Clinical trials: Anti-bacterial Agents
Atopic Dermatitis
Role of Antimicrobial Peptides in Host Defense Against Vaccinia Virus
Atopic dermatitis (AD) is a chronic inflammatory skin disorder characterized by recurrent viral skin infections. Recent studies have demonstrated that the skin of people with AD my have decreased antimicrobial peptide (AMP)…
- Trial name
- NCT00407069
- Where
- United States
- Volunteers
- 286 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Pneumonia
Cefepime vs. Ceftriaxone to Treat Nursing Home-Acquired Pneumonia
Randomized trial of nursing home residents with pneumonia to assess if intramuscular cefepime is a safe, efficacious, and cost-effective alternative to once daily intramuscular ceftriaxone for the treatment of elderly nursing…
- Trial name
- NCT00358202
- Testing
- cefepime, ceftriaxone
- Where
- United States
- Volunteers
- 69 people
- Sponsor
- CPL Associates
Periodontitis
Amoxicillin and Metronidazole During or After the Periodontal Treatment
This randomized clinical trial aimed to compare the clinical and microbiological effects of different times of administration of metronidazole (MTZ) and amoxicillin (AMX) in the treatment of periodontitis.
- Trial name
- NCT06177119
- Testing
- Scaling and root planing, Metronidazole during SRP, Amoxicillin during SRP
- Where
- Brazil
- Volunteers
- 72 people
- Sponsor
- Belén Retamal-Valdes
Complicated Skin and Skin Structure Infections
Efficacy and Safety Study of JNJ-32729463 for Treating Complicated Skin and Skin Structure Infections Compared to Linezolid (Zyvox)
The purpose of this study is to determine the clinical efficacy, safety, and tolerability of a 250 mg BID oral dose of JNJ-32729463 compared with linezolid in subjects with complicated skin and skin structure infections (cSSSIs).
- Trial name
- NCT01128530
- Testing
- JNJ-32729463, linezolid
- Where
- 27 sites in United States
- Volunteers
- 161 people
- Sponsor
- Furiex Pharmaceuticals, Inc
Out-of-hospital Cardiac Arrest
Prophylactic Antibiotics in Comatose Survivors of Out-of-hospital Cardiac Arrest
The purpose of this study is to determine whether there is potential benefits of prophylactic antibiotic treatment in comatose survivors of out-of-hospital cardiac arrest (OHCA) treated in intensive care unit with therapeutic…
- Trial name
- NCT02899507
- Testing
- Amoxicillin-Clavulanic acid
- Where
- Slovenia
- Volunteers
- 60 people
- Sponsor
- University Medical Centre Ljubljana
Nontuberculous Mycobacterial Lymphadenitis.
Comparison of Antibiotic Therapy Alone or Combined With Corticosteroids for the Treatment of Nontuberculous Mycobacterial Cervicofacial Lymphadenitis in Children: A Randomized Double-Blind Placebo-Controlled Study
Nontuberculous mycobacteriae (NTM) are a group of bacteria that typically cause infections of lymph nodes in the neck and face of otherwise healthy children. There are currently 3 strategies to manage these infections.
- Trial name
- NCT01614977
- Testing
- Methylprednisoline
- Sponsor
- Rabin Medical Center
Diabetic Foot Infection, Osteomyelitis
A Clinical Trial Testing the Efficacy of PDT in Preventing Amputation in Diabetic Patients
The feet of diabetic patients continue to be an important problem in medicine. In general, patients with diabetic foot have some sort of amputation, especially in underserved populations.
- Conditions
- Diabetic Foot Infection, Osteomyelitis, Photo Antimicrobial Chemotherapy
- Trial name
- NCT03380403
- Testing
- PDT, Ciprofloxacin
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Faculdade de Medicina do ABC
Skin Cancer, Skin Cancer Face
Nasal Iodine Swab Versus Oral Antibiotic to Prevent Surgical Site Infection After Undergoing Mohs Micrographic Surgery
The purpose of this study is to compare surgical site infection rates for patients treated with Mohs micrographic surgery after bilateral nasal swab with povidone iodine versus standard treatment including the use of a…
- Conditions
- Skin Cancer, Skin Cancer Face, Malignant Cutaneous Adnexal Neoplasm
- Trial name
- NCT06207786
- Testing
- Povidone-Iodine Swabs, Staphylococcus nasal swab, Antibiotic
- Sponsor
- Mayo Clinic
Surgery
Preoperative Chlorhexidine Gluconate (CHG) Cloth on Healthy Subjects
Evaluate the effects of Chlorhexidine Gluconate (CHG) cloth on the reduction of bacteria on the skin.
- Trial name
- NCT02222896
- Testing
- Chlorhexidine Gluconate, Vehicle, DynaHex-2
- Where
- United States
- Volunteers
- 347 people, healthy volunteers welcome
- Sponsor
- Medline Industries
Antibiotic Drug Resistance
Fecal ESBL Resurgence During Antibiotic Treatment
Norwegian hospitals are struggling to control spread of extended-spectrum beta-lactamase producing Enterobacteriaceae (ESBL-E) in health care settings.
- Trial name
- NCT03206879
- Volunteers
- 50 people
- Sponsor
- University Hospital, Akershus
Myelosuppression, Lactic Acidosis
Investigation of the Correlation Between Plasma Concentration of Linezolid Antibiotic and Treatment Response and Adverse Reactions
Linezolid is the second line agent in the treatment of MRSA and PRSP infections, and it is also the drug of choice for VRE infections.
- Conditions
- Myelosuppression, Lactic Acidosis, Peripheral Neuropathy
- Trial name
- NCT03126890
- Where
- Taiwan
- Volunteers
- 1,000 people
- Sponsor
- National Taiwan University Hospital
Ureteral Obstruction, Neoplasms
Antibiotic Prophylaxis in Percutaneous Nephrostomy Placements and Replacements for Malignant Urinary Tract Obstruction
This study aims to find out whether taking antibiotics to prevent a urinary tract infection after a medical procedure called percutaneous nephrostomy (placement of a catheter directly into the kidney to keep it working after the…
- Conditions
- Ureteral Obstruction, Neoplasms, Acute Kidney Injury, Nephrostomy; Complications
- Trial name
- NCT06801405
- Testing
- antibiotic prophylaxis
- Where
- Brazil
- Volunteers
- 320 people
- Sponsor
- Barretos Cancer Hospital
Scrub Typhus
Clinical Effectiveness of Tigecycline for Scrub Typhus.
This multicenter, randomized, open-label clinical trial evaluated the efficacy and tolerability of intravenous tigecycline compared with oral doxycycline in adults hospitalized with scrub typhus.
- Trial name
- NCT07513103
- Testing
- doxycycline, Tigecycline (Tygacil)
- Where
- 3 sites in South Korea
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Jin Soo Lee
Bronchiectasis
Bacterial Load Guided Therapy for Severe Bronchiectasis Exacerbations
From the British Thoracic Guidelines1 and a PUBMED search there are no randomised controlled trials exploring optimum antibiotic duration for chest infections.
- Trial name
- BLTBrIV (NCT02047773)
- Testing
- Duration, Colomycin, Meropenem
- Where
- United Kingdom
- Volunteers
- 90 people
- Sponsor
- University of Edinburgh
Drug Allergy
Multiple Drug Hypersensitivity Syndrome
Background: Multiple drug hypersensitivity syndrome (MDH) is defined as confirmed drug hypersensitivity reactions (DHRs) to at least 2 chemically and pharmacologically unrelated drugs.
- Trial name
- MDH (NCT03784482)
- Where
- France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Montpellier
Antimicrobial Agent, Cephalosporins
Effect of Ceftobiprole on Human Intestinal Microflora
The purpose of the study is to investigate the effect of ceftobiprole treatment on intestinal microflora in healthy volunteers.
- Conditions
- Antimicrobial Agent, Cephalosporins, Drug Resistance
- Trial name
- NCT00965042
- Testing
- Ceftobiprole
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Basilea Pharmaceutica
Infection With Multi-drug Resistant Organisms
FMT for Multidrug Resistant Organism Reversal
This proposed protocol involves the use of the fecal microbiota transplantation (FMT) to suppress or reverse colonization with multidrug resistant organisms (MDRO) in subjects with recurrent MDRO infections due to organisms of…
- Trial name
- NCT02312986
- Testing
- Fecal microbiota transplantation (FMT)
- Volunteers
- 1 people
- Sponsor
- Washington University School of Medicine
Cesarean Section; Complications, Wound, Dehiscence
The Role of Antimicrobial Foam Dressing in Prevention of Cesarean Section Wound Complications
Post-cesarean section wound infections are responsible for longer hospital stays, readmissions, and ultimately, increased costs to the healthcare system. Silver-containing dressings may prevent wound infections.
- Trial name
- NCT03136159
- Testing
- Silver-impregnated antimicrobial dressing
- Where
- United States
- Volunteers
- 380 people
- Sponsor
- Loyola University
Microbial Colonization
Effect of Antibiotics on Gut Microbiome and Plasma Metabolome
In recent years it has been observed that the gut microbiome can produce metabolites into systemic circulation and thus have important health effects even outside the gastrointestinal system.
- Trial name
- NCT03273296
- Testing
- Amoxicillin, Azithromycin, Vancomycin
- Where
- Finland
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Finnish Institute for Health and Welfare
Rosacea
Study to Evaluate the Safety and Efficacy of Topical Minocycline FXFM244 in Rosacea Patients
Acne rosacea is a chronic acneiform disorder affecting both the skin and the eye. It is a syndrome of undetermined etiology characterized by both vascular and papulopustular components involving the face and occasionally the neck…
- Trial name
- NCT01134991
- Testing
- Topical Minocycline Foam FXFM244
- Where
- Israel
- Volunteers
- 21 people
- Sponsor
- Vyne Therapeutics Inc.
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