Clinical trials: Ankle
Ankle Deformity, Ankle Arthritis
ViviGen Cellular Bone Matrix for Hindfoot or Ankle Arthrodesis
To evaluate the fusion status of the hindfoot bones after receiving the ViviGen graft, an FDA approved cellular bone matrix. This is used in a population indicated for hindfoot arthrodesis as an alternative to an autograft.
- Trial name
- ViviGen (NCT04138017)
- Testing
- ViviGen
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of Virginia
Traumatic Amputation of Lower Extremity
Effects of Wearing a Powered Ankle-Foot Prosthesis on Amputee Walking
Amputees wearing a conventional prosthesis require 20-30% more metabolic energy to walk at the same speeds as non-amputees and this discrepancy is more apparent at faster walking speeds.
- Trial name
- NCT00869947
- Testing
- Powered ankle-foot prosthesis, No device
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- US Department of Veterans Affairs
Chronic Pain, Ankle Fracture Surgery
Anesthesia for Pain After Ankle Fracture Surgery
This pilot study will test the hypothesis that prolonged regional peripheral nerve block will reduce development of chronic pain in patients undergoing surgery for ankle fracture compared to standard of care.
- Conditions
- Chronic Pain, Ankle Fracture Surgery, Regional Anesthesia
- Trial name
- NCT02950558
- Testing
- Ropivacaine, Nerve block
- Where
- 2 sites in United States
- Volunteers
- 14 people
- Sponsor
- University of Cincinnati
Sprain of Ankle
TAASS-Traumeel Ointment and Gel Compared With a Topical NSAID in Athletes With Acute Ankle Sprain
The objective of this study is to determine the efficacy of Traumeel S (both ointment and gel) compared to another antiinflammatory drug called Diclofenac in patients with a sprained ankle.
- Trial name
- TAASS (NCT01066520)
- Testing
- Traumeel S ointment, Traumeel S gel, Diclofenac gel
- Where
- Spain
- Volunteers
- 449 people
- Sponsor
- Biologische Heilmittel Heel GmbH
Hypertension
A Study to Evaluate Methodologies for Measuring Swelling of the Leg and Ankle (MK-0000-106)(COMPLETED)
This study will evaluate methodologies for measuring pedal edema associated with calcium channel blockers in middle-aged and elderly subjects and patients with hypertension.
- Trial name
- NCT00789321
- Testing
- Comparator: amlodipine besylate
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC
Athletic Injuries, Knee Injuries
Analysis of Balance and Functional Hop Tests in Athletes With Lower Extremity Injuries by Dual Task Study
Functional Hop tests and balance measurements are frequently used to decide on returning to sports after lower extremity injuries.
- Conditions
- Athletic Injuries, Knee Injuries, Ankle Injuries, Hip Injuries
- Trial name
- NCT05484778
- Testing
- Dual tasking paradigm
- Where
- Turkey (Türkiye)
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Istanbul University
Ankle Osteoarthritis, Healthy Ankles
Do Rocker Bottom Shoes and Ankle-Foot Orthoses Reduce Pain and Improve Mobility for Ankle Osteoarthritis Patients
Ankle osteoarthritis (OA) is a painful, progressive condition that can severely limit physical activity and reduce quality of life.
- Trial name
- RB/AFO (NCT03524729)
- Testing
- Rocker bottom shoe, Ankle foot orthosis, Standard walking shoe
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Ankle Arthrodesis, Hindfoot Arthrodesis
Foot and Ankle Clinic Application for Liposomal Related Anesthetic
The purpose of this study is to review the use of surgeon applied liposomal release anesthetic (Exparel) for post operative analgesia.
- Conditions
- Ankle Arthrodesis, Hindfoot Arthrodesis, Tibitalocalceal Arthrodesis
- Trial name
- NCT02586077
- Testing
- Exparel
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- OrthoCarolina Research Institute, Inc.
Intra-Articular Fractures
Effect of Early Saline Lavage on Synovial Fluid Composition Following Intra Articular Ankle Fractures
The purpose of this study is to examine the effect of early, percutaneous, intra-articular saline lavage on the undiluted synovial fluid microenvironment during the acute phase following intra-articular fracture of the human…
- Trial name
- NCT05465382
- Testing
- Saline Lavage, No intra-articular saline lavage, Lidocaine - intra-articular injection
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- Duke University
OSTEOARTHRITIS
Safety and Effectiveness of Agilus (Hyaluronic Acid) for Ankle Osteoarthritis
The purpose of this study is to determine whether Agilus is safe and effective in the treatment of mild to moderate ankle osteoarthritis.
- Trial name
- NCT00642382
- Testing
- Agilus, Normal saline
- Where
- 19 sites in United States
- Volunteers
- 17 people
- Sponsor
- Cartiva, Inc.
Multiple Sclerosis
Effectiveness of Ankle Foot Orthoses on Gait in Multiple Sclerosis
The purpose of this study is to investigate the impact of a specifically designed ankle foot orthosis (AFO, hinged, with tamarack joint and adjustable check strap) on the spatial and temporal gait parameters, electromyography…
- Trial name
- NCT01796860
- Testing
- AFO
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Texas Southwestern Medical Center
Pain
Effectiveness of Perineural Clonidine as an Adjuvant With Ropivacaine for Popliteal Nerve Block in Patients Undergoing Foot and Ankle Surgery
Nerve blocks are used to decrease the amount of pain you have after surgery. We are asking you to take part in a research study.
- Trial name
- NCT01986751
- Testing
- Clonidine, ropivacaine
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- University of Alabama at Birmingham
Orthopedic Disorder, Trauma
An Imaging Framework for Clinically Testing New Treatments to Prevent Post-traumatic OA
The immediate goal of the proposed research is to test the value of a new low-cost, low-dose standing CT system for efficient early detection of both joint degeneration and elevated contact stress.
- Conditions
- Orthopedic Disorder, Trauma, Ankle Fractures, Post-traumatic Osteoarthritis
- Trial name
- NCT03809520
- Testing
- pedCAT
- Where
- United States
- Volunteers
- 97 people
- Sponsor
- J L Marsh
Spider Veins
A Clinical Evaluation of the Treatment of Spider Veins on the Ankles
To evaluate the safety and effectiveness of the Excel V system for the treatment of lower extremity spider veins on the ankles.
- Trial name
- NCT02754479
- Testing
- Nd:YAG laser
- Where
- United States
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- Cutera Inc.
Sarcopenia
Ankle Assistance and Resistance in Older Adults
The goal of this research protocol is to improve mobility in older individuals through advances in wearable assistive devices by focusing on two specific aims.
- Trial name
- NCT06284525
- Testing
- Ankle resistance and biofeedback
- Where
- United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Northern Arizona University
Adult ALL, Healthy
Iterative Design of Custom Dynamic Orthoses
The proposed study evaluates the effect of carbon fiber brace design on forces across the ankle joint. It is expected that carbon fiber braces can be designed to reduce forces in the ankle.
- Trial name
- PRMRP-Norms (NCT04800510)
- Testing
- Carbon Fiber Custom Dynamic Orthosis (CDO)
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- University of Iowa
Ankle Osteoarthritis
Cryoneurolysis for Improvements in Pain, ADL and QOL in Patients With Ankle Osteoarthritis
This will be an open-label trial to describe the effects of cryoneurolysis with iovera° on symptom relief in patients with painful Kellgren-Lawrence (KL) grade 2-4 ankle osteoarthritis (OA).
- Trial name
- NCT03567187
- Testing
- iovera
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Kansas Medical Center
Pain
A Multicenter Efficacy Study of a Diclofenac+Menthol Gel in Subjects With Ankle Sprain
This Phase III pivotal efficacy study will assess efficacy and onset of pain relief of MFC51123 gel vs. placebo and MFC51123 gel vs.
- Trial name
- NCT02100670
- Testing
- 1% diclofenac sodium plus 3% menthol, 1% diclofenac sodium plus 0.09% menthol, 3% menthol
- Where
- 3 sites in Germany
- Volunteers
- 385 people
- Sponsor
- GlaxoSmithKline
Wound Heal, Necrotic Tissue Removal
A Clinical Evaluation of a Honey Impregnated Dressing at Removing Necrotic Tissue From Chronic Wounds
The purpose of this study is to evaluate the effectiveness of a honey-impregnated wound dressing at removing necrotic tissue in subjects with chronic foot or ankle wounds.
- Trial name
- NCT03412929
- Testing
- Honey Impregnated Dressing
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Medline Industries
Pain, Postoperative, Ankle Fractures
Efficacy of Multimodal Periarticular Injections in Operatively Treated Ankle Fractures
The purpose of this study is to determine the efficacy and safety of a peri-articular multimodal injection for post-operative pain control following operative management of closed, rotational ankle fractures.
- Trial name
- NCT02967172
- Testing
- Ropivacaine, Epinephrine, Morphine
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Iowa