Clinical trials: Anti-bacterial Agents
HIV Infections
Effects on the Immune System of Anti-HIV Drugs in Patients Recently Infected With HIV
The purpose of this study is to find out whether these powerful combinations of anti-HIV drugs are safe and effective for use in patients in the early stages of HIV infection and to find out how patients' immune systems react to…
- Trial name
- NCT00001119
- Testing
- Tetanus Toxoid Vaccine, Indinavir sulfate, Lamivudine/Zidovudine
- Where
- 12 sites in United States, Australia
- Volunteers
- 288 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Antibiotic-Associated Diarrhea
Probiotics for Prevention of Antibiotic-associated Diarrhea
The purpose of this study is to evaluate if ingestion of a probiotic formula (Jarrow-Dophilus EPS)reduces incidence of diarrhea and improves the quality of life of patients receiving antibiotic therapy.
- Trial name
- NCT00641199
- Testing
- Jarro-Dophilus EPS probiotics
- Where
- Canada
- Volunteers
- 204 people
- Sponsor
- University of Saskatchewan
Urinary Tract Infections, Pyelonephritis
Doripenem in the Treatment of Complicated Lower Urinary Tract Infection or Pyelonephritis
The purpose of this study is to compare the microbiological cure rate of doripenem versus a comparator antibiotic in the treatment of patients with complicated urinary tract infection or pyelonephritis.
- Trial name
- NCT00229021
- Testing
- doripenum
- Volunteers
- 741 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Hidradenitis Suppurativa
An Open-label, Single-arm Study to Evaluate Pharmacokinetics and Safety of Subcutaneous Sonelokimab in Adolescents With Moderate to Severe Hidradenitis Suppurativa (VELA-TEEN)
This is a study to evaluate the pharmacokinetic (PK) and safety of sonelokimab in adolescent patients with HS.
- Trial name
- NCT06768671
- Testing
- Sonelokimab
- Where
- 18 sites in United States
- Volunteers
- 35 people
- Sponsor
- MoonLake Immunotherapeutics AG
Newborn; Infection, Disinfection
Preoperative Antiseptic in Newborn Circumcision Comparison of Povidone Iodine and Hypochlorous Acid Used
Comparison of Povidone iodine and Hypochlorous acid used as a Preoperative Antiseptic in Newborn Circumcision abstract Aim: Circumcision is one of the most common surgical procedures in all age groups.
- Conditions
- Newborn; Infection, Disinfection, Circumcision
- Trial name
- NCT05175027
- Testing
- hypochlorous acid
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Hisar Intercontinental Hospital
Kerosene Pneumonitis
Antibiotic Efficacy in Pneumonitis Following Paraffin (Kerosene) Ingestion in Children
Paraffin (kerosene) ingestion in the developing world accounts for a large number of visits to healthcare facilities, especially amongst children.
- Trial name
- NCT01253980
- Testing
- Amoxicillin
- Where
- South Africa
- Volunteers
- 74 people
- Sponsor
- University of Cape Town
Candidemia, Mycoses
Study of Rezafungin Compared to Caspofungin in Subjects With Candidemia and/or Invasive Candidiasis
The purpose of this pivotal study is to determine if intravenous Rezafungin is efficacious and safe in the treatment of candidemia and/or invasive candidiasis when compared to caspofungin (followed by optional oral fluconazole).
- Conditions
- Candidemia, Mycoses, Fungal Infection, Invasive Candidiases
- Trial name
- ReSTORE (NCT03667690)
- Testing
- Rezafungin for Injection, Caspofungin, Fluconazole
- Where
- 132 sites in United States, Argentina and 16 more
- Volunteers
- 199 people
- Sponsor
- Cidara Therapeutics Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)
Infectious Disease
Perception of Smell and Taste During Antibiotic Treatment
Antibiotic use may be associated with effects on the perception of smell and taste. These effects are poorly known. The mechanisms can be very diverse, and the effect can be very variable depending on the type of antibiotic used…
- Trial name
- OGUSTA (NCT03893279)
- Testing
- Smell and Taste and questionnaire
- Where
- France
- Volunteers
- 3 people
- Sponsor
- Hospices Civils de Lyon
Antibiotic-associated Diarrhea
Evaluation of Butyrate Effect on Diarrhea
The goal of this clinical trial is to evaluate the effects of a Food Supplement containing calcium butyrate, vitamin D, and zinc, on the variation of intestinal microbiota and prevention of antibiotic-induced diarrhea, in…
- Trial name
- DBZ (NCT06982703)
- Testing
- Food Supplement DBZ (acronym for: DIBUZIN) containing calcium butyrate, vitamin D and zinc,
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- University of Padova
Common Infections, Urinary Tract Infections
Dissemination and Implementation of a Videoconference Antimicrobial Stewardship Team
Antimicrobial-resistant and healthcare-associated pathogens are a global health threat. The goals of antimicrobial stewardship are to minimize unnecessary and inappropriate antimicrobial use as a means to combat antimicrobial…
- Conditions
- Common Infections, Urinary Tract Infections, Pneumonia
- Trial name
- VAST (NCT05319561)
- Testing
- Antibiotic Use Report
- Where
- 2 sites in United States
- Volunteers
- 8 people
- Sponsor
- VA Office of Research and Development
Healthy
Pediatric Taste Test Study of Cefdinir (Omnicef) Versus Amoxicillin Antibiotic Suspension Medications
To compare the taste and smell acceptability scores of cefdinir (Omnicef) versus amoxicillin oral antibiotic suspension medications in pediatric subjects.
- Trial name
- NCT00644891
- Testing
- cefdinir (Omnicef), amoxicillin
- Where
- 3 sites in United States
- Volunteers
- 158 people, healthy volunteers welcome
- Sponsor
- Abbott
Hip Prosthesis Infection, Arthroplasty Complications
DAIR for Infected Total Hip Arthroplasty - Does the Operative Approach Influence the Functional Result?
The functional outcome and quality of life after treatment for an infected hip arthroplasty have been found to be significantly worse compared to an uncomplicated arthroplasty.
- Trial name
- NCT03161990
- Testing
- Transgluteal approach to the hip joint, Posterior approach to the hip joint
- Where
- Norway
- Volunteers
- 226 people
- Sponsor
- University Hospital, Akershus
Urinary Tract Infections
Short Therapy for Febrile UTI in Childhood
Febrile urinary tract infections (UTIs) are common in children, but there is no consensus concerning the duration of the antibiotic treatment.
- Trial name
- NCT04400110
- Testing
- Amoxicillin and Clavulanic Acid in Oral Dose Form
- Where
- 13 sites in Italy
- Volunteers
- 154 people
- Sponsor
- IRCCS Burlo Garofolo
Implementation of OPAT in Germany
German Register of Outpatient Parenteral Antibiotic Therapy
Many infectious diseases require a therapy that is administered intravenously due to a lack of oral treatments. Affected patients often have to stay weeks or even months in hospital just for receiving their therapy although they…
- Trial name
- OPATReg (NCT04413396)
- Testing
- Outpatient Parenteral Antibiotic Therapy
- Where
- Germany
- Volunteers
- 600 people
- Sponsor
- University of Cologne
Infertile Women Undergoing IVF or ICSI
Postbiotic Intervention on Vaginal Microbiota
This study investigates the effects of postbiotic intervention on vaginal microbiota in infertile patients. Using a pre-post test design, we will enroll 15 women aged 30-45 years with at least two IVF failures.
- Trial name
- NCT07278024
- Testing
- postbiotics
- Where
- Taiwan
- Volunteers
- 15 people
- Sponsor
- Kaohsiung Veterans General Hospital.
Antibiotic Resistant Infection
Opportunities for Antibiotic Optimisation and Outcomes Improvement in Patients With Negative Blood Culture (NO-BACT)
Patients with negative blood cultures represent 85-90 % from all patients with a blood culture taken during hospital admissions.
- Trial name
- NO-BACT (NCT03535324)
- Testing
- PROA for optimization, Control
- Where
- 3 sites in Spain
- Volunteers
- 659 people, healthy volunteers welcome
- Sponsor
- Fundación Pública Andaluza para la gestión de la Investigación en Sevilla
Diabete Type 2
Effect of Diode Laser, Gudmar and Vinegar in Diabetic Patients During Root Canal Treatment
Methodology Patient with diabetes 2 with informed consent -convenience sampling over a one year period.The tooth isolated with a rubber dam and the correct disinfection procedures will be used.
- Trial name
- NCT07549373
- Testing
- 940 nm diode laser, apple cider vinegar, Gymnema Sylvestre
- Where
- India
- Volunteers
- 90 people
- Sponsor
- Sharda University
Cystic Fibrosis, Lung Infection Bacterial
Clinical Performance of the AtbFinder® Test System for Selection of Antibiotic Therapy in Persons With Cystic Fibrosis
This prospective case-control study was planned to evaluate the efficacy of antibiotic therapy selected with the AtbFinder® in persons with cystic fibrosis.
- Trial name
- NCT05584982
- Testing
- AtbFinder
- Volunteers
- 35 people
- Sponsor
- TGV-Dx
Sepsis
Comparison Between Carbapenems and Noncarbapenem Beta-lactam Antibiotics in Septic Burn Patients
The aim of this work is to evaluate the efficacy associated with Meropenem(example of carbapenems) as initial therapy for sepsis in burn patients compared with Pipracillin/Tazobactam (example of non carbapenem beta lactam…
- Trial name
- NCT07096310
- Testing
- Meropenem I.V. 2g as a 3 hour infusion every 8 hours, Tazocin (pipercillin/tazobactam)
- Where
- Egypt
- Volunteers
- 400 people
- Sponsor
- Ain Shams University
Infection
Antimicrobial PK in Infants With Suspected or Confirmed Infection
The purpose of this protocol is to provide a mechanism for the ongoing collection of blood and urine samples in newborns that will be used to measure levels of antimicrobial products used in the newborn population where there are…
- Trial name
- NCT00491426
- Testing
- Ampicillin, Metronidazole, Piperacillin/Tazobactam
- Where
- 6 sites in United States
- Volunteers
- 450 people
- Sponsor
- Duke University
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