Clinical trials: Anti-bacterial Agents
Sinusitis
Maxillary Sinus Irrigation in the Management of Chronic Rhinosinusitis
The purpose of this study is to evaluate the effectiveness of maxillary sinus saline irrigation in conjunction with systemic antibiotic therapy versus systemic antibiotic therapy alone in the management of chronic rhinosinusitis…
- Trial name
- NCT00335309
- Testing
- Maxillary Sinus Irrigation, IV Amoxicillin and Clavulanate acid
- Where
- Israel
- Volunteers
- 50 people
- Sponsor
- Ohad Ronen
Respiratory Tract Infections, Urinary Tract Infections
Intervention Study to Improve Antibiotic Prescription in Outpatient Care
Antimicrobial resistance has become a world-wide problem and antibiotic consumption is a major driving force for the development of resistance.
- Trial name
- SAPI (NCT01358916)
- Testing
- Mailing of antibiotic therapy guidelines to the sentinel physicians
- Where
- Switzerland
- Volunteers
- 140 people
- Sponsor
- University of Bern
Acute Respiratory Infections, Febrile Illnesses
The Fever Clinic Acute Respiratory Cohort
This prospective cohort study aims to characterize the natural progression and outcomes of acute respiratory infections among patients presenting to fever clinics.
- Conditions
- Acute Respiratory Infections, Febrile Illnesses, Community-acquired Pneumonia, Viral Respiratory Tract Infections
- Trial name
- FACTS (NCT07278700)
- Testing
- No intervention involved
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Fudan University
Infection
Intravenous Antibiotic Treatment at Home
The purpose of the study is to develop and evaluate a new model for across services interaction with the use of welfare technology and telemedicine.
- Trial name
- Hosp@Home (NCT04898452)
- Testing
- A new model of interaction across health services with use of welfare technology and telemedicine
- Where
- Norway
- Volunteers
- 19 people
- Sponsor
- Helse Møre og Romsdal HF
Sepsis, Sepsis Bacterial
Molecular Culture for the Diagnosis of Pediatric Sepsis
Babies and children have an increased risk of getting an infection with a bacteria in the bloodstream (sepsis). It is often difficult for the doctor to determine whether a child has an infection of the bloodstream, because the…
- Conditions
- Sepsis, Sepsis Bacterial, Sepsis, Neonatal, Infection, Bacterial
- Trial name
- CHAMPIONS (NCT06018792)
- Testing
- Molecular Culture
- Where
- 2 sites in Netherlands
- Volunteers
- 1,835 people
- Sponsor
- Jip Groen
Impacted Tooth, Postoperative Complications in Maxillofacial Surgery
Effectiveness of Postoperative Topical and Oral Antibiotics on Impacted Mandibular 3rd Molar Surgery.
This randomized controlled trial evaluates the effectiveness of postoperative topical antibiotics compared with oral antibiotics in patients undergoing surgical extraction of impacted mandibular third molars.
- Conditions
- Impacted Tooth, Postoperative Complications in Maxillofacial Surgery, Surgical Wound Infection, Facial Pain
- Trial name
- POTA-M3S (NCT07573033)
- Testing
- Topical Antibiotic, Oral antibiotic therapy
- Where
- Pakistan
- Volunteers
- 90 people
- Sponsor
- Liaquat College of Medicine and Dentistry
Pulp Necrosis
Lesion Sterilization and Tissue Repair Antibiotic Paste Versus Zinc Oxide and Eugenol Pulpectomy for Treatment of Primary Molars With Pulp Necrosis
The goal of this clinical trial is to compare the efficacy of lesion sterilization and tissue repair (LSTR) antibiotic paste versus zinc oxide eugenol (ZOE) pulpectomy for the treatment of primary molars with pulp necrosis in…
- Trial name
- LSTR (NCT07475364)
- Testing
- Group A - LSTR Therapy (CTZ Paste), Group B - ZOE Pulpectomy
- Volunteers
- 180 people
- Sponsor
- University of Faisalabad
Bacterial Infection With One or More Extended Spectrum Betalactamases Remaining Susceptible to Temocillin
Study of Adverse Effects Occuring in Patients Receiving an Antibiotic Treatment With Temocillin
The Temocillin prescription frequency may be increased in order to reduce the use of carbapenems to reduce the progressive increase in carbapenem resistance observed in recent years.
- Trial name
- Témocilline (NCT03599999)
- Testing
- Adverse events detection
- Where
- France
- Volunteers
- 26 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Fractures, Open, Fractures, Closed
LOQTEQ® Antibacterial Pre-Market Study
aap001 is a randomized, controlled, subject-blinded, multi-center study to show the safety of the LOQTEQ® antibacterial silver-coated system is non-inferior in comparison with the uncoated LOQTEQ® system
- Conditions
- Fractures, Open, Fractures, Closed, Surgical Site Infection, Fracture of Fibula
- Trial name
- NCT05260463
- Testing
- Implantation
- Where
- 13 sites in Germany
- Volunteers
- 203 people
- Sponsor
- aap Implantate AG
Pneumonia, Urinary Tract Infection
Reducing Overuse of Antibiotics at Discharge Home
The goal of this two-arm parallel cluster-randomized trial of 40 hospitals is to test the effectiveness of the ROAD Home Intervention on days of antibiotic overuse at discharge in patients hospitalized with community-acquired…
- Conditions
- Pneumonia, Urinary Tract Infection, Antibiotic Stewardship, Care Transition
- Trial name
- ROAD Home (NCT06106204)
- Testing
- ROAD Home Intervention
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Utah
Antimicrobial Stewardship, Antimicrobial Drug Resistance
Peer Comparison Feedback As An Antimicrobial Prescribing Intervention To General Medicine Specialists
The purpose of this study is to evaluate the effect of a peer comparison feedback report, combined with a best practices toolkit, on the volume of antimicrobial use by general medicine physicians.
- Trial name
- PEER AIMS (NCT07189364)
- Testing
- Peer Comparison Feedback Report
- Where
- Canada
- Volunteers
- 650 people, healthy volunteers welcome
- Sponsor
- Fahad Razak
Acute Pyelonephritis Without Severity Symptoms Due to ESBL-producing E.Coli
Efficacy and Pharmacokinetic/Pharmacodynamic Parameters of Cefoxitin in Women With Acute Pyelonephritis Without Severity Symptoms Due to Extended-spectrum β-lactamase Producing Escherichia Coli
Escherichia coli is the primary cause of urinary tract infections and Gram-negative bacteremia worldwide. Since the early years of the 21st century, E.coli has acquired a new mechanism of resistance to antibiotics: extended…
- Trial name
- FOXICOLI (NCT01820793)
- Testing
- Cefoxitin
- Where
- France
- Volunteers
- 9 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Pneumonia, Bacterial
PROcalcitonin Impact on Antibiotic Reduction, adverSe Events and AVoidable healthcarE Costs (ProSAVE): A RCT
Trials comparing PCT-guided antibiotic algorithms to standard management show a significant reduction in antibiotic exposure without an increase in mortality or treatment failure.
- Trial name
- ProSAVE (NCT04158804)
- Testing
- procalcitonin
- Where
- 6 sites in United States
- Volunteers
- 700 people
- Sponsor
- Massachusetts General Hospital
Respiratory Virus Infection, Fever of Unknown Origin
Rapid Viral Diagnostics in Adults to Reduce Antimicrobial Consumption and Duration of Hospitalization
Viral respiratory infections are common and often require use of health care resources. Patients receive inappropriate bacterial antibiotics, which has many problems including side-effects, development of resistance and costs.
- Conditions
- Respiratory Virus Infection, Fever of Unknown Origin, Dyspnea, Chest Pain
- Trial name
- NCT02538770
- Testing
- Rapid diagnostics using Anyplex TMII RV16 Detection, Delayed diagnostics Anyplex TMII RV16 Detection
- Where
- 2 sites in Finland
- Volunteers
- 900 people
- Sponsor
- University of Oulu
Diarrhea
Azithromycin, With or Without Loperamide, to Treat Travelers' Diarrhea
In a previous study azithromycin proved as efficacious as levofloxacin in the treatment of travelers' diarrhea in Mexico. Because the addition of loperamide to some antibiotics (e.g., trimethoprim-sulfamethoxazole and ofloxacin)…
- Trial name
- NCT00359970
- Testing
- Azithromycin 500 mg, Azithromycin 1000 mg, Loperamide
- Where
- Mexico
- Volunteers
- 176 people
- Sponsor
- The University of Texas Health Science Center, Houston
Modality of Discharge Instructions
Effect of Modality on Discharge Instruction in Patients Receiving Outpatient Antibiotic Prescriptions From the Emergency Department
Outpatient antibiotics are frequently prescribed from the emergency department, and limited health literacy may impact compliance with recommended treatments.
- Trial name
- NCT01775969
- Testing
- Text Message, Voicemail
- Where
- United States
- Volunteers
- 2,874 people
- Sponsor
- Hennepin Healthcare Research Institute
Bacterial Infections
An Evaluation of a Antimicrobial Stewardship Recommendation Bundle for Staphylococcus Aureus Bloodstream Infections
In July 2020, a bundle (Appendix C) was implemented at Methodist Dallas Medical Center where all patients with SAB were reviewed by the antimicrobial stewardship pharmacist (Monday - Friday from 0700 to 1500), a note outlining…
- Trial name
- NCT06211829
- Where
- United States
- Volunteers
- 77 people
- Sponsor
- Methodist Health System
Cholangitis
Antibiotics to Decrease Post ERCP Cholangitis
Endoscopic retrograde cholangiopancreatography (ERCP) is an endoscopic procedure used to treat bile duct stones, obstructive jaundice, biliary leaks, and a variety of other conditions.
- Trial name
- NCT03087656
- Testing
- Ceftriaxone, Levofloxacin
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- University of Southern California
Microbiota, Anti-bacterial Agents
Healthy Patients & Effect of Antibiotics
The objective of this study is to evaluate the impact of antimicrobial (antibiotic) exposures on the microbiome in healthy adults, specifically during and after usual courses of the antimicrobials used to treat community acquired…
- Trial name
- NCT03098485
- Testing
- Levofloxacin, Azithromycin, Cefpodoxime
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Pulmonary Cystic Fibrosis, Neutralizing Antibodies
Characterization of Antibacterial Antibodies in Patients With Cystic Fibrosis
Most of the cystic fibrosis (CF) patients are or have been pulmonary colonized with bacteria such as Pseudomonas aeruginosa or Staphylococcus aureus.
- Trial name
- NCT04700358
- Testing
- Blood sampling
- Where
- Germany
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- University Hospital of Cologne
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.