Clinical trials: Anterior Cerebral Circulation
Stroke, Ischemic, Infarction, Middle Cerebral Artery
Testing of Identification Markers for Stroke
Stroke is the third leading cause of death and the first cause of physical disability and dementia worldwide. Ischemic stroke caused by large vessel occlusion (LVO) is responsible for the vast majority of deaths and disabilities.
- Conditions
- Stroke, Ischemic, Infarction, Middle Cerebral Artery, Infarction, Anterior Circulation, Brain
- Trial name
- TIME (NCT04292600)
- Testing
- POCKiT diagnostics' algorithm for LVO detection
- Where
- 3 sites in United States
- Volunteers
- 383 people
- Sponsor
- POCKiT diagnostics Ltd
Pediatric Anesthesia
Variation of Cerebral Blood Flow in Anterior Cerebral and Basilar Artery in Neonates and Infants in Genreal Anesthesia With Caudal Block
With this study we want to see how the blood flow in the anterior cerebral artery (ACA) and the basilar artery (BA) after the caudal block changes.
- Trial name
- NCT02761954
- Volunteers
- 50 people
- Sponsor
- Bürgerhospital Frankfurt
Acute Stroke
Endovascular Revascularization With Solitaire Device Versus Best Medical Therapy in Anterior Circulation Stroke Within 8 Hours
To evaluate the hypothesis that mechanical embolectomy with the Solitaire FR device is superior to medical management alone in achieving favorable outcome in the distribution of the modified Rankin Scale scores at 90 days in…
- Trial name
- REVASCAT (NCT01692379)
- Testing
- Solitaire FR device, Medical treatment
- Where
- 4 sites in Spain
- Volunteers
- 206 people
- Sponsor
- Fundacio Ictus Malaltia Vascular
Randomized Controlled Trial, Intracranial Aneurysm
Comparison of Clipping Via Keyhole Versus Traditional Approaches and Coiling for Ruptured Aneurysms
Endovascular coiling has become a strategy of choice of intracranial aneurysms due to its minimally invasiveness. However, there has few prospective randomized controlled studies on the comparison of therapeutic effect between…
- Conditions
- Randomized Controlled Trial, Intracranial Aneurysm, Microsurgery, Endovascular Procedures
- Trial name
- NCT05049564
- Testing
- keyhole microneurosurgery, conventional microneurosurgery, endovascular coiling
- Volunteers
- 150 people
- Sponsor
- ZhuQing
Thrombectomy, Tandem Occlusion
Stent Implantation Versus Balloon Dilation for Acute Anterior Circulation Tandem Occlusion
1. To evaluate whether stent implantation on the ipsilateral extracranial segment, after intracranial thrombectomy successful recanalization compared with balloon angioplasty (eTICI≥2b_50) for acute anterior circulation tandem…
- Conditions
- Thrombectomy, Tandem Occlusion, Stroke
- Trial name
- START (NCT05902000)
- Testing
- Carotid Stenting, Thrombectomy, Dual antiplatelet treatment
- Where
- China
- Volunteers
- 222 people
- Sponsor
- Xueli Cai
Stroke, Acute Ischemic
Endovascular Thrombectomy With and Without Intravenous Thrombolysis in Extended Time Window
The primary hypothesis being tested in this trial is that ischemic stroke patients in large vessel occlusion of anterior circulation at 4.5 - 9 hours post onset of stroke will have improved clinical outcomes when given…
- Trial name
- NCT05634382
- Testing
- Intravenous thrombolysis agents, endovascular thrombectomy
- Where
- China
- Volunteers
- 222 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Acute Ischemic Stroke
Mechanical Thrombectomy of Acute Ischemic Stroke Anterior Circulation Distal Vessel Occlusion
Ischemic stroke continues to be of the leading causes of disability and death. Distal vessel occlusion one of most presenting and disabling varieties of ischemic stroke.
- Trial name
- NCT06427187
- Testing
- an array of devices are used in thrombectomy. These include guide catheters, stent-retrievers, microcatheters, aspiration catheters, and aspiration pump systems
- Volunteers
- 30 people
- Sponsor
- Assiut University
Acute Ischemic Stroke, Large Vessel Occlusion
Tenecteplase vs Medical Management in 4.5-24h LVO no Access to EVT
The goal of this clinical trial is to learn if tenectplase works to acute ischemic stroke (AIS) with onset 4.5-9 hours. It will also learn about the safety of tenectplase in AIS with onset 4.5-9 hours.
- Conditions
- Acute Ischemic Stroke, Large Vessel Occlusion, Tenecteplase, Thrombolysis
- Trial name
- TNK LATE (NCT07168278)
- Testing
- TNK, Standard medical treatment
- Where
- China
- Volunteers
- 794 people
- Sponsor
- The First Affiliated Hospital of University of Science and Technology of China
Mild Stroke, Acute Ischemic Stroke
Endovascular Treatment for Mild Stroke With Acute Anterior Circulation Large Vessel Occlusion
Exploring the Efficacy and Safety of Emergent Endovascular Treatment in Patients with Mild Ischemic Stroke Caused by Acute Anterior Circulation Large Vessel Occlusion based on Perfusion Imaging Screening
- Conditions
- Mild Stroke, Acute Ischemic Stroke, Endovascular Treatment, Perfusion Imaging
- Trial name
- NCT06179017
- Testing
- Experimental group:Intervention Group, Control group:best medical treatment
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Zhangzhou Municipal Hospital
Collateral Circulation, Large-artery Occlusion
Study of Collateral Circulation in Patients With Symptomatic Intracranial Anterior Circulation Occlusion
Intracranial artery stenosis is the leading cause of stroke onset or recurrence in Asian. Multiple studies have shown that anterior circulation is most common in intracranial artery stenosis, especially the middle cerebral artery…
- Conditions
- Collateral Circulation, Large-artery Occlusion, Cerebral Infarction
- Trial name
- NCT04091412
- Testing
- Butylphthalide Soft Capsules
- Where
- China
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- The Second Hospital of Hebei Medical University
Ischemia Stroke, Thrombectomy
Intra-arterial Methylprednisolone After Endovascular Thrombectomy
The purpose of IMPACT-LVO trial is to investigate the efficacy and safety of early adjunctive intra-arterial combined with intravenous administration methylprednisolone sodium succinate after successful endovascular thrombectomy…
- Conditions
- Ischemia Stroke, Thrombectomy, Large Vessel Occlusion
- Trial name
- IMPACT-LVO (NCT07516522)
- Testing
- The methylprednisolone sodium succinate group
- Where
- China
- Volunteers
- 210 people
- Sponsor
- Tang-Du Hospital
Stroke, Ischemic
RCT of Ghrelin in Stroke Patients
About half of the patients with acute ischemic stroke treated with endovascular thrombectomy (EVT) remain dependent on the help of others or die in the first 90 days.
- Trial name
- MR GENTLE (NCT05726240)
- Testing
- Ghrelin
- Where
- 3 sites in Netherlands
- Volunteers
- 80 people
- Sponsor
- Rijnstate Hospital
Acute Ischemic Stroke From Large Vessel Occlusion, Endovascular Thrombectomy
Efficacy and Safety of Plasma Adsorption Combined With EVT for AIS-LVO
The purpose of this study is to determine the efficacy and safety of plasma adsorption for patients of acute ischemic stroke who underwent endovascular thrombectomy due to large vessel occlusion of anterior circulation.
- Trial name
- PROMOTE-EVT (NCT07042490)
- Testing
- Plasma adsorption, Endovascular Thrombectomy
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Yi Yang
Cerebral Edema, Ischemic Stroke, Acute
A Trial of Adacolumn on Cerebral Edema After Anterior Circulation Ischemic Stroke
The primary objective is to investigate whether treatment with Adacolumn can ameliorate the progression of cerebral edema within 72 hours in patients with anterior circulation ischemic stroke.
- Conditions
- Cerebral Edema, Ischemic Stroke, Acute, Malignant Cerebral Edema, Anterior Circulation Brain Infarction
- Trial name
- NCT07386262
- Testing
- Adacolumn®, Standard Reperfusion Therapy, Standard Medical Management
- Where
- China
- Volunteers
- 10 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Acute Ischemic Stroke
Efficacy and Safety of Interleukin-6 Receptor Inhibitor Combined With Endovascular Treatment in Patients With Acute Anterior Circulation Large Vessel Occlusion Stroke -2
This study is a randomized, double-blind, placebo-controlled clinical trial. Investigators aim to assess the efficacy and safety of interleukin-6 receptor inhibitor combined with endovascular treatment in patients with acute…
- Trial name
- IRIS-2 (NCT07263776)
- Testing
- Tocilizumab
- Where
- 54 sites in China
- Volunteers
- 692 people
- Sponsor
- Capital Medical University
Acute Ichemic Stroke, Anterior Cerebral Artery Stroke
Safety and Efficacy of Baricitinib After Endovascular Treatment in Acute Anterior Circulation Large Vessel Occlusion: A Multicenter, Randomized Controlled Clinical Trial
The primary purpose of this study is to evaluate the efficacy and safety of Baricitinib combined with endovascular therapy in patients with acute anterior circulation large vessel occlusion, to address futile recanalization with…
- Conditions
- Acute Ichemic Stroke, Anterior Cerebral Artery Stroke, Baricitinib
- Trial name
- NCT07449910
- Testing
- 2mg Baricitinib, 4mg Baricitinib, Guideline-based therapy
- Where
- China
- Volunteers
- 750 people
- Sponsor
- The First Affiliated Hospital of University of Science and Technology of China
Stroke, Acute, Infarction, Middle Cerebral Artery
Autologous Bone Marrow Stem Cells in Ischemic Stroke.
The aim of the study is to determine the safety and tolerability of an autologous CD34+ subset bone marrow stem cell infusion into the middle cerebral artery in patients who have suffered acute total or partial anterior…
- Trial name
- NCT00535197
- Testing
- Infusion of autologous CD34+ stem cells into middle cerebral artery
- Where
- United Kingdom
- Volunteers
- 5 people
- Sponsor
- Imperial College London
Behcet Syndrome
Neuro-ultrasound Assessment in Behcet's Disease
Assessment of structural changes that occur in large extracranial and intracranial arteries in patients with Behcet's disease
- Trial name
- NCT04738864
- Testing
- ultrasound
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Assiut University
Stroke, Acute Ischemic
Tirofiban for Successful Endovascular Stroke Thrombectomy
Up to 50% of acute ischemic stroke patients with large vessel occlusion failed to achieve functional independence even after successful reperfusion therapy, a phenomenon that is referred to as "futile recanalization".
- Trial name
- ADJUVANT-2 (NCT06373042)
- Testing
- Intraarterial and intravenous tirofiban
- Volunteers
- 712 people
- Sponsor
- Zhongming Qiu
Ischemic Stroke, Acute, Thrombectomy
CO2 Modulation in Endovascular Thrombectomy for Acute Ischemic Stroke
Acute ischemic stroke due to large vessel occlusion is responsible of cerebral blood flow impairment with a progressive and extensive ischemic process.
- Conditions
- Ischemic Stroke, Acute, Thrombectomy, Anesthesia, General, Cerebrovascular Circulation
- Trial name
- COMET-AIS (NCT05051397)
- Testing
- HYPERCAPNIA, NORMOCAPNIA
- Where
- France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Clermont-Ferrand