Clinical trials: Anesthesia Effectiveness
Intubation, Anesthesia
Comparative Efficacy of Intravenous Labetalol and Lignocaine in Mitigating Hemodynamic Responses to Laryngoscopy During Laparoscopic Cholecystectomy
Laryngoscopy and intubation during laparoscopic cholecystectomy often cause sudden increases in heart rate and blood pressure, which can be harmful in some patients.
- Conditions
- Intubation, Anesthesia, Laparoscopic Cholecystectomy, Hemodynamic Response to Laryngoscopy
- Trial name
- LAB-LIG RCT (NCT07192081)
- Testing
- Labetalol, Lignocaine
- Where
- Pakistan
- Volunteers
- 116 people
- Sponsor
- Dr. Waseem Ullah
Pain in Pediatric Dentistry, Dental Anxiety
Effectiveness of Digital Anesthesia Versus Conventional Techniques in Reducing Pain and Anxiety in Children
This multicenter randomized controlled clinical trial was conducted to evaluate the effectiveness of digital anesthesia using a computer-controlled intraosseous system (SleeperOne 5®) compared to traditional local anesthesia…
- Trial name
- DAPAED (NCT06992193)
- Testing
- Digital Anesthesia, Infiltration Anesthesia, Mandibular Block
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 79 people, healthy volunteers welcome
- Sponsor
- Ege University
Induction and Maintenance of General Anesthesia
A Study to Evaluate the Efficacy and Safety of HSK3486 in the Induction of General Anesthesia
This is a multi-center, randomized, single-blind, propofol injectable emulsion parallel-controlled Phase III clinical study. A total of patients undergoing elective surgery are intended to be enrolled and randomly assigned to…
- Trial name
- NCT04511728
- Testing
- HSK3486, Propofol
- Where
- China
- Volunteers
- 129 people
- Sponsor
- Haisco Pharmaceutical Group Co., Ltd.
Thalassemia in Children
Efficacy of Transdermal Microneedle Patch for Topical Anesthesia Enhancement in Paediatric Thalassemia Patients
Microneedle (MN) is the mimic of a hypodermic needle, composed of hundreds of micron-sized, out-of-plane protrusions, typically arranged in arrays on a patch that can be applied onto the skin.
- Trial name
- NCT05078463
- Testing
- Microneedle, 1 Finger Tip Unit (FTU) EMLA Cream (30-minute application time), 1 Finger Tip Unit (FTU) EMLA (15-minute application time)
- Where
- Malaysia
- Volunteers
- 20 people
- Sponsor
- Universiti Kebangsaan Malaysia Medical Centre
Hip Arthroplasty, Anesthesia, Regional
FAB Block vs. Placebo for Hip Arthroplasty Patients
Hip arthroplasty surgery can be associated with significant pain. A regional anesthesia technique, the femoral articular branch block (FAB), has recently been proposed to collectively block terminal femoral and accessory…
- Conditions
- Hip Arthroplasty, Anesthesia, Regional, Femoral Articular Branch Block
- Trial name
- NCT04301687
- Testing
- Femoral Articular Branch Block
- Volunteers
- 95 people
- Sponsor
- Women's College Hospital
Anesthesia, Incarcerated Inguinal Hernia
Safety and Efficacy of Local Anesthesia in Emergency Inguinal Hernia Surgery
This prospective randomized is designed to evaluate the safety and efficacy of hernia repairs using local anesthesia compared with those using general anesthesia for patients with incarcerated hernia.
- Trial name
- NCT02599623
- Testing
- Local Anesthesia, General Anesthesia
- Where
- China
- Volunteers
- 80 people
- Sponsor
- RenJi Hospital
General Anesthetic Drug Adverse Reaction
Factors Affecting the Effective End-tidal Concentration of Desflurane Anaesthesia
There is accumulating evidence that inappropriate depth of anaesthesia is associated with increased risk of postoperative complications including risk of death.
- Trial name
- NCT02617680
- Testing
- desflurane - oxygen in air, desflurane - oxygen in nitric oxide
- Where
- Czechia
- Volunteers
- 80 people
- Sponsor
- University Hospital Hradec Kralove
Anesthesia, Local
Compare the Efficacy of Various Pain Alleviating Methods in Reducing Pain in Children During Intraoral Local Anaesthetic Injections
The aim of study is to compare the efficacy of various pain alleviating methods by application of Emla gel, TENS, and topical cooling of injection sites compared with 20% benzocaine gel in reducing pain in children requiring…
- Trial name
- NCT05564442
- Testing
- 20% benzocaine gel, Transcutaneous electric nerve stimuli, Emla gel
- Where
- Egypt
- Volunteers
- 224 people, healthy volunteers welcome
- Sponsor
- Minia University
Hypersalivation, Prevention of Drooling
Efficacy of Intravenous Glyco-P® in Patients Undergoing Procedure That Require Anesthesia Service
This observational study was designed to prove clinical efficacy of the well known "glycopyrrolate" which is considered an orphan drug in Thailand.
- Conditions
- Hypersalivation, Prevention of Drooling, Bradycardia, Reversal of Muscle Relaxants
- Trial name
- NCT02102542
- Where
- Thailand
- Volunteers
- 65 people
- Sponsor
- Mahidol University
Pain After Total Knee Arthroplasty, Pain Management
Combined Distal Femoral Nerve Block for Pain Control After Knee Replacement
The goal of this clinical trial is to see whether a combined distal femoral nerve block improves pain relief after total knee replacement in adults having planned surgery.
- Trial name
- FEM-COMB (NCT07629388)
- Testing
- Combined distal femoral nerve block, Saphenous nerve block alone, Standard perioperative care in both groups
- Where
- France
- Volunteers
- 240 people
- Sponsor
- GCS Ramsay Santé pour l'Enseignement et la Recherche
Postoperative Pain
Analgesic Efficacy of Fascia Iliaca Compartment Block Compared With Intrathecal Nalbuphine for Hip Surgery Under Spinal Anesthesia
It is already known that fascia iliaca compartment block and intrathecal nalbuphine are very effective ways in postoperative pain control in patients having hip surgeries.
- Trial name
- NCT06818396
- Testing
- US-guided fascia iliaca compartment block (FICB) and spinal anesthesia, Intrathecal nalbuphine and spinal anesthesia, Spinal anesthesia
- Where
- Egypt
- Volunteers
- 120 people
- Sponsor
- Ain Shams University
Thoracotomy
Thoracotomy: Intercostal Nerve Block Versus Epidural Anesthesia
Postoperative pain and consecutive reduction of pulmonary function after thoracic surgery still is a major clinical problem and challenge in anesthesia.
- Trial name
- NCT01076894
- Testing
- epidural anesthesia, intercostal anesthesia
- Where
- Germany
- Volunteers
- 83 people
- Sponsor
- University of Ulm
Transurethral Resection of Prostate
Effectiveness of Nalbuphine as an Adjuvant to Subarachnoid Block on Postoperative Analgesia in TURP Surgery
The goal of this clinical trial is to compare pain after surgery in patients undergoing Transurethral Resection of Prostate. The main question it aims to answer are: Intrathecal nalbuphine as an adjuvant to local anesthetic will…
- Trial name
- NCT06153602
- Testing
- Nalbuphine Hydrochloride 10 MG/ML, Sodium Chloride 0.9 % in 5 ML Injection, Bupivacaine Hydrochloride, Spinal
- Where
- Thailand
- Volunteers
- 80 people
- Sponsor
- Chulalongkorn University
Analgesia
Effectiveness of Pre-administered Natural Sweet-tasting Solution (Honey) for Decreasing Pain of Needle Insertion
This study aims to assess Effectiveness of Pre-administered Natural Sweet-tasting Solution (honey) for Decreasing Pain Associated with Dental Injections (infiltration) prior to dental extraction in 6-8 years old healthy Children…
- Trial name
- NCT06393777
- Testing
- honey
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Cairo University
Anesthesia
Efficacy and Safety Profile of Remimazolam-alfentanil Combination for ERCP Sedation
Moderate to deep levels of sedation and analgesia are required for ERCP. Propofol-based sedation is simple, easy to use, and effective, but is not without cardiovascular and respiratory adverse effects.
- Trial name
- NCT04658173
- Testing
- remimazolam-alfentanil combination, propofol-alfentanil combination
- Where
- 2 sites in China
- Volunteers
- 1,000 people
- Sponsor
- Tianjin Nankai Hospital
Cataract Surgery
Efficacy Mydrane ® for Cataract Surgery in Patients With Concomitant Primary Open Angle Glaucoma.
The aim of this study is to compare Mydrane ®, mydriatic eye drops and Mydriasert ® in terms of pupil site stability, surgical time, visual field and anterior chamber configuration modifications among primary open angle glaucoma…
- Trial name
- MIGA (NCT05925894)
- Testing
- Efficacy of a Standardized Intracameral Combination of Mydriatics and Anesthetic (Mydrane ®) for Cataract Surgery in Patients With Concomitant Primary Open Angle Glaucoma
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Thoracic Surgery, Uniportal Video Assisted Thoracic Surgery (U-VATS)
Erector Spinae Plane Block in Uniportal VATS
The main aim of this study is to compare the effectiveness of three alternative techniques (continuous Erectus Spinae Plane Block : c-ESPB; continuous Serratus Anterior Plane Block : c-SAPB; and Intercostal Nerve Block: ICNB) in…
- Conditions
- Thoracic Surgery, Uniportal Video Assisted Thoracic Surgery (U-VATS), Lung Resections, Post-Operative Pain, Chronic
- Trial name
- ESPB-UVATS (NCT04892901)
- Testing
- c-ESPB, c-SAPB, ICNB
- Where
- Italy
- Volunteers
- 75 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Fluid Responsiveness Predictability, Hemodynamic Monitoring
Comparison of Acoustic Variability Index (AVI) and Pulse Pressure Variation (PPV) for Predicting Fluid Responsiveness in Mechanically Ventilated Patients
The goal of this clinical trial is to learn if a new medical device called ResQ works to predict fluid needs in adults undergoing surgery under general anesthesia.
- Conditions
- Fluid Responsiveness Predictability, Hemodynamic Monitoring, Anesthesia, General
- Trial name
- NCT07516470
- Testing
- Biological Signal Processing Device for Acoustic Variability Index, Patient monitor for pulse pressure variation, Hemodynamic monitor for cardiac Output and stroke volume variation
- Where
- South Korea
- Volunteers
- 122 people
- Sponsor
- Signal House Co., Ltd.
Morphine Adverse Reaction
Intrathecal Dexamethasone and Atropine on Morphine Induced Post-operative Nausea and Vomiting on Caesarean Section
Pain is a major problem during the postoperative period and can be considered as a challenge for the anesthesiologist. Low dose intrathecal morphine is proven efficient as a mode to reduce postoperative pain.
- Trial name
- NCT05560542
- Testing
- Atropine and Dexamethasone
- Where
- Egypt
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Assiut University
Endovascular Carotid Surgery, Preoperative Hypotension
Compared Efficacy and Tolerance of Two Vasopressors Used to Treat Preoperative Hypotension During Carotid Surgery
The effects on brain perfusion of the two currently vasopressors used to treat accidental hypotension occurring during carotid surgery (i.e.
- Trial name
- VP-hTA-XCar (NCT01794273)
- Testing
- ephedrine and phenylephrine
- Where
- France
- Volunteers
- 80 people
- Sponsor
- University Hospital, Clermont-Ferrand