Clinical trials: Anesthetic
Injuries, Hand, Anesthesia Conduction
Cardiovascular Safety Research: Bupivacaine With Vasoconstrictor Versus Ropivacaine in Brachial Plexus Block
The purpose of this study is to determine if bupivacaine (75% levobupivacaine plus 25% racemic bupivacaine) with vasoconstrictor is effective and safety as ropivacaine in brachial plexus block for orthopedic surgery.
- Conditions
- Injuries, Hand, Anesthesia Conduction, Anesthetics, Local
- Trial name
- NCT00523289
- Testing
- Bupivacaine, Ropivacaine
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Mammaplasty
The Use of Pecs Blocks in Combination With Exparel in Breast Reconstruction Surgery
This project intends to more thoroughly investigate the direct influence of Pecs blocks in the administration of Exparel, a non-opioid analgesic, in breast reconstruction surgery.
- Trial name
- NCT05171179
- Testing
- Breast Reconstruction (Mammaplasty), Pecs blocks, Exparel
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Colonoscopy, Anesthesia
Comparison of Post Anesthetic Recovery Time in Sedated Patients for Colonoscopy
Colonoscopy is an important diagnostic and therapeutic tool in colon disorders. Different drugs and levels of sedation can be used in its accomplishment. There is no consensus on which is the ideal.
- Trial name
- CPART (NCT03813303)
- Testing
- Midazolam, Fentanyl, Propofol
- Where
- Brazil
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Federal University of Minas Gerais
Opioid Pain Medication
Evaluating Postoperative Non-Opioid Pain Management Utilizing Local Anesthetics Coupled With Modulated Coagulation
This study is a prospective randomized trial examining the effect of topically combined antifibrinolytics (Tranexamic acid) with local anesthetics in all electively created surgical wound beds in hand surgery to provide long term…
- Trial name
- NCT04814433
- Testing
- Tranexamic acid, Aminocaproic acid, Recombinant Human Thrombin
- Where
- United States
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Postoperative Pain
Total Knee Replacement TIVA With Robotic Arm Assisted
Total knee replacement (TKR) is a commonly performed surgical procedure, and is associated with moderate to severe acute postoperative pain.
- Trial name
- NCT04002271
- Testing
- Propofol, Sevoflurane, Spinal anaesthesia
- Where
- 2 sites in Hong Kong
- Volunteers
- healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Healthy
The Impact of Local Anesthetic Dilution on Possible Blinding for Nerve Blocks
This study aims to determine the appropriate dosage of a placebo anesthetic to enable future placebo-controlled studies that can more accurately examine the effects of nerve blocks.
- Trial name
- NCT06668116
- Testing
- Ropivacaine 0,1%
- Where
- Switzerland
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Balgrist University Hospital
Nalbuphine,Fentanyl and Local Anesthetic Mixture
Nalbuphine, Fentanyl and no Additive to Local Anaesthetic Mixture
Nalbuphine has been used as an adjuvant to bupivacaine in intrathecal,epidural, caudal anesthesia and peripheral nerve blocks showing an increase in the efficacy and the duration of postoperative analgesia.
- Trial name
- NCT03824665
- Testing
- Nalbuphine Group, Fentanyl Group, Control Group
- Where
- Egypt
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Cairo University
Patients Undergoing Spine Surgery
Comparison of Postoperative QoR-15 Scores Between Propofol and Remimazolam
Remimazolam is a ultra-short-acting benzodiazepine, and unlike conventional benzodiazepine drugs, it is rapidly metabolized in plasma and not accumulates in the body for long periods of infusion or even with high dose…
- Trial name
- NCT04994704
- Testing
- Propfol group, Remimazolam group
- Where
- South Korea
- Volunteers
- 73 people, healthy volunteers welcome
- Sponsor
- Gangnam Severance Hospital
Pulmonary Aspiration, Emergency Surgery
Aspiration Risk Assessment by Gastric Ultrasound in eMErgency Surgery and ANesThetic Decision-making: The ARGUMENT Study
Pulmonary aspiration of gastric contents is a serious patient safety problem accounting for 50% of anesthesia-related mortality.
- Trial name
- NCT06303492
- Testing
- GUS
- Where
- Canada
- Volunteers
- 142 people, healthy volunteers welcome
- Sponsor
- Samuel Lunenfeld Research Institute, Mount Sinai Hospital
Healthy Volunteers
Local Anesthetic Properties of Neosaxitoxin
The purpose of this study is to evaluate the local anesthetic properties of neosaxitoxin in humans
- Trial name
- NCT00273065
- Testing
- Neosaxitoxin
- Where
- Chile
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Chile
Pain
The Anesthetic Efficacy of 3% Mepivacaine Plus 2% Lidocaine With 1:100,000 Epinephrine for Lower Jaw Dental Injections
The inferior alveolar nerve block (shot) is the most frequently used injection technique for achieving local anesthesia (numbness) for the teeth in the lower jaw.
- Trial name
- NCT01574807
- Testing
- mepivacaine + lidocaine followed by lidocaine +lidocaine, lidocaine + lidocaine followed by mepivacaine + lidocaine
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Ohio State University
Anesthesia
Anesthetic Efficacy in Irreversible Pulpitis
The purpose of this study was to compare the anesthetic efficacy of articaine, lidocaine and mepivacaine in patients with irreversible pulpitis of mandibular molar.
- Trial name
- NCT02054767
- Testing
- Intervention: inferior alveolar nerve block injection
- Where
- Brazil
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Scrotum Disease, Hydrocele Male
Efficacy of Inhaled Methoxyflurane (Penthrox) as Adjunct for Urologic Procedures Under Local Anesthetic: A Pilot Study
We wish to perform a prospective randomized controlled pilot study at the Men's Health Clinic and Health Science's Centre to assess whether or not the use of Penthrox as an adjunct to LA is associated with improved pain tolerance…
- Conditions
- Scrotum Disease, Hydrocele Male, Spermatocele, Scrotal Hematocele
- Trial name
- NCT07192198
- Testing
- Methoxyflurane, Control
- Where
- Canada
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Manitoba
Nitrous Oxide, Electroencephalography
Effect of Nitrous Oxide on EEG
Our recent preclinical observations suggest that monitoring of slow electroencephalogram (EEG) oscillations may be used to predict the efficacy of rapid-acting antidepressants such as ketamine or nitrous oxide.
- Conditions
- Nitrous Oxide, Electroencephalography, Anesthetic, Inhalation
- Trial name
- HUMANOID (NCT04884893)
- Testing
- Nitrous Oxide
- Where
- Finland
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Tampere University Hospital
Strain of Muscle and/or Tendon of Lower Leg, Fracture of Lower Leg
Onset Time of Nerve Block: A Comparison of Two Injection Locations in Patients Having Lower Leg/ Foot Surgery
The purpose of this study is to compare injecting local anesthetic (numbing medication) in different patterns around a major nerve in the leg.
- Conditions
- Strain of Muscle and/or Tendon of Lower Leg, Fracture of Lower Leg, Crushing Injury of Lower Leg, Fracture Malunion - Ankle and/or Foot
- Trial name
- NCT01542840
- Where
- United States
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Ochsner Health System
Emergence Agitation, Anesthetics
The Effect of Low Flow Anesthesia on Postoperative Emergence Agitation in Rhinoplasty
Emergence agitation, defined as restlessness, disorientation, arousal, and/or inconsolable crying, is a common phenomenon seen in the early phase of recovery from general anesthesia; this may cause respiratory depression, nausea…
- Conditions
- Emergence Agitation, Anesthetics, Rhinoplasty
- Trial name
- NCT05601674
- Testing
- : Conventional flow Anesthesia, Low Flow Anesthesia
- Where
- Turkey (Türkiye)
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Inonu University
Pain, Postoperative, Morbid Obesity
Clinical Proposal for the Comparison of Intraperitoneal Anesthetic to Injected Local Anesthetic
The purpose of this study is to determine if pre-incisional lidocaine injection, instilled liquid bupivacaine, intra-abdominal aerosolized bupivacaine, or post-operative bupivacaine injection is superior in post-operative pain…
- Trial name
- NCT00508976
- Testing
- Injected bupivacaine post-operatively, Streamed bupivacaine versus streamed normal saline, Aerosolized bupivacaine versus aerosolized saline
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Pinnacle Health System
Obesity (BMI>30), Postoperative Cognitive Function
Postoperative Cognitive Function After Different Anesthetic Techniques in Obese Patients
Obese patients are at increased risk of postoperative cognitive dysfunction (POCD). The effects of different anesthetic techniques on postoperative cognitive function remain controversial.
- Trial name
- NCT07665645
- Testing
- Sevoflurane (Volatile Anesthetic), propofol, Remifentanil
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Gaziantep City Hospital
Peer Review, Research
Effect of Maternal and Neonatal Oxygenation
Intraoperative supplemental oxygen has been given for most parturients undergoing cesarean section under spinal anesthesia. However, evidences supporting the practice is not clear nowadays, especially for healthy parturients who…
- Trial name
- NCT01530971
- Testing
- Supplemental 3LPM oxygen via canula
- Where
- Thailand
- Volunteers
- 325 people, healthy volunteers welcome
- Sponsor
- Mahidol University
Healthy Subjects
Cognitive Biases Under Ketamine
Characterise cognitive biases resulting from low dose ketamine infusion, used as a pharmacological model of psychosis. Our assumption is that low dose ketamine results in reasoning biases by impairing the way uncertainty is…
- Trial name
- KETABI (NCT02235012)
- Testing
- Ketamine
- Where
- France
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier St Anne