Clinical trials: Angina Pectoris, open to volunteers
Coronary Microvascular Disease
Coronary MicrovAscular Diseases Intervention With Compound Danshen Dropping Pills
Objective: To investigate the effect of Compound Danshen Dripping Pills （CDDP）on improving coronary flow reserve（CFR） in patients with coronary microvascular disease (CMVD) and to evaluate their efficacy and safety.
- Trial name
- MAID (NCT07885462)
- Testing
- Compound Danshen Dripping Pills
- Where
- China
- Volunteers
- 496 people
- Sponsor
- Qilu Hospital of Shandong University
Coronary Artery Disease (CAD) (E.G., Angina, Myocardial Infarction, and Atherosclerotic Heart Disease (ASHD)), Chronic Heart Failure
TELEREHAB-BR: Cardiovascular Rehabilitation Models Trial
Introduction: Cardiovascular diseases remain the leading cause of mortality worldwide. Despite the proven effectiveness of cardiac rehabilitation (CR) programs, adherence remains unsatisfactory, especially in public healthcare…
- Conditions
- Coronary Artery Disease (CAD) (E.G., Angina, Myocardial Infarction, and Atherosclerotic Heart Disease (ASHD)), Chronic Heart Failure, Acute Coronary Syndromes (ACS)
- Trial name
- TELEREHAB-BR (NCT07734831)
- Testing
- Hybrid Cardiac Telerehabilitation, Traditional Center-Based Cardiac Rehabilitation (TCR), Usual Care Group
- Where
- Brazil
- Volunteers
- 219 people
- Sponsor
- University of the State of Santa Catarina
Coronary Microvascular Dysfunction (CMD)
Multisensor Wireless Pressure Microcatheter For Microvascular Function Assessment In ANOCA/INOCA Patients: A Prospective, Multicenter, Single-Group Target Value Study
This study aims to evaluate the sensitivity and specificity of a multi-sensor wireless pressure microcatheter for the diagnosis of CMD in patients with ANOCA/INOCA, using quantitative myocardial perfusion imaging of cardiac…
- Trial name
- NCT07453381
- Where
- 5 sites in China
- Volunteers
- 114 people
- Sponsor
- Peking University Third Hospital
Coronary Artery Disease
Safety and Cost-efficiëncy of New Imaging Techniques in Patients Suspected of Coronary Artery Disease
Yearly, 180 000 patients in the Netherlands are referred to a cardiologist with symptoms suspected of coronary artery disease (CAD). To assess this, multiple diagnostic tests are available.
- Trial name
- iCORONARY (NCT04939207)
- Testing
- CT-FFR, Angiography-derived FFR, Angiography with invasive FFR-measurements
- Where
- 4 sites in Netherlands
- Volunteers
- 825 people
- Sponsor
- St. Antonius Hospital
Coronary Artery Disease, Coronary Artery Disease (CAD) (E.G., Angina, Myocardial Infarction, and Atherosclerotic Heart Disease (ASHD))
First-in-Human Study Using the SiroMax™ Sirolimus-Coated Balloon Catheter as a Percutaneous Transluminal Coronary Angioplasty (PTCA) Balloon Catheter to Treat Subjects Who Have Coronary Artery Disease (CAD) Involving In-Stent Restenosis (ISR) or an Unstented Lesion in a Small Coronary Vessel (DNSV).
The goal of this clinical trial is to learn if the SiroMax™ drug-coated balloon catheter is safe and works to treat stenotic coronary lesions in adults.
- Conditions
- Coronary Artery Disease, Coronary Artery Disease (CAD) (E.G., Angina, Myocardial Infarction, and Atherosclerotic Heart Disease (ASHD)), In-Stent Restenosis or De Novo Coronary Artery Lesions, In-Stent Stenosis (Restenosis) of Coronary Artery Stent
- Trial name
- SMART-I (NCT07811024)
- Testing
- Sirolimus-coated balloon catheter
- Where
- 2 sites in Uzbekistan
- Volunteers
- 60 people
- Sponsor
- Tonic Medical, Inc.
Acute Coronary Syndromes, Dyslipidemia
Early Triple Lipid-Lowering Therapy With Bempedoic Acid After Acute Coronary Syndrome
This randomized clinical trial will evaluate whether starting bempedoic acid in addition to high-intensity statin therapy and ezetimibe within 72 hours after percutaneous coronary intervention improves low-density lipoprotein…
- Trial name
- EARLY-BIRD ACS (NCT07824323)
- Testing
- bempedoic acid, Ezetimibe, High-Intensity Statin Therapy
- Where
- Taiwan
- Volunteers
- 400 people
- Sponsor
- Taipei Medical University Hospital
Pseudo Angina, Myofascial Pain Syndromes
Treatment of Pectoralis Trigger Points in Patients With Pseudo Angina
Pseudo-angina is a musculoskeletal condition characterized by chest pain that resembles angina but occurs due to non-cardiac causes, particularly myofascial trigger points in the chest wall muscles.
- Conditions
- Pseudo Angina, Myofascial Pain Syndromes, Pectoralis Muscles, Musculoskeletal Chest Pain
- Trial name
- GT-LIC (NCT07728357)
- Testing
- Graston Technique, Local Ischemic Compression
- Where
- Pakistan
- Volunteers
- 36 people
- Sponsor
- University of Faisalabad
Chest Pain, Ischemia
Evaluation of Patients With Non-obstructive Coronary Arteries
Patients with angina and non-obstructive CAD are common within clinical practice, but remain a challenge with regard to diagnosis and treatment.
- Trial name
- noCAD (NCT00823563)
- Testing
- 30 cc blood draw, Intravascular ultrasound (IVUS), Coronary pressure/flow wire testing
- Where
- United States
- Volunteers
- 2,000 people
- Sponsor
- Stanford University
Counterpulsation, Angina Pectoris
Effectiveness of ECP Therapy in Stable Angina Pectoris Patients
External Counterpulsation (ECP) is a non-invasive therapy using pressured cuff that is performed on patients with refractory stable angina pectoris to relieve symptoms and increase quality of life.
- Trial name
- NCT04873687
- Testing
- External Counter Pulsation (ECP) therapy
- Where
- Indonesia
- Volunteers
- 84 people
- Sponsor
- Universitas Padjadjaran
Acute Kidney Injury
Renal Angina Index for Predicting Acute Kidney Injury in Adult ICU Patients
Acute kidney injury (AKI) is a frequent complication of critical illness and is associated with increased morbidity and mortality.
- Trial name
- NCT07863505
- Testing
- Renal Angina Index Assessment
- Where
- Turkey (Türkiye)
- Volunteers
- 324 people
- Sponsor
- Izmir Katip Celebi University
Ventricular Tachycardia, Coronary Artery Disease
Coronary Flow During Rapid Heart Rates
The goal of this observational study is to learn about the factors which determine how well ventricular tachycardia (VT) is tolerated. The main questions it aims to answer are: 1.
- Conditions
- Ventricular Tachycardia, Coronary Artery Disease, Heart Failure, Coronary Microvascular Dysfunction
- Trial name
- VT flow (NCT05841199)
- Testing
- Pressure and flow measurement during simulated VT
- Where
- United Kingdom
- Volunteers
- 70 people
- Sponsor
- Imperial College London
Coronary Artery Disease, Ischaemic Heart Disease
Echocardiography: Value and Accuracy at REst and STress
EVAREST will identify and validate novel blood and imaging biomarkers of potential value for consistent and accurate interpretation of stress echocardiography.
- Conditions
- Coronary Artery Disease, Ischaemic Heart Disease, Angina Pectoris
- Trial name
- EVAREST (NCT03674255)
- Volunteers
- 23,000 people
- Sponsor
- University of Oxford
Refractory Angina Pectoris, Refractory Angina
Assessing the Safety and Effectiveness of Intracoronary Stem Cells in Patients With Refractory Angina
REGENERATE-COBRA will examine whether autologous stem cell treatment can improve angina symptoms and quality of life for patients with refractory angina.
- Trial name
- RegenCobra (NCT05711849)
- Testing
- Bone marrow aspiration and a single intracoronary infusion of autologous bone marrow-derived mononuclear cells.
- Where
- United Kingdom
- Volunteers
- 110 people
- Sponsor
- Barts & The London NHS Trust
Ischemic Heart Disease, Non STEMI
Coronary Computed Tomography Versus Invasive Angiography for Non-ST Elevation Acute Coronary Syndrome
Coronary computed tomography angiography (CCTA) is a widely accepted initial diagnostic test for individuals suspected of having chronic coronary syndromes.
- Conditions
- Ischemic Heart Disease, Non STEMI, Angina Pectoris, Unstable, Coronary Disease
- Trial name
- TRACTION (NCT06101862)
- Testing
- CCTA, Conventional ICA, Team-based interventional triage
- Where
- 6 sites in Denmark
- Volunteers
- 2,300 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Hypertrophic Cardiomyopathy
Coronary Sinus Reducer Objective Impact on SymptoMs, Ischaemia and miCrovascular Resistance in Non-obstructive Hypertrophic CardioMyopathy
Hypertrophic cardiomyopathy (HCM) is a common heart condition in which the heart muscle becomes abnormally thick. In non-obstructive HCM, blood flow out of the heart is not blocked, but many patients still experience chest pain…
- Trial name
- COSMIC-HCM (NCT07865364)
- Testing
- Coronary sinus reducer
- Where
- 8 sites in United Kingdom
- Volunteers
- 50 people
- Sponsor
- Imperial College London
Angina, Stable
Artificial Intelligence in ANOCA
Angina pectoris is diagnosed in >180.000 people in the Netherlands each year. Diagnosis in angina pectoris focuses on epicardial coronary stenosis, the identification of which may lead to guideline-directed medical therapy or…
- Trial name
- (AI)NOCA (NCT06387693)
- Testing
- Holter monitoring, intracoronary ECG
- Where
- Netherlands
- Volunteers
- 250 people
- Sponsor
- UMC Utrecht
Acute Coronary Syndromes (ACS), Ventricular Tachycardia (VT)
Analysis of Life-threatening ARrhythMias After Acute Coronary Syndrome
Patients admitted with an acute coronary syndrome (ACS) are at increased risk of malignant cardiac arrhythmias (MA), such as sustained ventricular tachycardia and ventricular fibrillation.
- Conditions
- Acute Coronary Syndromes (ACS), Ventricular Tachycardia (VT), Ventricular Fibrillation, Pulseless Electrical Activity
- Trial name
- ALARM-ACS (NCT07824050)
- Where
- Netherlands
- Volunteers
- 2,775 people
- Sponsor
- Catharina Ziekenhuis Eindhoven
Erectile Disfunction, Coronary Artery Disease (CAD)
"Erectile Function After PCI in MI and Non-MI Patients"
The goal of this observational study is to assess changes in patients' erectile function after percutaneous coronary intervention (PCI) using a standard IIEF (International Index of Erectile Function) questionnaire at 1, 3, and 6…
- Conditions
- Erectile Disfunction, Coronary Artery Disease (CAD), Diabete Mellitus, Anxiety
- Trial name
- ERECT-PCI (NCT07444697)
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Kırıkkale University
Coronary Heart Disease
Unstable Angina Pectoris in Comorbidity With Anxiety-depressive Syndrome
Introduction: Today it is necessary to emphasize that coronary heart disease is often associated with anxiety disorders. Research over the years has shown several and sometimes surprising links between coronary heart disease and…
- Trial name
- NCT04599621
- Testing
- Collection of blood samples to determine the level of certain cytokines (TNF-α, IL-1β, IL-4 and IL-10),Collection of blood samples to determine the level of uric acid
- Where
- Uzbekistan
- Volunteers
- 3 people
- Sponsor
- Samarkand State Medical Institute
ST Elevation Myocardial Infarction
Fractional Flow Reserve Guided Immediate Versus Staged Complete Myocardial Revascularization in Patients With ST-segment Elevation Myocardial Infarction With Multivessel Disease (Future Study)
It is a prospective, multicenter, randomised controlled, open-label, blinded endpoint assessment trial, to compare the strategy of immediate complete revascularisation and staged complete revascularisation in ST-segment-elevation…
- Trial name
- NCT05967663
- Testing
- PCI-immediate complete revascularisation, PCI-staged complete revascularisation
- Where
- China
- Volunteers
- 840 people
- Sponsor
- RenJi Hospital