Clinical trials: Anorectal Disorders
Bowel Cleansing Prior to Clinical Procedures, Colorectal Anastomosis
Oral Antibiotics vs. No Antibiotics in Pediatric Colorectal Surgery
This study aims to evaluate whether giving oral antibiotics before elective colorectal surgery can improve recovery and reduce complications in children.
- Trial name
- PEACO (NCT07713433)
- Testing
- oral antibiotics, No Oral Antibiotics
- Where
- Pakistan
- Volunteers
- 74 people
- Sponsor
- Muhammad Zubair Shoukat
Rectal Prolapse, Procidentia
An International Double Cohort Study to Compare Laparoscopic Ventral Rectopexy With Laparoscopic Resection Rectopexy
Background: Rectal prolapse (RP) is the descent of the upper rectum and is a common problem in the western world. Surgery is the only definite treatment and is preferably performed minimally invasive.
- Trial name
- LaProS (NCT01595412)
- Testing
- Laparoscopic Resection Rectopexy, Laparoscopic Ventral Rectopexy
- Where
- 6 sites in United States
- Volunteers
- 2 people
- Sponsor
- The Cleveland Clinic
Anal Cancer, Colorectal Cancer
Anal Sphincter Prosthesis in Treating Patients Who Are Undergoing Surgery for Anal or Rectal Cancer
RATIONALE: An anal sphincter prosthesis may replace the need for a permanent colostomy and may improve the quality of life of patients who are undergoing surgery for anal or rectal cancer.
- Conditions
- Anal Cancer, Colorectal Cancer, Perioperative/Postoperative Complications
- Trial name
- NCT00059891
- Testing
- conventional surgery, management of therapy complications
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Anorectal Malformation
Long-term Outcome in Patients With Anorectal Malformations
Background Anorectal malformations(ARM) are rare and cover congenital defective development of rectum. ARM include a range of congenital conditions and may in varying degrees involve the anorectum.
- Trial name
- LOPAM (NCT02624232)
- Volunteers
- 60 people
- Sponsor
- Odense University Hospital
Outpatients, General Surgery
Comparing the Effects of Levobupivacaine and Bupivacaine in Saddle Spinal Anesthesia
İn this study; it was aimed to investigate the effects of equipotent doses of hyperbaric bupivacaine and hyperbaric levobupivacaine in outpatient anorectal surgery under saddle block.
- Conditions
- Outpatients, General Surgery, Anorectal Disorder, Anesthesia
- Trial name
- NCT04245774
- Testing
- Levobupivacaine (as Levobupivacaine Hydrochloride) 75 Mg/10 mL Solution for Injection Ampoule, Bupivacaine/Dextrose
- Volunteers
- 60 people
- Sponsor
- Gazi University
Hemorrhoids, Hemorrhoid Pain
Preoperative Micronized Flavonoid Fraction (MFF) Use in Multimodal Anesthesia in Anorectal Surgery
Aim: To assess the efficiency of the micro-flavonoid fraction (MMF) administration prior to anorectal surgery with spinal anesthesia on postoperative pain severity reduction.
- Conditions
- Hemorrhoids, Hemorrhoid Pain, Hemorrhoidal Bleeding
- Trial name
- NCT05772351
- Testing
- micronized flavonoid fraction
- Where
- Russia
- Volunteers
- 182 people
- Sponsor
- Center of Endourology "Endocenter"
Ulcerative Colitis
Anal Manometry Examination in Patients With Ulcerative Colitis
Inflammatory bowel diseases (IBD), which include Crohn's disease (CD) and ulcerative colitis (UC), are chronic immune-related diseases.
- Trial name
- NCT05488041
- Testing
- Performing anorectal manometry
- Where
- Israel
- Volunteers
- 150 people
- Sponsor
- Assaf-Harofeh Medical Center
Cystic Fibrosis
Urinary and Anorectal Functional Disorders and Their Impact on CF Adults (PerineoMucoRMO)
This observational study evaluates prevalence of functional perinea disorders (stress urinary incontinence, overactive bladder syndrome, dysuria, anal incontinence) on CF adults patients of the North-West CF Network.
- Trial name
- PerineoMuco (NCT02894619)
- Where
- 6 sites in France
- Volunteers
- 180 people
- Sponsor
- Fondation Ildys
Hemorrhoids, Anal Fistula
Could Preoperative Assessment of Physical and Psychological Status Help Predict Pain After Anorectal Surgery?
The aim of this single-center prospective observational trial is to study the influence of physical and psychological factors on the intensity of pain syndrome after anorectal interventions and to determine the association…
- Conditions
- Hemorrhoids, Anal Fistula, Anal Fissure, Incontinence
- Trial name
- NCT06049524
- Where
- Russia
- Volunteers
- 200 people
- Sponsor
- Center of Endourology "Endocenter"
Cervical Cancer
Nerve Sparing Radical Hysterectomy VS Radical Hysterectomy: Safety and Clinical Efficacy
Cervical cancer in young patients increased significantly in recent years, and early surgical treatment for patients with 5 years of survival rate is as high as 90%, But the traditional extensive hysterectomy (RH) caused by…
- Trial name
- NCT03069040
- Testing
- nerve sparing radical hysterectomy, radical hysterectomy
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Chen Chunlin
Anorectal Fistulas
A Prospective, Multi-center, Observational Study of the Use of Permacol™ Collagen Paste to Treat Anorectal Fistulas
This will be a prospective, multi-center, post-market, single arm observational study to collect clinical outcome data on the use of Permacol™ Collagen Paste in the treatment of anorectal fistulas.
- Trial name
- NCT01624350
- Testing
- Permacol collagen paste
- Where
- 10 sites in Denmark, Italy and 1 more
- Volunteers
- 100 people
- Sponsor
- Medtronic - MITG
Fecal Incontinence (FI), Anorectal Malformations
Effectiveness of Electrical Stimulation and Biofeedback on Fecal Incontinence in Children With Repaired Anorectal Malformation
This study aimed to investigate and compare the effect of electrical stimulation and biofeedback with electrical stimulation alone on fecal incontinence in children with repaired imperforate anus, with ages from 6 to 10 years.
- Trial name
- NCT07366476
- Testing
- behavioral therapy, biofeedback, electrical stimulation
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Sinai University
Normal Subjects, Fecal Incontinence
Trial to Evaluate Fecobionics in Fecal Incontinence (FI) (NORMAL and ABNORMAL-FI)
The objective is to determine the length-tension properties of the anal sphincters using Fecobionics in normal subjects and FI patients during anal distension and during simulated evacuation.
- Trial name
- NCT05412069
- Testing
- Fecobionics
- Where
- 2 sites in United States
- Volunteers
- 155 people, healthy volunteers welcome
- Sponsor
- The California Medical Innovations Institute, Inc.
Anorectal Malformations
Frequency of Vertebrospinal Anomalies in Patients Presenting With Anorectal Malformations
To determine the frequency of different vertebrospinal anomalies in patients with ARM
- Trial name
- NCT06234020
- Testing
- To see the frequency of vertebrospinal anomalies in patients presenting with Anorectal Malformation
- Where
- Pakistan
- Volunteers
- 106 people
- Sponsor
- Shaheed Zulfiqar Ali Bhutto Medical University
Vestibular Fistulae
Rectovestibular Fistula Which Surgical Approaches?
This study was a prospective, randomized, comparative study that included female children with rectovestibular fistulae who were selected from patients with anorectal malformations treated at the pediatric surgical unit, Assiut…
- Trial name
- Vestibanus (NCT04970160)
- Testing
- TSARP, PSARP, Classic ASARP
- Volunteers
- 84 people
- Sponsor
- Aswan University Hospital
Anorectal Disorder
The Guarding Reflex Anal, Study of the Modulation Function of Rectal Distension
The term Guarding Reflex refers to a progressive, involuntary increase in the external urethral sphincter activity during bladder filling.This is a mechanism of continence, preventing from unwanted urine leakage in situation of…
- Trial name
- NCT04409054
- Testing
- Cough and Valsalva effort
- Where
- France
- Volunteers
- 10 people
- Sponsor
- Gérard Amarenco
Constipation
Hypnosis for Children Undergoing Anorectal Manometry
Partially blinded randomized controlled trial investigating the effect of a brief session of hypnosis prior to anorectal manometry in children
- Trial name
- NCT04471857
- Testing
- Hypnosis
- Volunteers
- 34 people
- Sponsor
- Nationwide Children's Hospital
Bowel Dysfunction
Bowel Function and Associated Risk Factors for Bowel Dysfunciton in Patients With Anorectal Malformation
The present study was designed to evaluate bowel function in preschool and early childhood in a large number of patients with anorectal Malformation and to identify the associated risk factors for bowel dysfunction.
- Trial name
- NCT05716230
- Testing
- bowel function score questionnaire survey
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Nanjing Children's Hospital
Anorectal Malformation
Role of (Saline- Glycerin) Rectal Enema in Treatment of Fecal Incontinence in Children
Using saline glycerin mixture once daily in children with fecal incontinence to reach aclean child without fecal accidents the next day.
- Trial name
- NCT07392203
- Testing
- Rectal enema using saline and glycerin mixture once daily
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Sohag University
Acute Anal Fissure, Anal Pain
Efficacy and Safety of GTN vs. Nifedipine in Acute Anal Fissure: A Clinical Trial
The goal of this clinical trial is to compare the therapeutic efficacy and safety profile of Glyceryl Trinitrate (GTN) and Nifedipine ointments in the treatment of acute anal fissures in adults.
- Conditions
- Acute Anal Fissure, Anal Pain, Anorectal Disorders, Sphincter Spasm
- Trial name
- NCT06859554
- Testing
- Glyceryl Trinitrate (GTN) 0.2% Ointment, Glyceryl Trinitrate (GTN) 0.4% Ointment, Nifedipine 0.2% Ointment
- Where
- Pakistan
- Volunteers
- 110 people
- Sponsor
- Hafiz Muhammad Hamza