Clinical trials: Anesthetics Agent
Drug Safety, Self Efficacy
Efficacy and Safety Study of Dexmedetomidine as an Additive to Local Anesthetics in Shoulder Surgery
The purpose of this study is to test the efficacy and safety of dexmedetomidine added to ropivacaine in patients undergoing shoulder surgery.
- Trial name
- NCT01557270
- Testing
- dexmedetomidine, saline
- Where
- Austria
- Volunteers
- 62 people
- Sponsor
- Prof. Peter Gerner, M.D.
Propofol, Ketamine
Propofol-Ketamine Versus Sevoflurane for Laryngeal Mask Anesthesia in Pediatric Cardiac Catheterization
Children undergoing cardiac catheterization will be given anesthesia using either a combination of propofol and ketamine or sevoflurane gas. The time taken to fall asleep will be recorded.
- Conditions
- Propofol, Ketamine, General Anesthetic Drug Adverse Reaction
- Trial name
- NCT07907796
- Testing
- Ketamine-Propofol, Sevoflurane
- Where
- Pakistan
- Volunteers
- 68 people
- Sponsor
- Rawalpindi Institute of Cardiology
Pain, Postoperative, Postoperative Pain
Intraperitoneal Aerosolized Delivery of a Local Anesthetic for Post Operative Pain Management. A Double Blind, Randomised Controlled Clinical Trial.
The purpose of this study is to determine the effectiveness of aerosolized pain medication (.5% bupivicaine) delivered into the peritoneal cavity after laparoscopic gastric bypass surgery.
- Conditions
- Pain, Postoperative, Postoperative Pain, Abdominal Pain, Obesity
- Trial name
- NCT00286286
- Testing
- Intraperitoneal Aerosolization System, IntraMyst
- Where
- 2 sites in United States
- Volunteers
- 50 people
- Sponsor
- Northgate Technologies
Glycopyrrolate, Post-spinal Hypotension
Effect of Glycopyrrolate on Vasopressors Requirement for Non-elective Caesarean Section Under Spinal Anaesthesia
This is prospective randomised double blind study conducted in parturients planned for non-elective caesarean section under spinal anaesthesia.
- Conditions
- Glycopyrrolate, Post-spinal Hypotension, Effect of Drug, Hemodynamic Instability
- Trial name
- NCT04401345
- Testing
- Glycopyrrolate 0.2 MG/ML, Normal saline
- Where
- Nepal
- Volunteers
- 258 people
- Sponsor
- Rajesh Deshar
Coronary Artery Bypass Graft Redo, General Anesthetic Drug Adverse Reaction
The Effect of Desflurane on Myocardial Function in Patients Undergoing Coronary Artery Bypass Grafting
This study is to assess the effect of desflurane on myocardial function in patents who underwent coronary artery bypass grafting.
- Trial name
- NCT02213718
- Testing
- Desflurane, propofol, sufentanil
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Huazhong University of Science and Technology
Aging, Face; Atrophy
Fractional Laser Drug Delivery of a Local Anesthetic
The purpose of this study is to assess the clinical efficacy of fractional CO2 laser-assisted delivery of a topically applied anesthetic to the perceived pain during filler injection.
- Trial name
- NCT05734248
- Testing
- Facial filler injection
- Where
- 2 sites in Greece
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University Hospital, Ioannina
Soft Tissue Injuries
Effectiveness of Phentolamine Mesylate as a Reversing Agent for Local Anesthesia in Children
Local anaesthesia is considered one of the most alarming and non-comfortable dental procedures for children. This goes back to the persisting effect of the local anaesthesia after finishing dental procedures.
- Trial name
- NCT05448807
- Testing
- OraVerse
- Where
- Egypt
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Cairo University
Myocardial Repolarization
The Effects of the Anesthetic Drug Propofol on the Way the Heart Recovers Between Beats
We are investigating a new technique for testing the effect of drugs on electrical activity in the heart. Disturbances of this electrical activity can cause life-threatening changes to heart rhythms.
- Trial name
- NCT00358618
- Testing
- Propofol
- Where
- Canada
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Hypotension Drug-Induced, Cesarean Section Complications
Spinal Anesthesia in Caesarean Section
Spinal anesthesia is a safe technique, widely used and tested in the gynecological field, so as to be considered the first choice technique in cesarean section, which allows to quickly obtain a valid sensor and motor block.
- Conditions
- Hypotension Drug-Induced, Cesarean Section Complications, Spinal Anesthetics Causing Adverse Effects in Therapeutic Use, Bradycardia
- Trial name
- NCT03743870
- Testing
- Levobupivacaine, Bupivacaine
- Where
- Italy
- Volunteers
- 250 people
- Sponsor
- Azienda Ospedaliera, Universitaria Policlinico Vittorio Emanuele
Spondylolisthesis, Analgesia, Postoperative
Ultrasound-Guided Erector Spinae Plane Block for Postoperative Pain Control in Lumbar Spondylolisthesis Surgery
This clinical trial aims to evaluate the effectiveness of ultrasound-guided erector spinae plane (ESP) block as an adjunct to general anesthesia for managing postoperative pain in patients undergoing lumbar spondylolisthesis…
- Conditions
- Spondylolisthesis, Analgesia, Postoperative, ESPB
- Trial name
- NCT07514806
- Testing
- Control Group: General Anesthesia Without Erector Spinae Plane Block, Intervention Group: General Anesthesia With Ultrasound-Guided Erector Spinae Plane Block
- Where
- Bangladesh
- Volunteers
- 50 people
- Sponsor
- Bangladesh Medical University
Anesthesia
Improving Information Extraction From EEG on Cerebral Anesthetic Drug Effects
This is an interventional, randomized controlled study in health volunteers that involves collecting data on raw EEG waves measuring various combinations of anesthetic drugs during standardized drug titration.
- Trial name
- NCT02043938
- Testing
- SedLine EEG sensor
- Where
- Netherlands
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Masimo Corporation
Osteoarthritis, Knee
Multimodal Drug Infiltration in Total Knee Arthroplasty: Is Posterior Capsular Infiltration Worth the Risk?
Multimodal local anesthetic infiltration (LAI) provides effective pain control in patients undergoing total knee arthroplasty (TKA).
- Trial name
- NCT02860949
- Testing
- 0.5% bupivacaine 100 mg, morphine sulfate 5 mg, 0.1% epinephrine 0.6 mg, and ketorolac 30 mg mixed NSS up to 100 mL, Drug injection at Anterior soft tissue (25 mL)+Medial gutter area (25 mL)+Lateral gutter area (25 mL)+Posterior capsular infiltration (25 mL), Drug injection at Anterior soft tissue (34 mL)+Medial gutter area (33 mL)+Lateral gutter area (33 mL
- Where
- Thailand
- Volunteers
- 90 people
- Sponsor
- Thammasat University
Blood Pressure, Hypotension Drug-Induced
Comparison Between Inhalation and Intravenous Induction of Anaesthesia During Interventional Mitral Valve Repair
The induction of anaesthesia is one of the most critical situations for high-risk-patients undergoing interventions surgery. For several reasons, it is crucial to maintain adequate blood pressure and cardiac output during this…
- Trial name
- COMPETENT (NCT04865614)
- Testing
- Etomidate, Sevoflurane
- Where
- Germany
- Volunteers
- 57 people
- Sponsor
- Heidelberg University
Laparoscopy, General Anesthesia
The Effect of Deep Neuromuscular Blockade on Requirement of Intravenous Anesthetic Agent
Recently, deep neuromuscular blockade during general anesthesia has been studied by many authors regarding various effects upon patients' outcomes and surgical conditions.
- Conditions
- Laparoscopy, General Anesthesia, Neuromuscular Blockade
- Trial name
- NCT03890406
- Testing
- Rocuronium: PTC(Post-tetanic count) 1~2, Rocuronium: TOF(Train-of-four) 1~2
- Where
- South Korea
- Volunteers
- 88 people
- Sponsor
- Seoul National University Bundang Hospital
Stroke
Ketamine for Thrombolysis in Acute Ischemic Stroke
KETA trial is a nonprofit, double-blind, randomized, controlled pilot trial with aiming to determine if co-administration of ketamine with recombinant of tissue type plasminogen activator (tPA) for thrombolysis in acute ischemic…
- Trial name
- KETA (NCT02258204)
- Testing
- Ketamine
- Where
- France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Caen