method during Transcatheter Aortic Valve Implantation (TAVI). Pain during the procedure may cause patients to move therefore hemodynamic instability.
- Conditions
- Anesthesia, Analgesia, Block, Aortic Valve Stenosis
- Trial name
- NCT06762288
- Testing
- Ultrasound, Local anesthesia and sedation
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Istanbul University - Cerrahpasa
Anesthesia
Dose-Ranging Study of Intranasal Kovacaine Mist in Pediatric Subjects
The purpose of this study is to assess the efficacy and safety of intranasally administered Kovacaine Mist for anesthetizing maxillary teeth in pediatric subjects.
- Trial name
- NCT01701505
- Testing
- 400uL of Kovacaine Mist, 200uL of Kovacaine Mist, 120uL of Kovacaine Mist
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- St. Renatus, LLC
Surgery, Anesthesia
Opioid-Free Anesthesia in Modified Radical Mastectomy
The aim of this study is to evaluate the efficacy of opioid-free general anesthesia for breast surgeries in female patients.
- Conditions
- Surgery, Anesthesia, Opioid Use
- Trial name
- NCT05693402
- Testing
- opioid anesthesia
- Where
- Lebanon
- Volunteers
- 116 people
- Sponsor
- Etienne El Helou
Knee Surgery, Arthroplasty
Does the Measurement of Pupillary Reactivity by an Automated Pupillometer Determine the Effectiveness of Local Anesthesia Under General Anesthesia?
The pupillary pain-meter AlgiScan ® with integrated nociceptive stimulator is a portable, battery-operated device which automatically measures, by means of an infrared camera, pupil diameter.
- Trial name
- ALGISCAN (NCT01685645)
- Testing
- AlgiScan
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Hemodynamics, Transcatheter Aortic Valve Replacement
Efficacy and Safety of Ciprofol for General Anaesthesia in Patients Undergoing Transcatheter Aortic Valve Replacement
Aortic valve stenosis is the most common debilitating valvular heart lesion in old patients. Transcatheter aortic valve replacement (TAVR) is an emergent technique for high-risk patients with aortic stenosis.
- Conditions
- Hemodynamics, Transcatheter Aortic Valve Replacement, General Anesthesia, Post-induction Hypotension
- Trial name
- NCT05881291
- Testing
- ciprofol, propofol
- Where
- China
- Volunteers
- 124 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Movement After Intravenous Cannulation
Optimum Time for Intravenous Cannulation After Induction With Sevoflurane in Pediatric Patient
This study aimed to determinate effective dose 95 (ED95) intravenous cannulation in pediatric patient after induction of sevoflurane 8 vol%
- Trial name
- NCT04284579
- Testing
- IV cannula
- Where
- Indonesia
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Universitas Indonesia
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