Clinical trials: Anesthetics, Intravenous
DNA Damage, Anesthesia
Comparison of the Genotoxicity of Desflurane and Propofol
The purpose of this study is to evaluate if the anesthetics propofol and desflurane can damage DNA according to comet essay in patients submitted to lumbar disc surgery.
- Trial name
- NCT05185167
- Testing
- Anesthetics, General Desflurane Maintenance, Anesthetics, General Propofol Maintenance
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Muğla Sıtkı Koçman University
Pain, Postoperative
The Effect of IV Dexamethasone on the Duration of Analgesia of Spinal Anaesthesia for C-Sections at a Jamaican Hospital
Dexamethasone is one of many adjuncts tested to prolong the duration of spinal anesthesia and its analgesic effect. The intent of this, a single-site, double-blinded, randomized controlled trial, is to determine if a single…
- Trial name
- NCT04624360
- Testing
- Dexamethasone
- Where
- Jamaica
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- The University of The West Indies
Hemodynamic Instability, Anesthesia
Hemodynamic Changes and Propofol Pharmacokinetic Variation During Anesthesia Induction and Knee-chest Positioning
Induction of anesthesia and the knee-chest position are associated with hemodynamic changes that may impact patient outcomes. Changes from baseline in cardiac output and other hemodynamic variables following induction of…
- Conditions
- Hemodynamic Instability, Anesthesia, Surgery
- Trial name
- NCT03961958
- Testing
- Propofol reduction
- Where
- Portugal
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Salamanca
Phobias
The Effect of Intravenous Anesthetics on Fear Learning and Memory
People often develop fearful responses to things, but have no conscious control over the fear. This is a basic form of unconscious memory, called "fear conditioning." Intravenous anesthetic drugs have remarkable effects on…
- Trial name
- NCT00767767
- Testing
- Propofol 0.45mcg/mL, Propofol 0.90mcg/mL, Thiopental 1.5mcg/mL
- Where
- United States
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Healthy
Study to Assess the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of AZD3043
The primary purpose of this study is to assess the safety and tolerability of AZD3043 following administration of single ascending bolus doses (Part A) and single ascending bolus doses followed by infusion (Part B).
- Trial name
- NCT00984880
- Testing
- AZD3043
- Where
- Sweden
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Acute Cholecystitis, Chronic Cholecystitis
Evaluation of Closed-loop TIVA Propofol, Sufentanil and Ketamine Guided by BIS Monitor
The purpose of this study is to compare a closed-loop intravenous anesthetic using Bispectral Index as a feedback loop and a controller based on reinforcement learning to titrate dose and intravenous anesthetic that is manually…
- Trial name
- NCT01942356
- Testing
- TIVA - Hypotension, TIVA - Hypertension, TIVA - Bradycardia
- Where
- United States
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center at San Antonio
Healthy
Study to Assess the Safety, Tolerability and Pharmacokinetics and Pharmacodynamics of AZD3043
This is a Phase I, single centre, open label study to assess the safety, tolerability, pharmacokinetics (PK) and pharmacodynamics of intravenous AZD3043 after single ascending doses in healthy male volunteers.
- Trial name
- NCT00918515
- Testing
- AZD3043
- Where
- Sweden
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Pain
A Study to Assess Therapeutic Equivalence Between Test EMLA Patch With Marketed EMLA Patch in Healthy Subjects.
A double-blind, randomized, 2-period, placebo-controlled, single-center, crossover study, efficacy study demonstrating the therapeutic equivalence of the test cellulose disc (matrix) in EMLA patch and the current commercial…
- Trial name
- EMLA (NCT03313336)
- Testing
- EMLA test patch, EMLA current reference patch
- Where
- Germany
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Pituitary Adenoma
Comparison of The Effects of Sevoflurane, Desflurane and Total Intravenous Anaesthesia on Pulmonary Function Tests
This study will compare the effects of sevoflurane, desflurane and total intravenous anaesthesia on pulmonary function tests in patients undergoing endoscopic endonasal transsphenoidal surgery of pituitary gland.
- Trial name
- NCT02709863
- Testing
- Sevoflurane, Desflurane, Propofol
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Istanbul University
Anxiety, Depression
The Impact of Anxiety or Depression on the Sedative Concentration of Propofol
120 consecutive female patients, 18-65 years old, American Society of Anesthesiologists (ASA) physical status I to II, scheduled for hysteroscopic surgery under propofol-based intravenous anesthesia will be recruited in this…
- Conditions
- Anxiety, Depression, Propofol, Anesthetics, Intravenous
- Trial name
- NCT03741361
- Testing
- anxiety and depression
- Where
- China
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Xuyu Zhang
Healthy
Neuroimaging the Effects of Intravenous Anesthetic on Amygdala Dependent Memory Processes
This study involves 60 healthy volunteers aged between 18 and 50 recruited from the general community. It involves doing a set of simple memory tests while inside a fMRI machine.
- Trial name
- Amygdala (NCT00504894)
- Testing
- Propofol, Thiopental
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Propofol, Anesthesia
Investigating Near-Threshold Perception During Anesthetic Sedation
The researchers expect to gain a deeper understanding of mental function during different levels of anesthesia. Propofol is FDA approved for use in patients undergoing an anesthetic for medical treatment but is not approved for…
- Conditions
- Propofol, Anesthesia, fMRI
- Trial name
- NCT06403852
- Testing
- Functional Magnetic Resonance Imaging (fMRI) with propofol
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Total Intravenous Anaesthesia, Eleveld Model, Obes
Prospective Validation Of The Eleveld TCI Model For Propofol In The Malaysian Obese Population
This is a prospective single blinded randomized trial to validate the 2014 published and widely used Eleveld TCI model which is a universal model suitable for use in all age groups and is suitable for all patients even in the…
- Trial name
- NCT05885100
- Testing
- Eleveld Model
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- National University of Malaysia
Laparoscopic Colon Resection, Perioperative Analgesia
Intravenous and Intraperitoneal Lignocaine for Perioperative Analgesia in Laparoscopic Colon Resections
The aim of this study is to investigate the analgesic effects of intraperitoneal lignocaine (IPL) compared with intravenous lignocaine (IVL) after laparoscopic colon resections.
- Trial name
- NCT03105193
- Testing
- IV Saline bolus and infusion, IP Saline bolus and infusion, IV lignocaine bolus and infusion
- Where
- New Zealand
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Auckland, New Zealand
Anesthesia
Hypnotic and Anti-nociceptive Components of Magnesium
The aim of our study is to evaluate the effect of magnesium on the hypnotic effect of propofol.
- Trial name
- NCT05005494
- Testing
- Magnesium sulfate IV
- Where
- Belgium
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Liege
Post-Traumatic Stress Disorders, Major Depressive Disorder
Repeated Ketamine Infusions for Comorbid PTSD and MDD in Veterans
Co-occurring post-traumatic stress disorder (PTSD) and major depressive disorder (MDD) is the most common response to trauma; it is associated with poor clinical outcomes and substantial human disability.
- Trial name
- NCT04032301
- Testing
- Ketamine, Normal Saline
- Where
- United States
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Analgesia, Effect of Drug
Comparison of Perioperative Analgesia Between Intravenous Paracetamol and Fentanyl for Rigid Hysteroscopy
Objective of study: To compare the efficacy of intravenous paracetamol and fentanyl for intra-operative and post-operative pain relief in patients undergoing diagnostic and therapeutic hysteroscopy.
- Trial name
- NCT04762147
- Testing
- paracetamol, the group P, fentanyl, group-F administered as an active comparator
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Aga Khan University
Obesity (BMI>30), Postoperative Cognitive Function
Postoperative Cognitive Function After Different Anesthetic Techniques in Obese Patients
Obese patients are at increased risk of postoperative cognitive dysfunction (POCD). The effects of different anesthetic techniques on postoperative cognitive function remain controversial.
- Trial name
- NCT07665645
- Testing
- Sevoflurane (Volatile Anesthetic), propofol, Remifentanil
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Gaziantep City Hospital
Obesity, Morbid
Pharmacokinetics of Propofol in Morbidly Obese Patients
The objectives of this study are To determine PK of propofol in bariatric patients To identify the physiological variables that induce propofol PK changes in bariatric patients, when compared to a normal-weight population.
- Trial name
- NCT01536002
- Testing
- Propofol
- Where
- Norway
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- Oslo University Hospital
Adverse Effect of Intravenous Anesthetics
Phase I Trial of Emulsified Isoflurane
In this trial, our primary goal is to investigate the safety of intravenous infusion of emulsified isoflurane. In order to protect volunteers, the investigators adopt the modified Fibonacci dose-escalation, starting from a very…
- Trial name
- NCT01302353
- Testing
- Emulsified Isoflurane
- Where
- China
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Sichuan University