Clinical trials: Anginal Pain
Angina CCS Classe II-IV - IMR, RFR, FFR,CFR
Characterization of Different Phenotypes of Microvascular Dysfunction and Their Impact on Angina Severity in Patients With Chronic Angina in the Absence of Obstructive Coronary Artery Disease.
The aim of the present study will be to identify different phenotypes of microvascular dysfunction and their associations with the severity of anginal symptoms assessed through the Seattle Angina Questionnaire(SAQ-7).
- Trial name
- MiVa (NCT05686707)
- Where
- Italy
- Volunteers
- 400 people
- Sponsor
- Federico II University
Acute Coronary Syndrome
Variation Between Hospitals in Short-term Mortality After Acute Coronary Syndromes: A CALIBER Study
We seek to investigate whether hospitals in England and Wales vary in their rate of mortality following admission for heart attack or unstable angina, the extent of such variation, whether discharge diagnosis affects the extent…
- Trial name
- NCT01111071
- Where
- United Kingdom
- Volunteers
- 316,648 people
- Sponsor
- University College, London
Coronary Syndrome
Effectiveness of Nursing Orientation for the Reduction of Anxiety and Stress
This study´s objective was to identify the effectiveness of nursing orientation for the reduction of anxiety and stress of patients that was waiting cardiac catheterization. Method. This is a randomized clinical trial.
- Trial name
- NCT03369873
- Testing
- Guidance Manual
- Volunteers
- 122 people
- Sponsor
- Federal University of São Paulo
Acute Coronary Syndrome, Myocardial Infarction
Rule Out Myocardial Infarction by Computer Assisted Tomography
The goal of this research is to determine noninvasively whether detection of coronary stenosis and plaque by multidetector computed tomography (MDCT) in patients with acute chest pain suspected of acute coronary syndrome (ACS)…
- Conditions
- Acute Coronary Syndrome, Myocardial Infarction, Unstable Angina Pectoris
- Trial name
- ROMICAT (NCT00990262)
- Testing
- Cardiac Computed Tomography
- Where
- United States
- Volunteers
- 368 people
- Sponsor
- Massachusetts General Hospital
Unstable Angina, Non-ST-Elevation Myocardial Infarction
Diagnosis and Treatment of Acute Coronary Syndrome in the ED & the Impact of Rapid Bedside cTnl on Outcome.
The primary outcome in this study will be time to discharge for low-risk patients and therapeutic turnaround time for patients with NSTEMI or unstable angina.
- Trial name
- NCT00276432
- Testing
- iSTAT point of care analyzer
- Where
- United States
- Volunteers
- 350 people
- Sponsor
- Mayo Clinic
Coronary Spasm
Efficacy of Endothelin Receptor Antagonism in Coronary Artery Spasm
The goal of this randomized clinical trial is to assess if adjunctive bosentan therapy, in comparison to placebo, can reduce the rate of epicardial vasospasm at follow-up spasm provocation CFT (fuCFT) in patients with previously…
- Trial name
- EDIT-CAS (NCT06432452)
- Testing
- Endothelin Receptor Antagonist
- Where
- 4 sites in Netherlands
- Volunteers
- 100 people
- Sponsor
- Radboud University Medical Center
Coronary Arterial Disease (CAD), Angina (Stable)
Effect of Beta-blockers on Coronary Flow and Resistance in Patients With ANOCA
The goal of this clinical trial is to learn whether beta-blockers can improve coronary blood flow and reduce resistance in patients with angina and no obstructive coronary arteries (ANOCA).
- Conditions
- Coronary Arterial Disease (CAD), Angina (Stable), Microvascular Circulation
- Trial name
- BEACON (NCT06864234)
- Testing
- Saline (NaCl), Metoprolol Tartrate
- Where
- Belgium
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- VZW Cardiovascular Research Center Aalst
Coronary Heart Disease, Angina Pectoris
The Effects of Diesel Exhaust Inhalation On Exercise Capacity In Patients With Stable Angina Pectoris
The purpose of this study is to determine whether exposure to diesel exhaust (air pollution) has a functional impact on patients with stable angina pectoris.
- Trial name
- NCT00737958
- Where
- United Kingdom
- Volunteers
- 19 people
- Sponsor
- University of Edinburgh
Slow Coronary Flow, Normal, or Near Normal Coronary Angiography
Effects of Nicorandil on Angina Symptoms in Patients With Coronary Slow Flow
Slow coronary flow is an angiographically diagnosed phenomenon defined as delayed opacification of epicardial arteries in the absence of significant arterial narrowing and blockade.
- Conditions
- Slow Coronary Flow, Normal, or Near Normal Coronary Angiography, Stable Angina
- Trial name
- NCT02254252
- Testing
- Nicorandil, Nitroglycerin
- Volunteers
- 54 people
- Sponsor
- Mashhad University of Medical Sciences
Post Acute Coronary Syndrome, Myocardial Ischemia
Efficacy and Safety of Aliskiren and Valsartan Versus Placebo in Patients Stabilized Following an Acute Coronary Syndrome
The purpose of this study is to test the hypothesis that the inhibition of the renin-angiotensin-aldosterone system (RAAS) with the angiotensin receptor blocker valsartan or the renin antagonist aliskiren will improve ventricular…
- Trial name
- NCT00409578
- Testing
- Aliskiren 300 mg, Valsartan 320 mg, Aliskiren/valsartan 300/320 mg
- Where
- 11 sites in United States, Belgium and 9 more
- Volunteers
- 1,101 people
- Sponsor
- Novartis
Disease Management, Diabetes Complications
Determining Rates of Cardiovascular Complications Among Patients of a Managed Diabetes Care Program
The primary objective of this study is to identify whether cardiovascular complication rates are lower in patients who participate in managed diabetes care, in comparison to provincial and national rates.
- Conditions
- Disease Management, Diabetes Complications, Diabetic Vascular Complications, Diabetic Neuropathy
- Trial name
- DECIDE (NCT00498147)
- Testing
- ADEC Program
- Where
- Canada
- Volunteers
- 1,213 people
- Sponsor
- Group Health Centre
Percutaneous Coronary Intervention, Myocardial Ischemia
Analysis of Myocardial Layer Specific Systolic and Diastolic Function During and After PCI
Investigators will analyzed systolic and diastolic function during and after ischemia induced by percutaneous coronary intervention.Also will be analyzed a local work index during acute ischemia induced by percutaneous coronary…
- Conditions
- Percutaneous Coronary Intervention, Myocardial Ischemia, Anginal Pain
- Trial name
- PCI-Strain (NCT02004483)
- Testing
- Percutaneous Coronary Intervention
- Where
- Germany
- Volunteers
- 19 people
- Sponsor
- RWTH Aachen University
Chronic Stable Angina
Phase IIb Study of STA-2 in Patients With Chronic Stable Angina
The objective of this study is to evaluate the dose-response of three different dose levels of STA-2 (900 mg daily, 1800 mg daily and 2700 mg daily for 42 days) versus placebo in patients with chronic stable angina.
- Trial name
- NCT01239511
- Testing
- green tea polyphenols (STA-2)
- Where
- 5 sites in Taiwan
- Volunteers
- 186 people
- Sponsor
- Sinphar Pharmaceutical Co., Ltd
Angina Pectoris, Acute Coronary Syndrome
Integrated Distance Management Strategy for Patients With Cardiovascular Diseases in the Context of COVID-19
Management of known patients with cardiovascular disease (in particular the whole spectrum of atherosclerotic ischaemic coronary artery disease, essential hypertension under treatment, and also patients with chronic heart failure…
- Conditions
- Angina Pectoris, Acute Coronary Syndrome, Coronary Syndrome, Coronary Artery Disease
- Trial name
- eCardioCovid19 (NCT04325867)
- Testing
- Tele-medicine platform
- Where
- 2 sites in Romania
- Volunteers
- 200 people
- Sponsor
- Professor Adrian Covic
Refractory Angina Pectoris
IMR Evaluation in Patients with Coronary Sinus Reducer Implantation (INROAD Study)
The INROAD is an investigator-driven, prospective, study in which patients undergoing coronary sinus reducer implantation (Reducer) for chronic refractory angina undergo evaluation of the index of microcirculatory resistance…
- Trial name
- INROAD (NCT05174572)
- Testing
- IMR
- Where
- Italy
- Volunteers
- 21 people
- Sponsor
- Consorzio Futuro in Ricerca
Rheumatoid Arthritis, Ankylosing Spondylitis
PatientSpot Formerly Known as ArthritisPower
Patient Power is a patient research network and database (registry) to collect prospective information about demographics, self-reported diagnoses and medications, and willingness to participate in research from participants with…
- Conditions
- Rheumatoid Arthritis, Ankylosing Spondylitis, Fibromyalgia, Gout
- Trial name
- NCT03840928
- Where
- United States
- Volunteers
- 40,000 people, healthy volunteers welcome
- Sponsor
- Global Healthy Living Foundation
Angina, Stable, Acute Coronary Syndrome
Genotyping GUided Antiplatelet theRapy in pAtieNts Treated With Drug Eluting stEnts (GUARANTEE)
The aim of this study is to assess the efficacy and safety of the CYP2C19 genotype guided antiplatelet treatment strategy, using clopidogrel in non-carriers of a CYP2C19*2 or *3 allele and ticagrelor in carriers of a CYP2C19*2 or…
- Conditions
- Angina, Stable, Acute Coronary Syndrome, Drug-Eluting Stents, Genotype
- Trial name
- NCT03783351
- Testing
- CYP2C19 genotype testing
- Where
- 9 sites in China
- Volunteers
- 4,009 people
- Sponsor
- Beijing Anzhen Hospital
Stable Angina Pectoris
Extended-Release RANCAD in the Patients With Stable Angina Pectoris
A double-blind, randomized, placebo-controlled, parallel study to evaluate the effects of add-on RANCAD on exercise tolerance and angina frequency in patients with stable angina pectoris.
- Trial name
- NCT02294942
- Testing
- RANCAD
- Where
- 6 sites in Taiwan
- Volunteers
- 75 people
- Sponsor
- TSH Biopharm Corporation Limited
Myocardial Infarction, Stable Angina
Barts Revascularisation Registry
Despite the year-on-year decrease, coronary artery disease (CAD) still remains one of the leading cause of mortality worldwide. With advances in technology and our understanding of cardiac disease, we can now treat CAD using…
- Trial name
- NCT05255705
- Testing
- Observation only
- Where
- United Kingdom
- Volunteers
- 20,000 people
- Sponsor
- Queen Mary University of London
Non ST Elevation Acute Coronary Syndromes, Stable Coronary Syndromes
Appropriateness of Coronary Angioplasty in PAtients With isCHEmic Heart Disease
An observational, retrospective, multicenter, blinded adjudication study to evaluate the clinical appropriateness of Percutaneous Coronary Intervention (PCI) indication and execution in patients with stable Coronary Artery…
- Conditions
- Non ST Elevation Acute Coronary Syndromes, Stable Coronary Syndromes, NSTEMI, Unstable Angina
- Trial name
- APACHE (NCT02748603)
- Where
- Italy
- Volunteers
- 400 people
- Sponsor
- Italian Society of Invasive Cardiology
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