Clinical trials: Angina, Microvascular
Metabolic Syndrome X, Insulin Resistance
Oral Contraceptives in the Metabolic Syndrome
Oral contraceptives (OCs) are the most widely used method of reversible birth control. However, the long-term cardiovascular safety of the widely used low-dose OCs (ethinyl-estradiol < 50 mcg) is still debated.
- Conditions
- Metabolic Syndrome X, Insulin Resistance, Obesity, Cardiovascular Diseases
- Trial name
- NCT00205504
- Testing
- Ortho Tri Cyclen
- Where
- United States
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Microvascular Coronary Dysfunction
Development of a Novel Stress Testing Protocol to Define the Relationship Between Coronary Microvascular Dysfunction and Diastology in Women With Angina But No Evidence of Obstructive Coronary Artery Disease
Microvascular coronary dysfunction (MCD) (abnormities in small blood vessels/arteries in heart) with symptoms of persistent chest pain, primarily impacts women.
- Trial name
- NCT02301663
- Testing
- Handgrip, Altitude simulation, Leg exercise
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Cedars-Sinai Medical Center
Blood Pressure, Metabolic Syndrome X
Dairy Products and Metabolic Syndrome
The purpose of this trial is to investigate the effect of dairy products on the so called metabolic syndrome. Metabolic syndrome is a cluster of risk factors, such as high blood pressure and high cholesterol, for the development…
- Trial name
- NCT01913756
- Testing
- Gamalost (Norwegian traditional cheese), Gouda-type cheese
- Where
- Norway
- Volunteers
- 153 people, healthy volunteers welcome
- Sponsor
- Norwegian University of Life Sciences
Metabolic Syndrome X, Heart Disease
Dairy Products and Metabolic Effects (Norwegian Part)
Foods containing more dairy fat (and thus a higher proportion of short and medium chain fatty acids and possibly some other nutrients or micronutrients with effect on energy intake, satiety or energy metabolism) affect energy…
- Trial name
- NCT00140816
- Testing
- Increased intake of dairy products
- Where
- Norway
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Oslo University Hospital
Obesity, Metabolic Syndrome X
Weight and Metabolic Effects of an Almond Enriched Hypocaloric, Low Fat Diet on Overweight and Obese Persons
The purpose of this trial is to study the safety, tolerability and efficacy of an almond enriched hypocaloric diet on weight loss and weight maintenance, as well as on established and emerging cardiovascular risk factors in…
- Conditions
- Obesity, Metabolic Syndrome X, Hyperlipidemia, Hypertension
- Trial name
- NCT00194428
- Testing
- Almond enriched diet, Low fat caloric diet
- Where
- United States
- Volunteers
- 123 people, healthy volunteers welcome
- Sponsor
- Temple University
Ischemia and No Obstructive Coronary Artery Disease, Coronary Microvascular Dysfunction
The DISCOVER INOCA Prospective Multi-center Registry
The overall objective of this multi-center registry is to identify specific phenotypes of INOCA with both an anatomic evaluation (coronary angiography and intravascular imaging) and physiologic assessment with the Abbott…
- Conditions
- Ischemia and No Obstructive Coronary Artery Disease, Coronary Microvascular Dysfunction, Coronary Vasospasm, Endothelial Dysfunction
- Trial name
- DISCOVER INOCA (NCT05288361)
- Testing
- Coroventis Coroflow Cardiovascular System and PressureWire™ X Guidewire
- Where
- 9 sites in United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Yale University
Metabolic Syndrome X
Effect of Food Consumption on microRNA Related to Metabolic Syndrome
The objective of the Project is to assess the effect of traditional food on the expression of micro-ribonucleic acid (miRNA), which regulate genes related to glucose metabolism. It will be a randomized experimental research.
- Trial name
- EFCMRNAMS (NCT02606812)
- Testing
- Traditional-food
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Universidad Juárez Autónoma de Tabasco
Metabolic Syndrome X
Effect of Exercise Training on the Function of the High Density Lipoprotein (HDL)-Cholesterol, Endothelial Function and Endothelial Progenitor Cells in Patients With Metabolic Syndrome(HERMET-Study)
The purpose of the present study is to characterize the quality of HDL-Cholesterol in patients with metabolic syndrome and reduced blood HDL-Cholesterol levels and to examine the effect of exercise training on the…
- Trial name
- HERMET (NCT00515476)
- Testing
- physical exercise
- Where
- Germany
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Hannover Medical School
Hyperlipidemia, Metabolic Syndrome X
Low Fat Plant-Based Supplemented Diet Effects on Risk Factors for Chronic Non-communicable Diseases
The effect of a diet free from animal-sourced nutrients on a variety of risk factors for chronic non-communicable diseases in weight reduction programs is not well established.
- Trial name
- LFPBDS2 (NCT02905448)
- Testing
- Low fat plant-based nutrition
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Barbara Jakše s.p.
Polycystic Ovary Syndrome
Effects of Metformin and Oral Hormonal Contraceptive in Adolescents With Polycystic Ovary Syndrome
The polycystic ovary syndrome is the most common endocrinopathy in reproductive age women. The pathophysiology of this syndrome remains unclear, but there are evidences that a decreased in insulin sensitivity may be related in…
- Trial name
- NCT00988078
- Testing
- Metformin
- Where
- Brazil
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Federal University of São Paulo
Metabolic Syndrome X
Effects the Glycemic Index on Metabolic Risk Markers
Recent population studies have shown that the glycemic index (GI) of food products is positively associated with the risk of developing type 2 diabetes and cardiovascular disease (CVD).
- Trial name
- NCT00695825
- Testing
- Low GI+high GI, High GI+low GI
- Where
- Netherlands
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Metabolic Syndrome X, Nutritional and Metabolic Diseases
Nutrition and Lifestyle Behaviour Peer Support Program Among Malaysian Adults With Metabolic Syndrome (PERSUADE)
The outlook of a community-based intervention targeting nutrition and lifestyle behaviour modification among adults with metabolic syndrome (MetS) has not been fully explored.
- Conditions
- Metabolic Syndrome X, Nutritional and Metabolic Diseases, Health Behavior
- Trial name
- PERSUADE (NCT03417128)
- Testing
- Peer support
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Monash University
Metabolic Syndrome X, Diabetes Mellitus Type 2
Metabolic Syndrome and Related Diseases in Healthcare Workers
This study aims to investigate the incidence and prevalence of metabolic syndrome and metabolism-related diseases among healthcare workers, identify potential risk factors for these diseases, evaluate the control status of these…
- Conditions
- Metabolic Syndrome X, Diabetes Mellitus Type 2, Hypertension, Hyperlipidemia
- Trial name
- NCT06543706
- Where
- China
- Volunteers
- 7,432 people, healthy volunteers welcome
- Sponsor
- Peking Union Medical College Hospital
Hyperlipidemias, Metabolic Syndrome X
Effect of Vegetable Oils for Use by the Snack Food Industry on Plasma Lipid Levels and Inflammatory Markers
The current study is designed to assess the effect of a conventional cooking oil (hydrogenated oil) and a reformulated fat low in trans fatty acids on cardiovascular disease risk factors.
- Conditions
- Hyperlipidemias, Metabolic Syndrome X, Cardiovascular Diseases
- Trial name
- NCT00175071
- Testing
- Comparison of cooking oils
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Tufts University
Insulin Resistance Syndrome X, Pancreatic Beta Cell Function
Mechanism of Fatty Acid-Induced Impairment of Glucose-Stimulated Insulin Secretion
A prolonged elevation of plasma free fatty acids (FFA) impairs glucose stimulated insulin secretion. The concept of fatty acid impairment of glucose stimulated insulin secretion (lipotoxicity) has now been well accepted.
- Trial name
- NCT00188773
- Testing
- N-acetylcysteine, intralipid, heparin
- Where
- Canada
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University Health Network, Toronto
Metabolic Syndrome, Type 2 Diabetes
LUPS-Lipids and Glucose Under Prospective Surveillance
Prospective, non-randomized cohort study to analyse genetic variations, dietary patterns, perceived stress and anxiety and early changes in lipid metabolism leading to the metabolic syndrome and type 2 diabetes
- Trial name
- LUPS (NCT01313156)
- Where
- 2 sites in Germany
- Volunteers
- 1,962 people, healthy volunteers welcome
- Sponsor
- Asklepios proresearch
Obesity, Overweight
Impact of Almond Supplementation on Body Composition in Overweight/Obese Minority Adults
The purpose of this study is to determine whether introducing almonds into the diet of overweight and obese Blacks and Hispanics improves body composition, decreases liver fat, and lowers cardiovascular disease profile.
- Conditions
- Obesity, Overweight, Fatty Liver, Metabolic Syndrome X
- Trial name
- NCT02347007
- Testing
- Almond, Cereal Bar
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Columbia University
Metabolic Syndrome x
PROCLAIM: Study Examining Effects of Clopidogrel Compared to Placebo on Inflammation in Subjects With Metabolic Syndrome
The purpose of this study is to examine the effects of clopidogrel compared to placebo on markers of inflammation in subjects with metabolic syndrome who are receiving background therapy including low dose aspirin.
- Trial name
- NCT00296803
- Testing
- clopidogrel
- Where
- United States
- Volunteers
- 216 people, healthy volunteers welcome
- Sponsor
- Sanofi
Metabolic Syndrome X
Defining Strategies for Improving Endothelial and Fibrinolytic Dysfunction in Obesity
The combination of high blood pressure and having central obesity is an increasing important factor for heart disease in men and women.
- Trial name
- NCT00608465
- Testing
- Eplerenone, Ramipril
- Where
- United States
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University
Cardiomyopathy, Hypertrophic, Coronary Disease
Analysis of Heart Muscle Function in Patients With Heart Disease and Normal Volunteers
Myocardial ischemia is a heart condition in which not enough blood supply and oxygen reaches the heart muscle. Damage to the major blood vessels of the heart (coronary artery disease), minor blood vessels of the heart…
- Conditions
- Cardiomyopathy, Hypertrophic, Coronary Disease, Healthy, Myocardial Ischemia
- Trial name
- NCT00001459
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)